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  • acute
  • Mitoxantrone is used to treat certain types of cancer, mostly metastatic breast cancer, acute myeloid leukemia, and non-Hodgkin's lymphoma. (wikipedia.org)
  • doses
  • The risk of heart damage may depend on the total amount of mitoxantrone given to a person over a lifetime, so your doctor will probably limit the total number of doses you receive if you are using this medication for MS. If you experience any of the following symptoms, call your doctor immediately: difficulty breathing, chest pain, swelling of the legs or ankles, or irregular or fast heartbeat. (empowher.com)
  • When mitoxantrone injection is used to treat MS, it is usually given once every 3 months for about 2 to 3 years (for a total of 8 to 12 doses). (empowher.com)
  • Additional doses of mitoxantrone should not be administered to multiple sclerosis patients who have experienced either a drop in LVEF to below the lower limit of normal or a clinically significant reduction in LVEF during mitoxantrone therapy. (nih.gov)
  • The purpose of this study is to show the dose-response relationship of three doses of mitoxantrone with regard to efficacy in patients with secondary progressive multiple sclerosis and to show the safety and tolerability of mitoxantrone in these patients. (clinicaltrials.gov)
  • docetaxel
  • Conjunctive treatment of prednisone with docetaxel has been shown to lead to improved survival rate as well as improved quality of life and reduction of pain compared with treatments with mitoxantrone. (wikipedia.org)
  • Congestive
  • Congestive heart failure (CHF), potentially fatal, may occur either during therapy with mitoxantrone or months to years after termination of therapy. (nih.gov)
  • Mitoxantrone may damage the heart and can cause congestive heart disease if taken over a long period of time. (mstrust.org.uk)
  • drugs
  • J. Cancer 82, 1300 (2000) A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone: J. Blasiak, et al. (scbt.com)
  • immune system
  • Mitoxantrone treats MS by stopping certain cells of the immune system from reaching the brain and spinal cord and causing damage. (empowher.com)
  • Mitoxantrone appears to work by suppressing the body's immune system for the period of treatment, depleting the number of cells that are attacking the myelin around nerves. (mstrust.org.uk)
  • As mitoxantrone suppresses the immune system, your white blood cell count is likely to fall, making you more prone to infections. (mstrust.org.uk)
  • vitro
  • Mitoxantrone has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNF╬▒, and IL-2. (nih.gov)
  • intercalates
  • Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. (nih.gov)
  • molecular
  • 49, 145 (2002) A molecular understanding of mitoxantrone-DNA adduct formation: effect of cytosine methylation and flanking sequences: B.S. Parker, et al. (scbt.com)
  • damage
  • PubMed 26333122) used Mitoxantrone as an inducer of double-strand breaks to bring new data about the subcellular distribution of proteins responding to DNA damage. (scbt.com)