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  • promotes
  • Here we show the spindle-associated protein FAM29A promotes MT-dependent MT amplification and is required for efficient chromosome congression and segregation in mammalian cells. (rupress.org)
  • TPX2
  • The small GTPase Ran plays a pivotal role in the process of spindle formation ( 9 ) by releasing target molecules ( 10 , 11 ) that promote microtubule stability, especially TPX2 ( 12 ), from inhibition by importin α/β receptors ( 13 ). (aacrjournals.org)
  • regulate
  • Other motors are required to tightly regulate microtubule behaviors in the mitotic spindle, and it is attractive to speculate that these motors might also help to regulate microtubule behaviors in the neuron. (jneurosci.org)
  • We suggest that Eg5 generates forces that help to regulate microtubule behaviors within the distal tips of developing axons and dendrites. (jneurosci.org)
  • This strategy is particularly important in cells such as neurons that must establish and regulate arrays of microtubules in locations far from their nucleation sites within the cell body. (jneurosci.org)
  • neurons
  • Here we show that a homolog of the mitotic kinesin-related motor known as Eg5 continues to be expressed in rodent neurons well after their terminal mitotic division. (jneurosci.org)
  • In neurons, Eg5 is directly associated with the microtubule array and is enriched within the distal regions of developing processes. (jneurosci.org)
  • kinase
  • Further data also suggest that BRCA1 is a potential target of the mitotic kinase Plk-1 after paclitaxel treatment. (theses.fr)
  • Puis, j'ai analysé sa régulation dans ces conditions et ai montré que la protéine kinase Chk2 phosphoryle BRCA1 sur la sérine 988 après dommages aux microtubules et ainsi module le rôle de BRCA1 dans la nucléation des microtubules. (theses.fr)
  • essential
  • In addition, microtubules are essential for vesicle transport, because vesicles use the microtubule network to meet and fuse with several different endocytic organelles ( Hehnly and Stamnes, 2007 ). (biologists.org)
  • Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). (uniprot.org)
  • Specifically, cytoplasmic dynein and the kinesin-related motor known as CHO1/MKLP1 are used within the mitotic spindle, and recent studies suggest that they are also essential for the establishment of the axonal and dendritic microtubule arrays of the neuron. (jneurosci.org)
  • Microtubules are essential for the differentiation of axons and dendrites. (jneurosci.org)