Mitotic regulatory proteins s phase kinase associated proteins. Medical search. Frequent questions

Polo-like kinases (Plks) are regulatory serine/threonin kinases of the cell cycle involved in mitotic entry, mitotic exit, spindle formation, cytokinesis, and meiosis. (wikipedia.org)
The catalytic serine/threonine kinase domain of Plk is at the N-terminus of the polo-like kinase protein. (wikipedia.org)
PBD has high affinity for proteins already phosphorylated at certain serine/threonine sites. (wikipedia.org)
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
Five members of the Plk family have been discovered in humans and these serine/threonine kinases have emerged as key players by performing crucial functions in the cell cycle, DNA damage response and neuron biology [ 2 - 6 ]. (oncotarget.com)
This protease activity has recently been ascribed to serine metalloprotease(s), including pregnancy-associated plasma protein-A (PAPP-A), which was first detected in human follicular fluid nearly 20 yr ago. (bioone.org)
The regulators of mitosis include the genes that encode several kinases, including the polo-like kinase (Plk) family of serine/threonine kinases. (wisc.edu)
Polo-like kinase (Plk) family of serine/threonine kinase play Key regulator for the mitotic progression in mammalian cells is the family known as polo-like kinases (Plks). (wisc.edu)
These paclitaxel resistant ovarian cells demonstrate: (1) Increased IC 50 for paclitaxel and docetaxel (10 to 75-fold) and cross-resistance to anthracyclines (2) Reduced cell apoptosis in the presence of paclitaxel (3) Gene depletion involving mitotic regulators BUB1 mitotic checkpoint serine/threonine kinase, cyclin BI (CCNB1), centromere protein E (CENPE), and centromere protein F (CENPF), and (4) Functional data validating gene depletion among mitotic regulators. (biomedcentral.com)

Cyclin-dependent kinase 2 (CDK2), a member of Cyclin-dependent kinases (CDKs), plays an important role in cell division and DNA replication. (mdpi.com)
Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. (kegg.jp)
Increasing numbers of sequence and biochemical data show the involvement of cyclin-dependent kinases (CDKs) and cyclins in regulation of the cell cycle progression in higher plants. (bibbase.org)
Progression through the cell cycle is driven by the oscillating activity of Cyclin Dependent Kinases (CDKs). (intechopen.com)
Cyclin-dependent kinases and tumor suppressor proteins are stimulators and modulators of cell division. (ptgcn.com)
Cyclins and cyclin-dependent kinases (cdks) are evolutionarily conserved proteins that are essential for cell-cycle control in eukaryotes. (bdbiosciences.com)
Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop. (proteopedia.org)
Additionally, MdANT1 and MdANT2 expression was positively correlated with that of A- and B-type CYCLINS , B-type CYCLIN-DEPENDENT-KINASES ( CDKBs ) and MdDEL1 . (biomedcentral.com)

The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. (fcgportal.org)
This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. (creative-biolabs.com)
Reversible phosphorylation of proteins by kinases and phosphatases plays a key regulatory role in several eukaryotic cellular functions including the control of the division cycle. (bibbase.org)
Phosphorylation assays also revealed that at least three kinase complexes (Cdc2Ms A/B, D and F) were successively active in G2/M cells after synchronization. (bibbase.org)
however tyrosine phosphorylation was indicated in the case of Cdc2Ms A kinase and the p13suc1-bound kinase activity was increased by treatment of this complex with recombinant Drosophila Cdc25. (bibbase.org)
article{meszaros_multiple_2000, title = {Multiple cyclin-dependent kinase complexes and phosphatases control {G2}/{M} progression in alfalfa cells}, volume = {43}, issn = {1573-5028}, url = {https://doi.org/10.1023/A:1006412413671}, doi = {10/cb64mn}, abstract = {Reversible phosphorylation of proteins by kinases and phosphatases plays a key regulatory role in several eukaryotic cellular functions including the control of the division cycle. (bibbase.org)
Dual phosphorylation of S145 and S149 in the TrCP1-binding motif of F-box only protein 5 (FBXO5) targets the protein to the SCF ubiquitin ligase complex, which marks it for degradation. (eu.org)
This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). (ayassbioscience.com)
Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. (ayassbioscience.com)
The main cyclin-cdks complexes formed in vertebrate cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1 (G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including p21 and p27Kip1. (bdbiosciences.com)
regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. (proteopedia.org)
Cyclin E/CDK2-mediated phosphorylation of NPAT at G1-S transition and until prophase stimulates the NPAT-mediated activation of histone gene transcription during S phase. (proteopedia.org)
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. (proteopedia.org)
The role of phosphorylation and the CDC28 protein kinase in cell cycle-regulated nuclear import of the S. cerevisiae transcription factor SWI5. (wikidata.org)
As a follow-up of this study, we are currently assessing if Plk1 plays a critical role in Notch signaling and melanoma development and survival through regulatory phosphorylation of Numb, an antagonist of NICD (Notch intracellular domain). (wisc.edu)
The RUNX1: heterodimer carrier represses thus inhibited in IL1 phosphorylation of transcription classical kinases, including GPAM, KCTD6 and AXIN1( Stender et al. (erik-mill.de)
The TP53 role anything, which is as heterodimerization of the RUNX1: loop repeat, was identified to directly eventually heat Phosphorylation of several proteins that are diseases of intellectual stages. (erik-mill.de)

CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. (kegg.jp)
The complexity represented by different types of CDKs and cyclins in a single species such as alfalfa, indicates that multicomponent regulatory pathways control G2/M transition. (bibbase.org)
The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)
Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. (bdbiosciences.com)

The polo-box domain (PBD) helps with specificity of substrate and localizes Plk to specific mitotic structures during mitosis. (wikipedia.org)
It is required in higher cells for entry into S-phase and mitosis. (caslab.com)
The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. (creative-biolabs.com)
Our previously reported finding that protein cysteine oxidation is increased during mitosis relative to other cell cycle phases suggests that redox modifications could play prominent roles in regulating mitotic processes. (cornell.edu)
The Aurora family of kinases and their downstream targets are key components of the cellular machinery that ensures the proper execution of mitosis and the accurate segregation of chromosomes to daughter cells. (cornell.edu)
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. (kegg.jp)
Polo-like kinase 1, a pivotal regulator of mitosis and cytokinesis, is highly expressed in a broad spectrum of tumors and its expression correlates often with poor prognosis, suggesting its potential as a therapeutic target. (oncotarget.com)
Plk1 is mainly expressed during the late G2 and M phase, where it regulates various stages of mitosis [ 2 , 7 ]. (oncotarget.com)
NEK6 belongs to the never in mitosis A (NIMA)-related kinases family and is a mitogen/threonine kinase with 313 amino acids. (hindawi.com)
activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. (proteopedia.org)
The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis. (wikidata.org)
Coupling of mitosis to the completion of S phase in Xenopus occurs via modulation of the tyrosine kinase that phosphorylates p34cdc2. (wikidata.org)
most of the genes becoming involved in G2/M phase and cellular mitosis. (healthyguide.info)
We used ChIP to verify that cyclin D1 bound the regulatory regions of genes involved in mitosis and QT-PCR to demonstrate the LY2157299 gene transcripts were induced in cyclin D1 rescued fibroblasts. (healthyguide.info)

If so, Plk1 could contribute to the resumption of mitotic progression on complete attachment of all chromosomes to the spindle apparatus. (wikipedia.org)
This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
The role of cell cycle checkpoint proteins is to integrate internal and external factors to determine whether the cell is prepared for progression of the cell cycle. (ptgcn.com)
We are studying the role and functional significance of mitotic regulators in cancer development and progression. (wisc.edu)
In another project, we are also trying to understand the role of nicotinamide adenine dinucleotide, NAD+-dependent deacetylases, Sirtuin family proteins in the development and/or progression of cancer. (wisc.edu)
Cytarabine blocks the progression from G1 to the S phase and, in turn, kills cells that undergo DNA synthesis in the S phase of the cell proliferation cycle. (medscape.com)

Human PLK1 phosphorylates early mitotic inhibitor 1 (EMI1), an inhibitor of the APC. (wikipedia.org)
Cdc5 (Plk found in budding yeast) directly phosphorylates the meiotic cohesin and promotes its dissociation from the chromosome arms to allow for recombination but not from the centromeric region in meiosis I. In some yeast cdc5 mutants, bipolar rather than monopolar attachment of the sister kinetochores occurs during meiosis I because a complex of proteins called monopolins fails to localize to the kinetochore. (wikipedia.org)
It is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. (caslab.com)
In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. (kegg.jp)
The enzyme deoxycytidine kinase phosphorylates this compound into active 5+-triphosphate derivative, which, in turn, breaks DNA strands and inhibits DNA synthesis. (medscape.com)

The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)
Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (ayassbioscience.com)

These include the centrosomes in early M phase, the spindle midzone in early and late anaphase and the midbody during cytokinesis. (wikipedia.org)
Spindle pole formation needs Plk1, and some proteins such as gamma-tubulin fail to recruit spindle poles in the absence of Plk1 for centrosome maturation. (wikipedia.org)
Localization of Cdc2Ms F kinase to the preprophase band (PPB), the perinuclear ring in early prophase, the mitotic spindle and the phragmoplast indicated a pivotal role for this kinase in mitotic plant cells. (bibbase.org)
The activity of NEK6 plays important roles in mitotic spindle kinetochore fiber formation, metaphase-anaphase transition, cytokinesis, and checkpoint regulation [ 3 , 4 ]. (hindawi.com)
Previous evidence points to numerous components of the spindle assembly checkpoint and mitotic regulation playing a major role in several cancers [ 11 , 12 ]. (biomedcentral.com)
Vinblastine inhibits microtubule formation, which disrupts formation of the mitotic spindle, causing cell proliferation to arrest at metaphase. (medscape.com)

CDC2 is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF) , which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. (caslab.com)
This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. (creative-biolabs.com)
Through bioinformatics approaches, miR-100-3p can bind the 3'-untranslated region (3'-UTR) of the mRNA encoding phosphoinositide 3-kinase regulatory subunit 1 (PIK3R1) such that miR-100-3p overexpression resulted in significant reductions in PIK3R1 expression. (bvsalud.org)
download of been proteins appears the architectural subunit of including acids within enzymes and represents the inhibitor gene conjugation SSA to intracellular families that initiate dramatically synaptic from those short at the thyroid beta. (erik-mill.de)

Polo-like kinase kinase 1 (Plkk1) and protein kinase A (PKA) have been shown to be able to phosphorylate Plk1 in vitro. (wikipedia.org)
p53 represses the promoter of Polo-like kinase 1, whereas Polo-like kinase 1 inhibits p53 and its family members p63 and p73 in cancer cells lacking functional p53. (oncotarget.com)
Thus, inactive p53 is not associated with a susceptible cytotoxicity of Polo-like kinase 1 inhibition and could rather foster the induction of polyploidy/aneuploidy in surviving cells. (oncotarget.com)
In addition, compared to the mono-treatment, combination of Polo-like kinase 1 inhibition with anti-mitotic or DNA damaging agents boosts more severe mitotic defects, effectually triggers apoptosis and strongly inhibits proliferation of cancer cells with functional p53. (oncotarget.com)
In this regard, restoration of p53 in tumor cells with loss or mutation of p53 will reinforce the cytotoxicity of combined Polo-like kinase 1 therapy and provide a proficient strategy for combating relapse and metastasis of cancer. (oncotarget.com)
Since the discovery of Polo kinase in Drosophila in 1988 [ 1 ], the Polo-like kinase (Plk) family has been attracting enormous attention, both in academia and in pharmaceutical industry. (oncotarget.com)

Mitotic cyclins stably associate with CDC2 and function as regulatory subunits. (caslab.com)

Mutations in these genes affect proteins involved in the signaling pathway for pigment production and explain a large amount of the color variation in mammals. (creation.com)
Specific substrates for cdk-cyclin complexes include nuclear lamins, histones, oncogenes (e.g., c-abl and SV40 large T-Ag), tumor suppressor genes (e.g., retinoblastoma protein, Rb), nucleolin and others. (bdbiosciences.com)
Misregulation of genes that govern the mitotic phase often lead to chromosomal instability (CIN). (healthyguide.info)
Previous research indicated coordinated changes in the expression of core cell cycle genes during different phases of fruit growth in apple [ 1 ]. (biomedcentral.com)

Plks are controlled at the level of protein synthesis and degradation, by the action of upstream kinases and phosphatases, and by localization to specific subcellular structures. (wikipedia.org)
Cell cycle-dependent redox changes can mediate transient covalent modifications of cysteine thiols to modulate the activities of regulatory kinases and phosphatases. (cornell.edu)

4 It encodes a receptor tyrosine kinase involved in the development and homeostasis of several cell lines including melanocytic (pigment), hematologic (blood), mast, and germ cells. (creation.com)

Entry into M phase is controlled through the activation of cyclin-dependent kinase 1 (CDK1)-cyclin B, and Cdc25 is a phosphatase that dephosphorylates Cdk1 to promote mitotic entry. (wikipedia.org)
This requires priming of substrates by Plk itself or other kinases such as Cdk1 to create a docking site. (wikipedia.org)
CDK1, also named as CDC2, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family and CDC2/CDKX subfamily.CDC2 plays a key role in the control of the eukaryotic cell cycle. (caslab.com)
Cyclin A is involved in both S-phase and G2/M transitions of the cell cycle through its association with cdk2 and cdk1, respectively. (bdbiosciences.com)

Several other potential Plk1 substrates and binding partners that are implicated in microtubule nucleation and dynamics have also been identified including the microtubule-severing protein katanin, the microtubule-stabilizing protein TCTP and the microtubule-destabilizing protein stathmin. (wikipedia.org)
Genetic as well as chemical inhibition of Plk1 results in a decrease in growth/viability nd induces a mitotic catastrophe, G2/M phase arrest and apoptosis in multiple melanoma cells without affecting the normal human melanocytes. (wisc.edu)

Dabrafenib inhibits some mutated forms of BRAF kinases with in vitro IC50 values of 0.65, 0.5, and 1.84 nM for BRAF V600E, BRAF V600K, and BRAF V600D enzymes, respectively. (medscape.com)

Recent breakthroughs have uncovered more and more DNA replication licensing machinery proteins (ORC, Cdc6, Cdt1, geminin, etc.) functioning in other cell cycle events, including centrosome replication, mitotic events, transcription and so on. (intechopen.com)
In this work, we integrated somatic mutations, transcription, (hydroxy)methylation, histone modifications, and chromatin accessibility to reveal the complexity of the epigenetic landscape, the simultaneous presence of multiple regulatory mechanisms affecting drivers of leukemogenesis, and remodeling of the enhancer landscape as an important driver of intratumoral heterogeneity. (nature.com)
The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
The role of SUN3 in the ER is reinforced by the identification of a protein interaction between SUN3 and the ER membrane-bound transcription factor maMYB. (brookes.ac.uk)
Cao L, Faha B, Dembski M, Tsai LH, Harlow E, Dyson N. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. (bdbiosciences.com)
The RUNX1: type pyrophosphate directly is change of the dendritic receptor, quantifying DNA transcription protein 1( CD35)( Kim et al. (erik-mill.de)
It involves located that the liver cathepsine transcription 2( SH2 Smart-Growth) of PLC-gamma and of regulatory presenting complexes( mammalian as Negotiating decay and compartment Reversible fibronectin) organize their mRNA toward telomeric differentiation transporters of the FGFR. (erik-mill.de)
Interestingly Ctcf is definitely a zinc finger DNA binding protein that regulates transcription governs enhancer function and is involved in sister chromatid cohesion. (healthyguide.info)

What pathways are this gene/protein implicaed in? (cancerindex.org)
This complex gene codes for a complex protein important in a number of pathways. (creation.com)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)

The lumen is the able protein of mRNA hetero-oligomerization). (erik-mill.de)

This review summarizes evidence for the role of proteolytic enzymes that degrade and inactivate insulin-like growth factor binding proteins (IGFBP) during follicular development in mammals. (bioone.org)

Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)
mitotic arrest deficien. (gsea-msigdb.org)
Our results demonstrate that Pulsatillae chinensis and particularly its bioactive ingredient β-peltatin suppress PAC by triggering cell cycle arrest at G2/M phase and apoptosis. (biomedcentral.com)

This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. (ayassbioscience.com)

Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. (creative-biolabs.com)
ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation. (kegg.jp)

This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. (ayassbioscience.com)

The C-terminal regulatory domain of p53 contains a functional docking site for cyclin A. J Mol Biol. (proteopedia.org)
We are currently evaluating the role and functional significance of SIRT proteins in age-related cancers such as prostate cancer (PCa) and melanoma. (wisc.edu)

β-peltatin initially arrested PAC cells at G2/M phase, followed by apoptosis induction. (biomedcentral.com)

The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. (fcgportal.org)
CCND3 belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. (creative-biolabs.com)
The precise regulations of pre-RC protein levels and assembly are effective ways to prevent reassembly of de novo MCM2-7 onto the replicated origins to re-license and re-replicate the genomic DNA in the subsequent phases of the same cell cycle ( Figure 1) . (intechopen.com)
A phase II study showed that patients with resected local-regionally advanced head and neck squamous cell carcinoma (HNSCC) had improved survival when pembrolizumab was added to adjuvant RT (NCT02641093). (nature.com)
The receptor makes a single pass through the cell membrane and contains an intracellular kinase catalytic region divided by a hydrophilic insert. (creation.com)
I'm using cell and molecular biology techniques, biochemistry as well as microscopy to characterise the plant SUN proteins. (brookes.ac.uk)
This includes finding out what other proteins the SUNs bind to and what functions they have during cell division. (brookes.ac.uk)
The passage of a cell through the cell cycle is controlled by proteins in the cytoplasm. (ptgcn.com)
The key role of checkpoint proteins is to detect DNA damage and send a signal to delay cell cycle advance until the damaged chromosomes are repaired (Figure 1). (ptgcn.com)
This phase is followed by a period of temporary cessation of growth around bloom associated with quiescence in cell production, a phenomenon which likely prevents fruit growth in the absence of pollination and fertilization [ 1 ]. (biomedcentral.com)
Anticytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is a humanized antibody that overcomes CTLA-4-mediated T-cell suppression to enhance the immune response against tumors. (medscape.com)
Pembrolizumab is a programed cell death-1 protein (PD-1) inhibitor. (medscape.com)
It is cell-cycle S-phase specific. (medscape.com)

Moreover, two upregulated proteins, namely, FBLN2 and NPR3, were validated to participate in the osteogenic differentiation process of MSCs. (bvsalud.org)
After that, we independently downregulated FBLN2 and NPR3 over seven days of osteogenic differentiation, and we performed quantitative proteomics analysis to determine how different proteins were regulated in knockdown vs. control cells. (bvsalud.org)

Cyclins function as regulators of CDK kinases. (creative-biolabs.com)

In this study, x-ray crystal structures of the Aurora A kinase domain delineate redox-sensitive cysteine residues that, upon covalent modification, can allosterically regulate kinase activity and oligomerization state. (cornell.edu)
Given the complexity of human transcriptional regulation in vivo and the multitude of potential epigenetic mechanisms cooperating to regulate transcriptional activity, questions remain about the interplay of regulatory mechanisms in patients with CMML. (nature.com)

Endothall elevated the kinase activity of p13suc1-bound fractions in G2-phase alfalfa cells. (bibbase.org)
The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). (ayassbioscience.com)
Trametinib is a reversible inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2 activation, and of MEK1 and MEK2 kinase activity. (medscape.com)

The end result is inhibition of DNA, ribonucleic acid (RNA), and protein synthesis. (medscape.com)

Fu et al was the first to display cyclin D1 is definitely recruited in the context of local chromatin which in turn recruited chromatin modifying proteins (SUV39 HP1α p300 HDAC 1 and HDAC 3) and modified the acetylation and methylation of chromatin connected histones [5]. (healthyguide.info)

Both methods yield antibody in solution that is free of most other soluble proteins, lipids, etc. (bdbiosciences.com)

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. (fcgportal.org)
Mid-SUN proteins are a neglected family of conserved type III membrane proteins of ancient origin with representatives in plants, animals and fungi. (brookes.ac.uk)
SIRTs are nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylases that belong to the Silent information regulator 2 (Sir2) family of proteins. (wisc.edu)

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes. (wikidata.org)

However, the role and regulatory mechanism of NEK6 on the development of colon adenocarcinoma (COAD) are not fully understood. (hindawi.com)
heme and calcium targets are leading with example unique to particles for distinctive PTEN, higher metabolism, specific mechanism, T dislocations, more protein or hydrogen. (erik-mill.de)

The rapid protocol (RP) PathScan ® RP Phospho-Aurora A (Thr288) Sandwich ELISA Kit is a solid phase sandwich enzyme-linked immunosorbent assay (ELISA) that detects endogenous levels of Aurora A protein phosphorylated at Thr288 in a reduced assay time of 1.5 hours. (cellsignal.com)

This means that in the absence of a phosphorylated ligand, the PBD interacts with the catalytic domain thereby preventing substrate binding or kinase activation. (wikipedia.org)

Protein and gene expression of apoptotic signaling pathway-related proteins such as caspase-3, cytochrome c, and PARP were determined to provide evidence for the mechanisms of action of Tan IIA in the treatment of psoriasis. (hindawi.com)
We screened for early-stage osteogenesis- or adipogenesis-based MSCs protein expression profiles using TMT-based quantitative proteomic analysis to identify novel participating molecules. (bvsalud.org)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

Interaction between alfalfa mitotic cyclin (Medsa;CycB2;1) and a kinase partner has been reported previously. (bibbase.org)
The present yeast two-hybrid analyses showed differential interaction between defined D-type cyclins and Cdc2Ms kinases functioning in G2/M phases. (bibbase.org)
Faha B, Ewen ME, Tsai LH, Livingston DM, Harlow E. Interaction between human cyclin A and adenovirus E1A-associated p107 protein. (bdbiosciences.com)

ALMS1 encodes a ~ 0.5 megadalton protein that localises to the base of centrioles. (springer.com)

Conservation of dynamic characteristics of transcriptional regulatory elements in periodic biological processes. (duke.edu)

The sympathetic nervous system regulates this function through β-adrenergic stimulation of brown mature adipocytes' dissipation of energy in the form of heat mediated by mitochondrial uncoupling protein-1 (UCP-1) activation. (springer.com)

Anatomy13

Organisms10

Diseases3

Chemicals and Drugs150

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes57

Disciplines and Occupations1

Information Science3

Serine9

Cyclin-depende8

Phosphorylation17

CDKs4

Mitosis14

Progression6

Phosphorylates5

Including D-type cyclins2

Spindle6

Subunit4

Polo-like kinase6

Cyclins stably associate1

Genes4

Phosphatases2

Tyrosine kinase1

Cdk14

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Vitro1

Transcription8

Pathways3

MRNA1

Enzymes1

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CDK42

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CDC21

Functional2

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Cell13

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