Aurora kinase B is a protein that functions in the attachment of the mitotic spindle to the centromere. (wikipedia.org)
Enables cyclin-dependent protein serine/threonine kinase regulator activity. (nih.gov)
It also directly binds to BubR1, a kinetochore-associated kinase implicated in the mitotic checkpoint, the major cell cycle control pathway in which unattached kinetochores prevent anaphase onset. (rupress.org)
Thus, CENP-E is required for enhancing recruitment of its binding partner BubR1 to each unattached kinetochore and for stimulating BubR1 kinase activity, implicating it as an essential amplifier of a basal mitotic checkpoint signal. (rupress.org)
NMS-153 is a highly potent and selective inhibitor of the MPS1 kinase, which is a mitotic regulator frequently overexpressed and activated in cancer. (nervianoms.com)
The mitotic kinase monopolar spindle 1 (Mps1) is a key regulator of the Spindle assembly checkpoint, which ensures the correct chromosome segregation. (lu.se)
Mitosis3
Prior to senescence, mutant RasV12 activation in primary human fibroblasts compromised mitosis, associated with abnormal expression of mitotic genes that enter M-phase. (nih.gov)
Simultaneously, RasV12 activation enhanced survival of damaged mitoses, culminating in extended mitotic arrest and aberrant exit from mitosis via mitotic slippage. (nih.gov)
Furthermore, high mitotic count and elevated Ki-67 expression were also associated with Clark's level of invasion and presence of vascular invasion. (biomedcentral.com)
High expression of PHH3 and MCM4 was correlated with high mitotic count, elevated Ki-67 expression and tumor ulceration, and increased PHH3 frequencies were associated with tumor thickness and presence of tumor necrosis. (biomedcentral.com)
Univariate analyses showed a worse outcome in cases with elevated Ki-67 expression and high mitotic count, whereas PHH3, MCM4 and mitosin were not significant. (biomedcentral.com)
the highest levels of expression were detected in the early stages of organ growth with high mitotic activity, and BB expression appeared to decline in concert with the decrease in cell divisions. (biomedcentral.com)
Promote mitotic1
In budding yeast, the phosphatase Cdc14 is released from nucleolus to promote mitotic exit (ME). (rockefeller.edu)
Chromosome segregation2
Recently, our lab has made the surprising discovery that mitotic regulators of chromosome segregation are repurposed to control insulin signaling during interphase, linking genomic stability to metabolism. (packard.org)
The encoded protein is part of the structural maintenance of chromosomes (SMC) 5/6 complex which plays a key role genome maintenance, facilitating chromosome segregation and suppressing mitotic recombination. (nih.gov)
Protein4
The mitotic reorganization of the Golgi is accompanied by a temporary block in Golgi functioning, as protein transport in and out of the Golgi stops. (biologists.com)
Centromere-associated protein-E (CENP-E) is an essential mitotic kinesin that is required for efficient, stable microtubule capture at kinetochores. (rupress.org)
Recent work published in The EMBO Journal and EMBO Reports reveals a novel role for the protein TECPR1 as a sensor for stressed membranes and regulator of lysosomal membrane repair. (babraham.ac.uk)
The aim of the present study was to evaluate the prognostic impact of mitotic count, Ki-67 expression and novel proliferation markers phosphohistone H3 (PHH3), minichromosome maintenance protein 4 (MCM4) and mitosin, and to compare the results with histopathological variables. (biomedcentral.com)
Progression3
our research has therefore identified Treacle and as novel in vivo regulators of spindle fidelity, mitotic progression, and proliferation in the maintenance and localization of neural progenitor cells. (genscript.com)
Title: Mammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells. (genscript.com)
All somatic cells proliferate via a mitotic process determined by progression through the cell cycle. (bioinf.org)
Cyclin2
Cdc14 release and ME is controlled by mitotic cyclin-Cdk oscillation, the FEAR network including a non-proteolytic function of separase (Esp1), and the Mitotic Exit Network (MEN) indirectly activated by spindle elongation through cohesin cleavage by the proteolytic function of Esp1. (rockefeller.edu)
Reducing mitotic cyclin-Cdk activity is critical for ME, but Cdc14 release and resequestration is not blocked by endogenous undegradable mitotic cyclin Clb2. (rockefeller.edu)
Centrosome1
Recent breakthroughs have uncovered more and more DNA replication licensing machinery proteins (ORC, Cdc6, Cdt1, geminin, etc.) functioning in other cell cycle events, including centrosome replication, mitotic events, transcription and so on. (intechopen.com)
Checkpoint1
Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis. (bvsalud.org)
Replication1
Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage. (nih.gov)
Proliferation1
Apoptosis and cell proliferation are linked by cell-cycle regulators and apoptotic stimuli that affect both processes. (bioinf.org)
Chromatin1
In non-synchronized cell populations, extraction from chromatin necessitated 300 mM NaCl whereas 150 mM was sufficient in mitotic cells. (wikigenes.org)
MPS11
We could confirm the increased polyploidy upon Mps1 inhibition in neuroblastoma cell lines and PDX model, leading to mitotic catastrophe activating the caspase-dependent mitochondrial apoptotic pathway. (lu.se)
Chromosomes4
Specifically, Aurora B localizes to the chromosomes in prophase, the centromere in prometaphase and metaphase, and the central mitotic spindle in anaphase. (wikipedia.org)
Inhibition of Aurora B function by RNA interference or microinjection of blocking antibodies impairs the alignment of chromosomes at the equator of the mitotic spindle. (wikipedia.org)
New findings from his lab published in the July 21 advance online issue of Nature demonstrate that the way the mitotic spindle-the machinery that separates chromosomes into daughter cells during cell division-aligns relative to the surface of the cell layer is essential for the maintenance of epithelial integrity. (stowers.org)
As division began, the mitotic spindle (which faithfully distributes chromosomes into each daughter cell) invariably oriented itself parallel to the apical surface of the epithelium. (stowers.org)
Transcriptional2
ERK-dependent transcriptional up-regulation of Mcl1 was responsible for enhanced slippage of cells with mitotic defects and subsequent cell survival. (nih.gov)
We propose that activated Ras induces transcriptional changes that predispose cells undergoing OIS to mitotic stress and multinucleation. (nih.gov)
Gene5
This class of noncoding RNAs is small, single stranded, and 19-25 nucleotide long that act as negative regulators involved in posttranscriptional silencing of the gene expression [ 5 ]. (hindawi.com)
p53 is a master gene regulator controlling diverse cellular pathways, by either activating or repressing downstream genes. (bioinf.org)
Transcriptomic analyses provide an efficient approach to explore the temporal gene expression profiles in embryos and to search for the developmental regulators. (biomedcentral.com)
This work underlines the complexity involved in precise quantitative control of gene expression and lays the foundation for identifying important upstream regulators that determine BB expression levels and thus final organ size. (biomedcentral.com)
The BIG BROTHER ( BB ) gene, encoding an E3 ubiquitin ligase, represents a central regulator of organ size. (biomedcentral.com)
Transition1
The human rotamase or peptidyl-prolyl cis-trans isomerase Pin1 is a conserved mitotic regulator essential for the G2/M transition of the eukaryotic cell cycle. (rcsb.org)
Processes1
Prezygotic transcripts included multiple regulators that are most likely involved in developmental processes that take place long after fertilization, such as components of ErbB, hedgehog, notch, retinoid, TGFb, VEGF and Wnt signaling pathways, as well as transcripts involved in the development of nervous system. (biomedcentral.com)
Activity2
Flower initiation is an irreversible process marked by histological changes and intensive mitotic activity. (ishs.org)
Gibson reasoned that the reported tumor-suppressive activity of these proteins might be linked to a role in keeping the mitotic spindle in line. (stowers.org)
Cells3
In other words, if you pointed a tiny camera in your gut toward dividing epithelial cells of its lining, you would "see" the mitotic spindle looking like a symmetrical web, exactly like it did in your high school biology textbook. (stowers.org)
Conclusions These findings ascertained an conversation between p53, c-myc, p21, p27, Bcl-2, PI3K/Akt pathway, and CF-induced apoptosis in MSTO-211H and HCT-116 cells, suggesting that CF acts as an important regulator of cell growth in human malignancy cell lines. (bioinf.org)
Treatment with the novel cyclophilin inhibitor NV651, presented a potent antiproliferative effect in HCC cell lines via cell cycle perturbations arresting cells in the mitotic phase. (lu.se)
Survival1
In some recent studies, however, mitotic frequency is a powerful predictor of survival [ 6 - 11 ], and the inclusion of this marker in staging of primary melanomas has been included in the 2010 edition of the AJCC pTNM staging system. (biomedcentral.com)
Control1
Microarray analyses detected a suite of master developmental regulators that control differentiation and maintenance of diverse cell lineages. (biomedcentral.com)
Proteins1
Occupational exposure limits with proteins such as topoisomerase inhibitors, and mitotic and meiotic spindle poisons. (cdc.gov)
Expression2
Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. (novusbio.com)
Increased mitotic count and elevated Ki-67 expression were strongly associated with increased tumor thickness, presence of ulceration and tumor necrosis. (biomedcentral.com)
Growth1
The use of plant growth regulators (PGRs) to increase flower formation in apples has been extensively used, however, the results are not always satisfactory, probably because of varietal differences and excessive crop load during flower induction and differentiation. (ishs.org)
Phase1
Targeting the cell cycle has been proposed as a therapeutic strategy in cancer treatment with special interest in the mitotic phase. (lu.se)
Critical1
In CKD patients or obstructive mice model, we observed that Plk1, a critical mitotic regulator, was upregulated in kidneys. (nature.com)
Function2
Cyclins function as regulators of CDK kinases. (novusbio.com)
SETD1A function in leukemia is mediated through interaction with mitotic regulators BuGZ/BUB3. (antibodiesinc.com)
Negative1
Conversely, plants expressing higher levels of BB produce smaller organs, indicating that BB acts as a negative regulator for organ size. (biomedcentral.com)
Data1
Together, these data identify V-ATPase as a universal regulator of CASM and indicate that SopF evolved in part to evade non-canonical autophagy. (babraham.ac.uk)