Mitotic progression cell cycle progression. Medical search. Frequent questions

Our results establish a crucial role for E4F during early embryonic cell cycles and reveal an unexpected function for E4F in mitosis. (cnrs.fr)
Here we show that cell cycle progression through mitosis following double-stranded DNA breaks leads to the formation of micronuclei, which precede activation of inflammatory signalling and are a repository for the pattern-recognition receptor cyclic GMP-AMP synthase (cGAS). (nature.com)
Inhibiting progression through mitosis or loss of pattern recognition by stimulator of interferon genes (STING)-cGAS impaired interferon signalling. (nature.com)
Figure 2: Progression through mitosis underlies inflammatory pathway activation. (nature.com)
His pictures of newt lung cells undergoing the various stages of mitosis have appeared on numerous covers of the aforementioned journals alongside his articles. (wikipedia.org)
Rieder pioneered the idea that cells remain in mitosis until each chromosome becomes attached to the spindle and only then mitotic exit is initiated. (wikipedia.org)
In yeast and mammalian cells, the catalytic disruption of Topo IIα is reported to induce a delay in mitosis. (ku.edu)
LmjMCA also translocates to the nucleus during mitosis, where it associates with the mitotic spindle. (strath.ac.uk)
282, 32053-32064), a key regulator of mitosis, suggesting a possible role for hMDC1 in controlling normal cell cycle progression. (ox.ac.uk)
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. (kegg.jp)
This event is required to promote mitotic progression and favors the activation of a transcriptional program required for mitosis. (ox.ac.uk)
At the onset of mitosis, centrosomes become the core structures of spindle poles and direct the formation of mitotic spindles. (biomedcentral.com)
In early mitosis, the cohesion between the two pairs of centrioles is broken and each of them participates in the formation of the mitotic spindle pole. (biomedcentral.com)
During mitosis the two centrosomes are present and form the mitotic spindle poles. (biomedcentral.com)
We characterized dCTCF-binding sites according to their occupancy status during the cell cycle, and identified three classes: interphase-mitosis-common (IM), interphase-only (IO) and mitosis-only (MO) sites. (biomedcentral.com)
Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis. (adooq.com)
Monastrol is a potent, cell permeable non-tubulin-interacting mitosis inhibitor. (adooq.com)
Monastrol blocks mitosis (IC5N/A = 14 μM) by binding to the mitotic kinesin Eg5, a motor protein required for spindle bipolarity. (adooq.com)
The Nek2 subfamily includes Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants prevented from entering mitosis. (umbc.edu)
NIMA is essential for mitotic entry and progression through mitosis, and its degradation is essential for mitotic exit. (umbc.edu)

Embryos lacking E4F die at the peri-implantation stage, while in vitro-cultured E4F(-/-) blastocysts exhibit defects in mitotic progression, chromosomal missegregation, and increased apoptosis. (cnrs.fr)
The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, 5-ethynyl-2′-deoxyuridine assay, propidium iodide (PI) staining, annexin V-fluorescein isothiocyanate/PI staining, and transwell assay were employed to test the proliferation, apoptosis, migration ability, and invasiveness of COAD cells. (hindawi.com)
Upregulating the level of miR-323a-3p impaired the proliferation, migration, and invasion of COAD cells and promoted apoptosis, whereas supplementing NEK6 alleviated the damage of the proliferation, migration, and invasion of COAD cells caused by miR-323a-3p and inhibited miR-323a-3p-induced apoptosis. (hindawi.com)
These findings indicate that miR-323a-3p regulates the proliferation, migration, invasion, and apoptosis of COAD cells by targeting NEK6. (hindawi.com)
Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. (hindawi.com)
Furthermore, Tan IIA-induced apoptosis and mitochondrial membrane potential changes were also further demonstrated by DNA fragmentation, single-cell gel electrophoresis assay (SCGE), and flow cytometry methods. (hindawi.com)
Therefore, based on clinical experience as well as cytotoxic activity against multiple human cancer cells, we hypothesized that induction of apoptosis is the underlying mechanism for the treatment of psoriasis. (hindawi.com)
Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. (caslab.com)
Conclusions These findings ascertained an conversation between p53, c-myc, p21, p27, Bcl-2, PI3K/Akt pathway, and CF-induced apoptosis in MSTO-211H and HCT-116 cells, suggesting that CF acts as an important regulator of cell growth in human malignancy cell lines. (bioinf.org)
Many physiological processes, including proper tissue development and homeostasis, require a balance between apoptosis and cell 123653-11-2 manufacture proliferation. (bioinf.org)
Apoptosis (programmed cell death) occurs in a wide variety of physiological NIK settings, where its role is to remove harmful, damaged or unwanted cells. (bioinf.org)
Apoptosis and cell proliferation are linked by cell-cycle regulators and apoptotic stimuli that affect both processes. (bioinf.org)
A failure in regulating proliferation together with suppression of apoptosis are the 123653-11-2 manufacture minimal requirements for a cell to become cancerous [4]. (bioinf.org)
Sirtuins are NAD + -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. (biomedcentral.com)
Here, we examined the role of the Bcl-2 family proteins in AURK inhibition-induced apoptosis in colon cancer cells. (bvsalud.org)
We found that alisertib and danusertib, two small-molecule inhibitors of AURK, are inefficient inducers of apoptosis in HCT116 and DLD-1 colon cancer cells, the survival of which requires at least one of the two antiapoptotic Bcl-2 family proteins, Bcl-xL and Mcl-1. (bvsalud.org)
We further identified Bcl-xL as a major suppressor of alisertib- or danusertib-induced apoptosis in HCT116 cells. (bvsalud.org)
Together, these results define the Bcl-2 protein network critically involved in AURK inhibitor-induced apoptosis and suggest that BH3-mimetics targeting Bcl-xL may help overcome resistance to AURK inhibitors in cancer cells. (bvsalud.org)
Additionally, miR-1291 induced cell apoptosis. (bvsalud.org)
Beginning after completion of hair morphogenesis (postnatal day 14 in the mouse), hair growth cycles commence with catagen, an involution process of the hair follicle during which the majority of its epithelial compartments undergo apoptosis [ 1 ]. (aging-us.com)

Polo-like kinases play critical roles during multiple stages of cell cycle progression. (pharmaceutical-technology.com)
2019) by serine/threonine kinases NEK6 and NEK7, leading to its dissociation from microtubules, which is necessary for the assembly of a dynamic mitotic spindle (Adib et al. (reactome.org)
2015). It is possible that other mitotic kinases, besides NEK6 and NEK7, also phosphorylate EML4. (reactome.org)
It also interacts with other mitotic kinases such as Polo-like kinase 1 and may play a role in spindle checkpoint. (umbc.edu)
Aurora kinases (AURKs) are mitotic kinases important for regulating cell cycle progression. (bvsalud.org)

SUMOylated Topo IIα C-terminus (CTD) interacts with Haspin kinase and recruits chromosome passenger complex (CPC) to the mitotic centromeres. (ku.edu)
Polo-like kinase (PLK) inhibitors targets the mitotic phase of the cell cycle. (pharmaceutical-technology.com)
Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4). (elifesciences.org)
The protein serine/threonine kinase Akt (also known as protein kinase B or PKB) plays an important role in averting cell death. (bioinf.org)
β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression. (ox.ac.uk)
A recurrent genomic rearrangement, reported in about 5% cases of non-small cell lung cancer (NSCLC) fuses the N-terminal portion of EML4 with the C-terminal portion of ALK (anaplastic lymphoma kinase), resulting in a constitutively active ALK (Soda et al. (reactome.org)
In this study, we investigated how TSPAN12 regulates OC cell proliferation both in vitro and in vivo and found that it contributed to tumor proliferation and poor prognosis in this disease through cyclin and cyclin-dependent kinase (CDK) pathways. (molcells.org)
CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM. (adooq.com)
Description: RET is a receptor kinase for GDNF (glial cell-line derived neurotrophic factor) family ligands (GFLs). (morulaivf.com)
Description: Bruton's tyrosine kinase or BTK, is an enzyme that plays a role in the functionality and maturation of B cells. (morulaivf.com)

miRNAs expressed in a wide variety of human cancers can regulate posttranscriptional gene expression by binding to the 3′ untranslated region of the target mRNAs and act as oncogenes or tumor suppressors to regulate cell signaling pathways, affecting tumorigenesis and tumor progression [ 17 ]. (hindawi.com)
Two proteins involved intimately in regulating cell proliferation are Akt and the tumor suppressor p53 (p53). (bioinf.org)
Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
Activation of wild-type RET is important in several cancers where it contributes to tumor progression through various mechanisms. (morulaivf.com)
therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)
In a study of 56 patients with Hürthle cell cancer treated at Memorial Sloan-Kettering Cancer center, recurrence was a significant predictor of tumor-related mortality, and extent of invasion was the most significant predictor of outcome. (medscape.com)

Our group has identified DNA topoisomerase IIα (Topo IIα) as one of the important mitotic proteins for SUMOylation. (ku.edu)
Defining the functional relationships between proteins is critical for understanding virtually all aspects of cell biology. (thebiogrid.org)
When cells are about to divide, they make a new set of centrioles by assembling a variety of proteins. (elifesciences.org)
I found that co-targeting HSP90 and its client proteins AR or Plk1 led to increased cancer cell death. (purdue.edu)
The precise regulation of the levels of cyclin proteins is fundamental to coordinate cell division with checkpoints, avoiding genome instability. (ox.ac.uk)
EML4 and NUDC proteins are required for mitotic spindle formation, attachment of spindle microtubule ends to kinetochores, and alignment of mitotic chromosome at the metaphase plate. (reactome.org)
Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)
Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)
Occupational exposure limits with proteins such as topoisomerase inhibitors, and mitotic and meiotic spindle poisons. (cdc.gov)

Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression. (ox.ac.uk)
However, a major unresolved question is how each cell regulates the precise number of its motile cilia during differentiation. (elifesciences.org)
Vertebrate Nek2 is a cell cycle-regulated STK, localized in centrosomes and kinetochores, that regulates centrosome splitting at the G2/M phase. (umbc.edu)

Small interfering RNA depletion of Bod1 in HeLa cells produces elongated mitotic spindles with severe biorientation defects. (rupress.org)
Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. (rupress.org)

The function of this protein in normal cell physiology remains largely unknown. (cnrs.fr)
The mitotic reorganization of the Golgi is accompanied by a temporary block in Golgi functioning, as protein transport in and out of the Golgi stops. (biologists.com)
By performing cell biological and biochemical experiments using human cells, Moyer and Holland show that PLK4 interacts with a protein called STIL that is found in the central part of the centriole. (elifesciences.org)
The modification of STIL at a specific location by PLK4 was needed to link it to another protein in the outer wall of the centriole, and was also necessary for the cells to build new centrioles. (elifesciences.org)
The p53 protein is a transcription factor that normally inhibits cell growth and stimulates cell death in response to myriad stressors, including DNA damage (induced by either UV or chemical agents such as hydrogen peroxide), oxidative stress, and deregulated oncogene expression [6-10]. (bioinf.org)
Mitotic cells lacking hMDC1 exhibit markedly reduced levels of APC/C activity characterized by reduced levels of Cdc20, and a failure of Cdc20 to bind the APC/C and CREB-binding protein. (ox.ac.uk)
In addition HIV-1 Vpr protein alters the cell-cycle regulation by hijacking centrosome functions. (biomedcentral.com)
However, changes of CTCF-binding sites during the cell cycle, and functions of this protein at different cell cycle phases, remain largely uncharacterized. (biomedcentral.com)
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. (genetex.com)
GSK-923295, is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E, (CENP-E). (adooq.com)
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. (adooq.com)
miR-1291 also suppressed DCLK1 mRNA and protein expression in HCT116 cells that expressed DCLK1. (bvsalud.org)

As a cell biologist, Rieder was the first to observe microtubule capture by kinetochores in live cells. (wikipedia.org)
By using the laser to ablate kinetochores on individual chromosomes, Rieder proved that the signal that delays mitotic progression is produced by kinetochores that lack attachment to spindle microtubules. (wikipedia.org)
2019). EML4, through its WD40 repeats, interacts with NUDC and recruits it to the kinetochores of the mitotic spindle (Chen et al. (reactome.org)
Bod1-depleted cells form syntelic attachments that can oscillate and generate enough force to separate sister kinetochores, suggesting that microtubule-kinetochore interactions were intact. (rupress.org)

These findings implicate temporal modulation of the cell cycle as an important consideration in the context of therapeutic strategies that combine genotoxic agents with immune checkpoint blockade. (nature.com)
The activity of NEK6 plays important roles in mitotic spindle kinetochore fiber formation, metaphase-anaphase transition, cytokinesis, and checkpoint regulation [ 3 , 4 ]. (hindawi.com)
Checkpoint systems allow the accurate execution of each cell-cycle phase. (ox.ac.uk)

p53 has an important protective role against undesired cell proliferation. (bioinf.org)
However, a function for SET8 in mammalian cell proliferation has not been determined. (rupress.org)
We show that small interfering RNA inhibition of SET8 expression leads to decreased cell proliferation and accumulation of cells in S phase. (rupress.org)
Further exploration showed that TSPAN12 overexpression accelerated proliferation and colony formation of OVCAR3 and SKOV3 OC cells. (molcells.org)
Knockdown of TSPAN12 expression in A2780 and SKOV3 cells decreased both proliferation and colony formation. (molcells.org)
Cancer cells obtain a growth advantage through uncontrolled cell proliferation ( Hanahan and Weinberg, 2011 ), which may be caused by mutations that help them adapt to the microenvironment through selective pressure. (molcells.org)
Both in vitro and in vivo, SRSF2 significantly accelerated the proliferation of colon cancer cells. (bvsalud.org)
Knockdown of SLMAP-L or CETN3-S splice isoform could suppress the growth of colon cancer cells, predicting their role in malignant proliferation of colon cancer cells. (bvsalud.org)
Rescue of SLMAP-L or CETN3-S splice isoform in SRSF2 knockdown colon cancer cells could effectively reverse the inhibition of cell proliferation by SRSF2 knockdown through mediating cell cycle progression. (bvsalud.org)
It was identified that miR-1291 significantly suppressed the proliferation, invasion, cell mobility and colony formation of CRC cells. (bvsalud.org)

Centrosomes nucleate the formation of the microtubule cytoskeleton in interphase cells and form the poles of the mitotic spindle during cell division. (elifesciences.org)
Each MCC contains hundreds of motile cilia, microtubule-based organelles that generate the motive force to move fluid over the surface of the cell. (elifesciences.org)
Centrosomes are the major microtubule organizing structures in vertebrate cells. (biomedcentral.com)
In animal cells, centrosomes represent the major microtubule-organizing structures (MTOC). (biomedcentral.com)

In support of a role for hMDC1 in controlling mitotic progression, depletion of hMDC1 by small interfering RNA results in a metaphase arrest that appears to be independent of both BubR1-dependent signaling pathways and ATM/ATR activation. (ox.ac.uk)
Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1). (nih.gov)
Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. (kegg.jp)
However, impaired splicing affects only a subset of human transcripts, enriched for mitotic cell cycle factors, leading to mitotic arrest. (biomedcentral.com)
Knockdown of SRSF2, its splicing targets SLMAP-L, or CETN3-S caused colon cancer cells to arrest in G1 phase of the cell cycle. (bvsalud.org)

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. (nih.gov)
Furthermore, we find that SET8 interacts with proliferating cell nuclear antigen through a conserved motif, and SET8 is required for DNA replication fork progression. (rupress.org)

Increases in the amount of PAPP-A mRNA in granulosa cells during follicular development occurs in some but not all species, indicating that other proteases or protease inhibitors may be involved in IGFBP degradation. (bioone.org)
Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. (kegg.jp)
however, the utility of these inhibitors as inducers of cancer cell death has thus far been limited. (bvsalud.org)

The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed the enormous progress in our understanding of the nature and behavior of chromosomes during the life cycle of the cell. (cshlpress.com)
Aurora B mislocalization on chromosomes utilizes the Haspin-H3T3P pathway and is a key factor for the mitotic delay. (ku.edu)
Each cell in our bodies contains over two meters of DNA, which is divided into 46 packages of information called chromosomes. (elifesciences.org)
This means that they also need to copy all of their DNA and then deliver identical sets of chromosomes to each new cell. (elifesciences.org)
Animal cells use structures called centrioles to help them divide their sets of chromosomes accurately. (elifesciences.org)
if too many or too few centrioles are built, cell division errors can occur that lead to the generation of new cells with abnormal numbers of chromosomes. (elifesciences.org)
We have combined the proteomic analysis of Xenopus laevis in vitro-assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. (rupress.org)
Mitotic chromosome segregation requires the coordination of both regulatory and mechanical molecular machines and culminates in the delivery of two complete sets of chromosomes to two daughter cells. (rupress.org)
Each cell (except for red blood cells) contains a nucleus that houses these chromosomes. (cdc.gov)

Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 with IC50 value of 200 nM. (adooq.com)
K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor with IC50 value of 1.3 uM. (adooq.com)
Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases. (adooq.com)

Using Xenopus egg extracts (XEEs) we have shown that disruption of mitotic SUMOylation causes chromosome segregation defects. (ku.edu)

A number of direct and indirect radiation interaction pathways can produce damage to the DNA of irradiated cells. (cdc.gov)

In this study, I found that co-targeting the p53 pathway and mitochondrial respiration led to inhibition of glycolysis and oxidative phosphorylation at the same time thus resulting in increased prostate cancer cell death. (purdue.edu)
Phosphorylation of IRS2 by Plk1 led to inhibition of the PI3K pathway and delayed mitotic exit, contributing to disorganized cell cycle progression and cancer progression. (purdue.edu)

2019). At mitotic entry, EML4 undergoes phosphorylation (Pollmann et al. (reactome.org)

CF treatment on leukemia cell lines induces cell death due to apoptotic mechanisms and altering 123653-11-2 manufacture cell metabolism through HIF-1 and GLUT-1 regulation [3]. (bioinf.org)

According to GlobalData, Phase II drugs for Diffuse Large B-Cell Lymphoma have a 40% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (genetex.com)
One of the surprises that came from this study was the finding that genes regulated by the core circadian clock mechanism showed expression changes that correlated with the hair growth cycle, with highest expression during the telogen-anagen transition. (aging-us.com)

Increased manifestation levels of p53, p21, and p27, downregulation of c-myc and Bcl-2, and inhibition of Akt activation were also found in CF-treated MSTO-211 and HCT-116 cells. (bioinf.org)

Further, to understand the role of SUMOylation more clearly in human cells we have targeted one of the important SUMOylation enzymes PIASy SUMO E3 ligase. (ku.edu)
Next, we sought to examine if PIASy has a conserved role in human cells. (ku.edu)
To address this question, we have established Tet-ON inducible ectopic expression of PIASy and SUMO interacting motif (SIM) mutants in human cells. (ku.edu)
Our results suggest that PIASy is an important E3 ligase that mediates mitotic SUMOylation in human cells. (ku.edu)
Testing the activity of PLK4 in fruit flies revealed that it plays a similar role as in human cells. (elifesciences.org)

Cyclin A2, Cyclin D1, Cyclin E2, CDK2, and CDK4) were significantly involved in the regulation of cell cycle downstream of TSPAN12. (molcells.org)
WB analysis of HeLa cell lysate using GTX33611 Cyclin D1 antibody [RM241]. (genetex.com)
IHC-P analysis of human mantle cell lymphoma tissue using GTX33611 Cyclin D1 antibody [RM241]. (genetex.com)

Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. (genetex.com)

He has published on the subjects of chromosome motility, spindle assembly, and mitotic checkpoints. (wikipedia.org)

His articles have appeared in highly ranked journals, including multiple publications in Science, Nature and The Journal of Cell Biology. (wikipedia.org)
It is rare to find such a wide-ranging perspective on this topic in one volume and this collection of papers will be valuable to investigators interested in many aspects of cell biology, genetics, and cancer. (cshlpress.com)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)

The total chromosomal content of a cell involves approximately 105 genes in a specialized macromolecule of deoxyribonucleic acid (DNA). (cdc.gov)

All somatic cells proliferate via a mitotic process determined by progression through the cell cycle. (bioinf.org)

Releasing Bod1-depleted cells from a monastrol block increases the frequency of syntelic attachments and the number of cells displaying biorientation defects. (rupress.org)

The activity of NEK6 is enhanced in several cancer cells, including colon adenocarcinoma (COAD) cells. (hindawi.com)
In this study, we aimed to investigate the effects of miRNAs targeting NEK6 in COAD cells. (hindawi.com)
Real-time polymerase chain reaction and western blotting were performed to determine the levels of NEK6 and miR-323a-3p in COAD cells. (hindawi.com)
In COAD cells, NEK6 was highly expressed, whereas miR-323a-3p was expressed at low levels and negatively regulated NEK6. (hindawi.com)

We investigated the effects of various concentrations of Tan IIA (5-10 μ g/mL) on mouse keratinocytes and human HaCat cells in vitro to confirm this hypothesis. (hindawi.com)

The company develops small molecule drugs that target various phases of cell cycle control for the treatment of cancer and other serious diseases. (pharmaceutical-technology.com)

Cell Biol. (nature.com)
J Cell Biol, 2007 Jan 1. (nih.gov)
Mol Cell Biol, 2006 Jul. (nih.gov)
J Cell Biol (2007) 179 (2): 187-197. (rupress.org)
J Cell Biol (2007) 179 (7): 1337-1345. (rupress.org)

Cell Death and Differentiation , 15. (strath.ac.uk)

Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. (kegg.jp)
Orderly progressions of events in the cell division cycle are necessary to ensure the replication of DNA and cell division. (ox.ac.uk)

Consistent with these observations, we found that E4F localizes to the mitotic spindle during the M phase of early embryos. (cnrs.fr)
Plogosertib is under clinical development by Cyclacel Pharmaceuticals and currently in Phase II for Diffuse Large B-Cell Lymphoma. (pharmaceutical-technology.com)
In G1 phase, cells have a single centrosome consisting of two centrioles joined by cohesion fibers. (biomedcentral.com)

A post-translational modification with SUMO (SUMOylation) can regulate various cellular events such as DNA replication, repair, transcription and cell cycle regulation. (ku.edu)
Involved in regulation of mitotic cell cycle. (nih.gov)
In our recent study we found that circadian clock genes play a role in regulation of the hair growth cycle during synchronized hair follicle cycling, uncovering an unexpected connection between these two timing systems within skin. (aging-us.com)

Our results revealed different functions of dCTCF during the cell cycle and suggested that dCTCF might contribute to the establishment of the three-dimensional architecture of the Drosophila genome by maintaining local chromatin compartments throughout the whole cell cycle. (biomedcentral.com)

Airway progenitor cells contain two parental centrioles (PC) and form structures called deuterosomes that nucleate centrioles during amplification. (elifesciences.org)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)

Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. (genetex.com)

Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. (elifesciences.org)
They localize in close proximity to the nucleus for the duration of interphase and play major roles in numerous cell functions. (biomedcentral.com)

Cells in which PLK4 was unable to modify STIL had too few centrioles when they were beginning to divide. (elifesciences.org)
In quiescent cells, centrioles dock at the plasma membrane and act as basal bodies that template the formation of cilia and flagella ( Breslow and Holland, 2019 ). (elifesciences.org)

Metacaspases (MCAs) are distant orthologues of caspases and have been proposed to play a role in programmed cell death in yeast and plants, but little is known about their function in parasitic protozoa. (strath.ac.uk)

An increase in the expression of the human NEK2 gene is strongly associated with the progression of non-Hodgkin lymphoma. (umbc.edu)

LmjMCA has a punctate distribution throughout the cell in interphase cells, but becomes concentrated in the kinetoplast (mitochondrial DNA) at the time of the organelle's segregation. (strath.ac.uk)
Centrosomes are animal-specific non-membranous organelles that localize in close proximity to the cell nucleus for the duration of interphase. (biomedcentral.com)

Clinically, grade 3B follicular lymphoma is treated like diffuse large B-cell lymphoma . (medscape.com)

Conly Leroy Rieder is a cancer researcher in the field of mitotic cellular division. (wikipedia.org)
2] Oncocytic cells in the thyroid are often called Hürthle cells, and oncocytic change is defined as cellular enlargement characterized by an abundant eosinophilic granular cytoplasm as a result of accumulation of altered mitochondria. (medscape.com)

This process was predicted by Mark Kirschner and Tim Mitchison in 1986, who formulated the so-called 'Search and Capture' hypothesis of mitotic spindle assembly. (wikipedia.org)

Hair follicles undergo continuous cycles of growth, involution and rest. (aging-us.com)

Our group has previously demonstrated the involvement of the alternatively spliced variants ERK1c and MEK1b (ERK1 is also known as MAPK3, and MEK1 as MAP2K1) in mitotic Golgi fragmentation. (biologists.com)

In this study, by comparing the activity of normal cell lines and cancer cell lines after treating with resveratrol, it was found that resveratrol has more significant cytotoxicity in cancer cell lines. (mdpi.com)

However, the molecular mechanism for this mitotic delay is not well understood. (ku.edu)
This is a conserved mechanism in XEEs and mammalian cells. (ku.edu)
Our results demonstrate that a cell-intrinsic surface area-dependent mechanism controls centriole and cilia abundance in multiciliated cells. (elifesciences.org)
Centrosome duplication is tightly regulated and limited at once per cell cycle through a mechanism that prevents re-duplication. (biomedcentral.com)
While these genes show a clear circadian pattern of expression in skin, as was previously demonstrated [ 9 - 11 ], their amplitude was higher during telogen and early anagen (Figure 1 ), indicating that in skin, the expression of clock controlled genes is dependent both on circadian mechanism and the hair growth cycle. (aging-us.com)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

Cell cycle adaptations of embryonic stem cells. (nih.gov)

Centrosomes were first described at the end of the 19th century by Theodor Boveri who had also the intuition of their central role in cell life [ 1 ]. (biomedcentral.com)
The number of centrosomes within a cell is strictly controlled [ 5 ] (Figure 1 ). (biomedcentral.com)

Although some treatments for prostate cancer inhibit prostate cancer progression, most patients eventually develop therapy resistance. (purdue.edu)
Since activation of androgen receptor (AR) is responsible for progression of prostate cancer and drug resistance, I further tested additional ways to inhibit AR to overcome therapy resistance. (purdue.edu)

Anatomy23

Organisms9

Diseases12

Chemicals and Drugs116

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes80

Disciplines and Occupations1

Information Science4

Health Care1

Mitosis20

Apoptosis21

Kinases5

Kinase10

Tumor7

Proteins9

Regulates3

Spindles2

Protein12

Kinetochores4

Checkpoint3

Proliferation10

Microtubule4

Arrest5

Interacts2

Inhibitors3

Chromosomes9

Kinesin3

Chromosome segregation1

Pathways1

Pathway2

Phosphorylation1

Induces1

Transition3

Inhibition1

HUMAN CELLS5

Cyclin3

Degradation1

Checkpoints1

Biology3

Chromosomal1

Somatic1

Defects1

NEK64

Vitro1

Small molecule1

Biol5

Differentiation1

Orderly2

Phase3

Regulation3

Chromatin1

Progenitor cells2

Overexpression1

Roles2

Centrioles2

Yeast1

Gene1

Interphase2

Diffuse large b-1

Cellular2

Hypothesis1

Undergo1

MEK11

Cancer cell1

Mechanism6

Embryonic1

Centrosomes2

Prostate cancer2