TumorsSpindleCarcinomaMitosisCorrelationHighInduceNuclearCellsStructuresCellularBreastActivityCellDensityCancerFactorImportantResultsCycleProliferative activityChromosome aberrationsCellular proliferationApoptosisAbnormalitiesProgressionIndicesArrestCircadianChromosomesPrognostic valuePredictiveMitosesActivityNecrosisProliferationHistologicalFiguresDiagnosisTumor cellsPrimaryTumourGeneticSignificantlyAnaphaseSuggestsDifferentiationLiverHttpsGradeStudiesCases
Tumors4
- Grading of well-differentiated pancreatic neuroendocrine tumors is improved by the inclusion of both Ki67 proliferative index and mitotic rate. (tobycornish.com)
- So I have had tumors with higher mitotic indices where I'm more concerned that this is going to be aggressive and that led me to treat perhaps more aggressively than if it had been lower. (dogcancer.com)
- The aim of this study was to evaluate radiomics for distinguishing GISTs from other intra-abdominal tumors, and in GISTs, predict the c-KIT , PDGFRA , BRAF mutational status, and mitotic index (MI). (springer.com)
- I am an author for 25 book chapters in breast disease including the WHO blue book and Fletcher Diagnostic Histopathology of Tumors new editions and I am acting as a reviewer to 20 indexed and high profile international journals and editor to three journals. (nottingham.ac.uk)
Spindle2
- Our results are the first to tubes (SWCNT) suggest the potential to interact report disruption of the mitotic spindle by with critical biological structures. (cdc.gov)
- The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)
Carcinoma1
- Unlike lymphoepithelial carcinoma, SNUC are characterized by a high mitotic index, frequent necrosis, and nuclear pleomorphism. (ucdavis.edu)
Mitosis8
- Mitotic index is defined as the ratio between the number of a population's cells undergoing mitosis to its total number of cells. (wikipedia.org)
- The mitotic index is the number of cells undergoing mitosis divided by the total number of cells. (wikipedia.org)
- So mitotic index is an indication of the ratio of cells in a cancer sample that are actively dividing, or in mitosis, proportional to the rest of the cells in the sample. (dogcancer.com)
- synthesis .of :proteins necessary for mitosis and retardation of mitotic kinetics. (erowid.org)
- We present data on the occurrence of mitosis in storage cells of the eutardigrade Richtersius coronifer (Richters, 1903), and analyse mitotic cells in relation to different body characteristics, including egg development stage, moulting, gut content, body length, number and size of oocytes, and shape and size of the storage cells. (researchgate.net)
- The proportion of cells with mitosis ('mitotic index') was low: 0.76% in juveniles and 1.47% in adults. (researchgate.net)
- In juveniles, none of the measured phenotypic characters had significant predictive power for mitosis, whereas in adult animals in moult or in late egg developmental or post-laying stage were more likely to have mitotic storage cells. (researchgate.net)
- The low mitotic index and the strong association with moulting suggests that mitosis in storage cells may be connected with somatic growth rather than cell renewal, and that the purpose of cell division may relate to a need of more cells to support the enlarged body after moulting. (researchgate.net)
Correlation1
- This study was conducted to determine the significance of Ki‑67 expression in oral potential malignant and malignant lesions (MLs) as well as correlation of mitotic index (MI) with MIB‑1 labeling index (LI) in these lesions. (who.int)
High6
- A typical figure of mitotic index includes statements like "10 mitotic figures are noted per 10 high power fields" followed by "4 mitotic figures noted per 50 high power fields. (wikipedia.org)
- The aggressive potential of some cancers is closely linked to the mitotic index, while others can still be treated successfully even if the mitotic index is sky-high. (dogcancer.com)
- And so when a pathologist gives a mitotic index - that's typically when you'll have that number reported - they're counting, physically counting, the number of dividing cells in the sample that they're looking at over typically 10 random, what we call high powered fields under the microscope. (dogcancer.com)
- Histopathology shows high mitotic index and multinucleated giant cells. (hindawi.com)
- PFAG positive, high Ki-67 index) (Figures 2(c) and 2(d) ). (hindawi.com)
- The high proportion of mitotic cells and resemblance to well-differentiated adenocarcinoma of the large intestine suggested that this neoplasm was adenocarcinoma rather than adenoma. (hindawi.com)
Induce1
- Figure 6: Antimitotic drugs induce different mitotic and interphase phenotypes. (nature.com)
Nuclear1
- Generalized kappa values indicated substantial agreement for tubule formation (0.64), moderate agreement for mitotic count (0.52), and near moderate agreement for nuclear pleomorphism (0.40). (nih.gov)
Cells5
- An elevated mitotic index indicates more cells are dividing. (wikipedia.org)
- In cancer cells, the mitotic index may be elevated compared to normal growth of tissues or cellular repair of the site of an injury. (wikipedia.org)
- Mitotic I = (P+M+A+T) N ⋅ 100 % {\displaystyle {\mbox{Mitotic I}}={\frac {\mbox{(P+M+A+T)}}{\mbox{N}}}\cdot 100\%} where (P+M+A+T) is the sum of all cells in phase as prophase, metaphase, anaphase and telophase, respectively and N is total number of cells. (wikipedia.org)
- At its most basic, mitotic index is the count of how many cells in your dog's tumor are actively dividing , or reproducing. (dogcancer.com)
- The tumor had a large proportion of mitotic cells and its resemblance to adenocarcinoma of the large intestine was striking. (hindawi.com)
Structures1
- The mechanisms underlying asbestos-induced mutagenesis and alterations in gene expression are varied, and include generation of reactive oxidants, induction of chronic inflammation, and direct physical interference with mitotic structures (Huang et al. (atlasgeneticsoncology.org)
Cellular2
- The mitotic index is a measure of cellular proliferation. (wikipedia.org)
- The narrow diame- association with cellular and mitotic tubulin as ter and great length of single-walled carbon nano- well as the chromatin. (cdc.gov)
Breast1
- For example, a low mitotic index loses any prognostic value for women over 70 years old with breast cancer. (wikipedia.org)
Activity4
- Thus, CENP-E is required for enhancing recruitment of its binding partner BubR1 to each unattached kinetochore and for stimulating BubR1 kinase activity, implicating it as an essential amplifier of a basal mitotic checkpoint signal. (rupress.org)
- Apical mitotic activity and growth in clones of Norway spruce in relation to cold hardiness. (upsc.se)
- article{westin_apical_1999, title = {Apical mitotic activity and growth in clones of {Norway} spruce in relation to cold hardiness}, volume = {29}, doi = {10/dgsxgs}, abstract = {Seasonal development of apical mitotic activity and growth in three clones of Norway spruce (Picea abies (L.) Karst. (upsc.se)
- A comparative study with Ki-67 and the mitotic activity index. (bvsalud.org)
Cell1
- It also directly binds to BubR1, a kinetochore-associated kinase implicated in the mitotic checkpoint, the major cell cycle control pathway in which unattached kinetochores prevent anaphase onset. (rupress.org)
Density1
- Symbiodinium density was similar among sites yet their mitotic index increased in anemones under elevated p CO 2 . (nature.com)
Cancer4
- The mitotic index is therefore an important prognostic factor predicting both overall survival and response to chemotherapy in most types of cancer. (wikipedia.org)
- Oncologist Brooke Britton breaks down what mitotic index means for your dog with cancer, and when having this number can be helpful. (dogcancer.com)
- Mitotic index is one of the many complicated-sounding medical terms that may be thrown at you after your dog is diagnosed with cancer. (dogcancer.com)
- Today, we're going to unravel one of those crazy vocabulary words that we hear about when it comes to dog cancer: mitotic index. (dogcancer.com)
Factor1
- Dr. Brooke Britton: Mitotic index is just one factor amongst many that goes into determining tumor behavior, that goes into clinical decision-making. (dogcancer.com)
Important1
- Listen in to learn about the nuances of mitotic index, how to get it for your dog's tumor, and when it is most important to know this number before you make treatment decisions. (dogcancer.com)
Results1
- In contrast to results with 2D culture, observed mitotic arrest was relatively low, suggesting involvement of additional mechanisms in their antitumor effect in vivo . (nature.com)
Cycle1
- Cytophotometry was us:ed to find mitotic index - at 1, 6 and l0 hr and.cycle and.phase durations. (erowid.org)
Proliferative activity1
- Therefore, proliferative activity, whether evaluated by mitotic figures or the variety of available proliferative markers, should be largely confined to the lower 15% of the normal ectocervical epithelium. (medscape.com)
Chromosome aberrations1
- Significant differences were also observed in chromosome aberrations (CA), micronucleus (MN) frequency, mitotic index (MI) and ratio of polychromatic erythrocytes (PCEs) in all treatment groups. (stopumts.nl)
Cellular proliferation2
- The mitotic index is a measure of cellular proliferation. (wikipedia.org)
- The BDO2-treated LU cells were evaluated for cell cycle progression, nuclear localization of arrest mediators, mitotic index, and cellular proliferation. (nih.gov)
Apoptosis1
Abnormalities1
- In almost all assayed samples a C-mitotic effects of the extracts was observed since the mitotic index decreased and mitotic abnormalities increased with increasing extract concentrations. (conicet.gov.ar)
Progression2
- Our results demonstrate a novel, isoform-specific localization of CaV1 channels during cell division and suggest a possible role for these channels in the calcium-dependent events underlying mitotic progression in pituitary corticotrophs. (hindawi.com)
- the critical point at which progression through mitotic stages is closely regulated has also been shown [ 20 - 24 ]. (hindawi.com)
Indices1
- In this study, we evaluated the total mitotic indices of the cervical epithelia in hysterectomy specimens from patients with and without dysplastic lesions and investigated a possible relationship between mitotic index and hormonal status, using the endometrial maturation phase as a surrogate indicator of the latter. (medscape.com)
Arrest1
- Our goal was to examine the role p53 plays in protecting cells from arsenite-induced mitotic arrest. (nih.gov)
Circadian1
- 1971. Circadian variations of DNA synthesis, mitotic activity, and cell size of hepatocyte population in young immature male mouse growing liver. (nih.gov)
Chromosomes3
- Faithful segregation of replicated chromosomes is essential for maintenance of genetic stability and seems to be monitored by several mitotic checkpoints. (nature.com)
- In eukaryotes, mitotic entry is marked by the profound reorganization of chromatin into mitotic chromosomes driven by the condensin complex ( Hirano, 2016 ). (elifesciences.org)
- While mitotic chromosome assembly or condensation is essential for the accurate transmission of the genome to daughter cells, our understanding of the mechanisms by which condensin associates with chromatin, shapes mitotic chromosomes, and contributes to their accurate segregation in anaphase remains incomplete. (elifesciences.org)
Prognostic value5
- For example, a low mitotic index loses any prognostic value for women over 70 years old with breast cancer. (wikipedia.org)
- The prognostic value of two histological and two morphometric grading methods was inferior to that of the M/V index. (ac.be)
- In Cox's regression analysis the clinical stage (FIGO), the M/V index, and nuclear DNA content had independent prognostic value. (ac.be)
- In order to try to improve the SBR prognostic value, we first studied the three components of the SBR separately: ductoglandular differentiation proved the least predictive and nuclear pleomorphism and mitotic index the most predictive. (nih.gov)
- Prognostic value of mitotic index. (nih.gov)
Predictive1
- Thus, we hypothesized that interobserver variability and lack of defined mitotic thresholds for IDH-mutant astrocytomas underlies poor predictive accuracy of current histologic grading approaches. (nih.gov)
Mitoses1
- The M/V index is less subject to variation in the amount of neoplastic epithelium between neoplasms or in size of the microscope field than conventional mitotic index (mitoses/high power fields). (ac.be)
Activity4
- The M/V index expresses the mitotic activity of epithelial cancer as the number of mitotic figures per square millimeter of neoplastic epithelium in the microscope field. (ac.be)
- In ovarian cancer, the mitotic activity had the best reproducibility among histoquantitative variables between different observers and laboratories. (ac.be)
- To test this hypothesis, we quantified total mitotic figures and maximum mitotic activity per 10 high-powered fields in an institutional cohort of IDH-mutant astrocytomas. (nih.gov)
- A comparative study with Ki-67 and the mitotic activity index. (bvsalud.org)
Necrosis1
- No mitotic figures or necrosis are noted. (pathologyoutlines.com)
Proliferation2
- In Vitro Toxicity Studies: Cell proliferation: DNA incorporation, mitotic index etc. (cdc.gov)
- They found that mitotic index (a method for measuring cell proliferation) was increased in the rabbits who received PRP. (ichelp.org)
Histological1
- These observations will provide insight into the contribution of mitotic defects to histological grade and the etiology of breast cancer. (lshtm.ac.uk)
Figures5
- A typical figure of mitotic index includes statements like "10 mitotic figures are noted per 10 high power fields" followed by "4 mitotic figures noted per 50 high power fields. (wikipedia.org)
- The intraepithelial distribution, density, and nature (typical or atypical) of mitotic figures are routinely utilized diagnostic criteria to grade dysplasia and to distinguish high-grade dysplasia from potential histologic mimics such as transitional metaplasia, atrophy or immature squamous metaplasia. (medscape.com)
- A cervical mitotic index (total mitotic figures/10 high-power fields in the most proliferative area) was determined for each case. (medscape.com)
- Pineal parenchymal tumor of intermediate differentiation (PPTID) may also be considered in the differential but tends to have more cell uniformity, open salt-and-pepper chromatin, more abundant cytoplasm, and generally fewer mitotic figures than pineoblastoma. (cap.org)
- Survival time is linked to MCT's grade, stage, the location of the primary tumor, status of surgical margins, and mitotic index (number of mitotic figures per 10 high-power fields) (11-15). (edu.vn)
Diagnosis1
- Is using the mitotic index mast cell tumor diagnosis useful? (dogcancerblog.com)
Tumor cells1
- Like pineoblastoma, central neurocytoma also expresses synaptophysin but is usually negative for neurofilament, demonstrates a low mitotic rate, and is comprised of monomorphic tumor cells, often with an oligodendroglial appearance. (cap.org)
Primary1
- 6. Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST). (nih.gov)
Tumour1
- The presence of VEGF-A and bFGF was not related to microvessel density or tumour cell type, location, or mitotic index. (bmj.com)
Genetic1
- Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade. (lshtm.ac.uk)
Significantly3
- It is concluded that hormonal status, as reflected in endometrial maturation, can significantly affect the mitotic index of dysplastic squamous epithelium of the uterine cervix. (medscape.com)
- Mitotic index was low in both groups but not significantly. (cdc.gov)
- Mean SCE/cell was elevated significantly without affecting mitotic index and cell cycle kinetics. (cdc.gov)
Anaphase1
- Mitotic I = (P+M+A+T) N ⋅ 100 % {\displaystyle {\mbox{Mitotic I}}={\frac {\mbox{(P+M+A+T)}}{\mbox{N}}}\cdot 100\%} where (P+M+A+T) is the sum of all cells in phase as prophase, metaphase, anaphase and telophase, respectively and N is total number of cells. (wikipedia.org)
Suggests2
- Determining just how aggressive the tumor is up front is important when it comes to making treatment decisions, which is why Dr. Ettinger, my oncologist co-author , suggests looking at the mitotic index for mast cell tumor assessment. (dogcancerblog.com)
- The timing of the fall in mitotic index suggests that cells are held at the S - G 2 transition. (rupress.org)
Differentiation1
- Differentiation from pineocytoma rests on that tumor's features of relatively uniform cell morphology, pineocytomatous rosettes, and very low mitotic rate. (cap.org)
Liver1
- 1969. Mitotic index in the regenerating liver of tumor-bearing mice. (nih.gov)
Https1
- Hannu Haapasalo , «Volume corrected mitotic index (m/v index) in ovarian cancer», Acta Stereologica [En ligne], Volume 11 (1992), Number 1 - Quantitative histopathology - Aug. 1992, 89-98 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=1834. (ac.be)
Grade2
- You will not know the grade of your dog's mast cell tumor until after the biopsy is performed, of course, so you can't use the mitotic index for mast cell tumor assessment until AFTER you get that tumor surgically removed (with wide margins, please! (dogcancerblog.com)
- Mitotic index is an important component of histologic grade and has an etiologic role in breast tumorigenesis. (lshtm.ac.uk)
Studies1
- Several small candidate gene studies have reported associations between variation in mitotic genes and breast cancer risk. (lshtm.ac.uk)
Cases2
- Notably, the average mitotic index for our cervical intraepithelial neoplasia 1 cases with late proliferative endometrium was higher than our cervical intraepithelial neoplasia 2 cases with secretory and atrophic endometrium. (medscape.com)
- The M/V index was the best morphometric predictor in ovarian cancer in 105 cases studied. (ac.be)