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Cyclin G1Cyclin GCyclinsCyclin BCyclin ACyclin D1Cyclin B1Cyclin A2Cyclin ECdh1 ProteinsMitosisCyclin D3Cyclin D2Ubiquitin-Protein Ligase ComplexesAnaphase-Promoting Complex-CyclosomeCyclin-Dependent KinasesCyclin B2Cyclin A1Cell CycleCyclin DCDC2 Protein KinaseCell Cycle ProteinsCdc20 ProteinsAnaphaseG1 PhaseApc8 Subunit, Anaphase-Promoting Complex-CyclosomeS PhaseLigasesSecurinCDC28 Protein Kinase, S cerevisiaeCyclin-Dependent Kinase 2G2 PhaseCyclin-Dependent Kinase Inhibitor ProteinsCyclin G2Cyclin CCyclin-Dependent Kinase 4Saccharomyces cerevisiae ProteinsCDC2-CDC28 KinasesSpindle ApparatusMolecular Sequence DataRetinoblastoma ProteinUbiquitin-Protein LigasesPhosphorylationCyclin TSaccharomyces cerevisiaeAmino Acid SequenceProtein-Serine-Threonine KinasesFungal ProteinsCyclin-Dependent Kinase Inhibitor p27MetaphaseCyclin HXenopusDrosophila ProteinsDrosophilaProtein BindingCyclin-Dependent Kinase 6Nuclear ProteinsSequence Homology, Amino AcidBase SequenceCyclin-Dependent Kinase Inhibitor p21HeLa CellsOncogene ProteinsProtein Phosphatase 2Cell DivisionTumor Suppressor Protein p53MutationCell ProliferationCell Line, TumorRNA, MessengerCell NucleusCyclin IGenes, bcl-1NIH 3T3 CellsCell LineDown-RegulationS-Phase Kinase-Associated ProteinsTumor Suppressor ProteinsProto-Oncogene ProteinsTumor Cells, CulturedTransfectionProteasome Endopeptidase ComplexGene Expression Regulation, NeoplasticInterleukin-12 Receptor beta 2 Subunit3T3 CellsGene Expression RegulationE2F Transcription FactorsProtamine KinaseProto-Oncogene Proteins c-mdm2Recombinant Fusion ProteinsTranscription FactorsApoptosisF-Box ProteinsMicrotubule-Associated ProteinsProliferating Cell Nuclear AntigenG0 PhaseEnzyme InhibitorsDNA DamageAdenocarcinoma, Papillarycdc25 PhosphatasesA Kinase Anchor Proteins
KinaseKinasesDegradationSubunitsCdk1AntibodyProteinsMitosisProteinRegulatoryComplexesSpecificityRegulationCycleArrestPhaseComplexExpressionHumanLevel
Kinase11
  • β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression. (ox.ac.uk)
  • β-TrCP recognizes cyclin F through a non-canonical degron site (TSGXXS) after its phosphorylation by casein kinase II. (ox.ac.uk)
  • Although we did not identify any highly Clb2-specific substrates, we found that Clb2-Cdk1 possessed higher intrinsic kinase activity than Clb5-Cdk1, enabling efficient phosphorylation of a broad range of mitotic Cdk1 targets. (nature.com)
  • Fisher, D. L. & Nurse, P. A single fission yeast mitotic cyclin B p34 cdc2 kinase promotes both S-phase and mitosis in the absence of G1 cyclins. (nature.com)
  • Targets of the cyclin-dependent kinase Cdk1. (nature.com)
  • Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. (nature.com)
  • Schulman, B. A., Lindstrom, D. L. & Harlow, E. Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. (nature.com)
  • This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. (novusbio.com)
  • This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. (novusbio.com)
  • The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. (cancerindex.org)
  • Dysregulation of CDK8 (Cyclin-Dependent Kinase 8) and its regulatory partner CycC (Cyclin C) , two subunits of the conserved Mediator (MED) complex, have been linked to diverse human diseases such as cancer. (sdbonline.org)
Kinases5
Degradation5
  • The degradation of cyclin F mediated by β-TrCP occurs at the G2/M transition. (ox.ac.uk)
  • The model depends on Cdh1-regulated cyclin degradation during G1, regulation of B cyclin/Cdk1 activity by cyclin A/Cdk via Wee1, and transcriptional control of the mitotic cyclins that reflects some of the current literature. (ebi.ac.uk)
  • We introduced autocatalytic transcription of E2F, E2F regulated transcription of cyclin B, Cdc20/Cdh1 mediated E2F degradation, enhanced transcription of mitotic cyclins during late S/early G2 phase, and the sustained synthesis of cyclin B during mitosis. (ebi.ac.uk)
  • Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. (novusbio.com)
  • Numerical simulations reproduce the main features of wild-type mitotic cycles: patterns of protein accumulation and degradation, lengthening of later cycles, and arrest in interphase 14. (vt.edu)
Subunits3
  • Mitotic cyclins stably associate with CDC2 and function as regulatory subunits. (caslab.com)
  • The activity of CDKs is controlled by their binding to coactivator subunits termed Cyclins, as well as by CDK inhibitory proteins termed CKIs. (intechopen.com)
  • Cyclins (regulatory subunits) bind to cdks (catalytic subunits) to form complexes that regulate the progression of the cell cycle. (bdbiosciences.com)
Cdk14
  • The model was built by integrating and modifying two previously published models such that the model outputs for cyclins A and B fit cyclin expression measurements and the activation of B cyclin/Cdk1 coincided with phosphorylation of histone H3. (ebi.ac.uk)
  • Here we compare the specificity of two budding yeast cyclins, the S-phase cyclin Clb5 and the M-phase cyclin Clb2, in the phosphorylation of 150 Cdk1 (Cdc28) substrates. (nature.com)
  • The main cyclin-cdks complexes formed in vertebrate cells are cyclin D-cdk4 (G0/G1), cyclin E-cdk2 (G1/S), cyclin A-cdk2 (S) and cyclin B1-cdk1 (G2/M). These complexes are regulated by activating and inhibitory phosphorylation events, as well as by interactions with small regulatory proteins including p21 and p27Kip1. (bdbiosciences.com)
  • Cyclin A is involved in both S-phase and G2/M transitions of the cell cycle through its association with cdk2 and cdk1, respectively. (bdbiosciences.com)
Antibody8
  • Immunocytochemistry/ Immunofluorescence: Cyclin H Antibody (1B8) [H00000902-M01] - Analysis of monoclonal antibody to CCNH on HeLa cell. (novusbio.com)
  • Immunohistochemistry-Paraffin: Cyclin H Antibody (1B8) [H00000902-M01] - Analysis of monoclonal antibody to CCNH on formalin-fixed paraffin-embedded human testis. (novusbio.com)
  • Western Blot: Cyclin H Antibody (1B8) [H00000902-M01] - CCNH monoclonal antibody (M01), clone 1B8 Analysis of CCNH expression in HeLa. (novusbio.com)
  • Sandwich ELISA: Cyclin H Antibody (1B8) [H00000902-M01] - Detection limit for recombinant GST tagged CCNH is approximately 1ng/ml as a capture antibody. (novusbio.com)
  • WB analysis of HeLa cell lysate using GTX33611 Cyclin D1 antibody [RM241]. (genetex.com)
  • IHC-P analysis of human tonsil tissue using GTX33611 Cyclin D1 antibody [RM241]. (genetex.com)
  • There are currently no references for Cyclin D1 antibody [RM241] (GTX33611) . (genetex.com)
  • ATCC CCL-243) were probed with the mouse anti-human cyclin A antibody at concentration of 2.0 µg/mL (lane 1), 1.0 µg/mL (lane 2), and 0.5 µg/mL (lane 3). (bdbiosciences.com)
Proteins3
  • The precise regulation of the levels of cyclin proteins is fundamental to coordinate cell division with checkpoints, avoiding genome instability. (ox.ac.uk)
  • The accumulation of both Cyclin and CKI proteins is tightly regulated at the level of transcription. (intechopen.com)
  • In addition, Cyclin and CKI proteins are controlled at the level of their destruction. (intechopen.com)
Mitosis1
  • This event is required to promote mitotic progression and favors the activation of a transcriptional program required for mitosis. (ox.ac.uk)
Protein3
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. (novusbio.com)
  • Specific substrates for cdk-cyclin complexes include nuclear lamins, histones, oncogenes (e.g., c-abl and SV40 large T-Ag), tumor suppressor genes (e.g., retinoblastoma protein, Rb), nucleolin and others. (bdbiosciences.com)
  • Faha B, Ewen ME, Tsai LH, Livingston DM, Harlow E. Interaction between human cyclin A and adenovirus E1A-associated p107 protein. (bdbiosciences.com)
Regulatory1
  • This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (genetex.com)
Complexes1
  • A- and B-type cyclins differentially modulate substrate specificity of cyclin-cdk complexes. (nature.com)
Specificity1
  • Miller, M. E. & Cross, F. R. Cyclin specificity: how many wheels do you need on a unicycle? (nature.com)
Regulation1
  • however, the mechanisms underlying the regulation of cyclin F are poorly understood. (ox.ac.uk)
Cycle1
  • Bifurcation analysis of the differential equations reveals the dependence of mitotic oscillations on cycle number, and how this dependence is altered by mutations. (vt.edu)
Arrest1
  • The model is consistent with mutations that introduce subtle changes in the number of mitotic cycles before interphase arrest. (vt.edu)
Phase1
  • Donaldson, A. D. The yeast mitotic cyclin Clb2 cannot substitute for S phase cyclins in replication origin firing. (nature.com)
Complex1
  • Cyclin A may also form a complex with the adenovirus oncoprotein E1A which has DNA binding activity. (bdbiosciences.com)
Expression1
Human1
  • Human cyclin A has been reported to migrate between 54-60 kDa by SDS-PAGE and clone BF683 reportedly does not cross-react with mouse, rat or mink cyclin A. (bdbiosciences.com)
Level1
  • During these mitotic cycles, there are barely detectable oscillations in the total level of B-type cyclins. (vt.edu)