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  • gene
  • Together, these data identify the cyclin A2 gene as a cellular target for RASSF1A through p120 E4F and for the first time suggest a transcriptional mechanism for RASSF1A-dependent cell cycle regulation. (aacrjournals.org)
  • ) The oscillations of the cyclins, namely fluctuations in cyclin gene expression and destruction by the ubiquitin mediated proteasome pathway, induce oscillations in Cdk activity to drive the cell cycle. (wikipedia.org)
  • By producing stably transformed cells of a synchronized culture with the Nicsy;CycB1;1 promoter/β-glucuronidase (gus) reporter gene fusion, we demonstrate that the 1149 bp promoter fragment mediates a gus transcriptional oscillation, indistinguishable from that of endogenous Nicsy;CycB1;1 cyclin B transcripts. (deepdyve.com)
  • Clb5
  • We looked for but did not obtain strong evidence for cyclin specificity in the use of different mechanisms to control rereplication: both the S-phase cyclin Clb5 and the mitotic cyclins Clb1-4 were inferred to be capable of imposing ORC-based and MCM-based controls. (genetics.org)
  • overexpression
  • Therefore, trichomes provide an ideal model system to monitor easily the changes that may be expected from the overexpression of D-type cyclins. (pnas.org)
  • CycB1
  • The deduced amino acid sequences of the isolated cDNAs (Arath;CycB1;3 and Arath;CycB1;4) show the highest sequence similarity with mitotic cyclins. (deepdyve.com)
  • Arath;CycB1;3 is most homologous to the plant CycB1group cyclins and contains a conserved motif that is typical of this group. (deepdyve.com)
  • Arath;CycB1;4, while homologous to Arath;CycB1;2, has some features that make it different from other known mitotic-like cyclins. (deepdyve.com)
  • expression
  • Similarly, expression of D-type cyclins in endoreduplicating human megakaryocytes leads to an increase in the DNA content ( 4 ). (pnas.org)
  • binds
  • Kaposi sarcoma herpesvirus ( KSHV ) encodes a D-type cyclin (ORF72) that binds CDK6 and is likely to contribute to KSHV-related cancers . (wikipedia.org)
  • contributes
  • During late anaphase and the next G1, the APC/C in complex with Cdh1 (APC/C Cdh1 ) contributes to the full removal of M cyclins (for review see Sullivan and Morgan, 2007 ). (rupress.org)
  • sequence
  • The initial cytoplasmic retention of cyclins Ib and II correlates with their possession of a sequence similar to the cytoplasmic-retention signal of animal cyclin B1. (deepdyve.com)
  • Cyclins are generally very different from each other in primary structure, or amino acid sequence. (wikipedia.org)