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  • yeast
  • In budding yeast, physiological perturbations that inhibit cell-cycle progression do so through checkpoints whose primary effect is thought to be maintenance of high mitotic CDK activity. (biomedcentral.com)
  • The idea that Cdc2 and cyclins play a key role in the control of the G2/M transition of the cell cycle came largely from genetic analysis of fission yeast and physiological studies of clam, frog, sea urchin and starfish eggs and oocytes. (biologists.org)
  • Positive feedback in the activation of G1 cyclins in yeast. (ox.ac.uk)
  • Yeast cells become committed to the mitotic cell cycle at a stage during G1 called Start. (ox.ac.uk)
  • accumulates
  • In prometaphase phospho‐APC accumulates on centrosomes where cyclin B ubiquitination is initiated, appears throughout the cytosol and disappears during mitotic exit. (embopress.org)
  • contrast
  • In contrast to CDK protein levels, which remain stable throughout the cell cycle, the levels of activating cyclins differ in different stages of cycle [ 2 ]. (omicsonline.org)
  • In contrast, cell division activity in the indeterminate nodules is maintained and forms an apical meristem (nodule zone I). Because the size of the meristem is constant, cell division activity and production of new sets of meristematic cells are balanced with the exit of the same number of cells from the mitotic cell cycle. (pnas.org)
  • regulation
  • Endocycles, therefore, offer a unique opportunity to examine the regulation of DNA replication in the absence of the mitotic program. (rupress.org)
  • regulates
  • Here, we report that HDAC10 regulates the cell cycle via modulation of cyclin A2 expression, and cyclin A2 overexpression rescues HDAC10 knockdown-induced G 2 /M transition arrest. (asm.org)
  • HDAC10 regulates cyclin A2 expression by deacetylating histones near the let-7 promoter, thereby repressing transcription. (asm.org)
  • Protein
  • The functional specificity of the BCR complex depends on the BTB domain-containing protein as the susbstrate recognition component. (abcam.com)
  • They also require the CDC28 protein kinase and at least one of three G1-specific cyclins encoded by CLN1, 2, and 3. (ox.ac.uk)
  • signals
  • The decisions of individual cells to enter the cell cycle, maintain proliferation competence, become quiescent, expand, differentiate, or die depend on the perception of various signals. (plantcell.org)