Loading...
  • gene
  • Together, these data identify the cyclin A2 gene as a cellular target for RASSF1A through p120 E4F and for the first time suggest a transcriptional mechanism for RASSF1A-dependent cell cycle regulation. (aacrjournals.org)
  • ) The oscillations of the cyclins, namely fluctuations in cyclin gene expression and destruction by the ubiquitin mediated proteasome pathway, induce oscillations in Cdk activity to drive the cell cycle. (wikipedia.org)
  • By producing stably transformed cells of a synchronized culture with the Nicsy;CycB1;1 promoter/β-glucuronidase (gus) reporter gene fusion, we demonstrate that the 1149 bp promoter fragment mediates a gus transcriptional oscillation, indistinguishable from that of endogenous Nicsy;CycB1;1 cyclin B transcripts. (deepdyve.com)
  • anaphase
  • Following anaphase, dephosphorylation of Hct1 by Cdc14 may help initiate cyclin destruction (Jaspersen, 1999). (sdbonline.org)
  • Two consecutive pathways, Cdc fourteen early anaphase release (FEAR) and mitotic exit network (MEN), contribute to the progressive activation of Cdc14 by regulating its release from the nucleolus, where it is kept inactive by Cfi1. (rupress.org)
  • During late anaphase and the next G1, the APC/C in complex with Cdh1 (APC/C Cdh1 ) contributes to the full removal of M cyclins (for review see Sullivan and Morgan, 2007 ). (rupress.org)
  • Clb5
  • We looked for but did not obtain strong evidence for cyclin specificity in the use of different mechanisms to control rereplication: both the S-phase cyclin Clb5 and the mitotic cyclins Clb1-4 were inferred to be capable of imposing ORC-based and MCM-based controls. (genetics.org)
  • stably
  • In A549 clones stably expressing RASSF1A, cyclin A2 levels were diminished compared with vector control. (aacrjournals.org)
  • However, electrophoretic mobility shift assays indicate that knockdown of endogenous RASSF1A in HB2 and HeLa cells leads to a reduction in the binding capacity of p120 E4F to the cyclin A2 promoter, whereas in the A549 clone stably expressing RASSF1A the binding capacity is increased. (aacrjournals.org)
  • cell
  • Cyclin II binds to all microtubule arrays during the cell cycle, becoming markedly concentrated in the phragmoplast, and cyclin III associates with the spindle and then the phragmoplast. (deepdyve.com)
  • A labile cyclin-GUS reporter was developed to facilitate the spatio-temporal analysis of cell division patterns. (nih.gov)
  • The chimeric reporter protein is turned over every cell cycle and hence its histochemical activity accurately reports individual mitotic cells. (nih.gov)
  • However, instead of larger cells with more branches, the ectopic expression of one of the D-type cyclins, CYCD3;1, induced cell divisions that led to multicellular trichomes. (pnas.org)
  • Our analysis reveals temporal variation in mitotic activity and the cell division is coordinated across clonally distinct layers of cells. (biologists.org)
  • By the way, the name cyclin, which I coined, was really a joke, it's because I liked cycling so much at the time, but they did come and go in the cell. (wikipedia.org)
  • Expression of human cyclins through the cell cycle . (wikipedia.org)
  • Cyclins were originally named because their concentration varies in a cyclical fashion during the cell cycle. (wikipedia.org)
  • Note that the cyclins are now classified according to their conserved cyclin box structure, and not all these cyclins alter in level through the cell cycle. (wikipedia.org)
  • Cyclins can be divided into four classes based on their behavior in the cell cycle of vertebrate somatic cells and yeast cells: G1 cyclins, G1/S cyclins, S cyclins, and M cyclins. (wikipedia.org)
  • This division is useful when talking about most cell cycles, but it is not universal as some cyclins have different functions or timing in different cell types. (wikipedia.org)
  • The cyclins also promote other activities to progress the cell cycle, such as centrosome duplication in vertebrates or spindle pole body in yeast. (wikipedia.org)
  • G1 cyclins do not behave like the other cyclins, in that the concentrations increase gradually (with no oscillation), throughout the cell cycle based on cell growth and the external growth-regulatory signals. (wikipedia.org)
  • The presence of G cyclins coordinate cell growth with the entry to a new cell cycle. (wikipedia.org)
  • Recombinant Hct1 activates the cyclin-ubiquitin ligase activity of APC isolated from multiple cell cycle stages. (sdbonline.org)
  • G0 is sometimes referred to as a "post-mitotic" state, since cells in G0 are in a non-dividing phase outside of the cell cycle. (wikibooks.org)
  • On occasion, a distinction in terms is made between a G0 cell and a 'post-mitotic' cell (e.g., heart muscle cells and neurons), which will never enter the G1 phase, whereas other G0 cells may. (wikibooks.org)
  • A common theme emerges where events that must happen only once per cycle, although intrinsically capable of oscillations, are limited to one occurrence by the cyclin-Cdk cell cycle engine. (rupress.org)
  • One of the most compelling pieces of evidence for direct involvement of the cell cycle machinery is the identification of the G 1 cyclin Hgc1 as a specific regulator of C. albicans hyphal development ( 52 ). (asm.org)
  • overexpression
  • Therefore, trichomes provide an ideal model system to monitor easily the changes that may be expected from the overexpression of D-type cyclins. (pnas.org)
  • CycB1
  • The deduced amino acid sequences of the isolated cDNAs (Arath;CycB1;3 and Arath;CycB1;4) show the highest sequence similarity with mitotic cyclins. (deepdyve.com)
  • Arath;CycB1;3 is most homologous to the plant CycB1group cyclins and contains a conserved motif that is typical of this group. (deepdyve.com)
  • Arath;CycB1;4, while homologous to Arath;CycB1;2, has some features that make it different from other known mitotic-like cyclins. (deepdyve.com)
  • CDK6
  • Kaposi sarcoma herpesvirus ( KSHV ) encodes a D-type cyclin (ORF72) that binds CDK6 and is likely to contribute to KSHV-related cancers . (wikipedia.org)
  • cells
  • Some types of cells, such as nerve and heart muscle cells, become post-mitotic when they reach maturity (i.e., when they are terminally differentiated) but continue to perform their main functions for the rest of the organism's life. (wikibooks.org)