Mitotic cell cycle progression mitotic cells cell cycle. Medical search. Frequent questions

Here we show that cell cycle progression through mitosis following double-stranded DNA breaks leads to the formation of micronuclei, which precede activation of inflammatory signalling and are a repository for the pattern-recognition receptor cyclic GMP-AMP synthase (cGAS). (nature.com)
Inhibiting progression through mitosis or loss of pattern recognition by stimulator of interferon genes (STING)-cGAS impaired interferon signalling. (nature.com)
Figure 2: Progression through mitosis underlies inflammatory pathway activation. (nature.com)
His pictures of newt lung cells undergoing the various stages of mitosis have appeared on numerous covers of the aforementioned journals alongside his articles. (wikipedia.org)
Rieder pioneered the idea that cells remain in mitosis until each chromosome becomes attached to the spindle and only then mitotic exit is initiated. (wikipedia.org)
LmjMCA also translocates to the nucleus during mitosis, where it associates with the mitotic spindle. (strath.ac.uk)
In yeast and mammalian cells, the catalytic disruption of Topo IIα is reported to induce a delay in mitosis. (ku.edu)
Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. (kegg.jp)
282, 32053-32064), a key regulator of mitosis, suggesting a possible role for hMDC1 in controlling normal cell cycle progression. (ox.ac.uk)
This event is required to promote mitotic progression and favors the activation of a transcriptional program required for mitosis. (ox.ac.uk)
At the onset of mitosis, centrosomes become the core structures of spindle poles and direct the formation of mitotic spindles. (biomedcentral.com)
In early mitosis, the cohesion between the two pairs of centrioles is broken and each of them participates in the formation of the mitotic spindle pole. (biomedcentral.com)
During mitosis the two centrosomes are present and form the mitotic spindle poles. (biomedcentral.com)
We characterized dCTCF-binding sites according to their occupancy status during the cell cycle, and identified three classes: interphase-mitosis-common (IM), interphase-only (IO) and mitosis-only (MO) sites. (biomedcentral.com)
Ispinesib (SB-715992) is a potent inhibitor of kinesin spindle protein, a kinesin motor protein essential for the formation of a bipolar mitotic spindle and cell cycle progression through mitosis. (adooq.com)
Monastrol is a potent, cell permeable non-tubulin-interacting mitosis inhibitor. (adooq.com)
Monastrol blocks mitosis (IC5N/A = 14 μM) by binding to the mitotic kinesin Eg5, a motor protein required for spindle bipolarity. (adooq.com)
During licensing, which occurs in late mitosis and early G1, post-mitotic unreplicated chromatin binds several protein complexes. (nih.gov)

He has published on the subjects of chromosome motility, spindle assembly, and mitotic checkpoints. (wikipedia.org)
This process was predicted by Mark Kirschner and Tim Mitchison in 1986, who formulated the so-called 'Search and Capture' hypothesis of mitotic spindle assembly. (wikipedia.org)
By using the laser to ablate kinetochores on individual chromosomes, Rieder proved that the signal that delays mitotic progression is produced by kinetochores that lack attachment to spindle microtubules. (wikipedia.org)
The activity of NEK6 plays important roles in mitotic spindle kinetochore fiber formation, metaphase-anaphase transition, cytokinesis, and checkpoint regulation [ 3 , 4 ]. (hindawi.com)
Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. (elifesciences.org)
Centrosomes nucleate the formation of the microtubule cytoskeleton in interphase cells and form the poles of the mitotic spindle during cell division. (elifesciences.org)
CCT251455 is a potent and selective mitotic kinase monopolar spindle 1 (MPS1) inhibitor with an IC50 of 3 nM. (adooq.com)
Occupational exposure limits with proteins such as topoisomerase inhibitors, and mitotic and meiotic spindle poisons. (cdc.gov)

The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, 5-ethynyl-2′-deoxyuridine assay, propidium iodide (PI) staining, annexin V-fluorescein isothiocyanate/PI staining, and transwell assay were employed to test the proliferation, apoptosis, migration ability, and invasiveness of COAD cells. (hindawi.com)
Upregulating the level of miR-323a-3p impaired the proliferation, migration, and invasion of COAD cells and promoted apoptosis, whereas supplementing NEK6 alleviated the damage of the proliferation, migration, and invasion of COAD cells caused by miR-323a-3p and inhibited miR-323a-3p-induced apoptosis. (hindawi.com)
These findings indicate that miR-323a-3p regulates the proliferation, migration, invasion, and apoptosis of COAD cells by targeting NEK6. (hindawi.com)
Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. (hindawi.com)
Furthermore, Tan IIA-induced apoptosis and mitochondrial membrane potential changes were also further demonstrated by DNA fragmentation, single-cell gel electrophoresis assay (SCGE), and flow cytometry methods. (hindawi.com)
Therefore, based on clinical experience as well as cytotoxic activity against multiple human cancer cells, we hypothesized that induction of apoptosis is the underlying mechanism for the treatment of psoriasis. (hindawi.com)
Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. (caslab.com)
Conclusions These findings ascertained an conversation between p53, c-myc, p21, p27, Bcl-2, PI3K/Akt pathway, and CF-induced apoptosis in MSTO-211H and HCT-116 cells, suggesting that CF acts as an important regulator of cell growth in human malignancy cell lines. (bioinf.org)
Many physiological processes, including proper tissue development and homeostasis, require a balance between apoptosis and cell 123653-11-2 manufacture proliferation. (bioinf.org)
Apoptosis (programmed cell death) occurs in a wide variety of physiological NIK settings, where its role is to remove harmful, damaged or unwanted cells. (bioinf.org)
Apoptosis and cell proliferation are linked by cell-cycle regulators and apoptotic stimuli that affect both processes. (bioinf.org)
A failure in regulating proliferation together with suppression of apoptosis are the 123653-11-2 manufacture minimal requirements for a cell to become cancerous [4]. (bioinf.org)
Sirtuins are NAD + -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. (biomedcentral.com)
Here, we examined the role of the Bcl-2 family proteins in AURK inhibition-induced apoptosis in colon cancer cells. (bvsalud.org)
We found that alisertib and danusertib, two small-molecule inhibitors of AURK, are inefficient inducers of apoptosis in HCT116 and DLD-1 colon cancer cells, the survival of which requires at least one of the two antiapoptotic Bcl-2 family proteins, Bcl-xL and Mcl-1. (bvsalud.org)
We further identified Bcl-xL as a major suppressor of alisertib- or danusertib-induced apoptosis in HCT116 cells. (bvsalud.org)
Together, these results define the Bcl-2 protein network critically involved in AURK inhibitor-induced apoptosis and suggest that BH3-mimetics targeting Bcl-xL may help overcome resistance to AURK inhibitors in cancer cells. (bvsalud.org)
Additionally, miR-1291 induced cell apoptosis. (bvsalud.org)
Beginning after completion of hair morphogenesis (postnatal day 14 in the mouse), hair growth cycles commence with catagen, an involution process of the hair follicle during which the majority of its epithelial compartments undergo apoptosis [ 1 ]. (aging-us.com)

Small interfering RNA depletion of Bod1 in HeLa cells produces elongated mitotic spindles with severe biorientation defects. (rupress.org)
Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. (rupress.org)

The mitotic reorganization of the Golgi is accompanied by a temporary block in Golgi functioning, as protein transport in and out of the Golgi stops. (biologists.com)
By performing cell biological and biochemical experiments using human cells, Moyer and Holland show that PLK4 interacts with a protein called STIL that is found in the central part of the centriole. (elifesciences.org)
The modification of STIL at a specific location by PLK4 was needed to link it to another protein in the outer wall of the centriole, and was also necessary for the cells to build new centrioles. (elifesciences.org)
The protein serine/threonine kinase Akt (also known as protein kinase B or PKB) plays an important role in averting cell death. (bioinf.org)
The p53 protein is a transcription factor that normally inhibits cell growth and stimulates cell death in response to myriad stressors, including DNA damage (induced by either UV or chemical agents such as hydrogen peroxide), oxidative stress, and deregulated oncogene expression [6-10]. (bioinf.org)
Mitotic cells lacking hMDC1 exhibit markedly reduced levels of APC/C activity characterized by reduced levels of Cdc20, and a failure of Cdc20 to bind the APC/C and CREB-binding protein. (ox.ac.uk)
In addition HIV-1 Vpr protein alters the cell-cycle regulation by hijacking centrosome functions. (biomedcentral.com)
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. (genetex.com)
However, changes of CTCF-binding sites during the cell cycle, and functions of this protein at different cell cycle phases, remain largely uncharacterized. (biomedcentral.com)
GSK-923295, is a small-molecule inhibitor of the mitotic kinesin centromere-associated protein E, (CENP-E). (adooq.com)
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. (adooq.com)
miR-1291 also suppressed DCLK1 mRNA and protein expression in HCT116 cells that expressed DCLK1. (bvsalud.org)

However, a major unresolved question is how each cell regulates the precise number of its motile cilia during differentiation. (elifesciences.org)
Mediator of DNA damage checkpoint 1 (MDC1) regulates mitotic progression. (ox.ac.uk)
In this study, we investigated how TSPAN12 regulates OC cell proliferation both in vitro and in vivo and found that it contributed to tumor proliferation and poor prognosis in this disease through cyclin and cyclin-dependent kinase (CDK) pathways. (molcells.org)

Two proteins involved intimately in regulating cell proliferation are Akt and the tumor suppressor p53 (p53). (bioinf.org)
p53 has an important protective role against undesired cell proliferation. (bioinf.org)
Here, we have investigated the role of ChoK in the development of breast cancer and found that ChoK is both necessary and sufficient for growth factor-induced proliferation in primary human mammary epithelial cells and an absolute requirement for the specific mitogenic response to heregulin in breast tumor-derived cells. (aacrjournals.org)
These results demonstrate that ChoK plays an essential role in both normal human mammary epithelial cell proliferation and breast tumor progression. (aacrjournals.org)
However, a function for SET8 in mammalian cell proliferation has not been determined. (rupress.org)
We show that small interfering RNA inhibition of SET8 expression leads to decreased cell proliferation and accumulation of cells in S phase. (rupress.org)
Further exploration showed that TSPAN12 overexpression accelerated proliferation and colony formation of OVCAR3 and SKOV3 OC cells. (molcells.org)
Knockdown of TSPAN12 expression in A2780 and SKOV3 cells decreased both proliferation and colony formation. (molcells.org)
Cancer cells obtain a growth advantage through uncontrolled cell proliferation ( Hanahan and Weinberg, 2011 ), which may be caused by mutations that help them adapt to the microenvironment through selective pressure. (molcells.org)
Both in vitro and in vivo, SRSF2 significantly accelerated the proliferation of colon cancer cells. (bvsalud.org)
Knockdown of SLMAP-L or CETN3-S splice isoform could suppress the growth of colon cancer cells, predicting their role in malignant proliferation of colon cancer cells. (bvsalud.org)
Rescue of SLMAP-L or CETN3-S splice isoform in SRSF2 knockdown colon cancer cells could effectively reverse the inhibition of cell proliferation by SRSF2 knockdown through mediating cell cycle progression. (bvsalud.org)
It was identified that miR-1291 significantly suppressed the proliferation, invasion, cell mobility and colony formation of CRC cells. (bvsalud.org)

miRNAs expressed in a wide variety of human cancers can regulate posttranscriptional gene expression by binding to the 3′ untranslated region of the target mRNAs and act as oncogenes or tumor suppressors to regulate cell signaling pathways, affecting tumorigenesis and tumor progression [ 17 ]. (hindawi.com)
therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)
In a study of 56 patients with Hürthle cell cancer treated at Memorial Sloan-Kettering Cancer center, recurrence was a significant predictor of tumor-related mortality, and extent of invasion was the most significant predictor of outcome. (medscape.com)

Eukaryotic cells respond to DNA damage by activating signaling pathways that promote cell cycle arrest and DNA repair. (kegg.jp)
In support of a role for hMDC1 in controlling mitotic progression, depletion of hMDC1 by small interfering RNA results in a metaphase arrest that appears to be independent of both BubR1-dependent signaling pathways and ATM/ATR activation. (ox.ac.uk)
A number of direct and indirect radiation interaction pathways can produce damage to the DNA of irradiated cells. (cdc.gov)

The 82nd Cold Spring Harbor Symposium focused on Chromosome Segregation & Structure and addressed the enormous progress in our understanding of the nature and behavior of chromosomes during the life cycle of the cell. (cshlpress.com)
Each cell in our bodies contains over two meters of DNA, which is divided into 46 packages of information called chromosomes. (elifesciences.org)
This means that they also need to copy all of their DNA and then deliver identical sets of chromosomes to each new cell. (elifesciences.org)
Animal cells use structures called centrioles to help them divide their sets of chromosomes accurately. (elifesciences.org)
if too many or too few centrioles are built, cell division errors can occur that lead to the generation of new cells with abnormal numbers of chromosomes. (elifesciences.org)
Aurora B mislocalization on chromosomes utilizes the Haspin-H3T3P pathway and is a key factor for the mitotic delay. (ku.edu)
We have combined the proteomic analysis of Xenopus laevis in vitro-assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. (rupress.org)
Mitotic chromosome segregation requires the coordination of both regulatory and mechanical molecular machines and culminates in the delivery of two complete sets of chromosomes to two daughter cells. (rupress.org)
Each cell (except for red blood cells) contains a nucleus that houses these chromosomes. (cdc.gov)

Our results revealed different functions of dCTCF during the cell cycle and suggested that dCTCF might contribute to the establishment of the three-dimensional architecture of the Drosophila genome by maintaining local chromatin compartments throughout the whole cell cycle. (biomedcentral.com)
Regulatory interactions occur on licensed or unlicensed chromatin as a response to environmental conditions that determine whether cells proceed or halt their progression through the cell cycle. (nih.gov)

When cells are about to divide, they make a new set of centrioles by assembling a variety of proteins. (elifesciences.org)
Our group has identified DNA topoisomerase IIα (Topo IIα) as one of the important mitotic proteins for SUMOylation. (ku.edu)
The precise regulation of the levels of cyclin proteins is fundamental to coordinate cell division with checkpoints, avoiding genome instability. (ox.ac.uk)
These interactions, primarily through modifications of the phosphorylation status of proteins involved in licensing and initiation, determine whether replication will occur on a specific template during a specific time of the cell cycle. (nih.gov)
Cells depend on their DNA for coding information to make various classes of proteins that include enzymes, certain hormones, transport proteins, and structural proteins that support life. (cdc.gov)
Specialized cell structures called ribosomes are the cellular organelles that actually synthesize the proteins (RNA transcription). (cdc.gov)

As a cell biologist, Rieder was the first to observe microtubule capture by kinetochores in live cells. (wikipedia.org)
Each MCC contains hundreds of motile cilia, microtubule-based organelles that generate the motive force to move fluid over the surface of the cell. (elifesciences.org)
Bod1-depleted cells form syntelic attachments that can oscillate and generate enough force to separate sister kinetochores, suggesting that microtubule-kinetochore interactions were intact. (rupress.org)
Centrosomes are the major microtubule organizing structures in vertebrate cells. (biomedcentral.com)
In animal cells, centrosomes represent the major microtubule-organizing structures (MTOC). (biomedcentral.com)

Prophase I arrest and progression to metaphase I in mouse oocytes are controlled by Emi1-dependent regulation of APC(Cdh1). (nih.gov)
However, impaired splicing affects only a subset of human transcripts, enriched for mitotic cell cycle factors, leading to mitotic arrest. (biomedcentral.com)
Knockdown of SRSF2, its splicing targets SLMAP-L, or CETN3-S caused colon cancer cells to arrest in G1 phase of the cell cycle. (bvsalud.org)

Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. (genetex.com)

Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4). (elifesciences.org)
SUMOylated Topo IIα C-terminus (CTD) interacts with Haspin kinase and recruits chromosome passenger complex (CPC) to the mitotic centromeres. (ku.edu)
β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression. (ox.ac.uk)

CF treatment on leukemia cell lines induces cell death due to apoptotic mechanisms and altering 123653-11-2 manufacture cell metabolism through HIF-1 and GLUT-1 regulation [3]. (bioinf.org)

Dimethylenastron is an inhibitor of mitotic motor kinesin Eg5 with IC50 value of 200 nM. (adooq.com)
K 858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor with IC50 value of 1.3 uM. (adooq.com)
Kif15-IN-2 is an inhibitor of the mitotic kinesin Kif15, and is used for the research of cellular proliferative diseases. (adooq.com)

All somatic cells proliferate via a mitotic process determined by progression through the cell cycle. (bioinf.org)

Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. (kegg.jp)
Cyclin A2, Cyclin D1, Cyclin E2, CDK2, and CDK4) were significantly involved in the regulation of cell cycle downstream of TSPAN12. (molcells.org)
This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. (genetex.com)
WB analysis of HeLa cell lysate using GTX33611 Cyclin D1 antibody [RM241]. (genetex.com)
IHC-P analysis of human mantle cell lymphoma tissue using GTX33611 Cyclin D1 antibody [RM241]. (genetex.com)

Using Xenopus egg extracts (XEEs) we have shown that disruption of mitotic SUMOylation causes chromosome segregation defects. (ku.edu)

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. (nih.gov)
Furthermore, we find that SET8 interacts with proliferating cell nuclear antigen through a conserved motif, and SET8 is required for DNA replication fork progression. (rupress.org)

These findings implicate temporal modulation of the cell cycle as an important consideration in the context of therapeutic strategies that combine genotoxic agents with immune checkpoint blockade. (nature.com)
Checkpoint systems allow the accurate execution of each cell-cycle phase. (ox.ac.uk)

We investigated the effects of various concentrations of Tan IIA (5-10 μ g/mL) on mouse keratinocytes and human HaCat cells in vitro to confirm this hypothesis. (hindawi.com)

Aurora kinases (AURKs) are mitotic kinases important for regulating cell cycle progression. (bvsalud.org)

Cell Biol. (nature.com)
J Cell Biol, 2007 Jan 1. (nih.gov)
Mol Cell Biol, 2006 Jul. (nih.gov)
J Cell Biol (2007) 179 (2): 187-197. (rupress.org)
J Cell Biol (2007) 179 (7): 1337-1345. (rupress.org)

His articles have appeared in highly ranked journals, including multiple publications in Science, Nature and The Journal of Cell Biology. (wikipedia.org)
It is rare to find such a wide-ranging perspective on this topic in one volume and this collection of papers will be valuable to investigators interested in many aspects of cell biology, genetics, and cancer. (cshlpress.com)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)

Cell Death and Differentiation , 15. (strath.ac.uk)

Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. (kegg.jp)
Orderly progressions of events in the cell division cycle are necessary to ensure the replication of DNA and cell division. (ox.ac.uk)

Increases in the amount of PAPP-A mRNA in granulosa cells during follicular development occurs in some but not all species, indicating that other proteases or protease inhibitors may be involved in IGFBP degradation. (bioone.org)
however, the utility of these inhibitors as inducers of cancer cell death has thus far been limited. (bvsalud.org)

Increased manifestation levels of p53, p21, and p27, downregulation of c-myc and Bcl-2, and inhibition of Akt activation were also found in CF-treated MSTO-211 and HCT-116 cells. (bioinf.org)

A post-translational modification with SUMO (SUMOylation) can regulate various cellular events such as DNA replication, repair, transcription and cell cycle regulation. (ku.edu)
Involved in regulation of mitotic cell cycle. (nih.gov)
In our recent study we found that circadian clock genes play a role in regulation of the hair growth cycle during synchronized hair follicle cycling, uncovering an unexpected connection between these two timing systems within skin. (aging-us.com)

Airway progenitor cells contain two parental centrioles (PC) and form structures called deuterosomes that nucleate centrioles during amplification. (elifesciences.org)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)

The molecular interactions involved in DNA replication insure coordinated replication of the entire genome once and only once per cell cycle. (nih.gov)

One of the surprises that came from this study was the finding that genes regulated by the core circadian clock mechanism showed expression changes that correlated with the hair growth cycle, with highest expression during the telogen-anagen transition. (aging-us.com)

Cells in which PLK4 was unable to modify STIL had too few centrioles when they were beginning to divide. (elifesciences.org)
In quiescent cells, centrioles dock at the plasma membrane and act as basal bodies that template the formation of cilia and flagella ( Breslow and Holland, 2019 ). (elifesciences.org)
In G1 phase, cells have a single centrosome consisting of two centrioles joined by cohesion fibers. (biomedcentral.com)

LmjMCA has a punctate distribution throughout the cell in interphase cells, but becomes concentrated in the kinetoplast (mitochondrial DNA) at the time of the organelle's segregation. (strath.ac.uk)
They localize in close proximity to the nucleus for the duration of interphase and play major roles in numerous cell functions. (biomedcentral.com)
Centrosomes are animal-specific non-membranous organelles that localize in close proximity to the cell nucleus for the duration of interphase. (biomedcentral.com)

Conly Leroy Rieder is a cancer researcher in the field of mitotic cellular division. (wikipedia.org)
2] Oncocytic cells in the thyroid are often called Hürthle cells, and oncocytic change is defined as cellular enlargement characterized by an abundant eosinophilic granular cytoplasm as a result of accumulation of altered mitochondria. (medscape.com)

Hair follicles undergo continuous cycles of growth, involution and rest. (aging-us.com)

Our group has previously demonstrated the involvement of the alternatively spliced variants ERK1c and MEK1b (ERK1 is also known as MAPK3, and MEK1 as MAP2K1) in mitotic Golgi fragmentation. (biologists.com)

Metacaspases (MCAs) are distant orthologues of caspases and have been proposed to play a role in programmed cell death in yeast and plants, but little is known about their function in parasitic protozoa. (strath.ac.uk)

Together these data suggest that in L. major active LmjMCA is essential for the correct segregation of the nucleus and kinetoplast, functions that could be independent of programmed cell death, and that the amount of LmjMCA is crucial. (strath.ac.uk)

This is a conserved mechanism in XEEs and mammalian cells. (ku.edu)

Overall, only about 33% of Hürthle cell tumors demonstrate signs of that invasive growth that indicates malignancy and the possibility of metastasis. (medscape.com)
Hürthle cell cancer has the highest incidence of metastasis among the differentiated thyroid cancers. (medscape.com)

Upon cytokinesis, each daughter cell receives only one centriole, which duplicates once per cell cycle. (biomedcentral.com)
Each cell inherits one centrosome after the completion of cytokinesis. (biomedcentral.com)

CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. (kegg.jp)

Other recent studies verified the presence of PAPP-A mRNA in granulosa cells of humans, monkeys, cattle, mice, and pigs. (bioone.org)
Laboratory studies suggest that ginger can protect brain cells from the plaques that cause Alzheimer's disease, but this effect has not been studied in humans. (mskcc.org)
One exception is hu- humanized SCID mice, the use of al oncogenic viruses that are strictly man T-cell lymphotropic virus type 1 surrogate hosts has not proven very species-specific, causing cancer in (HTLV-1): in addition to its ability to useful for defining tumour site con- humans only. (who.int)
that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)

This suggests that the modification of STIL by PLK4 is important for normal cell division across different species. (elifesciences.org)
Further, to understand the role of SUMOylation more clearly in human cells we have targeted one of the important SUMOylation enzymes PIASy SUMO E3 ligase. (ku.edu)
Earlier in XEEs, we found that PIASy is an essentially important E3 ligase for mitotic SUMOylation. (ku.edu)
Our results suggest that PIASy is an important E3 ligase that mediates mitotic SUMOylation in human cells. (ku.edu)
suggesting that establishment of the correct number of cilia per cell is important for function. (elifesciences.org)

In order to systematically discover transcriptional activity associated with the hair growth cycle, we profiled mRNA expression at a genome-wide level over multiple time points corresponding to morphogenesis and two synchronized hair growth cycles. (aging-us.com)

His research has contributed to the growing understanding of the process of cell division and the pathology of cancer. (wikipedia.org)
The activity of NEK6 is enhanced in several cancer cells, including colon adenocarcinoma (COAD) cells. (hindawi.com)
In this study, by comparing the activity of normal cell lines and cancer cell lines after treating with resveratrol, it was found that resveratrol has more significant cytotoxicity in cancer cell lines. (mdpi.com)
Hürthle cell carcinoma of the thyroid gland is an unusual and relatively rare type of differentiated thyroid cancer. (medscape.com)
In another study done at Memorial Sloan-Kettering Cancer center,[5] outcomes of 56 patients with Hürthle cell cancer were analyzed. (medscape.com)
Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
To this day, many low dose radiation carcinogenesis studies assume that the probability that one cell of a multicellular organism will acquire multiple mutations transforming it into cancer and the ability of that cancer to thrive can be described by a curve plotted against an axis that shows total radiation dose. (cdc.gov)

Centrosome duplication is tightly regulated and limited at once per cell cycle through a mechanism that prevents re-duplication. (biomedcentral.com)

Testing the activity of PLK4 in fruit flies revealed that it plays a similar role as in human cells. (elifesciences.org)
Next, we sought to examine if PIASy has a conserved role in human cells. (ku.edu)
To address this question, we have established Tet-ON inducible ectopic expression of PIASy and SUMO interacting motif (SIM) mutants in human cells. (ku.edu)
The human body has nearly 1013 cells. (cdc.gov)
In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. (lu.se)
Without this, the patient cells lost in PD could be replaced by grafted community is left trying to interpret complex scien- immature human dopaminergic neurons [3, 5]. (lu.se)

Anatomy31

Organisms15

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Chemicals and Drugs110

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes78

Disciplines and Occupations1

Information Science3

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Mitosis18

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Protein12

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