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  • cells
  • Strongly stains mitotic cells and can therefore be used in flow cytometric analyses of cell suspensions to detect the mitotic index. (abcam.com)
  • Cells use a tiny machine called the mitotic spindle to share genetic material equally between cells when they divide. (theconversation.com)
  • Anti-cancer drugs have been developed which target the mitotic spindle and destroy dividing cells in tumours. (theconversation.com)
  • Understanding and controlling the action of the mitotic spindle could help us to better target treatment by directly shutting down defective cells. (theconversation.com)
  • In order to prepare a slide for cytogenetic study, a mitotic inhibitor is added to the cells being studied. (wikipedia.org)
  • However, experiments using budding yeast cells with cdc28-as1, a INM-PP1 (ATP analog)-sensitive Cdk allele, proved that destruction of B-type cyclins (Clb) is not necessary for triggering irreversible mitotic exit. (wikipedia.org)
  • An elevated mitotic index indicates more cells are dividing, and thus obvious in cancer cells, The mitotic index may be elevated during necessary processes to life, such as the normal growth of plants or animals, as well as cellular repair the site of an injury. (wikipedia.org)
  • Rad52 mutant yeast cells have increased sensitivity to killing by X-rays, methyl methanesulfonate and the DNA crosslinking agent 8-methoxypsoralen-plus-UV light, suggesting that mitotic recombinational repair is required for removal of the different DNA damages caused by these agents. (wikipedia.org)
  • The forces that drive cell rounding have recently been characterized by researchers from the groups of Professors Tony Hyman and Daniel Muller, who used flat atomic force microscopy cantilevers to constrain mitotic cells and measure the response force. (wikipedia.org)
  • As a result, the surface tension and effective stiffness of the actin cortex increase as has been consistently observed in mitotic cells. (wikipedia.org)
  • In HeLa cells in vitro, the force generated by a half-deformed mitotic cell is on the order of 50 to 100 nanonewtons. (wikipedia.org)
  • Overall, the biochemical events governing the morphological and mechanical changes in mitotic cells are orchestrated by the mitotic master regulator Cdk1. (wikipedia.org)
  • Most human cells are produced by mitotic cell division. (wikipedia.org)
  • Survivin is necessary for proper creation of the mitotic spindle which strongly affects cell viability, therefore when cyclin B levels are disrupted cells experience difficulty polarizing. (wikipedia.org)
  • kinases
  • Analysis of non-proline site-containing phosphopeptides identified two unique motifs that suggest there are at least two undiscovered mitotic kinases. (uniprot.org)
  • nuclei
  • One can track the position of the nuclei during the 9th, 10th, 11th, 12th and 13th mitotic divisions as well as during gastrulation. (youtube.com)
  • onset
  • While degradation of Sic1 to a certain low level triggered the onset of S phase, accumulation of Sic1 to a certain high level was required to trigger irreversible mitotic exit. (wikipedia.org)
  • organisms
  • In asexual organisms, the study of mitotic recombination is one way to understand genetic linkage because it is the only source of recombination within an individual. (wikipedia.org)
  • Recent studies in the epithelia and epidermis of various organisms, however, show that mitotic cell rounding might serve several important functions. (wikipedia.org)
  • cyclin
  • Clb2 degradation did shorten the Cdk1-inhibition period required for triggering irreversible mitotic exit indicating that cyclin proteolysis contributes to the dynamic nature of the eukaryotic cell cycle due to slower timescale of its action but is unlikely to be the major determining factor in triggering irreversible cell cycle transitions. (wikipedia.org)
  • Cyclin B is a mitotic cyclin. (wikipedia.org)
  • occurs
  • The mitotic stingaree occurs within the management area of the North West Slope Trawl Fishery, but little actual fishing occurs within its range and this is unlikely to change in the future. (wikipedia.org)
  • Later experiments uncovered when mitotic recombination occurs in the cell cycle and the mechanisms behind recombination. (wikipedia.org)
  • There are several theories on how mitotic crossover occurs. (wikipedia.org)
  • apart
  • Aurora A is often amplified in tumours and clinical trials into inhibiting its role are already underway into drugs that cause the TACC3-ch-TOG-clathrin complex to fall apart and actually break away from the mitotic spindle altogether. (theconversation.com)
  • tissue
  • In 1935, one of the first published accounts of mitotic rounding in live tissue described cell rounding in the pseudostratified epithelium of the mammalian neural tube. (wikipedia.org)
  • Secondly, mitotic rounding has been proposed to be a driver for morphological events during tissue development. (wikipedia.org)