Intraocular PressurePhacoemulsificationOpen-angle glPostoperativeHypotonyAdjunctiveSurgeriesVersusPhaco-trabeculectomyOutcomesSecond trabeculectomyIntraoperative applicationScleralCataract extractionBlebProcedureChoroidal detachmentGlaucomasImplant1968PerforationScleraComplicationsSurgeryExcisionSubconjunctivalAqueousInitialPatientsVitrectomyFibrosisEyesFailureMedicallyCasePrimary
Intraocular Pressure10
- demonstrated that 44.5% of patients who had undergone trabeculectomy augmented with mitomycin C showed a success defined as an intraocular pressure of less than 16 mm Hg after 8 years [ 6 ]. (intechopen.com)
- Trabeculectomy is a surgical procedure used in the treatment of glaucoma to relieve intraocular pressure by removing part of the eye's trabecular meshwork and adjacent structures. (wikipedia.org)
- Before the development of the trabeculectomy, the available surgical methods of intraocular pressure (IOP) reduction had a high rate of serious complications such as hypotony, flat anterior chamber, and endophthalmitis. (medscape.com)
- After trabeculectomy, 42 out of 57 eyes (73.7%) reached the target pressure (≤21mmHg, and intraocular pressure reduction of at least 20%, without antiglaucoma medication, and without any additional intervention). (biomedcentral.com)
- Evaluating filtering blebs after trabeculectomy by using the Wuerzburg bleb classification score is a good technique for predicting intraocular pressure control in eyes attaining a minimum score of seven points. (biomedcentral.com)
- Surgical failure was defined by the need for additional glaucoma surgery, deterioration of visual acuity to no light perception, or intraocular pressure ≥21 mm Hg (criterion A) and ≥18 mm Hg (criterion B). Surgical outcomes were compared with those of 108 primary open-angle glaucoma (POAG) patients who underwent trabeculotomy and 42 steroid-induced glaucoma patients who underwent trabeculectomy. (entokey.com)
- Surgical procedures for intraocular pressure (IOP) reduction in eyes with steroid-induced glaucoma include trabeculectomy, trabeculotomy, viscocanalostomy, and laser trabeculoplasty. (entokey.com)
- A perfectly performed trabeculectomy can fail to lower intraocular pressure (IOP), even if mitomycin C has been used, because of pre-existing conjunctival scarring. (ophthalmologytimes.com)
- METHOD: We performed ultrasonography on a patient who, after trabeculectomy with mitomycin C, had an intraocular pressure of 1 mm Hg, an opaque cataract, and suspected hypotonous maculopathy in the left eye. (duke.edu)
- Two high-quality randomized controlled trials showed a non-statistically significant trend for lower intraocular pressure (IOP) with mitomycin-C (MMC). (sightsavers.org)
Phacoemulsification4
- PURPOSE: To compare the results of combined trabeculectomy with phacoemulsification and posterior chamber intraocular lens (IOL) implantation to those of trabeculectomy alone using mitomycin C (MMC) application intraoperatively in all cases. (tau.ac.il)
- however, the functional and anatomical results of the combined procedure of phacoemulsification, posterior chamber IOL implantation, and trabeculectomy with MMC application were as good as those of trabeculectomy alone with MMC. (tau.ac.il)
- 12. Midterm follow-up results of combined phacoemulsification, lens implantation, and mitomycin-C trabeculectomy procedure. (nih.gov)
- This scenario is now seen more frequently, especially in eyes in which an emport-piece trabeculectomy is associated with a one-site phacoemulsification. (ophthalmologytimes.com)
Open-angle gl6
- Purpose: To study the safety and hypotensive effect of trabeculotomy augmented by postoperative topical medical treatment in patients with open-angle glaucoma and to compare with trabeculectomy augmented by mitomycin C. (intechopen.com)
- The aim of this study is to study the safety and hypotensive effect of trabeculotomy augmented by postoperative medical treatment in patients with open-angle glaucoma and to compare with trabeculectomy augmented by mitomycin C. (intechopen.com)
- In a non-randomized consecutive case series, we studied 82 patients with open-angle glaucoma who underwent trabeculotomy augmented by postoperative medical therapy or trabeculectomy augmented with mitomycin C. A diagnosis of glaucoma was on the gonioscopic finding along with appearance of the optic nerve head cupping and visual alteration according to the guideline of Japan Glaucoma Society [ 10 ]. (intechopen.com)
- However, in many types and stages of glaucoma the ideal initial treatment is something other than trabeculectomy (eg, topical medication often is the first-line treatment for primary open-angle glaucoma). (medscape.com)
- Purpose: Our purpose was to evaluate the clinical safety and efficacy of CO2 laser-assisted sclerectomy surgery (CLASS) with Mitomycin C (MMC) in open angle glaucoma (OAG).Methods: This was a prospective, uncontrolled, interventional case series. (unige.it)
- Comparison of the Effect of Trabeculectomy with Mitomycin C on Corneal Hysteresis in Primary Open-angle Glaucoma and Pseudoexfoliative Glaucoma by: Ufuk Elgin, et al. (uitm.edu.my)
Postoperative6
- Serious postoperative complications are not infrequently associated with trabeculectomy [ 2 - 5 ]. (intechopen.com)
- the trabeculectomy group changed from 24.2±7.5 mm HG preoperative to 12.46±3.86 mm HG postoperative, P= 0.0001. (tau.ac.il)
- For this procedure, outcomes have been improved by intraoperative application of 5-FU (5-fluorouracil) or mitomycin, agents that reduce postoperative fibrosis which may result in channel closure. (pharmacology2000.com)
- The cost analysis used results from the clinical study to estimate operative costs (equipment and staff costs) and postoperative costs (follow-up visits, nonglaucoma medications, and postoperative procedures) per eye for PreserFlo and trabeculectomy. (skyscape.com)
- Although it is normally indicated for eyes that have not undergone previous filtrating surgery for glaucoma, canaloplasty is a viable alternative surgical option for a select number of eyes in which postoperative gonioscopic examination shows that the initial 'trabeculectomy' had been performed anterior to the trabecular structures - in other words, had in fact been a sclero-keratectomy - and that Schlemm's canal had been left intact. (ophthalmologytimes.com)
- Outcomes included the operation performed, the surgical location of the trabeculectomy incision, the antifibrosis agent used, iris manipulation, postoperative medications and method of cataract extraction. (sightsavers.org)
Hypotony7
- Prolonged hypotony-induced maculopathy is a serious complication of trabeculectomy with adjunctive mitomycin C. We performed trabeculectomies with intraoperative mitomycin C on 59 eyes of 52 consecutive patients. (nih.gov)
- Exposure time to mitomycin C was five minutes in the first seven patients, two of whom had prolonged hypotony-induced maculopathy. (nih.gov)
- Four additional cases of prolonged hypotony-induced maculopathy occurred among these 52 cases (7.7%), all of which were in the lower risk groups that received two- or three-minute exposure to mitomycin C. Four procedures failed, requiring further glaucoma surgery, and all of the patients were in the higher risk groups, receiving three- to five-minute exposures. (nih.gov)
- Our titration of the exposure time to mitomycin C may have reduced, but did not eliminate, the risk fo prolonged hypotony-induced maculopathy, and further study is needed to establish the optimum protocol for the use of this drug as an adjunct to trabeculectomy. (nih.gov)
- A separate case report describes a 36-year-old woman who had a corneal infiltrate, corneoscleral ulceration, a pupil peaked toward the ulceration (globe perforation not mentioned), hypotony, vitreous exudates, optic disc hyperemia, and macular edema after using 0.2 mg/mL of mitomycin-C 3 times daily for 3 weeks after pterygium surgery. (medscape.com)
- Trabeculectomy is often per-formed together with mitomycin C, and late onset hypotony is already an expected complication in these eyes. (beyoglueye.com)
- This case report presents a patient who developed dehiscence of the scleral flap and hypotony maculopathy after Valsalva maneuver after 5.5 years of trabeculectomy. (beyoglueye.com)
Adjunctive2
- There also seems to be an association between SINS and cases which use adjunctive beta-radiation or anti-metabolites such as mitomycin C, as one study reports 82% of SINS following pterygium surgery was associated with this use. (aao.org)
- Adjunctive mitomycin C in primary trabeculectomy in young adults: a long-term study of case-matched young patients. (new-glaucoma-treatments.com)
Surgeries3
- Ocular surgeries that have been associated with SINS include cataract extraction, trabeculectomies, strabismus corrective procedures, scleral buckles, pars plana vitrectomies, and pterygium surgeries. (aao.org)
- Incisional surgeries such as trabeculectomy reduce the resistance of the eye to trauma. (beyoglueye.com)
- However, large-scale, comparative clinical data remain elusive on, for example, whether trabeculotomy is more effective for steroid-induced glaucoma than POAG, whether trabeculotomy for steroid-induced glaucoma offers better IOP management than other surgeries such as trabeculectomy with mitomycin C (MMC), or which characteristics of patients with steroid-induced glaucoma exhibit better prognosis after trabeculotomy. (entokey.com)
Versus6
- This represents a 31.5% reduction in IOP in the combined group versus a 48.5% reduction in the trabeculectomy alone group (P=0.0001). (tau.ac.il)
- The Tube Versus Trabeculectomy Study supports the view that aqueous shunts can be a reasonable alternative in patients who have had prior eye surgery. (new-glaucoma-treatments.com)
- Tube Versus Trabeculectomy Study Group. (new-glaucoma-treatments.com)
- Treatement outcomes in the tube versus trabeculectomy study after one year of follow-up. (new-glaucoma-treatments.com)
- Objective of this study was to conduct clinical evaluation and cost analysis of mitomycin-C-augmented PreserFlo MicroShunt versus trabeculectomy. (skyscape.com)
- Authors also concluded that there was insufficient evidence to assess the efficacy of staged or combined procedures or that assess alternative glaucoma procedures versus trabeculectomy in combined procedures. (sightsavers.org)
Phaco-trabeculectomy1
- 3,4 Considering the patient's current VA, removing the cataract may not further improve the patient's VA. Some studies comparing trabeculectomy vs phaco-trabeculectomy failed to show evidence of VA improvement following phaco-trabeculectomy procedures. (paojournal.com)
Outcomes1
- This unicentric randomized clinical trial was designed to compare the surgical outcomes of mitomycin C-enhanced trabeculectomy (MMC-TRAB) with and without subtenon triamcinolone acetonide (TAAC) injection in patients with non-inflammatory glaucomas. (nih.gov)
Second trabeculectomy2
- One eye (3%) in the pseudophakic group required implantation of an Ahmed Glaucoma Valve, whereas 3 eyes (8%) in the phakic group required a second trabeculectomy ( P =0.942). (medscape.com)
- If this is the case, a second trabeculectomy will seldom provide adequate IOP control for precisely the same reasons that caused the initial surgical failure. (ophthalmologytimes.com)
Intraoperative application1
- A 59-year-old man underwent pterygium excision with intraoperative application of 0.2 mg/mL (0.02%) mitomycin-C placed on the scleral bed for 3 minutes. (medscape.com)
Scleral1
- Although beta radiation has become less prevalent for pterygium surgery, similar scleral thinning has been seen with aggressive cautery as well as after the application of mitomycin C. 2 It therefore may be prudent to use lamellar scleral grafts. (crstoday.com)
Cataract extraction2
- Trabeculectomy was performed a median (range) of 36 months (2 to 119 mo) after cataract extraction in the pseudophakic group. (medscape.com)
- Nineteen phakic eyes (49%) underwent cataract extraction after trabeculectomy after a median (range) of 8 months (3 to 85 mo). (medscape.com)
Bleb2
- There were no cases of bleb leakage in the combined group and two cases (6%) in the trabeculectomy group. (tau.ac.il)
- To report the 5-year incidence of bleb-related infection after mitomycin C-augmented glaucoma filtering surgery and to investigate the risk factors for infections. (eugs.org)
Procedure4
- Trabeculectomy has been a standard procedure for medically uncontrollable glaucoma [ 1 ]. (intechopen.com)
- PATIENTS AND METHODS: A retrospective comparative study of consecutive patients was conducted on two groups: 102 eyes of 90 patients studied in the combined procedure group, and 33 eyes of 30 patients in the trabeculectomy alone group. (tau.ac.il)
- Some surgeons prefer adjustable flap sutures during the trabeculectomy that can be loosened later on with forceps in a slit lamp office procedure. (wikipedia.org)
- Trabeculectomy can be performed under local anesthesia (retrobulbar, peribulbar, subconjunctival, or topical) or general anesthesia depending on patient and surgeon preference, on the patient's general health status, and on the estimated duration of the procedure for that particular case. (medscape.com)
Choroidal detachment1
- One phakic eye (3%) required drainage of choroidal detachment after trabeculectomy. (medscape.com)
Glaucomas1
- Rasheed el-S. Initial trabeculectomy with intraoperative mitomycin-C application in primary glaucomas. (new-glaucoma-treatments.com)
Implant1
- The Effect of Antiglaucoma Procedures (Trabeculectomy vs. Ex-PRESS Glaucoma Drainage Implant) on the Corneal Biomechanical Properties by: Aristeidis Konstantinidis, et al. (uitm.edu.my)
19682
- Cairns was the first to report success using the trabeculectomy in 1968. (medscape.com)
- Since first described by Cairns in 1968 [ 1 ], trabeculectomy (TE) has been widely used and remains the gold standard in surgical treatment of glaucoma. (biomedcentral.com)
Perforation2
- It includes goniotomy, trabeculectomy, and laser perforation. (curehunter.com)
- In one case (5%), CLASS was converted to trabeculectomy due to intraoperative perforation of the ablated area. (unige.it)
Sclera1
- Trabeculectomy consists in creating a trap door in the sclera (the white part of the eye) to allow fluid to leave the eye in a controlled manner. (palmereye.com)
Complications3
- Intraoperative single-dose application of topical mitomycin-C can be associated with serious complications. (medscape.com)
- A detailed report with serious, vision-threatening complications associated with mitomycin-C use after pterygium surgery has been published. (medscape.com)
- Mitomycin-C and beta radiation must be used with caution, knowing that complications may occur months to years later. (medscape.com)
Surgery8
- Although topical mitomycin-C is effective as an adjunct to pterygium surgery and may reduce recurrence, the safety and efficacy of various concentrations and dosing schedules need further definition. (medscape.com)
- Patients presenting with persistent pressure elevation may require surgery, trabeculectomy, to create alternative drainage routes for fluid from the eye. (pharmacology2000.com)
- There are several reported disadvantages of doing trabeculectomy prior to cataract surgery. (paojournal.com)
- First, similar to any intraocular surgery, the risk for cataract progression after a separate trabeculectomy is higher. (paojournal.com)
- 2 Trabeculectomy with Mitomycin-C (MMC) is really the only glaucoma surgery that can be expected to achieve an IOP in the range of 10mmHg 3 without the use of drops. (new-glaucoma-treatments.com)
- Realistically, as with anyone in need of such a low IOP, trabeculectomy with MMC is the only surgery that will achieve this target IOP without also using glaucoma drops. (new-glaucoma-treatments.com)
- Experience of introducing PreserFlo MicroShunt surgery showed it was safer than trabeculectomy and is a cost-saving and effective option that offers potential to free up highly limited National Health Service resources. (skyscape.com)
- Baseline characteristics were similar, except for more non-White patients in the trabeculectomy group (51% Black and Asian vs. 32% MicroShunt, P = 0.02) and more cases with prior ab externo glaucoma surgery in the MicroShunt group (19% vs. 3% in the trabeculectomy group, P = 0.004). (skyscape.com)
Excision1
- Anterior chamber opening/sclerostomy: A trabeculectomy punch (eg, Kelly) is recommended for more precise and controlled excision of the corneal block (sometimes inaccurately called the trabecular block) but this step also can be performed using forceps, a blade, and Vannas scissors. (medscape.com)
Subconjunctival1
- Trabeculectomy involves the creation of a fistula connecting the anterior chamber and the subconjunctival space. (medscape.com)
Aqueous1
- Flow of aqueous after a trabeculectomy. (medscape.com)
Initial2
- Course of IOP before and after initial trabeculectomy with mitomycin C in the pseudophakic and phakic groups. (medscape.com)
- An initial pocket is created under the conjunctiva and Tenon's capsule and the wound bed is treated for several seconds to minutes with mitomycin C (MMC, 0.5-0.2 mg/ml) or 5-fluorouracil (5-FU, 50 mg/ml) soaked sponges. (wikipedia.org)
Patients2
- Trabeculectomy with MMC, however, is really the only option for those patients who absolutely must have a very low IOP without the use of eye drops. (new-glaucoma-treatments.com)
- This retrospective cohort study was done across 3 teaching hospitals with total of 134 consecutive eyes of 129 patients (70 undergoing MicroShunt, 64 trabeculectomy). (skyscape.com)
Vitrectomy1
- One pseudophakic eye (3%) required anterior vitrectomy at the time of trabeculectomy. (medscape.com)
Fibrosis1
Eyes3
- Trabeculectomy was performed using a limbus-based approach in 10 (25.6%) pseudophakic and 12 (30.8%) phakic eyes ( P =0.775). (medscape.com)
- There were 97 eyes in the combined group (95%) and 32 eyes (97%) in the trabeculectomy group that had an IOP of less than 20 mm HG at the end of follow up. (tau.ac.il)
- 57 post-trabeculectomy eyes were included. (biomedcentral.com)
Failure2
- The relative contraindications to trabeculectomy are situations where the chance of failure is high, the risks outweigh the potential benefits, or the primary cause of the glaucoma is treatable. (medscape.com)
- At 18 months, surgical failure was 25% for MicroShunt compared with 35% for trabeculectomy (P = 0.18). (skyscape.com)
Medically1
- He underwent Trabeculectomy in RE as IOP could not be controlled medically. (pediatriconcall.com)
Case1
- The challenge lies in deciding when to choose trabeculectomy over other treatment methods that are appropriate for a particular case. (medscape.com)
Primary1
- Efficacy and safety of mitomycin-C in primary trabeculectomy: five-year follow-up. (new-glaucoma-treatments.com)