• Patients with recurrent/multifocal low-grade Ta lesions who require intravesical therapy should receive intravesical chemotherapy such as mitomycin, gemcitabine, epirubicin, or docetaxel instead of BCG. (auanet.org)
  • In a patient with suspected or known low- or intermediate-risk bladder cancer, a clinician should consider administration of a single postoperative instillation of intravesical chemotherapy (eg, gemcitabine, mitomycin C) within 24 hours of a transurethral resection for bladder tumor (TURBT). (medscape.com)
  • We evaluated the efficacy of combined bladder wall hyperthermia and intravesical mitomycin C instillation (thermo-chemotherapy) in cases of recurrence after bacillus Calmette-Guerin. (tau.ac.il)
  • We performed this study to evaluate the prognostic factors and the effect of induction chemotherapy in locally advanced non-small cell lung cancer (NSCLC). (e-roj.org)
  • Eighty-five patients were treated with radiotherapy alone, forty-five with induction chemotherapy and radiotherapy. (e-roj.org)
  • Complete response (CR) to overall treatments was 25% (21/84) in radiotherapy alone and 40.5% (17/42) in induction chemotherapy group (p=0.09). (e-roj.org)
  • According to treatment modalities, NSE (neuron-specific enolase) (p=0.006) and response to overall treatment (p=0.003) were associated with overall survival in radiotherapy alone group, and response to overall treatment (p=0.007) in induction chemotherapy group. (e-roj.org)
  • But, in patients with CR to overall treatment, distant metastasis were found in 11/19 patients with radiotherapy alone, and 3/13 patients with induction chemotherapy and radiotherapy (p=0.07). (e-roj.org)
  • Induction chemotherapy and radiotherapy achieved increased 2YSR compared to radio therapy alone. (e-roj.org)
  • At least in CR patients, there was decreased tendency in distant metastasis with induction chemotherapy. (e-roj.org)
  • This is a positive trial, a European trial, that actually suggests that induction chemotherapy may be of benefit in stage Ib to IIIa where patients had either surgery or MIP, mitomycin ifosfamide, platinum, and then surgery. (cancerstreatment.com)
  • So I'm showing you this to say that not all data are negative, but it's certainly not yet conclusively supporting induction chemotherapy. (cancerstreatment.com)
  • Bi-modality because it is chemo and surgery, looks at induction chemotherapy with carboplatin and paclitaxel in stage Ib through IIIa disease. (cancerstreatment.com)
  • This has been piloted in 94 patients with an objective response rate of the chemotherapy of 54%, which is not bad, and based on this the phase III trial has been activated where patients received either surgery or induction, not adjuvant, carbo and paclitaxel for three cycles. (cancerstreatment.com)
  • Induction Chemotherapy Followed by Chemoradiotherapy Compared with Chemoradiotherapy Alone for Regionally Advanced Unresectable Stage III Non-Small. (oncolink.org)
  • What about induction chemotherapy followed by CRT, would that give better systemic control without losing the advantage of better locoregional provided by concurrent CRT? (oncolink.org)
  • The immune system is likely to be modified that cause for starting mitomycin, gemcitabine given induction in V79 cells by the anabolic doping steroids desoxymethyltestosterone (madol) and 19-norandrostenedione. (offbeatguides.com)
  • Group 2: Receiving BCG treatment with the same protocol but they also received a 40 mg mitomycin instillation the day before. (urotoday.com)
  • The use of more reliable prognostic tools or staging systems may overcome this difficulty and a nonhistological prostate cancer staging system has already shown that patients with visceral involvement but minimal bone disease have the highest chance of responding to a combination of doxorubicin, mitomycin-C, and 5-fluorouracil. (cancernetwork.com)
  • After resection of the tumour(s), patients will receive either traditional regimen of Bacillus Calmette-Guérin (BCG) instillations or combination treatment consisting of sequential BCG-instillations and mitomycin C instillations administered with electromotive drug administration (EMDA) device. (bcan.org)
  • Their study aimed to evaluate recurrence-free survival of sequential Mitomycin (MMC) and Bacillus Calmette-Guérin (BCG) treatment versus BCG monotherapy in patients with High-risk Non-Muscle Invasive Bladder Cancer. (urotoday.com)
  • Both organisms also induced lysogenic mechanisms related to prophage induction ( S. aureus ) and R- and F- pyocin synthesis ( P. aeruginosa ), possibly as a response to stress resulting from nutrient limitation or cell damage. (biomedcentral.com)
  • Specifically, mitomycin C is commonly used in research for prophage induction for its ability to interfere with DNA replication, triggering an SOS response Los et al. (kasinotop.de)
  • However, prophage induction experiments performed with this organism led to a different conclusion. (elsevierpure.com)
  • Favorable response rates have also been demonstrated in trials of ketoconazole/Adriamycin or mitomycin-C combined with vinblastine/estramustine or vinblastine/Adriamycin. (cancernetwork.com)
  • Surface swabs were tested for lytic phages and bacterial isolates for mitomycin C-inducible prophages. (mdpi.com)
  • Thus, some laboratories attempt to isolate leptophage particles from environmental samples or following mitomycin C induction of bacterial cultures. (pasteur.fr)
  • X-rays or mitomycin, the prophage can be separated from bacterial chromosomes and enter the lytic cycle. (biologydiscussion.com)
  • UroToday.com) Dr. Cosimo De Nunzio and colleagues evaluated the effect of sequential mitomycin-C and BCG vs. BCG monotherapy alone in patients with high-risk non-muscle invasive bladder cancer (HR NMIBC), in a study called the MITO-BCG trial. (urotoday.com)
  • Based on this interim analysis of the MITO-BCG study, the results suggest no differences in terms of recurrence-free survival when comparing BCG alone vs sequential Mitomycin and BCG treatment. (urotoday.com)
  • Each treatment included 2, 30-minute cycles of 20 mg mitomycin C and bladder wall hyperthermia to 42C ± 2C. (tau.ac.il)
  • Induction of virus synthesis in polyoma transformed cells by ultraviolet light and mitomycin C. (wikidata.org)
  • Thus, one mechanism of epirubicin combined TACE treatment for HCC was through induction of synergistic DNA damage. (nature.com)
  • Mitomycin C (MMC) is the most used chemotherapeutic agent. (bcan.org)
  • Resultados: En este contexto, la huella bioenergética también ha resultado ser un marcador de la respuesta a quimioterapia en distintas células tumorales en cultivo, en tumores humanos y en modelos murinos como en pacientes con carcinoma de colon. (researchgate.net)
  • Another 6-week induction course may be administered if a repeat cystoscopy (see image above) reveals tumor persistence or recurrence. (medscape.com)
  • Cystoscopy and urine cytology were performed after the completion of induction treatment and every 3 months thereafter. (tau.ac.il)
  • Materials and methods: RT112 bladder cancer cells (Catalog No. ACC 418, Deutsche Sammlung von Mikroorganismen und Zellkulturen, Braunschweig, Germany) were exposed to a range of mitomycin C concentrations for 1 hour. (soton.ac.uk)
  • Induction of tolerance can be achieved with Modified Immune Cells (MIC) by infusion of mononuclear cells challenged with mitomycin C (MMC). (asn-online.org)
  • The iPS cells were cultured on mitomycin C treated MEFs in ES medium containing DMEM medium (Gibco Invitrogen, Carlsbad, CA) supplemented with 15% (v/v) fetal bovine serum (FBS), 1 mM L-glutamine, 0.1 mM mercaptoethanol, 1% nonessential amino acid stock, and 1000 U/ml LIF. (nih.gov)
  • The TSKM 2nd induction cells were deriven from TSKM iPS mice and cultured with Feeder Medium for 3 passages. (nih.gov)
  • Gene expression in pluripotent and TSKM-iPS induction cells. (nih.gov)
  • In this study, we established an in vitro differentiation system yielding in vivo hematopoietic reconstitution hematopoietic cells from mouse PSCs through a 3D induction system followed by coculture with OP9 stromal cells. (biomedcentral.com)
  • Flow cytometry analysis, RNA-seq, and cell cycle analysis were used to detect the in vitro hematopoietic ability of endothelial protein C receptor (EPCR, CD201) cells generated in our induction system. (biomedcentral.com)
  • The c-kit + cells from 3D self-assembling peptide induction system followed by the OP9 coculture system possessed apparently superiority in terms of in vivo repopulating activity than that of 3D induction system followed by the 0.1% gelatin culture. (biomedcentral.com)
  • Mitomycin C induction of lysogenized mutants 3107 indicated that phage propagation was not affected in these four mutant. (ku.dk)
  • Antibiotic-mediated phage induction may result in high-frequency transfer and the unintended consequence of promoting the spread of virulence and/or antibiotic resistance determinants. (biomedcentral.com)
  • The silver-stained SDS-PAGE gels of proteinase K digested whole cell lysates of strains PAO1, 6750, M7 and PAJ indicated that core LPS was affected in the presence of mitomycin C. In contrast, the rough strain AK1012 showed no observable differences. (aston.ac.uk)
  • To prevent cancer recurrence, long-term maintenance therapy following the induction phase is typically necessary. (medscape.com)
  • The purpose of this study was to determine the acute and long-term effects of mitomycin C (MMC) on quiescent rabbit corneal keratocytes regarding cell proliferation, myofibroblast differentiation and DNA repair. (molvis.org)
  • Birare, Narendrakumar , Lwaleed, Bashir A. and Cooper, Alan J. (2009) Multidrug resistance in a urothelial cancer cell line after 1-hour mitomycin C exposure. (soton.ac.uk)
  • A study by Fogh et al of induction chemoradiotherapy followed by surgery, a strategy that is widely used in treating esophageal cancer, found that perioperative morbidity and mortality with this approach was not significantly different in patients aged 70 years or older compared with younger patients. (medscape.com)
  • BCG treatment comprises an induction period, which includes six weekly instillations. (bcan.org)
  • Typically, BCG treatment begins with an induction course (once weekly for 6 weeks). (medscape.com)
  • Treatment includes induction therapy and postremission therapy (consolidation). (medscape.com)
  • Mitomycin C (MMC) was then used (in the presence of 3 ug/ml Cyt B) to investigate toxicity and micronuclei formation in EpiDerm. (mattek.com)
  • The trial was designed to have 80% power to detect a 40% increase in median survival, from about 13mo to 18.2 mo with the addition of induction chemo using a one-tailed log-rank test conducted at a 0.025 level of significance. (oncolink.org)
  • The presence of these genes resulted in the absence of Cu-dependent induction of pco genes encoding multiple proteins linked to Cu resistance, also present on SGI-4, suggesting that the system effectively limits the Cu availability in the periplasm, but did not affect SodCI-dependent macrophage survival. (uea.ac.uk)
  • Further, we innovatively demonstrated that notch signaling pathway is responsible for in vitro CD201 + hematopoietic cell induction from mouse PSCs. (biomedcentral.com)
  • For patients with high-risk NMIBC, high-grade T1 and CIS patients receiving induction therapy, they should be prioritized for use of full-strength BCG. (auanet.org)
  • Induction therapy followed by maintenance therapy (typically once weekly for 3 weeks, every 3-6 months, for 1-3 years) may provide more lasting results. (medscape.com)
  • They observe that many patients considered ineligible for radical cystectomy may be candidates for trimodality therapy, especially radiosensitization is performed with 5-fluorouracil and mitomycin. (medscape.com)
  • Assays for expression of colicins and induction of expression in negative strains using Mitomycin C (MMC) were used. (unifesp.br)
  • Induction of colicin expression was observed in only five strains of the O157: H7 serotype. (unifesp.br)
  • Results obtained using quantitative gas-liquid chromatographic analysis showed the amount of LPS fatty acids to be unaffected, however, the KDO and carbohydrate content in strains PAO1, 6750 and M7 under Fe+ and Fe- growth conditions were decreased by up to 4-fold in the presence of mitomycin C, indicating perturbed expression of LPS. (aston.ac.uk)
  • SGI-4 was excised from the chromosome, circularized, and transferred to recipient strains of S. Typhimurium at a frequency influenced by stress induced by mitomycin C, and oxygen tension. (uea.ac.uk)
  • The induction of protein G (OprG) in P.aeruginosa was found to be a sensitive indicator of media iron. (aston.ac.uk)
  • A method is proposed to allow quantitative estimates to be made of mutation frequency.The induction of SCE and cytogenetic aberrations in human lymphocytes and point-mutation in Salmonella has been investigated following exposure to a range of selected direct-acting chemical mutagens. (soton.ac.uk)
  • MMC also induced phosphorylation of the nuclear histone marker of DNA damage, γH2AX (a member of the H2A histone family), without induction of cell cycle entry or immediate DNA repair measured by Comet assay. (molvis.org)
  • In the laboratory, virus-like particles in the ISM culture increased more than 3 orders of magnitude following induction with mitomycin C. After careful examination of the ISM genome sequence, a putative prophage (ISM-prol) was identified. (elsevierpure.com)