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  • Drug
  • Non-muscle-Invasive Bladder cancer is mainly treated by tumor resection (Trans Urethral Resection - TUR), followed by series of intravesical instillations of prophylactic chemotherapeutic drugs as Mitomycin C (MMC).This treatment approach is limited due to rapid dilution the chemotheraputic drug by the incoming urine and clearance by urination. (clinicaltrials.gov)
  • Drugs
  • Using mitoMYcin together with capecitabine or other chemotherapy drugs may increase the risk of side effects, especially those that affect the bone marrow or gastrointestinal tract. (drugs.com)
  • Mitomycin C is the most commonly used agent because it was one of the first used drugs for this therapy and less expensive than some of the alternatives. (wikipedia.org)
  • effects
  • The genetic effects of mitomycin C in Drosophila melanogaster. (wikipedia.org)
  • The side effects of mitomycin and their severity depend on how much of the drug is given, and how it is given. (chemocare.com)
  • Since the growth of normal body cells may also be affected by mitomycin, other effects will also occur. (drugs.com)
  • Although there is no specific information comparing use of mitomycin in children with use in other age groups, it is not expected to cause different side effects or problems in children than it does in adults. (drugs.com)
  • health
  • If you notice redness or swelling at the IV site while you are receiving mitomycin, alert your health care professional immediately. (chemocare.com)
  • The amount of mitomycin that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. (chemocare.com)
  • time
  • Depending on the dose and length of time you have been on mitoMYcin, you may have a reduced response to the skin test. (drugs.com)
  • doctor
  • Mitomycin is to be administered only by or under the immediate supervision of your doctor. (drugs.com)
  • If you are currently being treated or have recently been treated with mitoMYcin, you should let your doctor know before receiving trichophyton skin test. (drugs.com)
  • contains
  • FANCG, involved in Fanconi anemia, confers resistance to both hygromycin B and mitomycin C. FANCG contains a 5-prime GC-rich untranslated region characteristic of housekeeping genes. (wikipedia.org)
  • cell
  • Mitomycin is not cell cycle specific but has its maximum effect against cells in late G and early S phases (Perry 2012). (drugs.com)
  • shown
  • mitomycin C has also been shown to reduce fibrosis in strabismus surgery. (wikipedia.org)
  • In the plant Arabidopsis thaliana, mutant strains defective in genes necessary for recombination during meiosis and mitosis are hypersensitive to killing by mitomycin C. Mitomycin C has been shown to have activity against stationary phase persisters caused by Borrelia burgdorferi, a factor in lyme disease. (wikipedia.org)
  • specific
  • In general, the biosynthesis of all mitomycins proceeds via combination of 3-amino-5-hydroxybenzoic acid (AHBA), D-glucosamine, and carbamoyl phosphate, to form the mitosane core, followed by specific tailoring steps. (wikipedia.org)
  • There is no specific information comparing use of mitomycin in the elderly with use in other age groups. (drugs.com)