The mechanism of action of a mitogen is that it triggers signal transduction pathways involving mitogen-activated protein kinase (MAPK), leading to mitosis. (wikipedia.org)
We observed activation of mitogen-activated protein kinase (MAPK) in basal and suprabasal keratinocytes of human and transgenic mouse psoriatic lesions and healing mouse skin wounds, correlating in each case with suprabasal integrin expression. (jci.org)
The opioid receptor activation regulates a variety of intracellular signaling, including the mitogen-activated protein kinase (MAPK) pathway. (iasp-pain.org)
The aim of this study was to evaluate the role of mitogen-activated protein kinase (MAPK) family in serum-induced secretion of LIF and IL-6 by bone marrow stromal cells. (unboundmedicine.com)
Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
Mitogen-activated protein kinases (MAPK) p38 and c-Jun N-terminal kinases (JNKs) are activated during the cellular response to stress signals. (datadryad.org)
We found that apigenin could inhibit PMA-induced phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK), which was involved in the down-regulation of the expression of matrix metalloproteinase-9 (MMP-9) at mRNA levels. (spandidos-publications.com)
The mitogen-activated protein kinase (MAPK) signaling pathways are essential to the adaptation to the human host. (bath.ac.uk)
For example, the mitogen-activated protein kinase (MAPK) p38 pathway mediates stabilization of tumor necrosis factor alpha (TNF-alpha) mRNA in myeloid cells stimulated with bacterial lipopolysaccharide (LPS). (ed.ac.uk)
The mitogen-activated protein kinase (MAPK) plays an important role in a variety of cell processes by controlling transcriptional or translational regulation [14]. (precisionfda.org)
The mitogen-activated protein kinase (MAPK) pathway is the canonical signaling pathway for many receptor tyrosine kinases, such as the Epidermal Growth Factor Receptor. (uni-giessen.de)
Mitogen-activated protein kinase (MAPK) and MAPK kinase (MAPKK) are activated during Xenopus oocyte maturation concomitant with the activation of maturation promoting factor (MPF). (elsevierpure.com)
Phosphorylation5
Silibinin also showed a strong phosphorylation of extracellular signal-regulated protein kinase 1/2, stress-activated protein kinase/c-JUN NH2-terminal kinase 1/2, and p38 mitogen-activated protein kinases but inhibited Akt phosphorylation and decreased survivin levels with an increase in cleaved caspase-3. (nih.gov)
We now provide evidence that two growth-regulated, nucleus- and cytoplasm-localized protein kinases, 90-kDa ribosomal S6 kinase (RSK) and mitogen-activated protein kinase (MAP kinase), contribute to the serum-induced phosphorylation of c-Fos. (nih.gov)
MAPK1 Recombinant (extracellular signal-regulated kinase) a Mitogen-Activated Protein Kinase, is a highly active form produced by phosphorylation of the purified ERK2/MAPK1 in vitro with MEK1 is a non-glycosylated polypeptide having a molecular mass of 44.6 kDa. (kendallscientific.com)
MAPK1 Recombinant (extracellular signal-regulated kinase) a Mitogen-Activated Protein Kinase, is a highly active form produced by phosphorylation of the purified ERK2/MAPK1 in vitro with MEK1 is a non-glycosylated polypeptide chain containing amino acids 2-480 and having a molecular mass of 44.6 kDa. (kendallscientific.com)
A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. (rush.edu)
Proliferation3
Aim of the present study was to investigate the possible involvement of ANF on rat aortic smooth muscle (RASM) cells proliferation induced by known mitogens and the mechanism involved. (torvergata.it)
Our data show that ANF, at physiological concentration range, inhibits RASM cell proliferation induced by known mitogens such as PDGF and insulin, and the effect seems to be elicited through the modulation of phosphatidic acid (PA) production and MAP kinases involvement. (torvergata.it)
Inhibits follicle proliferation, if induced by mitogens. (cdc.gov)
Lymphocyte1
Diagnosis is by detecting lymphopenia, absence or a very low number of T cells, and impaired lymphocyte proliferative responses to mitogens. (msdmanuals.com)
Proteins2
Mitogens act primarily by influencing a set of proteins which are involved in the restriction of progression through the cell cycle. (wikipedia.org)
Mitogen-activated protein kinases (MAPKs) comprise a large family of proteins activated by a wide range of proinflammatory cytokines and environmental stress. (molvis.org)
Extracellular3
5-Hydroxytryptamine (5-HT) activates the extracellular signal-regulated kinase (Erk) mitogen-activated protein kinases (MAPKs) in the vasculature, resulting in contraction. (aspetjournals.org)
The expression of c-Fos induced by potassium chloride was also suppressed by dibucaine, tetracaine (concentrations that inhibited 50% of the activity of positive control [IC50s] were 16.2+/-0.2 and 73.2+/-0.7 microM, respectively), and PD 98059, a mitogen-activated/extracellular receptor-regulated kinase inhibitor. (asahq.org)
It has recently been reported that mitogen-activated protein (MAP) kinase (also known as extracellular signal reactive kinase [Erk]) might play an important role in linking membrane depolarization to gene expression in the postsynaptic neurons. (asahq.org)
Pathway2
It, combined with the Ras pathway, downregulate cyclin D1, a cyclin-dependent kinase, if they are not stimulated by the presence of mitogens. (wikipedia.org)
An elevation of the intracellular calcium level, which is mediated by N-methyl-D-aspartate receptors and L-type Ca2+ channels both, activates the mitogen-activated protein (MAP) kinase signaling pathway involved in synaptic modification. (asahq.org)
MAPKs1
Mitogen Activated Protein Kinases (MAPKs) are a conserved family of enzymes that form distinct signaling cascades. (smith.edu)
Antigen1
The QFT Gold Plus system uses specialized blood collection tubes, which are used to collect whole blood via venipuncture, which include a Nil control tube, two TB Antigen tubes and a Mitogen tube (positive control). (cdc.gov)
Exposure to cerium oxide nanoparticle s is associated with activation of mitogen-activated protein kinases signaling and apoptosis in rat lungs. (cdc.gov)
Receptor5
One such example is HER2, a receptor tyrosine kinase that responds to the mitogen EGF. (wikipedia.org)
The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor during decidualization. (bioone.org)
Role of mitogen-activated protein kinases in endothelin ETB receptor up-regulation after organ culture of rat mesenteric artery. (lu.se)
We will not only review the well-known members of the family, such as kinase suppressor of Ras (KSR), but also put a special focus on the function of the recently identified or less studied scaffolders, such as fibroblast growth factor receptor substrate 2, flotillin-1 and mitogen-activated protein kinase organizer 1. (uni-giessen.de)
To do so, we mutated the proteolytically revealed TL sequence of rPAR 2 and examined the impact on stimulating intracellular calcium transients and mitogen-activated protein (MAP) kinase. (aspetjournals.org)
Pathways1
Cancer cells may lose their dependence on external mitogens by a variety of pathways. (wikipedia.org)
Kinases4
JNK Mitogen-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
This graph shows the total number of publications written about "JNK Mitogen-Activated Protein Kinases" by people in this website by year, and whether "JNK Mitogen-Activated Protein Kinases" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "JNK Mitogen-Activated Protein Kinases" by people in Profiles. (rush.edu)
Role of mitogen-activated protein kinases and Mcl-1 in apoptosis induction by withaferin A in human breast cancer cells. (rush.edu)
ELISA Kit1
Description: A sandwich ELISA kit for detection of Mitogen Activated Protein Kinase Kinase 1 from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (ibiomagazine.org)
Tumor1
This can result in a deadly positive feedback loop - tumor cells produce their own mitogens, which stimulate more tumor cells to replicate, which can then produce even more mitogens. (wikipedia.org)
Gene1
The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
Serum-induced1
TY - JOUR T1 - Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. (unboundmedicine.com)
Stimulation1
First, cancer cells can produce their own mitogens, a term called autocrine stimulation. (wikipedia.org)
Search1
When ansible_python_interpreter is set to search for Python in the env, mitogen fails. (github.com)
Receptors2
Second, cancer cells can have mutated cell-surface receptors for mitogens. (wikipedia.org)
The protein kinase domain found on mitogenic receptors is often hyperactivated in cancer cells, remaining turned on even in the absence of external mitogens. (wikipedia.org)
Role1
This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)
Cells5
This is usually a combination of two abnormalities: first, cancer cells lose their dependence on mitogens. (wikipedia.org)
Second, cancer cells are resistant to anti-mitogens. (wikipedia.org)
Rather than requiring endogenous or external mitogens to continue the cell cycle, cancer cells are able to grow, survive, and replicate without mitogens. (wikipedia.org)
With this mutation, cells are stimulated to divide by abnormally low levels of mitogens. (wikipedia.org)
In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta-thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)
Culture1
Dans la présente étude, les taux de production des interleukines 12 et 13 (IL-12 et IL-13) ont été mesurés à l'aide de la méthode ELISA dans les surnageants de culture de cellules mononucléées de sang périphérique stimulées par des mitogènes chez 30 cas de bêta-thalassémie non splénectomisés présentant une surcharge martiale ainsi que chez 20 individus en bonne santé appariés pour l'âge et le sexe. (who.int)
Positive1
The kits also include phytohemaglutinin (a mitogen used as a positive assay control), and saline (negative control or nil). (cdc.gov)
Control1
Endogenous mitogens function to control cell division is a normal and necessary part of the life cycle of multicellular organisms. (wikipedia.org)
Effects2
This is not true for all growth factors, as some growth factors instead appear to cause mitogenic effects like growth indirectly by triggering other mitogens to be released, as evidenced by their lack of mitogenic activity in vitro, which VEGF has. (wikipedia.org)
Mitogens are important in cancer research due to their effects on the cell cycle. (wikipedia.org)
Cell division1
A mitogen is a small bioactive protein or peptide that induces a cell to begin cell division, or enhances the rate of division (mitosis). (wikipedia.org)
Human1
Orthologous to human MAPK1 (mitogen-activated protein kinase 1). (nih.gov)
Form1
instead, they can produce their own mitogens in the form of p28sis. (wikipedia.org)
Growth factor1
Some growth factors, such as vascular endothelial growth factor, are also capable of directly acting as mitogens, causing growth by directly inducing cell replication. (wikipedia.org)