MAPKPathwaysPathwayPhosphorylationInhibitionSerineCellularInhibitorsMAPKsGenesRegulationTyrosine kinase activityDownstreamAMPKMiceReceptorActivationOncogenicVitroReceptorsRegulatesKineticsJNK1HumansMutationsAdaptorMitogenicThreonineBiologicalCascadeInsulinSuperfamilyReactiveTumorsActivityNuclearCellMolecularInduces
MAPK31
- Delphinidin was conclusively shown to repress pathological cardiac hypertrophy by modulating oxidative stress through the AMPK/NADPH oxidase (NOX)/mitogen-activated protein kinase (MAPK) signaling pathway. (nih.gov)
- An activating hotspot mutation occurs at V600E and results in constitutive MAPK signalling and uncontrolled cellular growth. (hindawi.com)
- The secretion of inflammatory factors as well as the marker proteins in the mitogen-activated protein kinase (MAPK) pathway were detected by Western blot. (frontiersin.org)
- Activation of the MAPK signaling pathway was observed in epilepsy rats. (frontiersin.org)
- 2002 ). As a pivotal biochemical cascade, the MAPK signaling pathway is involved in diverse fundamental events in cells and signal transduction pathways, namely, differentiation, proliferation, apoptosis, activation of other specific regulatory factors, acute responses to hormones, and developmental alteration of organisms (Pearson et al. (frontiersin.org)
- Cripto-1 overexpression in U87 glioblastoma cells activates MAPK, focal adhesion and ErbB pathways. (eurekaselect.com)
- High salt enhanced the activity of the p38 mitogen-activated protein kinase (p38/MAPK) and increased the interleukin (IL)-8 release in a p38/MAPK-dependent manner. (frontiersin.org)
- Extracellular signal-regulated kinase (ERK) is a part of the mitogen-activated protein kinase (MAPK) signaling pathway which allows the transduction of various cellular signals to final effectors and regulation of elementary cellular processes. (mdpi.com)
- Deregulation of the MAPK signaling occurs under many pathological conditions including neurodegenerative disorders, metabolic syndromes and cancers. (mdpi.com)
- Targeted inhibition of individual kinases of the MAPK signaling pathway using synthetic compounds represents a promising way to effective anti-cancer therapy. (mdpi.com)
- Cross-talk of the MAPK signaling pathway with other proteins and signaling pathways have a crucial impact on clinical outcomes of targeted therapies and plays important role during development of drug resistance in cancers. (mdpi.com)
- We discuss cross-talk of the MAPK/ERK signaling pathway with other signaling pathways, in particular interplay with the Hippo/MST pathway. (mdpi.com)
- In FC, both the mitogen-activated protein kinase (MAPK) and reactive oxygen species (ROS) signal transduction pathway of Na+/K+-ATPase were involved in the increase of the calcium transient induced by Str, but only activation of the MAPK pathway increased the calcium transient in NC. (unboundmedicine.com)
- The signal transduction pathways for AP-1 activation were also investigated and the results demonstrate that TiO2 stimulates mitogen-activated protein kinase (MAPK) family members, including extracellular signal-regulated protein kinases (ERKs), p38 kinase, and C-Jun N-terminal kinase UN Ks). (cdc.gov)
- For example, the mitogen-activated protein kinase (MAPK) p38 pathway mediates stabilization of tumor necrosis factor alpha (TNF-alpha) mRNA in myeloid cells stimulated with bacterial lipopolysaccharide (LPS). (ed.ac.uk)
- We present evidence that phosphorylation of TTP is mediated by the p38-regulated kinase MAPKAPK2 (MAPK-activated protein kinase 2). (ed.ac.uk)
- It belongs to the MAPK superfamily of stress-activated protein kinases. (thermofisher.com)
- Johan Lennartsson's research focuses on platelet-derived growth factor receptor (PDGFR) and mitogen-activated protein kinase (MAPK) signaling in normal physiology and cancer. (onclive.com)
- The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. (wikipathways.org)
- Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. (wikipathways.org)
- Over the last few decades, it has been studied that the mechanisms of cisplatin-induced kidney damage are complex and involved numerous cellular and molecular processes including inflammation, apoptosis, accumulation of cisplatin in renal tubular cells via renal drug transporters, Ctr1 and OCT2, and involvement of mitogen-activated protein kinases (MAPK) pathways [ 3 ] [ 4 ]. (thieme-connect.com)
- In particular, extracellular-regulated kinase (ERK) 1/2, one of the MAPK pathway is considered as an important mediator of signal transduction processes, namely cell survival, cell division, gene expression, and cell metabolism that plays role in injury, death, and inflammation of kidney tubular cells due to cisplatin administration [ 5 ]. (thieme-connect.com)
- Our study showed that both p38 MAPK inhibitors at 10 μM significantly inhibited constitutive and IL-4-upregulated CD23 protein expression in epithelial cells. (mcmaster.ca)
- Previous studies have shown that S118 can be phosphorylated by the ERK1/2 mitogen activated protein kinases (MAPK) and by the cyclin-dependent protein kinase Cdk7. (dundee.ac.uk)
- Feedback loops, both positive and negative are embedded in the Mitogen Activated Protein Kinase (MAPK) cascade. (biomedcentral.com)
- It was observed that the positive feedback emerging from an oscillating MAPK cascade and functional in an external signal processing module can trigger oscillations in the target module, provided that the target module satisfy certain parametric requirements. (biomedcentral.com)
- A positive feedback from an oscillating MAPK cascade was shown to induce oscillations in an external signal processing module, uncovering a novel regulatory aspect of MAPK signal processing. (biomedcentral.com)
- Signal transduction pathways such as the Mitogen Activated Protein Kinase (MAPK) cascade responds to wide range of external stimuli to trigger growth, cell-division and proliferation[ 1 , 2 ]. (biomedcentral.com)
- The evolutionarily conserved structure of the three layer MAPK cascade consists of the MAPKKK (henceforth referred as M3K), MAPKK (henceforth referred as M2K) and MAPK (henceforth referred as MK) from yeast to human, which processes the incoming signal through a series of covalent modification cycles[ 1 ]. (biomedcentral.com)
- Dual-specificity phosphatase 8 (DUSP8) is a MAPK phosphatase that dephosphorylates and inactivates the kinase JNK. (bvsalud.org)
- En los mamíferos, existen varias vías de MAPK diferentes, como la vía de ERK (cinasa regulada por señales extracelulares), la vía de SAPK/JNK (proteína-cinasa activada por el estrés/cinasa c-jun) y la vía de la cinasa p38. (bvsalud.org)
Pathways22
- Mitogen-activated protein (MAP) kinases are serine/threonine kinases that mediate intracellular signal transduction pathways. (rcsb.org)
- Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
- AMPK pathways inhibit biosynthetic pathways with energy consumption, such as protein, fatty acid and glycogen synthesis. (springer.com)
- NF-κB pathways can be mainly activated by two pathways. (springer.com)
- Microarray analysis was performed to screen aberrantly expressed mRNAs and activated signaling pathways between epileptic rats and normal controls. (frontiersin.org)
- Cancer cell biology takes advantage of identifying diverse cellular signaling pathways that are disrupted in cancer. (eurekaselect.com)
- Signaling pathways are an important means of communication from the exterior of cell to intracellular mediators, as well as intracellular interactions that govern diverse cellular processes. (eurekaselect.com)
- Unraveling of dysregulated signaling pathways may advance the understanding of tumor pathophysiology and lead to the improvement of targeted tumor therapy. (eurekaselect.com)
- In this review article, different signaling pathways and how their dysregulation contributes to the development of tumors have been discussed. (eurekaselect.com)
- The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways focused on the plant hormone signal transduction and mitogen-activated protein kinase signaling pathway. (researchsquare.com)
- To determine whether different Na+/K+-ATPase signal transduction pathways have positive inotropic effects on normal ventricular myocytes (NC) and failing ventricular myocytes (FC), and are involved in an increase of [Ca2+]i induced by strophanthidin (Str). (unboundmedicine.com)
- The present study suggests that Na+/K+-ATPase signaling pathways involved in the inotropic effects of Str in NC and FC are consistent, and Na+/K+-ATPase signaling pathways involved in the increase of [Ca2+]i by Str in NC and FC are different. (unboundmedicine.com)
- These findings demonstrate that TiO2 nanoparticle s stimulated the generation of ·OH radical and induces AP-1 activation, which may be mediated throughp38 kinase and ERKs pathways. (cdc.gov)
- Signal transduction pathways regulate gene expression in part by modulating the stability of specific mRNAs. (ed.ac.uk)
- JNK pathways are activated by stress and inflammatory signals. (thermofisher.com)
- He is an expert in a wide variety of oncogenic signaling pathways, including the SCF/KIT pathway, to which he has made numerous seminal research contributions. (onclive.com)
- Another avenue of exploration is to identify drugs that have multiple targets, thereby inhibiting several signaling pathways essential for the cancer cell. (onclive.com)
- These results represent a novel mechanism by which alkylphospholipids modulate transcription, and may contribute to the discovery of new signal transduction pathways crucial for normal and neoplastic cell cycle control. (conicet.gov.ar)
- What pathways are this gene/protein implicaed in? (cancerindex.org)
- Various feedback loops, both positive and negative in nature are abundant in the biological signal processing pathways. (biomedcentral.com)
- Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. (geneticsmr.com)
- In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. (bvsalud.org)
Pathway16
- The expression of transthyretin, a protein shown to sequester Aβ and prevent amyloid fibril formation in vitro , and several genes in the insulin-signaling pathway, e.g., insulin-like growth factor-2, were increased selectively in the hippocampus of APP Sw mice. (jneurosci.org)
- The BRAF oncogene is an integral component of the MAP kinase pathway, and an activating V600E mutation occurs in 15% of sporadic colorectal cancer. (hindawi.com)
- This signal transduction pathway is initiated by epidermal growth factor ligands binding to and activating receptor tyrosine kinases (RTK) at the cell membrane. (hindawi.com)
- Understanding the mTOR signaling pathway via mathematical modeling. (crossref.org)
- Thus integrins modulate the efficiency of the Erk (extracellular-signal-regulated kinase)/MAP kinase (mitogen-activated protein kinase) pathway, acting at several distinct levels. (nih.gov)
- We have shown that both cAMP-dependent protein kinase and PAKs (p21-activated kinases) play a role in integrin regulation of the Erk pathway, acting primarily at the level of Raf-1. (nih.gov)
- This transcriptome analysis provides a valuable resource for elucidating the signaling pathway of NaCl and KCl stress and is a substantial genetic resource for discovering genes related to the NaCl and KCl stress response of M. hupehensis . (researchsquare.com)
- The p38 pathway is required for the induction of TNF-alpha RNA-binding activity and for the expression of TTP protein and mRNA. (ed.ac.uk)
- Our findings demonstrate a direct link between a specific signal transduction pathway and a specific RNA-binding protein, both of which are known to regulate TNF-alpha gene expression at a posttranscriptional level. (ed.ac.uk)
- What is the future for this signaling pathway in cancer research? (onclive.com)
- This enables rhein hydrogels to significantly dephosphorylate IκBα, inhibiting the nuclear translocation of p65 at the NFκB signalling pathway in lipopolysaccharide-induced BV2 microglia. (nature.com)
- Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1. (conicet.gov.ar)
- Moreover, we showed that perifosine activates the mitogen-activated protein/extracellular signal-regulated kinase pathway, and this activation promotes the phosphorylation of Sp1 in known mitogen-activated protein kinase residues (threonine 453 and 739), thereby leading to increased Sp1 binding and enhanced p21(waf1/cip1) transcription. (conicet.gov.ar)
- B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP. (wikidata.org)
- In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)
- In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)
Phosphorylation4
- Concomitant activation of the insulin-like growth factor-1 receptor, Akt, and extracellular signal-regulated protein kinase 1 and 2 as well as increased phosphorylation of Bad also were unique to the hippocampus of APP Sw mice. (jneurosci.org)
- M3K is activated upon single phosphorylation whereas M2K and MK are both activated upon double phosphorylation[ 2 - 4 ]. (biomedcentral.com)
- Parallel to the phosphorylation by kinases, phosphatases present in the cellular volume dephosphorylates the phosphorylated kinases. (biomedcentral.com)
- The Signal phosphorylates M3K to M3K* where "*" represents phosphorylation. (biomedcentral.com)
Inhibition4
- Mechanistically, delphinidin reduced ROS accumulation upon Ang II stimulation through the direct activation of AMP-activated protein kinase (AMPK) and subsequent inhibition of the activity of Rac1 and expression of p47 phox . (nih.gov)
- Inhibition of the 3 classical mitogen-activated protein kinases (p38 kinase, ERK, and JNK) revealed kinase-dependent differences in reductions in cytokine production by the 2 Candida species. (bath.ac.uk)
- Inhibition of ERKs, p38 kinase, but not JN Ks with specific inhibitors SB203580, PD98059, and SP 600125, inhibited TiO2 nanoparticle s-induced AP-1 activation, respectively. (cdc.gov)
- The inhibition of Fog signaling induced accelerated growth of dlg mutant tumors, possibly through its regulatory function on myosin activity. (edu.hk)
Serine3
- The BRAF (v-raf murine sarcoma viral oncogene homolog B) gene encodes a protein that belongs to the Raf family of serine/threonine protein kinases. (hindawi.com)
- Mitogen-activated protein kinases (MAPKs) consist of a family of protein-serine/protein-threonine kinases followed by proline, prevalent in mammals (Pearson et al. (frontiersin.org)
- MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. (thermofisher.com)
Cellular2
- BRAF is a protein kinase and part of the MAP kinase signalling cascade which involves transduction of a growth signal from the cell membrane to the nucleus via a chain of protein kinases and is responsible for cellular proliferation and survival. (hindawi.com)
- Activated by stress, p38 MAPKs regulate vital cellular responses such as migration, contraction, cytokine production, and death in macrophages and myocardial and endothelial cells (Marber et al. (frontiersin.org)
Inhibitors4
- Pyridinyl imidazole compounds block pro-inflammatory cytokine production and are specific p38 kinase inhibitors. (rcsb.org)
- The effects of 25 micromol/L Str with different signal-transducing inhibitors on contractility and the calcium transient of NC or FC from guinea pigs were simultaneously assessed and compared with those in the 25 micromol/L Str-only group by a video-based, motion-edge detection system. (unboundmedicine.com)
- Therefore, these receptors have been used as targets for drug development, including low-molecular-weight kinase inhibitors (eg, the clinically used drug Gleevec), but other possibilities are neutralizing antibodies against the receptor (similar to the HER2-targeting antibody Herceptin) or ligand (similar to the vascular endothelial growth factor-targeting antibody Avastin). (onclive.com)
- 1999). p38 mitogen-activated protein kinase inhibitors-mechanisms and therapeutic potentials. (geneticsmr.com)
MAPKs3
- Signaling through the p38 mitogen-activated protein kinases (MAPKs) is essential for cartilage formation in primary cultures of limb mesenchyme. (biologists.com)
- Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. (wikipathways.org)
- Mitogen-activated protein kinases (MAPKs) are ubiquitous signal transduction components in eukaryotes. (biomedcentral.com)
Genes3
- This abrogated expression of the decidual marker genes, insulin like growth factor binding protein 1 ( IGFBP1 ) and prolactin ( PRL ), and prevented adoption of decidual cell morphology. (bioone.org)
- Analysis of the blue coral transcriptome revealed enrichment of genes involved in stress response, including heat-shock proteins and antioxidants, as well as genes participating in signal transduction and stimulus response. (nature.com)
- Since activator protein- 1 (AP- 1) is known to play an important role in the induction of neoplastic transformation and regulation of multiple genes involved in cell proliferation and inflammation, we investigate the potency of TiO2 nanoparticle s on reactive oxygen species (ROS) generation and AP-1 signaling in a mouse epithermal cell line, JB6 cells. (cdc.gov)
Regulation2
- Limb bud regulation and development of the lungs, liver, teeth and facial mesenchyme cells are other important functions attributed to BMP4 signaling. (wikipedia.org)
- Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
Tyrosine kinase activity1
- 2001 ), which can be activated by tyrosine kinase activity upstream through signal transduction (Oldenhof et al. (frontiersin.org)
Downstream2
- The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor during decidualization. (bioone.org)
- Use of effector domain mutants of Rac suggest that Nischarin acts downstream of Rac, probably at the level of PAK-family kinases. (nih.gov)
AMPK3
- Glucose transport can be activated in skeletal muscle in response to insulin via activation of phosphoinositide (PI) 3-kinase and in response to contractions or hypoxia, presumably via activation of 5′ AMP-activated protein kinase (AMPK). (diabetesjournals.org)
- We determined the effects of insulin and muscle contraction/hypoxia on PI 3-kinase, AMPK, and glucose transport activity in epitrochlearis skeletal muscle from insulin-resistant Zucker ( fa/ fa ) rats. (diabetesjournals.org)
- The protein kinase AMPK, CK1α, or MAP4K3 phosphorylates ACE2 protein and induces ACE2 protein levels by decreasing its ubiquitination. (bvsalud.org)
Mice3
- Tg2576 mice overexpress a mutant form of human amyloid precursor protein with the Swedish mutation (APP Sw ), resulting in high β-amyloid (Aβ) levels in the brain. (jneurosci.org)
- This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
- ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
Receptor4
- Overactivity of SCF/KIT signaling occurs through a number of different mechanisms, for example, mutational activation, SCF expression in an autocrine fashion, or receptor overexpression. (onclive.com)
- It has become clear that a large number of tumors have aberrant expression of receptor tyrosine kinases, and that this class of cell surface receptors frequently regulates functions such as proliferation, migration, and survival-functions that are deregulated in tumor cells. (onclive.com)
- This most likely occurs from defects in postreceptor insulin signal transduction at the level of insulin receptor substrate-1 and phosphoinositide (PI) 3-kinase ( 6 - 9 ) as well as defects in trafficking and/or function of GLUT4 ( 10 , 11 ), the major insulin-regulated GLUT isoform expressed in skeletal muscle ( 12 ). (diabetesjournals.org)
- The protein encoded by this gene is a receptor for C-C type chemokines. (cancerindex.org)
Activation2
- For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. (wikipathways.org)
- Mechanistically, DUSP8 dephosphorylated the transcriptional repressor Pur-α upon TGF-ß signaling, leading to the nuclear export of Pur-α and subsequent IL-9 transcriptional activation. (bvsalud.org)
Oncogenic1
- Oncogenic mutations or abnormal expression of signaling components disrupt the regulatory networks that govern cell function, thus enabling tumor cells to undergo dysregulated mitogenesis, to resist apoptosis, and to promote invasion to neighboring tissues. (eurekaselect.com)
Vitro1
- Thus, the principle of protein or peptide haptenation could be used in in vitro assays to predict the sensitization potential of a new chemical entity. (cdc.gov)
Receptors1
- It belongs to family 1 of the G protein-coupled receptors. (cancerindex.org)
Regulates1
- The zinc finger protein tristetraprolin (TTP) is expressed in response to LPS and regulates the stability of TNF-alpha mRNA. (ed.ac.uk)
Kinetics1
JNK11
- Human recombinant protein fragment corresponding to amino acids 1-384 of human JNK1 produced in E.coli. (thermofisher.com)
Humans1
- Bone morphogenetic protein 4 is a protein that in humans is encoded by BMP4 gene. (wikipedia.org)
Mutations2
- For instance, familial AD is linked to mutations in the amyloid precursor protein (APP), presenilin 1, and presenilin 2, all of which lead to increased levels of Aβ. (jneurosci.org)
- Scope includes mutations and abnormal protein expression. (cancerindex.org)
Adaptor1
- Adaptor proteins, GRB2 and SOS, are then sequentially recruited to stimulate the release of GDP from KRAS which permits binding of GTP to activate KRAS. (hindawi.com)
Mitogenic1
- Integrins clearly play a key role in regulating both mitogenic signalling and cell migration. (nih.gov)
Threonine1
- Mutagenesis data suggested a single residue difference at threonine 106 between p38 and other MAP kinases is sufficient to confer selectivity of pyridinyl imidazoles. (rcsb.org)
Biological1
- This analysis discriminates between different biological mechanisms to achieve a transient signal from a sustained TGF-b input, where one mechanism is to use a negative feedback to turn the signal off. (lu.se)
Cascade1
- It is an integral component of the MAP (mitogen-activated protein) kinase cascade. (hindawi.com)
Insulin2
- Insulin signaling–mathematical modeling comes of age. (crossref.org)
- Insulin-stimulated glucose transport in isolated skeletal muscle was reduced 47% in obese versus lean rats, with a parallel 42% reduction in tyrosine-associated PI 3-kinase activity. (diabetesjournals.org)
Superfamily2
- BMP4 is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. (wikipedia.org)
- BMP4 is a polypeptide belonging to the TGF-β superfamily of proteins. (wikipedia.org)
Reactive1
- The basis of hapten- molecular mechanisms of the sensitization pro- protein binding work is the hypothesis that upon cess will result in novel opportunities for the skin absorption, only protein-reactive chemicals development of alternative methods for assessing (or those that can be metabolically or chemically skin sensitization hazard and relative potency of converted to protein-reactive species) are able to chemicals. (cdc.gov)
Tumors1
- Our data suggested that Fogmyosin signaling may regulate the growth of nTSG mutation-induced tumors through modulating JNK signaling activity. (edu.hk)
Activity1
- Previous studies showed JNK signaling is a potential target of actomyosin activity. (edu.hk)
Nuclear1
- The lilli gene encodes a nuclear protein related to the AF4/FMR2 family. (sdbonline.org)
Cell4
- Deregulation of cell signaling in cancer. (eurekaselect.com)
- Cell signaling and cancer. (eurekaselect.com)
- SCF/KIT signaling most likely has different functions in different cell types. (onclive.com)
- I believe it is important to identify which signaling circuits are activated by KIT, and how these circuits contribute to the observed effects on cell survival, growth, and migration. (onclive.com)
Molecular2
- Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. (yeastgenome.org)
- One of the key molecular events in skin sensitization is protein haptenation, i.e. the chemical modification of self-skin protein(s) thus forming macromolecular immunogens. (cdc.gov)
Induces1
- In this report, we investigated the mechanism by which perifosine induces p21(waf1/cip1) protein expression. (conicet.gov.ar)