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  • mediates
  • This indicates that T. brucei may have a single IM translocase that with compositional variations mediates import of presequence-containing and carrier proteins. (blogspot.com)
  • pathway
  • These proteins participate in the apoptotic pathway, and the interaction between them may serve as a target for anticancer lead compounds. (nih.gov)
  • Figure 3 shows a probable pathway. (wikipedia.org)
  • However, cyanobacteria appear to not use homogentisate for synthesizing plastoquinol, possibly resulting in a pathway different from the one shown below. (wikipedia.org)
  • In either prokaryotes or mitochondria they are localized to the outer membrane, and have been shown to bind and transport dicarboxylic tetrapyrrole intermediates of the haem biosynthetic pathway. (wikipedia.org)
  • In animals, the peripheral benzodiazepine receptor is a mitochondrial protein (located in the outer mitochondrial membrane) characterised by its ability to bind with nanomolar affinity to a variety of benzodiazepine-like drugs, as well as to dicarboxylic tetrapyrrole intermediates of the haem biosynthetic pathway. (wikipedia.org)
  • brucei
  • Rhomboid-like proteins were proposed to form the protein translocation pore of the ER-associated degradation system, suggesting that they may contribute to pore formation in the presequence translocase of T. brucei. (blogspot.com)
  • These data, together with the observation of other abnormal phenotypes, show that all the corresponding mitochondrial proteins are involved, directly or indirectly, in the correct progress or, less likely, in the regulation, of the cell cycle in T. brucei . (biomedcentral.com)
  • sequence
  • View conserved domains detected in this protein sequence using CD-search. (nih.gov)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • The Fe2S2 ferredoxin from Clostridium pasteurianum (Cp2FeFd) has been recognized as distinct protein family on the basis of its amino acid sequence, spectroscopic properties of its iron-sulfur cluster and the unique ligand swapping ability of two cysteine ligands to the [Fe2Scluster. (wikipedia.org)
  • All carriers contain a common sequence, referred to as the MCF motif, in each repeated region, with some variation in one or two signature sequences. (wikipedia.org)
  • Though they differ in sequence and length, the four isoforms still share a similar topological structure, including six transmembrane domains, one of which is responsible for localization to the outer mitochondrial membrane (OMM), and two N-terminal apoptotic domains. (wikipedia.org)
  • In this system, the N-terminal P450 domain is fused to the reductase domain that shows sequence similarity to phthalate dioxygenase reductase and consists, in its turn, of FMN-binding domain and C-terminal plant-type ferredoxin domain. (wikipedia.org)
  • The amino acid sequence of soybean FLbR2 has considerable homology with soybean FLbR1 and pea leaf mitochondria DLDH and contains a 30-residue mitochondrial transit peptide. (wikipedia.org)
  • Phosphorylation
  • There is a mitochondrial GTP:AMP phosphotransferase, also specific for the phosphorylation of AMP, that can only use GTP or ITP as the phosphoryl donor. (wikipedia.org)
  • many independent labs have demonstrated that, in addition to the classical ion transporting, this membrane protein can also relay extracellular ouabain-binding signalling into the cell through regulation of protein tyrosine phosphorylation. (wikipedia.org)
  • The downstream signals through ouabain-triggered protein phosphorylation events include activation of the mitogen-activated protein kinase (MAPK) signal cascades, mitochondrial reactive oxygen species (ROS) production, as well as activation of phospholipase C (PLC) and inositol triphosphate (IP3) receptor (IP3R) in different intracellular compartments. (wikipedia.org)
  • aldehyde
  • The eukaryotic molybdopterin binding domain is currently found in only five other human genes, xanthine dehydrogenase, sulfite oxidase (mitochondrial precursor), aldehyde oxidase, erythropoietin receptor precursor and the ATPbinding cassette, sub-family A, member 2 (ABCA2). (wikipedia.org)
  • sequences
  • The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. (nih.gov)
  • According to GeneDB [ 6 ], 4539 and 575 CDSs (Coding DNA Sequences) are annotated as encoding 'hypothetical proteins, conserved' and 'hypothetical proteins, unlikely', respectively. (biomedcentral.com)