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  • analyses
  • Using the same strategy we have now reconstructed this inventory separately for human and for mouse based on (i) improved gene transcript models, (ii) updated literature curation, including results from proteomic analyses of mitochondrial sub-compartments, (iii) improved homology mapping and (iv) updated versions of all seven original data sets. (nih.gov)
  • Using translatome analyses, we show that the translation of mitochondrial proteins is highly down-regulated in yeast lacking RP paralogs required for normal mitochondrial function (e.g. (rupress.org)
  • gene
  • (B) LogOdds scores for gene ECHDC1 , in MitoCarta2.0 but not MitoCarta1.0, highlights improvements in three data sources (C) LogOdds scores for gene NFXL1 , in MitoCarta1.0 but not MitoCarta2.0, highlights improvements to RefSeq gene models-as previous 58aa protein fragment XP_001052092 has been replaced with 918aa full-length protein NP_598682. (nih.gov)
  • redox
  • The formation of this complex was enhanced by replacing the CxxU motif with SxxC, but abolished when it was replaced with SxxS, suggesting a redox interaction of SelO with another protein through its Sec residue. (harvard.edu)
  • Taken together, these results show that SelO is a redox-active mitochondrial selenoprotein. (harvard.edu)
  • Genome
  • It is built by combining a large training set of 960 mitochondrial genes (based on literature curation, APEX-based mass spectrometry experiments and GFP-tagging/microscopy) with a Bayesian integration of seven genome-scale data sets, updated extensively from the previous MitoCarta1.0 inventory. (nih.gov)
  • Thus
  • In enzymology, a mitochondrial protein-transporting ATPase (EC 3.6.3.51) is an enzyme that catalyzes the chemical reaction ATP + H2O ⇌ {\displaystyle \rightleftharpoons } ADP + phosphate Thus, the two substrates of this enzyme are ATP and H2O, whereas its two products are ADP and phosphate. (wikipedia.org)
  • sequences
  • A DNA sequence analysis tool ( MitoMorphy ) was developed to compare polymorphisms of different human mitochondrial DNA sequences. (nist.gov)
  • This tool allows the user to select mitochondrial sequences from any two human populations and compare them for sequences variations. (nist.gov)
  • cytosol
  • The incorporation into the cytosol protein of the flight muscles appeared to be inhibited by more than 99.5% with the antibiotic. (wur.nl)
  • yeast
  • One such protein is Selenoprotein O (SelO), the largest mammalian selenoprotein with orthologs found in a wide range of organisms, including bacteria and yeast. (harvard.edu)
  • researchers
  • Authored by 24 researchers from various centers and involving a significant contribution by Aida Rodríguez-Nuevo, Angels Díaz-Ramos and Eduardo Noguera from Zorzano's lab, this study focuses on the protein Opa1. (news-medical.net)
  • Researchers at Yale School of Medicine have found that a thyroid hormone in the brain is linked to the "uncoupling" protein UCP2, which can maintain appetite during periods// of fasting so that the body is ready to eat when food is reintroduced. (bio-medicine.org)
  • metabolic
  • Expression of this protein could be verified in HEK 293T cells by metabolic labeling of cells with 75Se, and it was abolished when selenocysteine was replaced with serine. (harvard.edu)
  • expression
  • In order to address these open issues, permanent cell lines were generated within the frame of the present thesis in which the expression of single proteins implicated in mitochondrial import can be inhibited via RNA interference (RNAi). (hu-berlin.de)
  • Cells
  • This protein was reversibly oxidized in a time- and concentration-dependent manner in HEK 293T cells when cells were treated with hydrogen peroxide. (harvard.edu)
  • showed that the rpl1b Δ translatome is distinct from respiratory-competent rpl1a Δ cells, the former being deficient in the production of mitochondrial and cell wall proteins. (rupress.org)
  • demonstrate
  • Scientists at the Institute for Research in Biomedicine (IRB Barcelona) headed by Antonio Zorzano, also full professor of the University of Barcelona and researcher in the CIBERDEM programme, now demonstrate that the removal of a single mitochondrial protein in mouse muscle leads to severe inflammation throughout the body, causing the premature death of the animal. (news-medical.net)
  • different
  • Although MLCL AT-1 and MTP are different proteins, in 2012 the same lab discovered that MTP did indeed have cardiolipin remodeling capabilities. (wikipedia.org)