• The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction leading to reduced energy supply, impaired neuroplasticity, and finally cell death as one major pathomechanism underlying the continuum from brain aging over mild cognitive impairment to initial and advanced late onset Alzheimer's disease. (nih.gov)
  • The difficulty in understanding and treating human pathologies caused by mitochondrial dysfunction arises from the complex relationships between mitochondria and other cellular processes, as well as the genetic background of such diseases. (biomedcentral.com)
  • Mitochondrial dysfunction in metabolic syndrome]. (elsevierpure.com)
  • I have been saying all along that mitochondrial dysfunction-the inability of mitochondria to generate sufficient energy (ATP)-is at the heart of the metabolic origins theory of cancer. (tuitnutrition.com)
  • A group of authors critically evaluated and interpreted the evidence linking mitochondrial dysfunction and metabolic changes to the pathogenesis of Alzheimer's disease (AD). (news-medical.net)
  • The association between diet soft drink intake and metabolic dysfunction-associated steatotic liver disease (MASLD). (news-medical.net)
  • Importantly, it has been suggested that mitochondrial dysfunction might precede the metabolic change. (intechopen.com)
  • Mitochondrial dysfunction is associated with an increased risk of developing metabolic syndrome (MetS). (elsevierpure.com)
  • Metabolic dysfunction directly causes or significantly contributes to many human diseases including heart disease, obesity, diabetes, cancer and aging. (upenn.edu)
  • One of the underlying mechanisms of long COVID may be mitochondrial dysfunction. (mdpi.com)
  • The hallmarks of neurodegeneration include oxidative stress, proteasome impairment, mitochondrial dysfunction and accumulation of abnormal protein aggregates as well as metabolic alterations. (lu.se)
  • MAT promotes mitochondrial biogenesis - the generation of new mitochondria within cells. (progenmethod.com)
  • Mitochondrial biogenesis is a complicated process involving more than 1,000 genes. (hormonesynergy.com)
  • 1) Caloric restriction and aerobic exercise promote mitochondrial biogenesis. (hormonesynergy.com)
  • It contains ingredients that help restore your metabolic edge by activating the critical molecular "switches" that control mitochondrial biogenesis-the very same switches activated by caloric restriction and aerobic exercise. (hormonesynergy.com)
  • Mitochondrial fitness includes mitochondrial biogenesis, mitochondrial respiration, mitochondrial protein synthesis, increased reliance on fatty acid substrates by mitochondria, and better handling of oxidative stress. (caredir.com)
  • RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in PGC-1α acetylation and an increase in PGC-1α activity. (johnshopkins.edu)
  • MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control. (nih.gov)
  • MiRNA-378a-3p acts as a negative regulator of mitochondrial metabolic and biogenesis pathways. (cdc.gov)
  • Cardiolipin is the distinctive inner mitochondrial membrane phospholipid coupling structure with metabolism and signaling function. (barthsyndrome.org)
  • The goal is to trigger specific physiological adaptations that improve the metabolism of lipids, glucose, and insulin sensitivity, ultimately enhancing overall metabolic fitness. (progenmethod.com)
  • Although mitochondrial haplotypes have no direct impact on mitochondrial respiration, some haplotypes are associated with stress- and metabolism-related phenotypes, including food intake in males. (ista.ac.at)
  • Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel," Nature Metabolism , vol. 1, no. 12. (ista.ac.at)
  • This comprehensive analysis provides insights into the neuroimmune relationships affecting metabolism, offering potential new therapeutic strategies for metabolic diseases. (news-medical.net)
  • Scope of review: The question of whether 'inborn' mitochondrial deficiencies and/or defective mitochondrial metabolism contribute to metabolic disease, or if environmental factors are the major determinant, will be examined. (edu.au)
  • Metabolic myopathies affect the metabolism of carbohydrates, in particular glucose and fats, which are the two main energy sources of skeletal muscles. (medicover-genetics.com)
  • The mTOT complex functions as a molecular 'sensor switch' connecting mitochondrial metabolism to important cellular activities, such as carbohydrate, lipid, and amino acid metabolism, that are out of balance in patients with type 2 diabetes. (news-medical.net)
  • Nano-titanium dioxide (nano -TiO2), though one of the most utilized and produced engineered nanomaterial s (ENMs), diminishes cardiovascular function through dysregulation of metabolism and mitochondrial bioenergetics following inhalation exposure. (cdc.gov)
  • MiRNA-378a regulated proteins involved in mitochondrial fusion, transcription, and fatty acid metabolism. (cdc.gov)
  • Overview of Hereditary Metabolic Disorders Hereditary metabolic disorders are inherited genetic conditions that cause metabolism problems. (msdmanuals.com)
  • The United Mitochondrial Disease Foundation promotes research for and education about mitochondrial disorders to those affected by them. (chop.edu)
  • The Metabolic Support UK organization funds research and provides information to families affected by metabolic disorders. (chop.edu)
  • PG) polyphenols on metabolic disorders. (news-medical.net)
  • Incidence and prevalence are still largely unknown, although mitochondrial disorders are the most common cause of metabolic myopathies with a prevalence of 1:8,000. (medicover-genetics.com)
  • Mitochondrial diseases are a group of metabolic disorders. (medlineplus.gov)
  • In secondary carnitine deficiency, which is caused by other metabolic disorders (eg, fatty acid oxidation disorders, organic acidemias), carnitine depletion may be secondary to the formation of acylcarnitine adducts and the inhibition of carnitine transport in renal cells by acylcarnitines. (medscape.com)
  • This group includes lysosomal storage disorders, various mitochondrial diseases, other neurometabolic disorders, and several other miscellaneous disorders. (medscape.com)
  • Mitochondrial disorders cause mitochondria to stop working properly, so that less and less energy is generated within the cells. (msdmanuals.com)
  • These high-energy organs are particularly susceptible to the problems caused by mitochondrial disorders. (msdmanuals.com)
  • The following are examples of mitochondrial disorders. (msdmanuals.com)
  • Increasingly, tandem mass spectrometry (MS/MS) is being used for newborn screening because this laboratory testing technology substantially increases the number of metabolic disorders that can be detected from dried blood-spot specimens. (cdc.gov)
  • Another leg of this table is mitochondrial insufficiency -too few mitochondria, even if they are functioning perfectly well. (tuitnutrition.com)
  • For our purposes here, we can think of free radicals as being pinballs inside our cells (and inside the mitochondria): they bang around and crash into things here and there, only instead of racking up points like you do in a video game, each time the pinball hits into something (such as the fatty acids that make up the mitochondrial membranes), it causes damage. (tuitnutrition.com)
  • This article reviews the literature on the role of mitochondria in metabolic health, physical activity, and cancer. (caredir.com)
  • Mitochondria are essential organelles that perform a wide range of functions within cells, such as producing ATP and metabolic intermediates, as well as assisting in cellular stress responses. (caredir.com)
  • Mitochondria regulate cellular processes, such as metabolic adaptation, calcium homeostasis, and cell proliferation or death. (caredir.com)
  • The concept of "mitochondrial fitness" refers to the biological efficiency and adequacy of the mitochondria. (caredir.com)
  • The results showed in this study suggest that, together with cytoskeletal proteins, mitochondria and metabolic proteins are changing their post-translational status in brains of obese mice. (lu.se)
  • Subsequently, acyl-carnitines are translocated across the inner mitochondrial membrane by cartinine acyl translocase. (biomedcentral.com)
  • Recall from last time that the electron transport system-which is the ultimate mechanism by which large amounts of ATP are generated-is embedded within the inner mitochondrial membrane. (tuitnutrition.com)
  • It provides a link between the mitochondrial matrix and cytosol by transporting citrate through the impermeable inner mitochondrial membrane in exchange for malate from the cytosol. (wikipedia.org)
  • The amino and carboxy termini are located on the cytosolic side of the inner mitochondrial membrane. (wikipedia.org)
  • Using a novel drug analog photo-catalyzable affinity probe and mass spectrometry-based proteomics, MSDC scientists identified two phylogenetically-conserved proteins in the inner mitochondrial membrane, meaning these proteins are present in, and play an important role in the development of, organisms from yeast and fruit flies to humans. (news-medical.net)
  • This review attempts to provide a summary of the background knowledge and recent developments in mitochondrial processes relating to mitochondrial-associated metabolic diseases arising from defects or deficiencies in mitochondrial function, as well as insights into current and future avenues for investigation. (biomedcentral.com)
  • as in all diseases with mitochondrial transmission, the disease is inherited via the ovum and hence always from the mother. (medscape.com)
  • Cardiac mitochondrial function is altered in a variety of inherited and acquired cardiovascular diseases. (jci.org)
  • This buildup of lactic acid may help distinguish a mitochondrial disorder from other metabolic diseases. (msdmanuals.com)
  • The course in metabolic diseases is part of the programme and is taught by staff at LUDC. (lu.se)
  • The course focuses on (some of the) endocrine and metabolic diseases that are included in the strong research areas at Lund University. (lu.se)
  • The course also addresses cardiovascular complications that arise in connection with the metabolic syndrome and highlights genetic aspects of metabolic diseases. (lu.se)
  • Obesity constitutes a major global health threat and is associated with a variety of diseases ranging from metabolic and cardiovascular disease, cancer to neurodegeneration. (lu.se)
  • Cells isolated from the hepatopancreas of estivating snails ( Helix aspersa) have strongly depressed mitochondrial respiration compared with controls. (ox.ac.uk)
  • Mitochondrial respiration was divided into substrate oxidation (which produces the mitochondrial membrane potential) and ATP turnover and proton leak (which consume it). (ox.ac.uk)
  • These primary changes resulted in a lower mitochondrial membrane potential in hepatopancreas cells from estivating compared with active snails, leading to secondary decreases in respiration to drive ATP turnover and proton leak. (ox.ac.uk)
  • The respiration to drive ATP turnover and proton leak decreased in proportion to the overall decrease in mitochondrial respiration, so that the amount of ATP turned over per O2consumed remained relatively constant and aerobic efficiency was maintained in this hypometabolic state. (ox.ac.uk)
  • At least 75% of the total response of mitochondrial respiration to estivation was caused by primary changes in the kinetics of substrate oxidation, with only 25% or less of the response occurring through primary effects on ATP turnover. (ox.ac.uk)
  • As development progresses, nephron progenitors switch from glycolysis to mitochondrial respiration for energy-mediated by an unknown mechanism-and undergo differentiation. (lww.com)
  • A switch from glycolysis to mitochondrial respiration drives these cells toward differentiation, but the mechanisms that control this switch are poorly defined. (lww.com)
  • VHL knockout nephron progenitors also exhibit persistent Six2 and Wt1 expression, as well as decreased mitochondrial respiration and prolonged reliance on glycolysis. (lww.com)
  • At the end of the exposure, both fresh brain (cortical and hippocampal tissue) and heart (apical tissue) were immediately harvested to measure mitochondrial respiration and reactive oxygen species (ROS) generation and blood was collected to assess plasma cytokine concentrations. (lu.se)
  • Main results: Animals in the CO group showed significantly decreased Complex IV-linked mitochondrial respiration in hippocampal and apical heart tissue but not cortical tissue. (lu.se)
  • Cardiac function, utilizing the Vevo 2100 Imaging System, electron transport chain complex activities, and mitochondrial respiration assessed cardiac and mitochondrial function. (cdc.gov)
  • The development of cancer is linked to metabolic and mitochondrial alterations, which are closely related to epigenetics, which are largely modifiable factors that can act as triggers for the activation and expression of certain proteins that regulate metabolic pathways related to cancer. (caredir.com)
  • These genetic changes can occur in cells throughout an individual's lifespan and can alter the signaling pathways that control metabolic programming. (caredir.com)
  • In addition, different cell types exhibit preference for specific metabolic pathways (fatty acid oxidation/FAO, glycolysis or oxidative phosphorylation/OxPhos). (upenn.edu)
  • Multidrug tolerance results from drug-induced quiescence, which enables parasites to survive exposure to unrelated antimalarial drugs that inhibit a variety of metabolic pathways. (cdc.gov)
  • Specifically, proteins involved in metabolic pathways and in mitochondrial functions are mainly downregulated in mice fed with obesogenic diets compared to SD. (lu.se)
  • Our findings identify a novel role for VHL in mediating nephron progenitor differentiation through metabolic regulation, and suggest that VHL is required for normal kidney development. (lww.com)
  • Mitochondrial Dynamics and Metabolic Regulation. (nih.gov)
  • These risk-factors have been linked to impairments in skeletal muscle mitochondrial function. (edu.au)
  • Major conclusions: We contend that impaired whole-body insulin resistance along with impaired skeletal muscle handling of carbohydrate and lipid fuels (i.e., metabolic inflexibility) is associated with a reduced skeletal muscle mitochondrial content which, in large part, is a maladaptive response to an 'inactivity cycle' which predisposes to a reduced level of habitual physical activity. (edu.au)
  • Any process that modulates the frequency, rate or extent of mitochondrial DNA metabolic process. (mcw.edu)
  • The nature and extent of mitochondrial DNA variation in a population and how it affects traits is poorly understood. (ista.ac.at)
  • This tool provides information to help families and practitioners learn more about mitochondrial disease. (chop.edu)
  • Martínez-Reyes, I. & Chandel, N. S. Mitochondrial TCA cycle metabolites control physiology and disease. (nature.com)
  • A new calculator estimates a person's risk for cardiovascular disease (CVD) over the next 30 years by combining measures of cardiovascular, kidney and metabolic health for the first time, according to a new American Heart Association Scientific Statement published today in the Association's flagship journal Circulation. (news-medical.net)
  • Fighting Mitochondrial Disease. (thelilyfoundation.org.uk)
  • Raising awareness about mitochondrial disease, and about The Lily Foundation, is always top of our agenda so we were delighted to accept an invitation to talk about our work at the Annual Cambridge Paediatric Mitochondrial Meeting earlier in November. (thelilyfoundation.org.uk)
  • With Newcastle's last Patient Information Day having taken place back in 2019, it was clear by the attendance this year that mitochondrial disease patients were delighted to have this social engagement back on the calendar. (thelilyfoundation.org.uk)
  • A huge thank you to everyone who got involved in events before and during World Mitochondrial Disease Week earlier this month. (thelilyfoundation.org.uk)
  • Last week, BBC Points West ran a story about team member Sarah, who came across The Lily Foundation back in 2018 after losing her two daughters to mitochondrial disease. (thelilyfoundation.org.uk)
  • Every summer the organisers of the Royal Parks Half Marathon launch their Inspire campaign to seek out five inspirational runners, and this year one of their winners is Lily supporter Reanna, whose daughter Milanna was diagnosed with mitochondrial disease at the age of 7 months. (thelilyfoundation.org.uk)
  • While genetic components play a role in the pathogenesis of metabolic disease, exercise is a powerful environmental stimulus capable of restoring the metabolic flexibility of fuel selection and reduces risk-factors for metabolic disease in genetically-susceptible individuals. (edu.au)
  • General significance: Given the apathy towards voluntary physical activity in most Western societies, it is clear that there is an urgent need for innovative, clinically-effective exercise strategies, coupled with changes in current attitudes and methods of delivering exercise prescription and dietary advice, in order to improve metabolic health and reduce metabolic disease risk at the population level. (edu.au)
  • The symptoms of mitochondrial disease can vary. (medlineplus.gov)
  • What Is Mitochondrial Disease? (medlineplus.gov)
  • The diagnosis and management of the acutely ill child with suspected metabolic disease can present a formidable challenge to even the most astute clinician. (springer.com)
  • Metabolic disease may present in a fulminate fashion to the pediatric intensivist with profound biochemical disturbances, encephalopathy and even cardiac failure. (springer.com)
  • This chapter serves as a guide to the recognition of metabolic disease based on presenting signs, symptoms and screening laboratory tests. (springer.com)
  • The rapid implementation of therapy for children with suspected or known metabolic disease will also be reviewed. (springer.com)
  • We are actively understanding the biology of GDF15 as it has become an important therapeutic target for metabolic disease and cancer cachexia with clinical trials ongoing. (upenn.edu)
  • 2. Single cell multiomics to understand metabolic and cardiac biology and disease. (upenn.edu)
  • Funded with several NIH and DOD grants, we are currently applying single-cell multiomics to understand metabolic and cardiac biology and disease. (upenn.edu)
  • d) Single-cell multiomics to understand cell-type specific metabolic changes in heart disease. (upenn.edu)
  • Cardiomyopathy due to mitochondrial disease may produce typical cardioembolic strokes in some patients. (medscape.com)
  • Some mitochondrial mutations may give rise to "overlap" syndromes, which present with clinical features of more than one disease entity. (medscape.com)
  • Using tandem mass spectrometry for metabolic disease screening among newborns: a report of a work group. (cdc.gov)
  • In addition to identifying VHL as a critical regulator of nephron progenitors' metabolic switching, the authors' findings demonstrate that this switch also plays a large role in the differentiation process, and suggest that VHL is required for normal kidney development. (lww.com)
  • These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis. (johnshopkins.edu)
  • Recent studies have identified the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1 (PGC-1) as a regulator of mitochondrial function in tissues specialized for thermogenesis, such as brown adipose. (jci.org)
  • Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
  • When applied to a mouse model of pediatric mitochondrial cardiomyopathy, we uncovered profound cell type-specific modifications of the cardiac transcriptional landscape at single-nucleus resolution, including changes of subtype composition, maturation states, and functional remodeling of each cell type. (upenn.edu)
  • If you have a metabolic disorder , something goes wrong with this process. (medlineplus.gov)
  • Fatty acids, which are often found in chains as CoA-esters, are first transported across the outer mitochondrial membrane by palmitoyl transferase I, resulting in translocation to the intermembrane space and transformation into an acyl-carnitine form. (biomedcentral.com)
  • Sometimes, electrons "leak out" of the pipes & tubes they need to pass through inside the mitochondrial membrane in order to create ATP. (tuitnutrition.com)
  • Here we propose that succinate has evolved as a signaling modality because its concentration reflects the coenzyme Q (CoQ) pool redox state, a central redox couple confined to the mitochondrial inner membrane. (nature.com)
  • Crystal structure of mitochondrial respiratory membrane protein complex II. (nature.com)
  • The importance of cardiolipin in mitochondrial function is evidenced by the X-linked inherited pathology Barth syndrome a result of cardiolipin remodeling deficiency. (barthsyndrome.org)
  • Yet another pattern of regional metabolic abnormality was present in the MELAS syndrome, where proton spectroscopic imaging demonstrated focal localization of abnormally increased lactate/creatine and decreased N -acetylaspartate/creatine to the regions of the stroke-like lesions on conventional MR images. (neurology.org)
  • The syndrome of mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS) has strokelike events that are acute in onset, often transient, and occasionally associated with a febrile illness. (medscape.com)
  • The newly identified mitochondrial protein complex is being referred to as the mitochondrial Target of Thiazolidinediones (TZDs), or mTOT ™ (ADA Abstract #1096-P). (news-medical.net)
  • abstract = "Background: Mitochondrial DNA (mtDNA) copy number and deletion ratio may be asymmetrically determined using physiologic or pathologic conditions. (elsevierpure.com)
  • The prevalence of mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS) is 16-18/100,000, with the highest reported diagnostic rate in Western regions and the lowest rate in Asia. (medscape.com)
  • The landscape around mitochondrial research is changing all the time as new approaches are considered and new projects undertaken, and we spoke with mitochondrial specialist Bert Smeets about how a trial using stem cells to treat muscle damage in mitochondrial myopathy patients could help in mitochondrial care. (thelilyfoundation.org.uk)
  • Accordingly, improving mitochondrial function has become an important strategy to treat the early stages of this continuum. (nih.gov)
  • The metabolic enhancer piracetam has been proposed as possible prototype for those compounds by increasing impaired mitochondrial function and related aspects like mechanisms of neuroplasticity. (nih.gov)
  • Impaired fission and fusion balance can also be induced by a reduction of the mitochondrial permeability transition pore (mPTP) function as atractyloside which indicates the mPTP has similar effects on mitochondrial dynamics. (nih.gov)
  • These findings suggest the mPTP as an important target for the beneficial effects of piracetam on mitochondrial function. (nih.gov)
  • These energy powerhouses play a crucial role in converting nutrients into usable energy, enhancing endurance and metabolic function. (progenmethod.com)
  • A growing body of evidence shows that mitochondrial function and antioxidant defense are also crucial under low nutrient conditions. (nature.com)
  • ELAVL1), enhanced both antioxidant defense and mitochondrial function under nutrient withdrawal. (nature.com)
  • More specifically, we suspected that the products of the oxidative wtIDH1 reaction, NADPH and αKG, directly power antioxidant defense and mitochondrial function to promote PDAC survival. (nature.com)
  • And let's remember: since structure determines function, if mitochondrial structure is compromised, then function will be compromised as well. (tuitnutrition.com)
  • Normothermic Machine Perfusion of the Liver Supports Protein Translation and Mitochondrial Function While Reducing Protein Degradation and Metabolic Imbalance: A Proteomics Study. (ox.ac.uk)
  • This mitochondrial fitness can be divided into function and quality, both of which can be improved through physical exercise and nutrition. (caredir.com)
  • We tested whether resveratrol (RSV), which is known to extend lifespan, impacts mitochondrial function and metabolic homeostasis. (johnshopkins.edu)
  • Objectives: The purpose of this study is the development of a porcine model of carbon monoxide (CO) poisoning to investigate alterations in brain and heart mitochondrial function. (lu.se)
  • Conclusions: Low-dose CO poisoning is associated with early mitochondrial disruption prior to an observable phenotype highlighting the important role of mitochondrial function in the pathology of CO poisoning. (lu.se)
  • MiRNA-378a knockout animals provide a protective effect against nano-TiO2 inhalation exposure by altering mitochondrial structure and function. (cdc.gov)
  • Carnitine deficiency is a metabolic state in which carnitine concentrations in plasma and tissues are less than the levels required for normal function of the organism. (medscape.com)
  • Fig. 1: Mitochondrial bioenergetics and the coenzyme Q (CoQ) pool. (nature.com)
  • Muscle glycogenosis and mitochondrial hepatopathy in an infant with mutations in both the myophosphorylase and deoxyguanosine kinase genes. (springer.com)
  • Finally, we suggested that C1QBP is correlated with genes encoding ribosome RPL-related proteins and mitochondrial MRPL-related proteins in HCC patients. (jcancer.org)
  • MTT analysis, PI/Annexin V staining, transwell and metabolic flux assays were performed to examine the effects of C1QBP on proliferation, apoptosis, migration, invasion, and oxidative phosphorylation of HCC cells. (jcancer.org)
  • Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. (johnshopkins.edu)
  • Based on our previous studies revealing IDH1 as a regulatory target of HuR, and the enzyme's direct role in the generation of NADPH and αKG through the oxidation of isocitrate, we hypothesized that wtIDH1 is essential for PDAC cells under metabolic stress. (nature.com)
  • OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy. (nih.gov)
  • Usually, high ambient temperature leads to stress associated problems such as production losses, metabolic changes, growth depression, and poor efficiency ( 6 , 7 ). (frontiersin.org)
  • Lowering the mitochondrial magnesium mitigated the adverse effects of prolonged dietary stress," said co-lead author Manigandan Venkatesan, PhD, postdoctoral fellow in the Muniswamy lab. (sciencedaily.com)
  • This article explores the concept of Mitochondrial Activation Training (MAT) - a tailored exercise regimen designed to enhance metabolic fitness and combat insulin resistance. (progenmethod.com)
  • These effects go parallel with improvement of impaired mitochondrial dynamics shifting back fission and fusion balance to the energetically more favorable fusion site. (nih.gov)
  • MAT promotes a redistribution of intramyocellular triglycerides, positioning them in closer proximity to mitochondrial membranes. (progenmethod.com)
  • Tumor cells can bypass metabolic constraints by acquiring genetic mutations, such as tumor suppressors and oncogenes. (caredir.com)
  • Daily consumption of sea buckthorn berries, its extracts, or bilberries may boost the overall metabolic profiles of overweight women, says a new study from Finland. (nutraingredients.com)
  • Using a nuclear magnetic resonance (NMR) metabolomics, researchers from the University of Turku, the University of Oulu, and Aromtech evaluated the effects of sea buckthorn, select fractions, and bilberry on the overall metabolic profile of overweight women, which has not been investigated by any other group. (nutraingredients.com)
  • The metabolomics results showed that all the interventions produced a "significant effect on the overall metabolic profiles" ​, said the researchers. (nutraingredients.com)
  • In pancreatic cancer cells a cytosolic metabolic enzyme, wild-type isocitrate dehydrogenase 1 (wtIDH1), enables adaptation to these conditions. (nature.com)
  • Is metabolic and bariatric surgery a safe and effective therapeutic option for adolescents with severe obesity? (medscape.com)
  • We used histologic, immunofluorescence, RNA sequencing, and metabolic assays to characterize kidneys from these mice and controls during development and up to postnatal day 21. (lww.com)
  • Here we resequence the mitochondrial genomes of 169 Drosophila Genetic Reference Panel lines, identifying 231 variants that stratify along 12 mitochondrial haplotypes. (ista.ac.at)
  • As electrons are shuttled through the complexes I, III and IV by electron carriers, protons (H + ) are moved from the mitochondrial matrix into the intermembrane space. (biomedcentral.com)
  • This connection is of general importance because CoQ redox state integrates three bioenergetic parameters: mitochondrial electron supply, oxygen tension and ATP demand. (nature.com)
  • Hou G, Lu Z, Wang Z, Yang X. The Mitochondrial Protein C1QBP Promotes Hepatocellular Carcinoma Progression by Enhancing Cell Survival, Migration and Invasion. (jcancer.org)
  • Researchers at Metabolic Solutions Development Company, LLC (MSDC) have identified a mitochondrial protein complex through which anti-diabetic drugs exert their insulin sensitizing effects when used to treat patients diagnosed with type 2 diabetes . (news-medical.net)
  • A review in Advanced Science explores the interaction between the immune system and the sympathetic nervous system in regulating vital metabolic organs like the pancreas, liver, and adipose tissues. (news-medical.net)
  • This improved microcirculation enhances the delivery of oxygen and nutrients to muscle cells, supporting energy production and metabolic efficiency. (progenmethod.com)
  • Study explored the association between dietary insulin index (DII) and dietary insulin load (DIL) with metabolic healthy (MH) status and the serum levels of brain-derived neurotrophic factor (BDNF) and adropin among the Iranian adult population. (news-medical.net)
  • On 18 October 2006, the first parents meeting took place at the Metabolic Centre of the Paediatric Hospital of Salzburg. (mito-center.org)
  • Welcome to the next installment in my ongoing series exploring the metabolic theory of cancer . (tuitnutrition.com)
  • "In whole sea buckthorn berries, potentially all compounds in the soft parts of the berry, including flavonols, carotenoids, fatty acids, tocopherols, tocotrienos, and phytosterols of the pulp oil, were expected to affect the metabolic profile," ​ explained the researchers. (nutraingredients.com)
  • This article is part of a Special Issue entitled Frontiers of Mitochondrial Research. (edu.au)
  • Serial studies emphasized that the regional metabolic abnormalities in MELAS are highly variable as the stroke-like lesions appear and evolve. (neurology.org)
  • Patients with D-2/L-2-hydroxyglutaric aciduria display neonatal onset metabolic encephalopathy, infantile epilepsy, global developmental delay, muscular hypotonia and early death. (wikipedia.org)
  • To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)