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  • enzyme
  • Carnitine palmitoyltransferase I (CPT1) also known as carnitine acyltransferase I, CPTI, CAT1, CoA:carnitine acyl transferase (CCAT), or palmitoylCoA transferase I, is a mitochondrial enzyme responsible for the formation of acyl carnitines by catalyzing the transfer of the acyl group of a long-chain fatty acyl-CoA from coenzyme A to l-carnitine. (wikipedia.org)
  • His lab was the first to clone the cDNAs and the gene coding for adrenodoxin reductase - the first enzyme in the electron transfer chain of the mitochondrial P450 system. (wikipedia.org)
  • The ATP-dependent cytosolic enzymes hexokinase, glucokinase, and glycerol kinase, as well as the mitochondrial enzyme creatine kinase, have all been found to bind to VDAC. (wikipedia.org)
  • enzymes
  • Mutations in ATP10 induce a loss of rutamycin sensitivity in the mitochondrial ATPase, but do not affect the respiratory enzymes. (wikipedia.org)
  • During his Ph.D. thesis research, Israel isolated the mitochondrial enzymes that catalyze the first step in the synthesis of steroid hormones in all steroidogenic tissues, including the adrenal cortex, and the reproductive organs. (wikipedia.org)
  • localization
  • Although PINK1 has a predicted mitochondrial import sequence, its cellular and submitochondrial localization remains unclear in part because it is rapidly degraded. (rupress.org)
  • assays
  • Here, we demonstrate manufacturable wafer-scale mitochondrial functional assay lab-on-a-chip devices, which require mitochondrial protein quantities three orders of magnitude less than current assays, integrated onto 4′′ standard silicon wafer with new fabrication processes and materials. (rsc.org)
  • cristae
  • Cristae significantly increase the total membrane surface area compared to a smooth inner membrane and thereby the available working space. (wikipedia.org)
  • Cristae membranes are studded on the matrix side with small round protein complexes known as F1 particles, the site of proton-gradient driven ATP synthesis. (wikipedia.org)
  • Cristae and the inner boundary membranes are separated by junctions. (wikipedia.org)
  • The end of cristae are partially closed by transmembrane protein complexes that bind head to head and link opposing crista membranes in a bottleneck-like fashion. (wikipedia.org)
  • Crista junction model - Daems and Wisse proposed that cristae are connected to the inner boundary membrane via tubular structures characterized by rather small diameters, termed crista junctions (CJs). (wikipedia.org)
  • The cristae greatly increase the surface area of the inner membrane on which the above-mentioned reactions may take place. (wikipedia.org)
  • sequence
  • However, PINK1 has an apparent N-terminal mitochondrial import sequence predicted to mediate import through the TIM23 complex either to the matrix or spanning the inner membrane. (rupress.org)
  • The ∼60-kD band would be consistent with the molecular mass of PINK1 with a mitochondrial targeting sequence (MTS) deleted (ΔMTS) after mitochondrial processing protease (MPP) cleavage ( Fig. 1 a ). (rupress.org)
  • Parkinson's
  • PINK1 is a mitochondrial kinase mutated in some familial cases of Parkinson's disease. (rupress.org)
  • These results suggest that PINK1 and Parkin may normally participate in a mitochondrial quality control pathway that is defective in certain familial forms of Parkinson's disease. (rupress.org)
  • metabolic
  • It has been reported that mitochondrial metabolic and biophysical parameters are associated with degenerative diseases and the aging process. (rsc.org)
  • matrix
  • Septa model - Sjöstrand suggested that sheets of inner membrane are spanned like septa (plural of septum) through the matrix, separating it into several distinct compartments. (wikipedia.org)
  • adenine nucleotide t
  • The antiapoptotic function of TXN2 is attributed to its involvement in GSH-dependent mechanisms to scavenge ROS, or its interaction with, and thus regulation of, thiols in the mitochondrial permeability transition pore component adenine nucleotide translocator (ANT). (wikipedia.org)
  • neurons
  • We found that rotenone, staurosporine, 6-hydroxydopamine and other pro-mitophagy stimuli caused externalization of cardiolipin to the mitochondrial surface in primary cortical neurons and SH-SY5Y cells. (cdc.gov)