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  • permeability tran
  • this dampens electron transfer and effectively reduces reperfusion reactive oxygen species generation and ameliorates oxidative inactivation of complexes II-IV and aconitase, thus preventing mitochondrial permeability transition pore opening and cytochrome c release. (nih.gov)
  • Excessive generation of reactive oxygen species (ROS) in mitochondria and the opening of the nonselective mitochondrial permeability transition pore are important factors that promote cardiac pathologies and dysfunction. (nih.gov)
  • inner membrane insertion
  • The positive charges are not required for interaction with the Tim9p-Tim10p complex, but are essential for cross-linking of Tim23p to components of the inner membrane insertion machinery, including Tim54p, Tim22p, and Tim12p. (nih.gov)
  • Tim21 is specific for a TIM23 form that cooperates with TOM and promotes inner membrane insertion. (edu.au)
  • Tim17 is crucial for the switch by performing two separable functions: promotion of inner membrane insertion and binding of Pam18 to form the functional TIM-PAM complex. (edu.au)
  • oxidative
  • Although the mechanism of nitrite-mediated cytoprotection is unknown, NO is a mediator of the ischemic preconditioning cell-survival program.This cytoprotection is associated with increases in mitochondrial oxidative phosphorylation.These data suggest that nitrite dynamically modulates mitochondrial resilience to reperfusion injury and may represent an effector of the cell-survival program of ischemic preconditioning and the Mediterranean diet. (nih.gov)
  • This cytoprotection is associated with increases in mitochondrial oxidative phosphorylation. (nih.gov)
  • Import and oxidative folding of proteins are kinetically and functionally coupled and depend on the expression of Mia40, ALR, and the intracellular glutathione pool. (nih.gov)
  • mammalian
  • AtTIM17 differed from the yeast (Saccharomyces cerevisiae) and mammalian homologs in that two genes encoded proteins that were longer and one gene encoded a shorter protein. (edu.au)
  • Background: CRISPR-Cas (clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins) are RNA-guided nuclease effectors that are utilized for precise genome editing in mammalian systems (1). (cellsignal.com)
  • pathway
  • These proteins participate in the apoptotic pathway, and the interaction between them may serve as a target for anticancer lead compounds. (nih.gov)
  • Liver
  • Lactate is transported back to the liver where it is converted into pyruvate by the Cori cycle using the enzyme lactate dehydrogenase. (wikibooks.org)
  • humans
  • Vesicular glutamate transporter 1 ( VGLUT1 ) is a protein that in humans is encoded by the SLC17A7 gene . (thefullwiki.org)
  • In humans, this family comprises four proteins, TIF1α/TRIM24, TIF1β/TRIM28/KAP1, TIF1γ/TRIM33/Ectodermin, and TIF1δ/TRIM66, which are characterized by an amino-terminal tripartite motif (TRIM) domain consisting of a RING domain, two B boxes, a coiled-coil domain, and a carboxy-terminal PHD finger and bromodomain (1). (cellsignal.com)
  • Binding
  • Background: The transcriptional intermediary factor 1 (TIF1) family represents a group of proteins with multiple histone-binding domains. (cellsignal.com)
  • The two specific binding sites between the proteins were determined to be tBID residues 59-73 that bind MTCH2 residues 140-161, and tBID residues 111-125 that bind MTCH2 residues 240-290. (nih.gov)
  • B and C , shown are representative binding curves for the interaction between the tBID protein and the peptides derived from MTCH2: MTCH2 240-290 ( B ) MTCH2 140-161 ( C ). Binding was quantified using fluorescence anisotropy and measured at various ionic strengths. (nih.gov)
  • C , MTCH2 binding sites, as discovered in the peptide array screening, are colored on the three-dimensional structure of BID (Protein Data Bank ID code 2BID). (nih.gov)
  • catalyzes
  • Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17 or MICU1 (PubMed:16185709, PubMed:26387864, PubMed:19182799, PubMed:21059946, PubMed:23186364). (nih.gov)
  • UCP1 catalyzes a highly regulated proton leak, converting energy stored within the mitochondrial proton electrochemical potential gradient to heat. (diabetesjournals.org)
  • identity
  • The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. (thefullwiki.org)
  • form
  • The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (PubMed:16185709, PubMed:19182799, PubMed:21059946). (nih.gov)
  • potential
  • In aggregate these data suggest that the Mia40/lfALR system has a broad sequence specificity and that potential substrates may be protected from adventitious oxidation by kinetic sequestration within the mitochondrial IMS. (nih.gov)
  • lack
  • Therefore species that lack intra-mitochondrial PEP, oxaloacetate must be converted into malate or asparate, exported from the mitochondrion, and converted back into oxaloacetate in order to allow gluconeogenesis to continue. (wikibooks.org)
  • novel
  • 2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). (thefullwiki.org)
  • formation
  • Mediates formation of disulfide bond in MICU1 in the IMS, promoting formation of the MICU1-MICU2 heterodimer that regulates mitochondrial calcium uptake (PubMed:26387864). (nih.gov)
  • Ooplasmic, autophagophore-associated GABARAP protein is also involved in zygotic autophagosome formation, although it may not be essential. (kclifesciences.org)
  • Furthermore, TIF1β promotes heterochromatin-mediated gene silencing formation by serving as a cofactor for heterochromatin protein HP1 (5). (cellsignal.com)