Mitochondrial matrix proteins iron sulfur proteins. Medical search. Frequent questions

Mitochondrial complex activity assays, blue native gel electrophoresis (BN-PAGE), Complex III immunoprecipitation, and an ATP assay were performed to examine the effects of diabetes on the status of respiratory complexes and energy levels in renal mitochondria. (biomedcentral.com)
Interestingly, of all four respiratory complexes only cytochrome c reductase (Complex-III) activity was significantly decreased, whereas two Complex III subunits, Core 2 protein and Rieske protein, were up regulated in the diabetic renal mitochondria. (biomedcentral.com)
Presequences play an important role in protein import into mitochondria-like organelles. (plasignaling.com)
It contains the targeting signals and directs the import of most matrix proteins, many inner membrane proteins and some intermembrane space proteins into mitochondria-like organelles (Chacinska et al. (plasignaling.com)
To contribute to the knowledge of mitochondrial biogenesis and function, we focused on studies of two key mitochondrial processes, the processing of preproteins that are imported to the mitochondria, and mechanism of pyruvate transport to these organelles. (nusl.cz)
This metal is essential for function of numerous proteins, particularly for iron-sulfur proteins in mitochondria. (nusl.cz)
Multiply 66% times 2 million mitochondria per neuron, and you realize we're talking about a massive loss of mitochondrial energy. (grasslandbeef.com)
Much iron is trafficked into mitochondria where it is used for iron-sulfur cluster assembly and heme biosynthesis. (biomedcentral.com)
At the next level of complexity, the cell was divided into three regions, including cytosol, mitochondria, and vacuoles, each of which was presumed to contain a single form of iron. (biomedcentral.com)
Mitochondrial energetic adaptations encompass a plethora of conserved processes that maintain cell and organismal fitness and survival in the changing environment by adjusting the respiratory capacity of mitochondria. (nature.com)
Mitochondria are semi-autonomous intracellular double membrane-bound organelles, which include an outer membrane, a highly folded inner membrane (crista), a matrix space surrounded by the inner membrane, and an inter-membrane space between the inner and outer membranes. (encyclopedia.pub)
The primary function of mitochondria is to support the TCA cycle and aerobic respiration by oxidative phosphorylation, generating ATP through the mitochondrial respiratory chain to fulfill the energy needs for cell survival. (encyclopedia.pub)
One unique feature of mitochondria is that they possess their own supercoiled, double-stranded circular genetic material called mitochondrial DNA (mtDNA) that encodes rRNAs, tRNAs, and proteins essential for electron transport and oxidative phosphorylation, as well as their own genetic repair mechanisms. (encyclopedia.pub)
Thirteen proteins are encoded by mtDNA, while approximately 1000 mitochondrial proteins are encoded by the nuclear genome, translated in the cytoplasm and transported into the mitochondria by a specific transport system. (encyclopedia.pub)
These two pools of proteins are required to maintain mitochondria as a cellular power hub and a signaling nexus that are essential for normal cell function. (encyclopedia.pub)
After Glycolysis the pyruvate enters mitochondria and the acetyl-CoA formation reaction occurs in the matrix of mitochondria. (lambdageeks.com)
It has been shown that, in mammalian mitochondria, almost all of complex I is assembled into a supercomplex and directly interacts with complex III, and that impairment of complex III assembly results in a severe reduction in the amount of complex I (Acin-Perez et … We attribute the complex I autophagy defect to the inability to increase MAMs, limiting phosphatidylserine decarboxylase (PISD) activity and mitochondrial phosphatidylethanolamine (mtPE), which support autophagy. (gowebamerica.com)
The protein is synthesized as a 67-kDa precursor which is targeted to mitochondria and processed in a single step to a 64-kDa mature form located in the mitochondrial membrane. (thermofisher.com)

The electron carriers then enter the electron transport chain, located in the inner mitochondrial membrane, where oxidative phosphorylation takes place. (microbiologynote.com)

Iron is an essential part of prosthetic groups such as heme and iron-sulphur clusters, which are involved in various redox reactions of central importance for life. (lu.se)
Two tightly regulated biochemical processes, metallation of porphyrin at the last stage of heme biosynthesis and the generation of iron-sulphur clusters (ISC), take place inside the mitochondrial matrix and utilise around 80% of the iron acquired by organisms. (lu.se)
Ferrochelatase catalyses iron insertion into protoporphyrin IX at the terminal step of heme biosynthesis, while IscU assists in the formation of iron-sulphur clusters. (lu.se)
It is an important element in the synthesis of iron-sulfur clusters which function as cofactors during the above-mentioned reactions. (nusl.cz)
It is present in many forms including heme centers, iron-sulfur clusters (ISCs), nonheme mononuclear species, and iron-oxo dimeric centers. (biomedcentral.com)
1], The proposed pathway for electron transport prior to ubiquinone reduction is as follows: NADH - FMN - N3 - N1b - N4 - N5 - N6a - N6b - N2 - Q, where Nx is a labelling convention for iron sulfur clusters. (gowebamerica.com)
10] The high reduction potential of the N2 cluster and the relative proximity of the other clusters in the chain enable efficient electron transfer over long distance in the protein (with transfer rates from NADH to N2 iron-sulfur cluster of about 100 μs). (gowebamerica.com)
A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III. (nih.gov)

It may play roles in cyanide detoxification, the formation of iron-sulfur proteins, and the modification of sulfur-containing enzymes. (wikipedia.org)
Key role in aerobic respiration, in which mitochondrial enzymes accept electrons from electron carriers reduced in glycolysis and the tricarboxylic acid cycle. (yeastgenome.org)
Enzymes and other proteins use ATP to power reactions, maintain ion gradients across membranes, contract muscle fibers, and transport molecules across cellular membranes. (microbiologynote.com)
Reduced coenzyme Q passes the electrons to cytochrome b and releases 2H+ into the mitochondrial matrix The oxidation of ubiquinol involves the successive action of 2 enzymes: a) - Ubiquinol (coenzyme Q) dehydrogenase which transfers electrons to cytochrome c. (drugstorepdfsearch.com)
The enzymes of the electron transport chain are organized in the inner mitochondrial membrane in the form of four enzyme complexes. (drugstorepdfsearch.com)
High levels of intracellular calcium ion activate proteolytic enzymes (known as calpains) that break down many cell proteins, particularly those in the cytoskeleton of neurons (spectrin, neurofilament and microtubule-associated protein). (benbest.com)
Overall, mitochondrial dysfunction caused by mtDNA mutations, malfunctioned TCA cycle enzymes, electron respiratory chain leakage and subsequent oxidative stress, and/or aberrant oncogenic and tumor suppressor signaling is known to alter cellular metabolic pathways, disrupt redox balance, and cause resistance to apoptosis and therapies that significantly contribute to the development of multiple types of human cancers. (encyclopedia.pub)
At least two cytosolic enzymes, glutathione reductase (GR) and thioredoxin reductase (Trx1), and two mitochondrial enzymes, lipoamide dehydrogenase and thioredoxin reductase (Trx2), reduce LA. SLA is stereoselectively reduced by cytosolic GR whereas Trx1, Trx2 and lipoamide dehydrogenase stereoselectively reduce RLA. (curecrowd.com)

The cytosolic and mitochondrial redox state is maintained in a reduced state relative to the extracellular matrix and plasma due to high concentrations of glutathione. (curecrowd.com)

These results represent the first genome-wide transcriptional profiling analysis of age-associated dynamics following influenza vaccination, and implicate changes in mitochondrial biogenesis and function as a critical factor in human vaccine responsiveness. (gsea-msigdb.org)

The nucleus stores chromatin (DNA plus proteins) in a gel-like substance called the nucleoplasm.The nucleolus is a condensed region of chromatin where ribosome synthesis occurs.The boundary of the nucleus is called the nuclear envelope.It consists of two phospholipid bilayers: an outer membrane and an inner membrane.The nuclear membrane is continuous with the endoplasmic reticulum.Nuclear pores allow substances to enter and exit the nucleus. (coursehero.com)
The endoplasmic reticulum modifies proteins and synthesizes lipids, while the golgi apparatus is where the sorting, tagging, packaging, and distribution of lipids and proteins takes place. (coursehero.com)
Well, suddenly you've got lysosomes being the recycling center and the endoplasmic reticulum being where the proteins are going to get made. (grasslandbeef.com)

This is achieved by oxidizing ubiquinol (ubihydroquinone) which reacts from the membrane phase, reducing cytochrome c in the intermembrane space, and using the free energy change to transport H+ ions across the membrane from the matrix to the inter membrane space. (yeastgenome.org)
According to some reports, mitochondrion of trypanosomes represent an ancient form of this organelle, which is supported by identification of putative "archaic" translocase of the outer mitochondrial membrane (ATOM) and finding of only a single type of translocation pore in. (nusl.cz)
The electron carriers are found within four membrane-bound enzyme-complexes, which are imbedded in the inner mitochondrial membrane. (drugstorepdfsearch.com)
It is a small molecule, which is soluble in lipid, so it is freely mobile in the inner mitochondrial membrane colleting reducing equivalents from the more fixed component of the respiratory chain. (drugstorepdfsearch.com)
Cytochrome c is a water soluble, peripheral membrane protein. (drugstorepdfsearch.com)
Countering NADH production, calcium action on the mitochondrial permeability transition pores increases inner membrane permeability thereby reducing proton potential, causing the matrix to swell and ultimately releasing cytochrome c (an initiator of apoptosis). (benbest.com)
α-helix Notice that one of the peptides of each subunit invades the space of the other monomeric unit, and labels show the orientation of the complex within the inner mitochondrial membrane. (slimwithlynne.com)
The cytochrome bc 1 complex (also known as ubiquinol-cytochrome c oxidoreductase or complex III) is a multi-subunit dimeric integral membrane protein complex. (slimwithlynne.com)
Aminoacid degradation and urea cycle The cytochrome bc1complex (ubiquinone:cytochrome coxidoreductase) is the central integral membrane protein in the mitochondrial respiratory chain as well as the electron-transfer chains of many respiratory and photosynthetic prokaryotes. (slimwithlynne.com)
A yeast strain in which Mrs3/4, the high-affinity iron importers on the mitochondrial inner membrane, are deleted exhibits a slow-growth phenotype when grown under iron-deficient conditions. (biomedcentral.com)
1. The electron transport chain is a series of electron carriers in the inner mitochondrial membrane of eukaryotic cells, through which the electrons obtained from the glycolysis and Krebs cycle are released. (sciencequery.com)
These changes can promote mitochondrial biogenesis and membrane dynamics that in turn support mitochondrial respiration. (nature.com)
Fig. 4: Post-translational mechanisms governing respiratory control and the role of mitochondrial membrane dynamics. (nature.com)
It is also very significant because due to this process the pyruvate cross the plamsa membrane and travels into the mitochondrial matrix from the cytoplasm of cell. (lambdageeks.com)
Additionally, thelysosome-damaging ability of arsenite has been demonstrated [ 13 ] and it is also known that excessive mitochondrial ROS production requires more iron to cross the mitochondrial membrane. (biomedcentral.com)
Complex I is the first enzyme in the respiratory chain, a series of protein complexes in the inner mitochondrial membrane. (gowebamerica.com)
Complex I is an L-shaped integral membrane protein. (gowebamerica.com)
Electron-transferring-flavoprotein dehydrogenase in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. (thermofisher.com)

Subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH1 and SDH2 form the catalytic dimer. (ymdb.ca)
Cloning and characterization of the iron-sulfur subunit gene of succinate dehydrogenase from Saccharomyces cerevisiae. (ymdb.ca)

Its reduced form (NADH+H+) passes its hydrogen to flavoprotein containing FMN and iron sulfur protein (FeS). (drugstorepdfsearch.com)

We also identified a mitochondrial signature in young vaccine responders containing genes mediating mitochondrial biogenesis and oxidative phosphorylation that was consistent in two different vaccine seasons and verified by analyses of mitochondrial content and protein expression. (gsea-msigdb.org)
Mitochondrial biogenesis requires the coordinated expression of both mtDNA- and nuclear DNA-encoded genes. (encyclopedia.pub)
Inactivity and hypoxia resulted in a significant increase in the genus Bacteroides in HBR, in genes coding for proteins involved in iron acquisition and metabolism, cell wall, capsule, virulence, defense and mucin degradation, such as beta-galactosidase (EC3.2.1.23), α-L-fucosidase (EC3.2.1.51), Sialidase (EC3.2.1.18), and α-N-acetylglucosaminidase (EC3.2.1.50). (frontiersin.org)
The fact that the genus Bacteroides and proteins involved in iron acquisition and metabolism, cell wall, capsule, virulence and mucin degradation were enriched at the end of HBR suggest that both constipation and EC decreased intestinal metal availability leading to modified expression of co-regulated genes in Bacteroides genomes. (frontiersin.org)

Our results show that Nse1 impacts the ubiquitination of several proteins involved in ribosome biogenesis and metabolism that, importantly, extend beyond canonical functions of Smc5/6. (bvsalud.org)
The understanding of iron metabolism in the cell can facilitate the development of new medicaments, an example being iron chelators. (nusl.cz)
If you don't have copper in your diet, hemoglobin production becomes impaired, along with many other aspects of iron metabolism. (grasslandbeef.com)
Iron plays crucial roles in the metabolism of eukaryotic cells. (biomedcentral.com)
The developed model highlights the importance of an Fe II mitochondrial pool and the necessary exclusion of O 2 in the mitochondrial matrix for eukaryotic iron-sulfur cluster metabolism. (biomedcentral.com)
This review described the factors that affect growth properties and metabolism at elevated oxygen concentrations that cells may be exposed to, in bioreactor sparged with oxygen enriched air which could affect the yield and quality of the recombinant proteins produced by high cell density schemes. (biomedcentral.com)
The purpose of this review is to summarize the known information on the physiological response of organisms exposed to high molecular oxygen concentrations, especially the effect on growth, metabolism, enzyme activity, protein oxidation, and gene expression. (biomedcentral.com)
Sirtuin-3 (SIRT3) performs a vital role in regulating metabolism, mitochondrial function, and oxidative stress. (mdpi.com)

E.A. Orabi and A.M. English ( 2018 ) Modeling protein S-aromatic motifs reveals their structural and redox flexibility, J. Phys Chem. (concordia.ca)
All cytochrome bc1 complexes contain three electron transfer proteins which contain four redox prosthetic groups. (slimwithlynne.com)

Frataxin (FXN) is an essential protein that forms part of a supercomplex dedicated to the iron-sulfur (Fe-S) cluster assembly within the mitochondrial matrix. (curefa.org)

ROS may induce intracellular calcium increase and subsequent contraction of PASMCs via direct or indirect interactions with protein kinases, phospholipases, sarcoplasmic calcium channels, transient receptor potential channels, voltage-dependent potassium channels and L-type calcium channels, whose relevance may vary under different experimental conditions. (ersjournals.com)
Although the intracellular environment is strongly reducing, both free LA and its reduced form, dihydrolipoic acid (DHLA), have been detected in cells after administration of LA. Most endogenously produced RLA is not "free" because octanoic acid, the precursor to RLA, is bound to the enzyme complexes prior to enzymatic insertion of the sulfur atoms. (curecrowd.com)
Cuproptosis is a newly discovered type of cell death in tumor, which is characterized by accumulation of intracellular copper leading to the aggregation of mitochondrial lipoproteins and destabilization of proteins. (biomedcentral.com)

Thus, mitochondrial adaptive cellular processes are important for physiological responses, including to nutrient availability, temperature and physical activity, and their failure leads to diseases associated with mitochondrial dysfunction such as metabolic and age-associated diseases and cancer. (nature.com)
A better understanding of the roles of mitochondrial dysfunction in cancer is essential for the future design of effective therapeutic strategies against diverse types of cancers. (encyclopedia.pub)
Significance of Mitochondrial-Dysfunction in Cancer" Encyclopedia , https://encyclopedia.pub/entry/1619 (accessed December 08, 2023). (encyclopedia.pub)
In the following sections, we will present current knowledge on these aspects of mitochondrial dysfunction pertaining to the pathologies of various forms of human malignancies. (encyclopedia.pub)
Studies indicate that hypertensive patients have reduced SIRT3 expression, leading to an upsurge in reactive oxygen species (ROS) levels and mitochondrial dysfunction. (mdpi.com)

Complex III is a multisubunit transmembrane protein encoded by both the mitochondrial (cytochrome b) and the nuclear genomes (all other subunits). (slimwithlynne.com)
transmembrane protein 243 [Source:HG. (gsea-msigdb.org)
These mitochondrial responses are governed by general principles of regulatory biology exemplified by changes in gene expression, protein translation, protein complex formation, transmembrane transport, enzymatic activities and metabolite levels. (nature.com)
RANK binds to transmembrane protein nuclear factor-κB receptor activating factor ligand (RANKL) to activate RANK/RANKL, TRAF6/RANKL/MAPKs, TRAF6/ RANKL/NF-κB, Wnt/RANKL/RANKL, and JAK2/STAT3/RANKL. (frontiersin.org)

Complex III possesses a Fe-S protein like complex I. Mitochondrial cytochrome bc1 complex performs two functions: It is a respiratory multienzyme complex and it recognizes a mitochondrial targeting presequence. (slimwithlynne.com)

Therefore, the nucleus houses the cell's DNA and directs the synthesis of proteins and ribosomes, the cellular organelles responsible for protein synthesis. (coursehero.com)
D. Martins and A.M. English ( 2015 ) Peroxynitrite and hydrogen peroxide elicit a similar cellular stress response mediated by the Ccp1 sensor protein, Free Rad. (concordia.ca)
Defects in many of the mitochondrial components are causal for a multitude of cellular diseases. (encyclopedia.pub)
In cellular respiration process basically the nutrient or food molecule like carbohydrate, proteins participates in respiration process to produce energy. (lambdageeks.com)
An unusual cellular factor potentiates protein-DNA complex assembly between Oct-1 and Vmw65. (mcmaster.ca)
Proteins that regulate cellular and organismal iron homeostasis. (bvsalud.org)

Inactivation of mitochondrial respiratory complexes or alteration of their critical subunits can lead to generation of mitochondrial oxidants, mitochondrial damage, and organ injury. (biomedcentral.com)
Thus, one goal of this study was to determine the status of mitochondrial respiratory complexes in the rat kidney during the early stages of diabetes (5-weeks post streptozotocin injection). (biomedcentral.com)
However, the effect that short-term hyperglycemia has on renal mitochondrial complexes has not been examined in detail, and may lead to a more precise understanding of the initiating events involved with mitochondrial oxidant production during diabetes. (biomedcentral.com)
In this study, we have examined the status of renal mitochondrial complexes during the early stages (5-weeks) of experimental Type-1 diabetes using the streptozotocin-induced diabetes rat model. (biomedcentral.com)
The sulfur and iron are thought to take part in the oxidation-reduction mechanism between flavoproteins and coenzyme Q as the iron atom in these complexes oscillates between oxidation and reduction that allows them to either give up or accept electrons. (drugstorepdfsearch.com)
The carbon atom at C6 is chiral and the molecule exists as two enantiomers ( R )-(+)-lipoic acid (RLA) and ( S )-(-)-lipoic acid (SLA) and as a racemic mixture ( R / S )-lipoic acid (R/S-LA). Only the ( R )-(+)-enantiomer exists in nature and is an essential cofactor of four mitochondrial enzyme complexes. (curecrowd.com)

The product of this gene is a mitochondrial matrix enzyme that is encoded by the nucleus. (wikipedia.org)

This diagram displays the protein subunits (blue) of the complex and how they interact with each other. (yeastgenome.org)
Its reaction mechanism is initiated by the binding of a quinol molecule to an active site, followed by a series of charge transfer reactions between the quinol and protein subunits. (slimwithlynne.com)
The bc1 complex contains 11 subunits, 3 respiratory subunits (cytochrome B, cytochrome C1, Rieske protein), 2 core proteins and 6 low-molecular weight proteins. (slimwithlynne.com)
Point mutations in various complex I subunits derived from mitochondrial DNA (mtDNA) can also result in Leber's Hereditary Optic Neuropathy. (gowebamerica.com)

Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis. (nih.gov)
They play an important biological role by maintaining iron levels that are adequate for metabolic need, but below the toxicity threshold. (bvsalud.org)

Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species. (ymdb.ca)
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. (nature.com)

Fe 2+ may also be toxic to organisms, since it can promote the generation of highly reactive oxygen species that are capable of causing severe damage to proteins and nucleic acids. (lu.se)

This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain. (expasy.org)
Famoxadone and related inhibitors bind like methoxy acrylate inhibitors in the Qo site of the BC1 compl and fix the rieske iron-sulfur protein in a positio close to but distinct from that seen with stigmatellin and other 'distal' Qo inhibitors. (edu.pl)

In addition, gene expression of mitoferrin-2, a mitochondrial iron uptake transporter, was increased 4 to 5 fold after exposure to As 2 O 3 (5 μM) for 48 hours. (biomedcentral.com)
A second group of methods, which includes DNA microarrays and proteomics, have advantages that overcome the limitations implicit in signature-tagged mutagenesis and in vivo expression technology, namely, the ability to directly measure expression (gene or protein) levels on a true genome-wide scale, but their application to analysis of bacterial pathogens during real infections is still in its infancy. (cdc.gov)

This table lists all participants of the complex (proteins, small molecules, nucleic acids, etc.) and their respective stoichiometry. (yeastgenome.org)

Consequently, most, if not all, of the hydrogenosomal proteins are encoded by the nuclear DNA, synthesized in the cytosol, and then imported into hydrogenosome via a protein import machinery. (plasignaling.com)

Cells require a constant supply of energy to perform vital functions, including nutrient uptake, protein synthesis, DNA replication, and active transport across cell membranes. (microbiologynote.com)
The nucleus houses the cell's DNA and directs the synthesis of proteins and ribosomes. (coursehero.com)

Fig. 3: Translational control of mitochondrial respiratory chain assembly. (nature.com)
Defining the interactome of the human mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors. (nih.gov)

CDC28 protein kinase regulatory subu. (gsea-msigdb.org)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)
Further, there are signaling pathways that participate in regulation, such as Wnt channel, mitogen-activated protein kinase (MAPK) channel, bone morphogenetic protein (BMPs) channel, peroxisome proliferator activated-receptors (PPARs) channel, and Notch channel. (frontiersin.org)

ferrous state) during the physiological action of cytochromes, while the iron of haemoglobin remains in the reduced form during its physiological action. (drugstorepdfsearch.com)
The first one recognizes all mono-heme cytochrome c proteins (except class II and f-type cytochromes). (expasy.org)

E.A. Orabi and A.M. English ( 2016 ) Sulfur-Aromatic Interactions: Modeling Cysteine and Methionine Binding toTyrosinate and Histidinium Ions to Assess Their Influence on Protein Electron Transfer , Isr. (concordia.ca)
It consists of a cluster of cysteine residues which complex iron through covalent bonds with the sulfur of cysteine. (drugstorepdfsearch.com)
USA.gov. [15], The N2 cluster's proximity to a nearby cysteine residue results in a conformational change upon reduction in the nearby helices, leading to small but important changes in the overall protein conformation. (gowebamerica.com)
In proteins belonging to the c-type cytochrome family [ 1 ], the heme group is covalently attached by thioether bonds to two conserved cysteine residues located in the cytochrome c center. (expasy.org)

Moreover, we also investigated uptake of iron by T. brucei. (nusl.cz)
Therefore, we investigated whether mitoferrin-2, a mitochondrial iron uptake transporter, participates in As 2 O 3 -induced cell killing in human gliomas. (biomedcentral.com)

CDGSH iron sulfur domain 1 [Source:H. (gsea-msigdb.org)

The authors concluded that the contribution of particular side chains to the conformational stability of FXN might be highly subordinated to their impact on both the protein function and the stability of the functional supercomplex. (curefa.org)
Nevertheless, the role that hyperglycemia has on renal mitochondrial respiratory complex function has not been thoroughly investigated. (biomedcentral.com)
These results suggest that in the early stages of hyperglycemia Complex III has assembly defects which could cause oxidant generation, leading to impairment of mitochondrial and renal function during hyperglycemia. (biomedcentral.com)
As an example, Parkinson's disease is rooted in defective mitochondrial function in this area of the brain. (grasslandbeef.com)
Mitochondrial remnant organelles of Giardia function in iron-sulphur protein maturation. (nature.com)

Cytochrome c, an electron carrier protein located in the mitochondrial matrix. (expasy.org)

Our findings indicated that mitoferrin-2 participates in mitochondrial ROS-dependent mechanisms underlying As 2 O 3 -mediated damage in glioma cells. (biomedcentral.com)

When available from the Protein Data Bank (PDB), the physical structure of the macromolecular complex is displayed. (yeastgenome.org)
In summary, these findings show for the first time that early (and selective) inactivation of Complex-III may contribute to the mitochondrial oxidant production which occurs in the early stages of diabetes. (biomedcentral.com)
Hemoglobin During photosynthesis, the cytochrome b6f complex is one step along the chain that transfers electrons from Photosystem II to Phot… Stigmatellin, a Q(P) site inhibitor, inhibits electron transfer from iron-sulfur protein (ISP) to cytochrome c1 in the bc1 complex. (slimwithlynne.com)
The reaction is analogous to the reaction catalyzed by cytochrome bc1 (Complex III) of the mitochondrial electron transport chain. (slimwithlynne.com)
adaptor related protein complex 2 su. (gsea-msigdb.org)

G protein nucleolar 1 (putative) [So. (gsea-msigdb.org)
GTP binding protein 6 (putative) [So. (gsea-msigdb.org)

Fig. 2: Transcriptional control of mitochondrial biogenesis through PGC1α. (nature.com)

Further, it regulates osteoblastic extracellular matrix such as osteopontin (OPN), osteocalcin (OCN), bone sialoprotein (BSP) in late differentiation. (frontiersin.org)

Excessive reactive hydroxyl radicals could damage DNA, proteins, and membranes. (biomedcentral.com)

Anatomy4

Diseases1

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes2

Information Science2

Mitochondria18

Located in the inner mitochon1

Clusters8

Enzymes8

Cytosolic1

Biogenesis and function1

Endoplasmic reticulum3

Membrane18

Subunit2

NADH1

Genes4

Metabolism8

Redox2

Cluster assembly1

Intracellular3

Dysfunction5

Transmembrane4

Presequence1

Cellular6

Complexes6

Enzyme1

Subunits4

Metabolic2

Succinate2

Reactive oxygen1

Rieske2

Gene2

Nucleic acids1

Nuclear1

Synthesis2

Respiratory chain assembly2

Kinase3

Cytochromes2

Cysteine4

Uptake2

CDGSH1

Function5

Electron carrier1

Participates1

Complex5

Putative2

Transcriptional1

Extracellular1

Membranes1