Mitochondrial matrix proteins. Medical search. Frequent questions

[5] The eukaryote Monocercomonoides is known to have completely lost its mitochondria, [6] and the multicellular organism Henneguya salminicola is known to have retained mitochondrion-related organelles in association with a complete loss of their mitochondrial genome. (wikipedia.org)
The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix. (nih.gov)
Although studies suggest that αSyn and its missense mutant, A53T, preferentially accumulate in the mitochondria, the mechanisms by which αSyn and mitochondrial proteins regulate each other to trigger mitochondrial and neuronal toxicity are poorly understood. (springer.com)
Despite these findings suggesting that mitochondria might be a key link between αSyn toxicity and neuronal degeneration in PD, the field still lacks an understanding of how αSyn abnormality and mitochondrial functional deficiency influence each other. (springer.com)
In line with this notion, mitochondria are highly dynamic organelles that undergo fission and fusion and move into the cell along the microtubules to generate the mitochondrial network [ 6 ]. (hindawi.com)
The mitochondria have their own chaperones and proteolytic enzymes that remove damaged or unfolded proteins [ 18 - 20 ]. (hindawi.com)
A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed. (livecareer.com)
Recent studies suggest that the mitochondria contain fidelity proteins and MnSOD constitutes an integral part of the nucleoid complex. (duke.edu)
When expressed in S. cerevisiae , the S. pombe Mdm12p homolog conferred a dominant-negative phenotype of giant mitochondria and aberrant mitochondrial distribution, suggesting partial functional conservation of Mdm12p activity between budding and fission yeast. (rupress.org)
This study evaluated the roles of PINK1 mitochondrial kinase, and Parkin E3 ubiquitin ligase in targeting depolarized mitochondria for degradation in vivo, using quantitative measurements of mitochondria in Drosophila nervous system. (sdbonline.org)
The hypotheses was tested that impairment of mitochondrial quality control via suppression of PINK1 function should produce failures of turnover, accumulation of senescent mitochondria in the axon, defects in mitochondrial traffic, and a significant shift in the mitochondrial fission-fusion steady state. (sdbonline.org)
Loss of PINK1 also produced specific, directionally balanced defects in mitochondrial transport, without altering the balance between stationary and moving mitochondria. (sdbonline.org)
The Parkinson's disease genes pink1 and parkin , which encode a mitochondrially targeted protein kinase, and an E3 ubiquitin ligase, respectively, participate in a key mitochondrial quality-control pathway that eliminates damaged mitochondria. (sdbonline.org)
Mitochondria are surrounded by a double membrane consisting of a mitochondrial matrix, an inner membrane, an intermembrane space, and an outer membrane. (assignmentexpert.com)
The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. (novusbio.com)
Within the cell, TSPO is predominantly located in mitochondria, specifically in the outer mitochondrial membrane. (uni-regensburg.de)
This means that although the mitochondria absorb iron, the enzyme ferrochelatase does not incorporate the iron into protoporphyrin as effectively as it should and the iron accumulates in the mitochondrial matrix. (keyence.com)
The difficulty in understanding and treating human pathologies caused by mitochondrial dysfunction arises from the complex relationships between mitochondria and other cellular processes, as well as the genetic background of such diseases. (biomedcentral.com)

Both α-Synuclein (αSyn) accumulation and mitochondrial dysfunction have been implicated in the pathology of Parkinson's disease (PD). (springer.com)
Although the mechanisms underlying PD remain elusive, α-Synuclein (αSyn) accumulation and mitochondrial dysfunction have been recognized as major contributors [ 1 , 57 ]. (springer.com)
Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)
Mitochondrial dysfunction has also been associated with ageing and most of the so-called age-related diseases [ 13 - 17 ]. (hindawi.com)
One of the underlying mechanisms of long COVID may be mitochondrial dysfunction. (mdpi.com)
Mitochondrial dysfunction has been linked to the pathogenesis of a large number of inherited diseases in humans, including Parkinson's disease, the second most common neurodegenerative disorder. (sdbonline.org)

[22] A mitochondrion contains outer and inner membranes composed of phospholipid bilayers and proteins . (wikipedia.org)
Tim50 is a subunit of the TIM23 complex that links protein translocation across the outer and inner mitochondrial membranes. (nih.gov)
The gating of this protein-selective pore has been extensively studied in patch clamp experiments on isolated mitochondrial membranes. (frontiersin.org)
Notice the inner and outer membranes, the cristae, and the mitochondrial matrix. (pressbooks.pub)
The compartment between the inner and outer mitochondrial membranes. (flashcardmachine.com)

In this review, we discuss the functional cross talk of proteostasis and mitostasis in cellular homeodynamics and the impairment of mitochondrial quality control during ageing, cancer, and neurodegeneration. (hindawi.com)

Here, a genome-wide analysis of the human mitochondrial transcriptome shows that 2'- O -methylation is limited to residues of the mitoribosomal large subunit (mtLSU) 16S mt-rRNA, introduced by MRM1, MRM2 and MRM3, with the modifications installed by the latter two proteins being interdependent. (nature.com)
The human mitochondrial genome is encoded in multiple copies of ~16.6 kb circular double-stranded DNA molecules (mtDNA) present in mitochondrial nucleoids in the mitochondrial matrix. (nature.com)
Expression of this genome entails several, highly regulated processes, with newly synthesised transcripts being cleaved, chemically modified, polyadenylated and further matured in neighbouring structures known as mitochondrial RNA granules (MRGs). (nature.com)
Almost half of these MRPs are evolutionarily exclusive to mitochondrial ribosomes, some of which were repurposed and accreted during reductive genome evolution 4 , 5 . (nature.com)
The mtDNA polymerase (Polγ), a major constituent of nucleoids, is responsible for the replication and repair of the mitochondrial genome. (duke.edu)
The mitochondrial genome is a 16569 base-pair closed circular loop of double-stranded DNA found in multiple copies within the mitochondrial matrix. (medscape.com)
The mitochondrial genome encodes the genetic information for the 13 polypeptide subunits essential for the process of oxidative phosphorylation. (medscape.com)
[ 13 ] The mitochondrial genome is remarkably concise, containing little noncoding capacity and no introns. (medscape.com)

[10] Mitochondrial biogenesis is in turn temporally coordinated with these cellular processes. (wikipedia.org)
The biogenesis of most proteins in the mitochondrial matrix and the inner membrane relies on the function of the TIM23 complex. (frontiersin.org)
MRM2 controls mitochondrial respiration by regulating mitoribosome biogenesis. (nature.com)

Genetic and structural characterization of the human mitochondrial inner membrane translocase. (nih.gov)
These similarities are supported by studies where the single-ring human mitochondrial homolog, Hsp60 with its cochaperonin, Hsp10 were expressed in an E. coli strain, engineered so that the GroE operon is under strict regulatory control. (enzolifesciences.com)

Predicted to be involved in protein import into mitochondrial matrix. (nih.gov)

NPM is an acidic ribosomal chaperone (protein) involved in preribosomal processing and nuclear exportation independent of p53, and oligomerizes with itself and p14ARF. (wikipedia.org)
In addition, mitochondrial DNA (mtDNA) encodes 2 ribosomal RNA genes and 22 transfer RNA (tRNA) genes necessary for the intramitochondrial synthesis of these 13 polypeptides. (medscape.com)

Genotoxic agents, such as ultraviolet (UV) radiation, generates oxidative stress and cause mitochondrial DNA (mtDNA) damage. (duke.edu)
The results suggest that these proteins form a complex for the repair of UVB-associated mtDNA damage. (duke.edu)
The accuracy of mitochondrial DNA (mtDNA) replication depends on the coordinated action of many nuclear-encoded proteins and on the correct balance of nucleotides within the mitochondrial matrix. (novusbio.com)
The NADH binding site, FMN and eight FeS clusters are located in the promontory part, whereas the seven membrane-spanning proteins are all encoded by mitochondrial DNA in eukaryotes, in fact the Complex I encoding genes make up half of the mtDNA in mammals. (lu.se)
Alternatively, diagnosis may be established by muscle biopsy with histochemistry and mitochondrial DNA (mtDNA) analysis for major rearrangements. (medscape.com)
Located within the mitochondrial matrix, and lacking the efficient repair mechanisms available to nuclear DNA, mtDNA has a relatively high rate of mutation. (medscape.com)

These compartments or regions include the outer membrane, intermembrane space , inner membrane , cristae , and matrix . (wikipedia.org)
The removal of protons from the matrix and deposition of protons in the intermembrane space creates a concentration difference of protons across the inner membrane. (roadlesstraveledstore.com)
It involves the electrons moving energetically downhill, the complexes then capture the released energy and uses it to pump H+ ions from the matrix to the intermembrane space. (roadlesstraveledstore.com)
As electrons are shuttled through the complexes I, III and IV by electron carriers, protons (H + ) are moved from the mitochondrial matrix into the intermembrane space. (biomedcentral.com)
This creates a net positive charge in the intermembrane space, and a net negative charge in the matrix. (biomedcentral.com)
The preferred route for protons in the intermembrane space to re-enter the matrix, in an attempt to flow down the gradient and re-establish equilibrium, is to enter through the ATP synthase enzyme complex. (biomedcentral.com)
Fatty acids, which are often found in chains as CoA-esters, are first transported across the outer mitochondrial membrane by palmitoyl transferase I, resulting in translocation to the intermembrane space and transformation into an acyl-carnitine form. (biomedcentral.com)

It has been reported that C1QBP is mainly localized in the mitochondrial matrix and is less expressed in the cytoplasm, nucleus and on the cell surface [ 9 - 11 ]. (jcancer.org)
The product of this gene functions as a gated pore that translocates ADP from the mitochondrial matrix into the cytoplasm. (thermofisher.com)
SLC30A8/ZnT8 is the carrier protein responsible for the transport of zinc from the cytoplasm to the insulin granules. (bvsalud.org)
It serves as a mechanism for transport of long-chain fatty acids from the cytoplasm across the inner mitochondrial membrane and into the mitochondrial matrix, the site of b-oxidation of fatty acids for energy generation. (medscape.com)
The classical Complex I enzyme is composed of seven membrane-spanning protein subunits and seven protein subunits protruding into the cytoplasm (in bacteria) or into the mitochondrial matrix (in eukaryotes). (lu.se)

Overexpression of ClpP reduces αSyn-induced mitochondrial oxidative stress through enhancing the level of Superoxide Dismutase-2 (SOD2), and suppresses the accumulation of αSyn S129 phosphorylation and promotes neuronal morphology in neurons derived from PD patient iPS cells carrying αSyn A53T mutant. (springer.com)
Mdm12p is the third mitochondrial outer membrane protein required for normal mitochondrial morphology and distribution to be identified in S. cerevisiae and the first such mitochondrial component that is conserved between two different species. (rupress.org)
Somatic mitochondrial morphology was also compromised. (sdbonline.org)

Three transcript variants encoding the same protein have been identified for this gene. (origene.com)
Specific sessions will be dedicated to organelle evolution, their gene expression systems, the import of proteins and their assembly into functioning complexes, signaling pathways and stress response, disintegration of organelles during aging and senescence, and how all these are being translated to agriculture and medicine. (grc.org)
This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. (thermofisher.com)
The protein encoded by this gene is a Krebs tricarboxylic acid cycle enzyme that catalyzes the synthesis of citrate from oxaloacetate and acetyl coenzyme A. The enzyme is found in nearly all cells capable of oxidative metabolism. (thermofisher.com)
Carnitine-acylcarnitine translocase deficiency (CACT) typically presents in an autosomal-recessive fashion with seizures, apnea, and an irregular heart beat in the neonatal period (although presentation can occur as late as age 15 months) and results from mutations in the CACT protein ( SLC25A20 gene), a carnitine-acylcarnitine exchanger on the inner mitochondrial membrane. (medscape.com)

The TIM23 complex is a hub for translocation of preproteins into or across the mitochondrial inner membrane. (frontiersin.org)
Deletion of Mgr2p has been found to delay protein translocation into the matrix and accumulation in the inner membrane. (frontiersin.org)
The core of the TIM23 complex contains a pore that is essential for protein insertion into or translocation across the inner membrane. (frontiersin.org)
Taken together, these findings suggest that autophosphorylation of PINK1 is essential for the mitochondrial translocation of Parkin and for subsequent phosphorylation and activation of Parkin. (sdbonline.org)
Therefore, in the lab we working with molecular biological approaches such as making mutants and fusion proteins but also purely biochemical/biophysical projects, purifying proteins for reconstitution into liposomes, where the ion translocation activities can be measured by Na+ NMR using a shift reagent or by a pH sensitive, membrane-impermeable dye denoted Glu3. (lu.se)

It is located near the genes for the tandem repeats INK4a and INK4b, which are 16 kDa (p16INK4a) and 15 kDa (p15INK4b) proteins, respectively. (wikipedia.org)
The Rb protein limits cell proliferation by blocking the activity of E2F transcription factors, which activate the transcription of genes needed for DNA replication. (wikipedia.org)
Finally, we suggested that C1QBP is correlated with genes encoding ribosome RPL-related proteins and mitochondrial MRPL-related proteins in HCC patients. (jcancer.org)

Complement C11 binding protein (C1QBP, also named p32 and HABP1) is a multifunctional protein which plays a pivotal role in diverse cellular processes such autophagy and cell apoptosis [ 7 , 8 ]. (jcancer.org)
The protein is implicated in the function of the permability transition pore complex (PTPC), which regulates the release of mitochondrial products that induce apoptosis. (thermofisher.com)
C1QBP significantly increased ROS level, apoptosis, and the expression of apoptotic proteins such as cleaved caspase-3 and bax/bcl2 via regulating XDH. (medsci.org)

Tim50, a component of the mitochondrial translocator, regulates mitochondrial integrity and cell death. (nih.gov)

Similar to other systems, the mitochondrial ribosome is composed of a small (mtSSU) and a large (mtLSU) subunit, with their core rRNAs, 12S and 16S mitochondrial (mt-) rRNAs, respectively, surrounded by MRPs (30 for the mtSSU and 52 for the mtLSU). (nature.com)
The mammalian mitochondrial ribosome is endowed with a number of specific features. (nature.com)

Similarly, hydrogen ions in the matrix space can only pass through the inner mitochondrial membrane through a membrane protein called ATP synthase. (roadlesstraveledstore.com)
Protons flow down their concentration gradient into the matrix through the membrane protein ATP synthase, causing it to spin (like a water wheel) and catalyze conversion of ADP to ATP. (roadlesstraveledstore.com)
A chemiosmotic gradient causes hydrogen ions to flow back across the mitochondrial membrane into the matrix, through ATP synthase, producing ATP. (roadlesstraveledstore.com)
As protons flow through the channel domain of ATP synthase, a motor force is generated, which is used to rotate a large, rotating catalytic domain facing the matrix, which couples adenosine diphosphate (ADP) to an inorganic phosphate moiety (P i ) to yield ATP[ 4 ]. (biomedcentral.com)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)

The cristae and the matrix have different roles in cellular respiration. (pressbooks.pub)

Complement component 1 Q subcomponent binding protein (C1QBP) plays a vital role in the progression and metabolism of cancer. (medsci.org)
Carnitine is an important small water-soluble molecule that binds to long-chain fatty acids and facilitates their transport across the inner mitochondrial membrane and into the mitochondrial matrix to undergo fatty acid oxidation (metabolism). (medscape.com)

An interconnected highly integrated system of mitochondrial and cytosolic chaperones and proteases along with the fission/fusion machinery represents the surveillance scaffold of mitostasis. (hindawi.com)
While RNA makes up most of the composition of bacterial and cytosolic eukaryotic ribosomes, mammalian mitochondrial ribosomes present a more elaborate protein shell, which aids coping with the oxidative microenvironment. (nature.com)
Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. (novusbio.com)

This dual sorting mechanism is currently being investigated, and in yeast appears to be regulated by a recently discovered subunit, the Mgr2 protein. (frontiersin.org)

1) Phylogenomics tree matrix, (2) mitochondrial metabolic protein alignments and individual phylogenies, and (3) transcriptome assemblies generated in this study. (mendeley.com)
This review attempts to provide a summary of the background knowledge and recent developments in mitochondrial processes relating to mitochondrial-associated metabolic diseases arising from defects or deficiencies in mitochondrial function, as well as insights into current and future avenues for investigation. (biomedcentral.com)

The molecular mechanisms and cellular components that mediate this mitochondrial inheritance are beginning to be elucidated through the analysis of Saccharomyces cerevisiae mutants exhibiting specific defects in mitochondrial distribution. (rupress.org)
Characterization of some of the mdm mutants has indicated that mitochondrial inheritance is a specific, active process that depends on a number of novel cellular components ( Yaffe, 1996 ). (rupress.org)

Although a variety of studies have shown that Complement C11 binding protein (C1QBP) may play a tumor-promoting or tumor-suppressive role in cancer, the functions and mechanisms of C1QBP in HCC progression are under-investigating. (jcancer.org)
These results strongly circumscribe the possible mechanisms of PINK1 action in the mitochondrial life cycle and also raise the possibility that mitochondrial turnover events that occur in cultured embryonic axons might be restricted to the cell body in vivo, in the intact nervous system. (sdbonline.org)

Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
Human HTT codes for a large protein of 3144 amino acids, which is ubiquitously expressed in various tissues and is present in several sub-cellular locations. (nature.com)
Although theymitochondria have circular DNA and protein synthesis apparatus, most of the proteins are encoded by cellular DNA and come from the cytosol. (assignmentexpert.com)
At the sub-cellular scale, maps document the spatial organization of proteins, RNA, DNA, and metabolites with nanometer precision and temporal acuity on the order of seconds. (stanford.edu)
Hsps are intracellular proteins which are thought to serve protective functions against infection and cellular stress, however several studies indicate that members of the Hsp60 family are linked to a number of autoimmune diseases, artherosclerosis and chlamydial disease. (enzolifesciences.com)
Cellular component GO terms and their p-values for co-expressed proteins. (lu.se)

Phosphorylation of PINK1 is not only required for the PINK1-mediated mitochondrial recruitment of Parkin but also induces its kinase activity toward Parkin. (sdbonline.org)

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. (rndsystems.com)
Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
The transporter was identified by probing a mammalian-expressed sequence tag database with 2 fungal mitochondrial ornithine carrier protein sequences. (medscape.com)

Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. (nih.gov)

Deficiency in ClpP induces an overload of mitochondrial misfolded/unfolded proteins, suppresses mitochondrial respiratory activity, increases mitochondrial oxidative damage and causes cell death. (springer.com)
The invaginations of the inner mitochondrial membrane & reflects the respiratory activity of the cell. (flashcardmachine.com)

Identification of proteins interacting with the mitochondrial small heat shock protein Hsp22 of Drosophila melanogaster: Implication in mitochondrial homeostasis. (nih.gov)
This work identifies a key checkpoint during mtLSU assembly, essential to maintain mitochondrial homeostasis. (nature.com)

EPIC: software toolkit for elution profile-based inference of protein complexes. (nih.gov)
The mitochondrial hydrogen ion gradient is generated as electrons pass through three membrane complexes. (roadlesstraveledstore.com)
IFN signaling: 3C protease inhibits activation of antiviral protein complexes. (cdc.gov)

The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
The stroma also contains the ___,____, and ribosomes involved in the synthesis of several chloroplast proteins. (flashcardmachine.com)

These INK4 proteins directly inhibit the cyclin D-dependent kinases CDK4 and CDK6. (wikipedia.org)

The authors concluded that the contribution of particular side chains to the conformational stability of FXN might be highly subordinated to their impact on both the protein function and the stability of the functional supercomplex. (curefa.org)

Mgr2p/Romo1 bridges TIM23 to the presequence translocase-associated motor (PAM) and is thought to regulate the lateral release of proteins harboring stop-transfer sequences. (frontiersin.org)

p14ARF is an atypical protein, in terms of its transcription, its amino acid composition, and its degradation: it is transcribed in an alternate reading frame of a different protein, it is highly basic, and it is polyubiquinated at the N-terminus. (wikipedia.org)
In humans, ARF is translated into the 14kDa, 132 amino acid [[p14ARF]] protein, and in mice, it is translated into the 19kDa, 169 amino acid p19Arf. (wikipedia.org)
As with other mitochondrial carrier family proteins, the ornithine carrier is composed of 300 amino acids that constitute 3 repeated motifs of approximately 100 amino acids each. (medscape.com)
A protein modification that effectively converts a source amino acid residue to an L-cysteine. (reactome.org)
The yeast metal resistance proteins, which are 850-900 amino acyl residues in length, also exhibit two or three putative TMSs. (tcdb.org)
The CorA proteins of E. coli and S. typhimurium are each 316 amino acyl residues in length. (tcdb.org)
Recombinant fusion protein containing a sequence corresponding to amino acids 216-485 of human POLG2 (NP_009146.2). (novusbio.com)

Predicted to enable protein transmembrane transporter activity. (nih.gov)

Hyaluronan binding protein 1 (HABP1), also known as C1qBP/C1qR and p32, is a ubiquitous acidic glycoprotein that functions in spermatogenesis and as a receptor for proinflammatory molecules (1, 2). (rndsystems.com)
Cell surface HABP1 binds a wide range of extracellular molecules, including hyaluronan, vitronectin, complement component C1q, HMW kininogen, and bacterial and viral proteins (2, 6 - 9). (rndsystems.com)
Within the cell, HABP1 binds to molecules containing the C1q globular domain, multiple isoforms of PKC, mitochondrial Hrk, the cytoplasmic tails of adrenergic and GABA-A receptors, the mRNA splicing factor ASF/SF2, and the CBF transcription factor (10 - 16). (rndsystems.com)

The human Hsp60 is a member of a highly conserved family which includes molecular chaperones from several species including plant Hsp60 (known as Rubisco binding protein), and bacterial GroEL, a major antigen of mycobacteria. (enzolifesciences.com)

A total of 5 enzymes in 2 subcellular compartments (mitochondrial matrix and cytosol) convert ammonia into urea, which is excreted by the kidney (see image below). (medscape.com)
Two general families of chaperones are reconized: Molecular chaperones, which bind and stabilize un- folded or partly folded proteins, thereby preventing these proteins from aggregating and being degraded Chaperonins, which directly facilitate the folding of proteins Molecular chaperones consist of Tradee and its homologs: Hsp70 in the cytosol and mitochondrial matrix, BiP in the en- doplasmic reticulum, and DnaK in bacteria. (forextrading-madeeasy.com)

This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. (thermofisher.com)
Manganese superoxide dismutase is a nuclear encoded primary antioxidant enzyme localized exclusively in the mitochondrial matrix. (duke.edu)

Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
Recombinant protein encompassing a sequence within the center region of human IDH2. (novusbio.com)

The crystal structure of the CorA homologue from Thermotoga maritima has been solved at 3.9 Å resolution for the full-length protein and at 1.85 Å resolution for the cytoplasmic domain ( Lunin et al . (tcdb.org)

The matrix also contains the mitochondrial genetic machinery-DNA, RNA, and ribosomes-that generates several (but by no means all) mitochondrial proteins. (flashcardmachine.com)

It is freely permeable only to GAS O2, CO2, and H2O and contains, in addition to respiratory chain proteins, numerous transport proteins that control the passage of metabolites such as ATP, ADP, pyruvate, Ca2+, and phosphate. (flashcardmachine.com)
The outer mitochondrial membrane permeable to what? (flashcardmachine.com)
The electrons cause conformation changes in the shapes of the proteins to pump H+ across a selectively permeable cell membrane. (roadlesstraveledstore.com)

Compensating for the loss of ClpP in the substantia nigra of αSyn A53T mice by viral expression of ClpP suppresses mitochondrial oxidative damage, and reduces αSyn pathology and behavioral deficits of mice. (springer.com)

However, it is not known whether or how MnSOD participates in the mitochondrial repair processes. (duke.edu)

In eukaryotes, Hsp60 is localized in the mitochondrial matrix while plant Hsp60 is localized in the chloroplast. (enzolifesciences.com)
SDS-PAGE analysis: Lane 1: MWM, Lane 2: 1.0 µg of purified Human Hsp60 protein. (enzolifesciences.com)

The first 2 steps of the urea cycle occur in the mitochondrial matrix. (medscape.com)

This fact combined with the high degree of homology between the divergent Hsp60s would indicate that these proteins carry out a primitive but important function which is conserved in divergent species. (enzolifesciences.com)

No yeast two-hybrid interactions found for this protein. (yeastrc.org)
Overexpression of the yeast proteins, Al R 1p and Mn R 2p, overcomes toxicity to aluminum and manganese, respectively. (tcdb.org)
The yeast proteins appear to exhibit broad specificity transporting a wide range of di- and trivalent metal cations. (tcdb.org)

Anatomy31

Organisms11

Diseases3

Chemicals and Drugs150

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes42

Disciplines and Occupations1

Information Science3

Mitochondria18

Dysfunction6

Membranes5

Impairment of mitochondrial quality control1

Genome8

Biogenesis3

Human mitochondrial2

Import into mitochondrial matrix1

Ribosomal2

MtDNA6

Intermembrane space7

Cytoplasm5

Morphology3

Gene5

Translocation5

Genes3

Apoptosis3

Regulates1

Ribosome2

Synthase5

Cristae1

Metabolism2

Cytosolic3

Subunit1

Metabolic2

Mutants2

Mechanisms2

Cellular6

Kinase1

Carrier protein3

Translocase complex1

Respiratory activity2

Homeostasis2

Complexes3

Synthesis2

Kinases1

Functional1

Regulate1

Amino7

Transmembrane transporter activity1

Molecules3

Bacterial1

Cytosol2

Nuclear2

Molecular1

Recombinant2

Cytoplasmic1

Genetic1

Permeable3

Viral1

Processes1

Hsp602

Occur1

Homology1

Yeast3