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Mitochondrial Membrane Transport ProteinsMembrane Transport ProteinsIntracellular MembranesMitochondrial MembranesMitochondriaBiological TransportMembrane Potential, MitochondrialMitochondrial ProteinsCell MembraneMembrane ProteinsCarrier ProteinsMembranesSubmitochondrial ParticlesMitochondria, LiverSymportersMembrane PotentialsMolecular Sequence DataMitochondrial ADP, ATP TranslocasesAmino Acid SequenceMonosaccharide Transport ProteinsEscherichia coli ProteinsMembrane LipidsBiological Transport, ActiveProtein TransportEscherichia coliSaccharomyces cerevisiaeElectron Transport Complex IVSaccharomyces cerevisiae ProteinsCardiolipinsCatecholamine Plasma Membrane Transport ProteinsMitochondrial SwellingCell Membrane PermeabilityMembranes, ArtificialMitochondria, HeartBacterial ProteinsFatty Acid Transport ProteinsAdenosine TriphosphateBase SequenceProtein ConformationKineticsMitochondrial Proton-Translocating ATPasesModels, BiologicalErythrocyte MembraneMutationATP-Binding Cassette TransportersElectron TransportCloning, MolecularIon ChannelsModels, MolecularOligomycinsOxidative PhosphorylationPermeabilityHydrogen-Ion ConcentrationProtein BindingMultidrug Resistance-Associated ProteinsMembrane FluidityFungal ProteinsUncoupling AgentsCalciumMicroscopy, ElectronBacterial Outer Membrane ProteinsOxygen ConsumptionProtein Structure, TertiaryRecombinant Fusion ProteinsCell LineCytochromes cLiposomesAnionsCells, CulturedIon TransportProtein PrecursorsElectron Transport Complex IApoptosisCell FractionationCytochrome c GroupElectrophoresis, Polyacrylamide GelCarbonyl Cyanide m-Chlorophenyl HydrazoneSubcellular FractionsATP-Dependent ProteasesProton-Translocating ATPasesVoltage-Dependent Anion ChannelsSequence Homology, Amino AcidAdenine Nucleotide Translocator 1Cytochromes c1Protein Sorting SignalsDigitoninBasement MembraneCell RespirationGolgi ApparatusTrityl CompoundsCytosolDiffusionEar, InnerAdenosine TriphosphatasesProtonsSulfanilic AcidsValinomycinMicroscopy, FluorescenceMicroscopy, ConfocalCation Transport Proteins
MitochondriaOuter membraneBiogenesisIntermembrane spaceMitochondrionCristaeTransportersPlasma membraneReactive OxygenOxidativeSynthaseDysfunctionEndoplasmic reticulumElectron transTranslocator ProteinRespirationSubunitElectronsProcessesCellular membranesComplexCytosolic chaperonesRegulationGeneMolecularRespiratoryMoleculesCompartmentLipidsNucleotideSubstancesMetabolismGenomeChloroplastKinaseMeSHSynthesisNeurotransmitterSaccharomycesCytochromePhysiological and pathologicalAmino AcidsCarnitineMiceOrganellesLipidVDAC1CardiolipinComplexesOrganelleBacterialSam35Metabolites
Mitochondria26
Outer membrane13
  • The outer membrane is porous, whereas the inner membrane restricts the movement of all molecules. (wikipedia.org)
  • The outer membrane consists of two types of integral proteins, including proteins with transmembrane β-barrel and proteins with one or more α-helical membrane anchors. (wikipedia.org)
  • The SAM Complex is essential for sorting and assembling beta-barrel proteins from the intermembrane space side into the outer membrane. (wikipedia.org)
  • The β-barrel of Sam50 is the functional domain that inserts and folds substrate proteins into the outer membrane. (wikipedia.org)
  • VDAC (voltage-dependent anion ion channel) is important for the exchange of small hydrophilic ions and metabolites with the cytosol, which is driven by the gradient concentration across the outer membrane. (wikipedia.org)
  • VDAC is the most abundant protein in the outer membrane. (wikipedia.org)
  • VDAC plays a crucial role in facilitating energy metabolism by transporting ADP and ATP in and out of the outer membrane. (wikipedia.org)
  • The import pathways of α-helical membrane anchors or signal-anchored proteins are carried out mainly by outer membrane proteins. (wikipedia.org)
  • Because of the porosity of the outer membrane, the intermembrane space is equivalent to the cytosol in its small-molecule composition. (flashcardmachine.com)
  • These compartments or regions include the outer membrane, intermembrane space , inner membrane , cristae , and matrix . (wikipedia.org)
  • Any process that activates or increases the frequency, rate or extent of protein insertion into mitochondrial outer membrane. (planteome.org)
  • Link to all annotated objects annotated to positive regulation of protein insertion into mitochondrial outer membrane. (planteome.org)
  • With about 10 000 copies per cell the voltage-dependent anion channels (VDACs) are the most abundant proteins of the mitochondrial outer membrane and are known to be involved in mitochondrial processes such as ATP-, calcium or ROS-transport. (uni-marburg.de)
Biogenesis5
  • These changes can promote mitochondrial biogenesis and membrane dynamics that in turn support mitochondrial respiration. (nature.com)
  • Fig. 2: Transcriptional control of mitochondrial biogenesis through PGC1α. (nature.com)
  • Remarkably, enhancing mitochondrial biogenesis through pharmacological inhibition of the Tank binding kinase 1 (TBK1) restores energy homeostasis, mitigates mitochondrial swelling with neuroprotection against acute mitochondrial damage for glaucomatous hRGCs, revealing a novel neuroprotection mechanism. (wms-site.com)
  • [10] Mitochondrial biogenesis is in turn temporally coordinated with these cellular processes. (wikipedia.org)
  • As a biochemist - cell biologist he works on the biogenesis of iron-sulfur proteins in eukaryotes and on mitochondrial transporters. (hstalks.com)
Intermembrane space3
  • The TOM complex forms two exit sites for precursor proteins-Tom40, Tom7, and the intermembrane space domain of Tom22-promote the transfer of presequence-containing precursors to the TIM23 complex. (wikipedia.org)
  • Explanation: The electron transport chain is used to pump protons into the intermembrane space. (roadlesstraveledstore.com)
  • This energy is used to pump hydrogen ions out of the mitochondrial matrix into the intermembrane space. (athletic.healthcare)
Mitochondrion10
  • However, a glaucomatous Optineurin mutant (E50K) hRGCs show high ATP production rate with fewer mitochondrion compared to the wild-type neurons causing mitochondrial swelling and disruption of homeostasis. (wms-site.com)
  • [22] A mitochondrion contains outer and inner membranes composed of phospholipid bilayers and proteins . (wikipedia.org)
  • This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. (nih.gov)
  • Ferdinando Palmieri mainly investigates Biochemistry, Mitochondrion, Mitochondrial carrier, Transport protein and Inner mitochondrial membrane. (research.com)
  • His Mitochondrion study combines topics from a wide range of disciplines, such as mitochondrial fusion, Molecular biology, Carnitine and Cytosol. (research.com)
  • His main research concerns Biochemistry, Mitochondrion, Mitochondrial carrier, Inner mitochondrial membrane and Molecular biology. (research.com)
  • The Mitochondrion study combines topics in areas such as Chromatography, Membrane transport, Liposome and Cytosol. (research.com)
  • Ferdinando Palmieri spends much of his time researching Biochemistry, Mitochondrial carrier, Mitochondrion, Inner mitochondrial membrane and Cell biology. (research.com)
  • His primary areas of study are Biochemistry, Mitochondrial carrier, Mitochondrion, Inner mitochondrial membrane and Cell biology. (research.com)
  • The mitochondrial matrix, the innermost compartment of the mitochondrion, is a specialized, membrane-bound organelle that is responsible for producing energy in eukaryotic cells. (passemall.com)
Cristae7
  • This has important functional implications because it would result in a locally greater pH gradient across cristal membranes than across inner membranes that are not part of cristae, thereby significantly influencing the rate of oxidative phosphorylation (Section 18-3). (flashcardmachine.com)
  • Major structure giving elements of the inner membrane are the so-called cristae junctions. (db-engine.de)
  • This short, tubular membrane segments connect the flat inner boundary membrane with the morphological dynamic cristae membranes. (db-engine.de)
  • Cristae junctions are rather uniform with inner diameters between 15 - 35 nm and hence display high degrees of membrane curvature. (db-engine.de)
  • Understanding how cristae junctions are formed and maintained or in other words, unraveling the molecular mechanisms of membrane remodeling at cristae junctions, is therefore of utmost importance. (db-engine.de)
  • Unlike membrane remodeling in classical curvature-dependent processes like clathrin-mediated endocytosis, cristae junctions are most likely shaped by integral membrane proteins. (db-engine.de)
  • At least some of these proteins are likely to be found within the MICOS complex (mitochondrial contact site and cristae organizing system). (db-engine.de)
Transporters1
  • There are 53 discovered human mitochondrial membrane transporters, with many others that are known to still need discovered. (wikipedia.org)
Plasma membrane3
  • It mediates fusion of synaptic vesicles with the presynaptic plasma membrane resulting in exocytosis of neurotransmitters. (researchgate.net)
  • 9) The cell walls of bacteria, fungi, and plant cells an the extracellular matrix cells are all external to the plasma membrane. (easynotecards.com)
  • Redox catalysis of plasma membrane PS oxidation constitutes an important redox-dependent function of cyt c in apoptosis and phagocytosis. (cdc.gov)
Reactive Oxygen3
  • AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species. (uchicago.edu)
  • A tight regulation of proton transport in the inner mitochondrial membrane is crucial for physiological processes such as ATP synthesis, heat production, or regulation of the reactive oxygen species as proposed for the uncoupling protein family members (UCP). (uni-linz.ac.at)
  • Execution of apoptotic program in cells is accompanied by substantial and early mitochondrial production of reactive oxygen species (ROS). (cdc.gov)
Oxidative4
Synthase2
  • His Mitochondrial carrier research integrates issues from Mitochondrial membrane transport protein, ATP-ADP translocase, Saccharomyces cerevisiae and Citrate synthase. (research.com)
  • Chemiosmosis is the process by which the hydrogen ions flow back into the mitochondrial matrix through ATP synthase. (athletic.healthcare)
Dysfunction5
  • Ageing leads to a gradual dysfunction of the proteostasis network and thus to proteome instability due to accumulation of damaged and/or misfolded proteins [ 2 ]. (hindawi.com)
  • Mitochondrial dysfunction has also been associated with ageing and most of the so-called age-related diseases [ 13 - 17 ]. (hindawi.com)
  • Thus, mitochondrial adaptive cellular processes are important for physiological responses, including to nutrient availability, temperature and physical activity, and their failure leads to diseases associated with mitochondrial dysfunction such as metabolic and age-associated diseases and cancer. (nature.com)
  • One of the underlying mechanisms of long COVID may be mitochondrial dysfunction. (mdpi.com)
  • Mitochondrial dysfunction is the second process that leads to HSPs. (medscape.com)
Endoplasmic reticulum1
Electron trans18
Translocator Protein1
  • Reference: "Structure of the Mitochondrial Translocator Protein in Complex with a Diagnostic Ligand" by Łukasz Jaremko, Mariusz Jaremko, Karin Giller, Stefan Becker and Markus Zweckstetter, 21 March 2014, Science . (scitechdaily.com)
Respiration2
  • Students use simple, everyday objects as hydrogen ions and electrons and play the roles of the various proteins embedded in the inner mitochondrial membrane to show how this specific process in cellular respiration produces ATP. (bioone.org)
  • Fe participates in cellular respiration, synthesis, and stabilization of chlorophyll, photosynthetic electron transport, and various other metabolic functions ( Grotz and Guerinot, 2006 ). (frontiersin.org)
Subunit1
  • AT3G10110.1 - [+] show detail - Mitochondrial import inner membrane translocase subunit Tim17/Tim22/Tim23 fam. (riken.jp)
Electrons3
Processes2
  • AIMS: To review the role played by the mitochondrial permeability transition pore (MPTP) in different physiological and pathological processes. (lu.se)
  • The Meinecke lab focuses on the in vitro reconstitution of processes at and across cellular membranes. (db-engine.de)
Cellular membranes2
  • Enzymes and other proteins use ATP to power reactions, maintain ion gradients across membranes, contract muscle fibers, and transport molecules across cellular membranes. (microbiologynote.com)
  • We are interested in recruiting highly motivated and creative Postdocs and PhD students to study the fascinating molecular organization of cellular membranes. (db-engine.de)
Complex21
  • The TOM complex, part of the TOM/TIM supercomplex, is essential for the translocase of almost all mitochondrial proteins which consists of at least 7 different subunits. (wikipedia.org)
  • Tom40 is the protein-conducting channel of the complex with beta-barrel structure, which forms a cation-selective channel. (wikipedia.org)
  • Three small proteins Tom5, Tom6, Tom7 interact closely with Tom40 to assemble and stabilize the complex. (wikipedia.org)
  • The TOM complex also consists of a dimer of Tom40 or small Tom proteins that are held together by two Tom22 subunits. (wikipedia.org)
  • Protein sorting into the mitochondrial compartments always starts at the TOM complex. (wikipedia.org)
  • The SAM complex consists of three subunits: The β-barrel protein Sam50 and two peripheral subunits Sam35 and Sam37. (wikipedia.org)
  • Sam37 accommodates the release of the folded β-barrel proteins from the SAM complex. (wikipedia.org)
  • Tom70 transfers the precursor proteins to the MIM Complex. (wikipedia.org)
  • These mitochondrial responses are governed by general principles of regulatory biology exemplified by changes in gene expression, protein translation, protein complex formation, transmembrane transport, enzymatic activities and metabolite levels. (nature.com)
  • Using nuclear magnetic resonance spectroscopy, two teams working with the Göttingen-based scientists Markus Zweckstetter and Stefan Becker have now shown the complex three-dimensional structure of the protein "at work" in atomic detail. (scitechdaily.com)
  • It belongs to a multimeric complex and is associated with other proteins.The pleiotropic actions of TSPO render this protein an interesting target in the nervous system. (uni-regensburg.de)
  • Mutations in this gene contribute to mitochondrial complex 1 deficiency. (nih.gov)
  • The SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 both anchored to the presynaptic membrane. (researchgate.net)
  • His studies in Saccharomyces cerevisiae, Transport protein, Amino acid, Carnitine and Oxoglutarate dehydrogenase complex are all subfields of Biochemistry research. (research.com)
  • His Oxoglutarate dehydrogenase complex research is multidisciplinary, relying on both Membrane transport protein and Stereochemistry. (research.com)
  • The cytosolic surface of the rough ER is covered by ribosomes that synthesize proteins that are then transported to the rough ER, then to the Golgi complex, and finally out of the cell. (villajoyosacf.info)
  • Biological membranes exhibit function-related shapes, leading to a plethora of complex and beautiful cell and cell organellar morphologies. (db-engine.de)
  • These organelles are surrounded by two membranes and especially the convoluted inner membrane displays a complex ultra-structure. (db-engine.de)
  • In the case of prokaryotic cells, glycolysis is shrouded in mystery as it takes place in the vast and complex cytoplasm, which lacks the membrane-bound organelles present in eukaryotic cells. (passemall.com)
  • Prohibitin 1 and prohibitin 2 form a ring-shaped complex in the INNER MITOCHONDRIAL MEMBRANE. (bvsalud.org)
  • It is part of the m-AAA protease, an adenosine triphosphate (ATP) ̶ dependent proteolytic complex located at the mitochondrial inner membrane, which controls protein quality and regulates ribosome assembly. (medscape.com)
Cytosolic chaperones2
  • The receptor proteins Tom70 and Tom20 recognize incoming precursor proteins, in which Tom70 is responsible for docking of precursors of hydrophobic proteins accompanied by cytosolic chaperones and Tom 20 recognizes precursor proteins of the presequence pathways. (wikipedia.org)
  • An interconnected highly integrated system of mitochondrial and cytosolic chaperones and proteases along with the fission/fusion machinery represents the surveillance scaffold of mitostasis. (hindawi.com)
Regulation5
  • In my master thesis, I investigated the regulation of mitochondrial motility by actin/myosin force generation. (uni-regensburg.de)
  • Fig. 1: Regulation of mitochondrial respiratory capacity. (nature.com)
  • Moreover, modulation of the proteins involved in cellular metal homeostasis may help in the regulation of metabolism, adaptability to a diverse range of environmental conditions, and biofortification. (frontiersin.org)
  • Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins. (uchicago.edu)
  • Specific regulation of proton transport is thus becoming increasingly important in the therapy of obesity and inflammatory, neurodegenerative, and ischemic diseases. (uni-linz.ac.at)
Gene10
  • The TAFAZZIN gene provides instructions for making a protein called tafazzin. (medlineplus.gov)
  • TAFAZZIN gene mutations result in the production of tafazzin proteins with little or no function. (medlineplus.gov)
  • Gentaur AntibodiesOverview: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. (caslab.com)
  • Gentaur AntibodiesOverview: This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. (caslab.com)
  • Altered gene expression of uncoupling protein-2 and -3 in stroke-prone spontaneously hypertensive rats. (uchicago.edu)
  • Increased adipose expression of the uncoupling protein-3 gene by thiazolidinediones in Wistar fatty rats and in cultured adipocytes. (uchicago.edu)
  • Cloning of rat uncoupling protein-3 and uncoupling protein-2 cDNAs: their gene expression in rats fed high-fat diet. (uchicago.edu)
  • His Biochemistry research focuses on Gene isoform, Yeast, Mitochondrial matrix, Gene and Membrane transport protein. (research.com)
  • His work deals with themes such as Amino acid, Transport protein, Nucleotide, Gene and Stereochemistry, which intersect with Inner mitochondrial membrane. (research.com)
  • A rare type of X-linked HSP, however, has been associated with a myelin protein gene mutation. (medscape.com)
Molecular5
  • The proteostasis network (PN) is an assembly of distinct dynamic molecular pathways that control the functionality of the proteome (proteome homeodynamics) during protein synthesis, folding, trafficking, and degradation. (hindawi.com)
  • This difficult task is carried out by a molecular transport protein named TSPO in the outer mitochondrial membrane. (scitechdaily.com)
  • Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing. (nih.gov)
  • A molecular understanding of how this membrane is shaped is missing to a large extent. (db-engine.de)
  • The true molecular nature of the protein is unknown [3] . (chemeurope.com)
Respiratory5
  • Fig. 3: Translational control of mitochondrial respiratory chain assembly. (nature.com)
  • Fig. 4: Post-translational mechanisms governing respiratory control and the role of mitochondrial membrane dynamics. (nature.com)
  • The invaginations of the inner mitochondrial membrane & reflects the respiratory activity of the cell. (flashcardmachine.com)
  • It is freely permeable only to GAS O2, CO2, and H2O and contains, in addition to respiratory chain proteins, numerous transport proteins that control the passage of metabolites such as ATP, ADP, pyruvate, Ca2+, and phosphate. (flashcardmachine.com)
  • Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (reactome.org)
Molecules2
  • They serve to transport molecules and other factors, such as ions, into or out of the organelles. (wikipedia.org)
  • 3) Which of the following macro-molecules leaves the nucleus of a eukaryotic cell through pores in the nuclear membrane? (easynotecards.com)
Compartment2
Lipids2
  • To create particular shaped cells and cell organelles, membranes must undergo deformations which are determined by the structure and elasticity of the membrane and this process is most probable driven by proteins, lipids and/or interplay of both. (db-engine.de)
  • Small angle neutron scattering (SANS) provides unique insight into biomacromolecular complexes by combining solvent contrast variation (H2O:D2O exchange) with either natural contrast between different classes of biomolecules (proteins, RNA/DNA, lipids/detergents) and/or by applying artificial contrast, i.e. deuteration of specific biomolecules. (lu.se)
Nucleotide1
  • Using cantilever tips with different cross-linker lengths, we determined the location of the nucleotide binding site inside the membrane with 1 precision. (uni-linz.ac.at)
Substances1
  • This being the case, the action would be mediated by the permeability of its membranes, through the formation of the mitochondrial permeability transition pore, and would involve phenomena such as the dissipation of the mitochondrial electrochemical potential and the release of substances from within it. (lu.se)
Metabolism4
  • Here, we review progress in the understanding of different subcellular metal transport components in plants and discuss the prospects of regulating cellular metabolism and strategies to develop biofortified crop plants. (frontiersin.org)
  • New members of uncoupling protein family implicated in energy metabolism. (uchicago.edu)
  • B[a]P caused enhanced metabolism of each dye assessed despite reductions in mitochondrial membrane potential and was reversed by 6-aminonicotinamide (6AN)-a glucose-6-phosphate dehydrogenase inhibitor. (cdc.gov)
  • These results demonstrate differential sensitivity of standard cytotoxicity assessments on the PPP, thus (1) decoupling 'mitochondrial activity' as an interpretation of cellular formazan and Alamar Blue metabolism, and (2) demonstrating the implicit requirement for investigators to sufficiently verify interaction of these methods in routine cytotoxicity and proliferation characterization. (cdc.gov)
Genome1
  • His studies in Transport protein integrate themes in fields like Glycerol-3-phosphate dehydrogenase, NAD+ kinase, Membrane transport, Genome and Membrane protein. (research.com)
Chloroplast1
Kinase3
  • His research in Mitochondrial carrier intersects with topics in Membrane transport, ATP-ADP translocase, NAD+ kinase and Solute carrier family. (research.com)
  • Glutamate excitation induced a rapid alteration in the AMP:ATP ratio that was associated with the activation of the AMP-activated protein kinase (AMPK). (jneurosci.org)
  • Notably, inhibition of the CaMKK (calmodulin-dependent protein kinase kinase) had little affect on GLUT translocation, whereas the inhibition or knockdown of AMPK (compound C, siRNA) activity prevented GLUT3 translocation to the cell surface after glutamate excitation. (jneurosci.org)
MeSH1
  • Uncoupling Protein 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Synthesis2
  • The _____ membrane encloses the stroma, a concentrated solution of ______, including those required for ______ synthesis. (flashcardmachine.com)
  • Cells require a constant supply of energy to perform vital functions, including nutrient uptake, protein synthesis, DNA replication, and active transport across cell membranes. (microbiologynote.com)
Neurotransmitter1
  • Together with Syntaxin-1A and SNAP25, it forms the core membrane fusion machinery that is responsible for neurotransmitter release and, therefore, signal transmission between neurons. (researchgate.net)
Saccharomyces1
Cytochrome3
  • Gentaur AntibodiesOverview: Cytochrome c is a 12-15 kDa electron transporting protein located in the inner mitochondrial membrane. (caslab.com)
  • Mitochondrial steroidogenic cytochrome P450 (CYP) enzymes, such as P450 side-chain cleavage, rely on electron transfer from the redox partner ferredoxin (FDX1) for catalytic activity. (endocrine-abstracts.org)
  • Since the (re)discovery of cytochrome c (cyt c) in the early 1920s and subsequent detailed characterization of its structure and function in mitochondrial electron transport, it took over 70 years to realize that cyt c plays a different, not less universal role in programmed cell death, apoptosis, by interacting with several proteins and forming apoptosomes. (cdc.gov)
Physiological and pathological1
  • The mitochondrial transporter family (SLC25): physiological and pathological implications. (research.com)
Amino Acids2
  • All recognized mutations for AD are associated with increased deposition of amyloid-beta (Abeta), a peptide fragment comprising 39-43 amino acids that derive from the catabolism of the amyloid precursor protein (APP) molecule. (medscape.com)
  • Therefore, we designed a protein-free dispersion media containing phospholipids and amino acids in an isotonic balanced electrolyte solution, a solution for nasal and olfactory transport (SNOT). (cdc.gov)
Carnitine1
  • CACT is located in the inner mitochondrial membrane and operates a carnitine/acylcarnitine exchange across this membrane. (orpha.net)
Mice2
  • Furthermore, I will perform mouse phenotyping experiments to reveal if the loss of mitochondrial SPIRE1 function contributes to the increased fear of SPIRE1-mutant mice. (uni-regensburg.de)
  • Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. (nature.com)
Organelles1
  • Impaired cellular membrane trafficking, more particularly, axonal transport of macromolecules and organelles, is the best-characterized genetic mechanism of HSP. (medscape.com)
Lipid3
  • The tafazzin protein is involved in altering a fat (lipid) called cardiolipin, which plays critical roles in the mitochondrial inner membrane. (medlineplus.gov)
  • Specifically, we use recombinantly expressed proteins and purified native protein complexes in combination with a wide variety of model membrane systems, including planar lipid bilayers (single channel electrophysiology), giant unilamellar vesicles, lipid nanodiscs and supported bilayers. (db-engine.de)
  • Here we use the topographic and recognition (TREC) mode of an atomic force microscope to visualize UCP1 reconstituted into lipid bilayers and to analyze the ATP-protein interaction at a single molecule level. (uni-linz.ac.at)
VDAC13
  • We have recently shown that it is possible to restore the normal function of beta-cells by blocking the protein VDAC1 (Voltage-Dependent Anion Channel 1), which is dramatically increased in beta cells of people with T2D. (lu.se)
  • Studying the mechanisms underlying increased VDAC1 expression and membrane translocation in pancreatic beta cells, vascular endothelial cells, adipocytes, and macrophages in pathological conditions such as long-lasting hyperglycemia or low-grade inflammation. (lu.se)
  • The long-term goal is to develop a new class of drugs, which targets the mitochondrial protein VDAC1. (lu.se)
Cardiolipin2
  • Once altered by tafazzin, cardiolipin is key in maintaining mitochondrial shape, energy production, and protein transport within cells. (medlineplus.gov)
  • A lack of functional cardiolipin and an excess of MLCL are thought to impair normal mitochondrial shape and functions. (medlineplus.gov)
Complexes2
  • New technologies for purifying membrane-bound protein complexes in combination with cryo-electron microscopy (EM) have recently allowed the exploration of such complexes under near-native conditions. (researchgate.net)
  • In a first couple of examples, I will show how distance and shape restraints from SANS have helped to improve the uniqueness of structural models for two multi-protein-RNA complexes, in combination with NMR restraints and building blocks from crystallography [1, 2]. (lu.se)
Organelle1
  • Moreover, nonreversible mitochondrial damage targets the organelle to a specific autophagic removal, namely, mitophagy. (hindawi.com)
Bacterial1
  • After a postdoc on bacterial membrane transport at UCLA, he got his Habilitation on mitochondrial protein import again from the University of München. (hstalks.com)
Sam352
  • Sam35 caps the Sam50 β-barrel, stabilizing the core of the protein translocase. (wikipedia.org)
  • Sam50 and Sam35 are responsible for the binding of precursors of β-barrel proteins, which contain conserved β-signal that is formed by the last β-strand. (wikipedia.org)
Metabolites1