• This structure and ability is essential because it allows it to interact with ADP which will activate the Drp1 protein. (wikipedia.org)
  • Instead of a co-factor ligand, it was found that MID49 has a loop structure on its surface that allows it to physically interact with the Drp1 protein. (wikipedia.org)
  • To recap, the MID51 and MID49 are both similar proteins that recruit Drp1 protein to induce mitochondrial binary fission but they have small differences in structure which allows them to bind Drp1 in different ways. (wikipedia.org)
  • The MID49 peripheral protein will attract the Drp1 to the surface of the mitochondrial membrane which then induces endoplasmic reticulum contact. (wikipedia.org)
  • With this constriction in the middle, the MID49 keeps recruiting more and more Drp1 proteins to make a sort of chain structure to wrap around that narrowed area called the oligomeric ring. (wikipedia.org)
  • The Drp1 proteins will eventually disassociate with the MID49 proteins through hydrolysis which causes a much tighter constriction around the mitochondria. (wikipedia.org)
  • It can directly recruit the fission mediator dynamin-related protein 1 (Drp1) to the mitochondrial surface. (wikipedia.org)
  • It is regulated by the recruitment of the GTPase Dynamin-related protein 1 (Drp1) by adaptors at actin- and endoplasmic reticulum-mediated mitochondrial constriction sites. (cam.ac.uk)
  • Drp1 oligomerization followed by mitochondrial constriction leads to the recruitment of Dynamin 2 to terminate membrane scission. (cam.ac.uk)
  • We combined time-lapse microscopy and correlative light and electron microscopy to track individual mitochondria in neurons lacking the fission-promoting protein dynamin-related protein 1 (Drp1) and delineate the kinetics of PINK1-dependent pathways of mitochondrial quality control," they pointed out. (genengnews.com)
  • Furthermore we found that mHtt deregulates the levels and the subcellular distribution of fission/fusion proteins while activation of D1 receptors promotes an increase in the levels of the fission protein Drp1 and its translocation to the mitochondria. (bmj.com)
  • We demonstrated that mHtt-induced Cdk5 activation is involved in the deregulation of the Drp1 GTPase activity since its inhibition prevents the aberrant activation of this fission protein. (bmj.com)
  • The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
  • This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)
  • Notably, Debcl modulates Drp1 mitochondrial localization during apoptosis. (sdbonline.org)
  • Dynamin-Related-Protein 1 (DRP1) is known to regulate the fission/spliting of mitochondria, the powerhouse within the cells. (usda.gov)
  • In this article, we report that DRP1 proteins can also migrate to another cellular structure called endoplasmic reticulum (ER). (usda.gov)
  • Dynamin-Related-Protein 1 (DRP1) critically regulates mitochondrial and peroxisomal fission in multicellular organisms. (usda.gov)
  • To further investigate the function of DRP1 on ER-lipid droplet (LD) dynamics and the metabolic subsequences, we generated an adipose tissue-specific DRP1 knockout model (Adipo-Drp1flx/flx). (usda.gov)
  • Dynamin-related protein 1 (DRP1), a cytosolic dynamin-related GTPase, plays a central role in fission by promoting mitochondrial division through its oligomerization into multimeric spiral structures [5]. (centrodinoferrari.com)
  • among them, mitochondrial fission 1 and mitochondrial fission factor have been proposed to be involved in DRP1 recruitment, although recent in vitro studies seem to not support this hypothesis [6, 7]. (centrodinoferrari.com)
  • Aberrant mitochondrial fragmentation controlled by the mitochondrial fission protein, dynamin-related protein 1 (Drp1), may result in cell death. (ncku.edu.tw)
  • Herein, we investigated the effect of melatonin and the role of Drp1 on MPP + -induced mitochondrial fission in rat primary cortical neurons. (ncku.edu.tw)
  • We found that MPP + induced a rapid increase in the ratio of GSSG:total glutathione (a marker of oxidative stress) and mitochondrial fragmentation, Drp1 upregulation within 4 hours, and finally resulted in neuron loss 48 hours after the treatment. (ncku.edu.tw)
  • however, neurons overexpressing dominant-negative Drp1 K38A or cotreated with melatonin exhibited significantly reduced MPP + -induced mitochondrial fragmentation and neuron death. (ncku.edu.tw)
  • Moreover, melatonin cotreatment prevented an MPP + -induced high ratio of GSSG and mitochondrial Drp1 upregulation. (ncku.edu.tw)
  • The prevention of mitochondrial fission by melatonin was not found in neurons transfected with wild-type Drp1. (ncku.edu.tw)
  • These results provide a new insight that the neuroprotective effect of melatonin against MPP + toxicity is mediated by inhibiting the oxidative stress and Drp1-mediated mitochondrial fragmentation. (ncku.edu.tw)
  • Activated ERK1/2 also phosphorylates the GTPase dynamin-related protein (Drp1), which then stimulates mitochondrial fission. (cdc.gov)
  • The mitochondrial cascade hypothesis of dementia assumes mitochondrial dysfunction leading to reduced energy supply, impaired neuroplasticity, and finally cell death as one major pathomechanism underlying the continuum from brain aging over mild cognitive impairment to initial and advanced late onset Alzheimer's disease. (nih.gov)
  • We hypothesized that testosterone deprivation aggravates LV dysfunction and cardiac autonomic imbalance via the impairment of cardiac mitochondrial function and dynamics proteins, a reduction in insulin receptor function, and an increase in apoptosis in obese insulin-resistant rats. (konexionsnc.com)
  • Given that young adults born premature also demonstrate skeletal muscle dysfunction, future studies are merited to determine whether this dysfunction as well as reduced aerobic capacity is due to reduced mitochondrial oxidative capacity and metabolic dysfunction. (frontiersin.org)
  • Higher levels of SJL have been associated with lower levels of cardiorespiratory fitness, and increased incidence of cardiometabolic disease, which may be due, in part, to mitochondrial dysfunction. (wku.edu)
  • Find out how microplate readers advance research into mitochondrial dysfunction and different neurodegenerative diseases. (bmglabtech.com)
  • In this blog, we look at the relationship between mitochondrial dysfunction and neurodegenerative disease. (bmglabtech.com)
  • We also discuss how microplate readers can be used in neuroscience research to reveal the impact mitochondrial dysfunction has on health. (bmglabtech.com)
  • Many factors can contribute to mitochondrial dysfunction including genetic mutations, aging, environmental factors, nutritional deficiencies, and metabolic disorders. (bmglabtech.com)
  • Several lines of evidence suggest the involvement of mitochondrial dysfunction in Alzheimer's disease. (bmglabtech.com)
  • Evidence also points to multiple genes being linked to mitochondrial dysfunction in Alzheimer's disease. (bmglabtech.com)
  • Altered mitochondrial dynamics, including excessive fission and fusion of mitochondria, also contribute to mitochondrial dysfunction in Alzheimer's disease. (bmglabtech.com)
  • This can impair processes like mitochondrial transport and the clearance of proteins leading to bioenergetic deficits and neuronal dysfunction. (bmglabtech.com)
  • In Parkinson's disease, a strong link between mitochondrial dysfunction and disease-associated genes has been documented. (bmglabtech.com)
  • One of the underlying mechanisms of long COVID may be mitochondrial dysfunction. (mdpi.com)
  • In this issue, we generally review the mechanisms of cellular senescence in diabetic nephropathy, which involve telomere attrition, DNA damage, epigenetic alterations, mitochondrial dysfunction, loss of Klotho, Wnt/ β -catenin signaling activation, persistent inflammation, and accumulation of uremic toxins. (hindawi.com)
  • 1,2 The molecular mechanisms underlying striatal vulnerability are still unknown, but growing evidences suggest that mitochondrial dysfunction occurs during the pathogenesis of the disease. (bmj.com)
  • Mitochondrial dysfunction and oxidative stress are involved in the pathogenesis of Parkinson's disease (PD). (ncku.edu.tw)
  • Mitochondrial dysfunction weakens the ability of mesenchymal stem cells (MSCs) to repair the distal lung epithelium, which is a probable pathogenesis of IPF. (bvsalud.org)
  • This gene encodes an outer mitochondrial membrane protein that functions in the regulation of mitochondrial morphology. (wikipedia.org)
  • Mitochondrial fusion is driven by a two-step process with the outer mitochondrial membrane fusion mediated by mitofusins 1 and 2 followed by inner membrane fusion, mediated by optic atrophy 1. (cam.ac.uk)
  • Depolarized mitochondria recruit Parkin to the outer mitochondrial membrane, triggering autophagosome formation, rapid lysosomal fusion, and Parkin redistribution," the team noted. (genengnews.com)
  • The most relevant proteins involved in the mitochondrial fusion process are three GTPase dynamin-like proteins: mitofusin 1 (MFN1) and 2 (MFN2), located in the outer mitochondrial membrane, and optic atrophy protein 1 (OPA1), in the inner membrane. (centrodinoferrari.com)
  • Fusion of the outer mitochondrial membrane depends on two GTPase family members: mitofusin 1 (MFN1) and mitofusin 2 (MFN2). (centrodinoferrari.com)
  • The metabolic enhancer piracetam has been proposed as possible prototype for those compounds by increasing impaired mitochondrial function and related aspects like mechanisms of neuroplasticity. (nih.gov)
  • Dr. Sieck's team is exploring whether the age-related loss of phrenic motor neurons is due to altered mitochondrial function or changes in motor neuron autophagy and mitophagy. (mayo.edu)
  • The alteration of LD dynamics, combined with abnormal mitochondrial and autophagy functions in adipose tissue, ultimately lead to abnormalities in lipid metabolism in Adipo-Drp1flx/flx mice. (usda.gov)
  • Mfn2-mediated mitochondrial fusion promotes autophagy and suppresses ovarian cancer progression by reducing ROS through AMPK/mTOR/ERK signaling. (nih.gov)
  • Their transient and rapid morphological adaptations are crucial for many cellular processes such as cell cycle, immunity, apoptosis and mitochondrial quality control. (cam.ac.uk)
  • In mammals and C. elegans , Bcl-2 family proteins facilitate apoptosis by regulating mitochondrial dynamics but do they play a similar role during apoptosis in Drosophila ? (biologists.com)
  • Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)
  • 4 Interestingly, Cdk5 has been shown to act as a mitochondrial regulator during neuronal apoptosis. (bmj.com)
  • Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis. (bmj.com)
  • Both proteins can localize at the mitochondrion , but the way they control apoptosis still remains unclear. (sdbonline.org)
  • These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
  • STAT3 protein belongs to a group of intracellular transcription factors that mediate a variety of functions such as cellular differentiation, proliferation, and apoptosis. (biolegend.com)
  • The OPA3 protein is thought to play a role in the organization of the shape and structure of the mitochondria and in controlled cell death (apoptosis). (medlineplus.gov)
  • Fructose supplementation reduced the expression of antioxidant enzymes and altered the amount of proteins involved in mitochondrial fusion/fission in the frontal cortex. (springer.com)
  • This review provides an overview of the basic molecular mechanisms involved in mitochondrial fusion and focuses on the alteration in mitochondrial DNA amount resulting from impairment of mitochondrial dynamics. (centrodinoferrari.com)
  • MFN2 is also present in the endoplasmic reticulum, controlling its morphology and facilitating mitochondrial calcium influx from endoplasmic reticulum stores [8]. (centrodinoferrari.com)
  • These mitochondrial dynamics, they report, are dependent on caspases, the Bcl-2 family, the mitochondrial fission and fusion machinery and the autophagic machinery. (biologists.com)
  • Mitochondrial morphology is dynamic and precisely regulated by the mitochondrial fission and fusion machinery. (ncku.edu.tw)
  • In conclusion, cognitive deficits induced by chronic liquid fructose consumption are not exclusively related to increased caloric intake and are correlated with hypertriglyceridemia, impaired insulin signaling, increased oxidative stress and altered mitochondrial dynamics, especially in the frontal cortex. (springer.com)
  • Mutations in the core machinery components and defects in mitochondrial dynamics have been associated with numerous human diseases. (cam.ac.uk)
  • Mutations in these same proteins also cause hereditary forms of Parkinson's disease. (genengnews.com)
  • In addition, mutations in mitochondrial DNA have been associated with an increased risk of the disease. (bmglabtech.com)
  • Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. (centrodinoferrari.com)
  • This and other OPA3 gene mutations that cause autosomal dominant optic atrophy and cataract lead to abnormal mitochondrial function. (medlineplus.gov)
  • Costeff syndrome is caused by mutations in both copies of the OPA3 gene in each cell, leading to a complete loss of OPA3 protein function. (medlineplus.gov)
  • Therefore, this study aimed to identify a set of point mutations distributed throughout the T. solium mitochondrial genome that differentiate the African-American from the Asian genotype. (cdc.gov)
  • Jensen-Shannon and Grantham scores were computed for mutations in protein-coding genes to evaluate whether they affected protein function. (cdc.gov)
  • These mutations were distributed across the mitochondrial genome, differentiating the African-American from the Asian genotype. (cdc.gov)
  • In my master thesis, I investigated the regulation of mitochondrial motility by actin/myosin force generation. (uni-regensburg.de)
  • We also review the literature describing the main disorders associated with the disruption of mitochondrial fusion. (centrodinoferrari.com)
  • We first observed that striatal cells expressing mutant huntingtin (mHtt) present increased mitochondrial fragmentation that worsens after dopaminergic stimuli. (bmj.com)
  • Understanding the molecular mechanisms controlling mitochondrial dynamics is crucial to decipher how mitochondrial shape meets the function and to increase the knowledge on the molecular basis of diseases associated with morphology defects. (cam.ac.uk)
  • The growth cone is the site of axon extension, and it is characterized by a complex morphology wholly dependent on the actin filaments that underlie filopodia and lamellipodia formation and dynamics ( Dent and Gertler, 2003 ). (jneurosci.org)
  • Mitochondrial dynamics: overview of molecular mechanisms. (cam.ac.uk)
  • This article will describe an overview of the molecular mechanisms that govern mitochondrial fission and fusion in mammals. (cam.ac.uk)
  • For this program, therapeutic approaches to Alzheimer's disease (AD) and related dementias (ADRD) should have a focus on biological mechanisms related to mitochondrial/bioenergetics and inflammation. (alz.org)
  • including biologic or small molecule approaches) targeting mitochondrial/bioenergetics and related biological mechanisms (i.e., inflammation response). (alz.org)
  • Nakamura is senior author of the researchers' published paper in Science Advances , which is titled, " Longitudinal tracking of neuronal mitochondria delineates PINK1/Parkin-dependent mechanisms of mitochondrial recycling and degradation . (genengnews.com)
  • Mechanisms of toxicity include inhibition of enzyme activity and protein synthesis, alterations in nucleic acid function, and changes in cell membrane permeability. (medscape.com)
  • This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. (nih.gov)
  • We also did selective epitope mapping using BLAST and showed similarities and homology between spike, nucleoprotein, and many other SARS-CoV-2 proteins with the human tissue antigens mitochondria M2, F-actin and TPO. (frontiersin.org)
  • First of all, I will examine whether the mitochondrial SPIRE1 actin nucleator regulates the localization of mitochondria in neurons. (uni-regensburg.de)
  • Proteins of the Sla2p/Hip1R family bind to actin and clathrin at endocytic sites in yeast and mammals. (rupress.org)
  • These vesicles contain the mannose 6-phosphate receptor involved in targeting proteins to the lysosome, and the actin nucleating Arp2/3 complex. (rupress.org)
  • We believe the answer is probable, since some of the systemic disease clinical manifestations of COVID-19 cannot be explained solely by the binding of SARS-CoV-2 spike proteins with cell membranes of tissues that exhibit angiotensin-converting enzyme 2 (ACE2). (frontiersin.org)
  • 2018). Here, in order to understand how MreB filament dynamics affects their cellular distribution, we model how MreB filaments bind and translocate on membranes with different geometries. (elifesciences.org)
  • In the second step, fusion of the inner membranes requires a motor-like process driven by OPA1 and coordinated by various other proteins, including the prohibitins. (centrodinoferrari.com)
  • This work gives us unprecedented insight into mitochondria's life cycle and how they are recycled by key proteins that, when mutated, cause Parkinson's disease," Nakamura commented. (genengnews.com)
  • While the role of PINK1 and Parkin in mitophagy has been heavily studied in many cell types, it has been unclear whether these proteins act the same way in neurons, which are also the cells that die in Parkinson's disease. (genengnews.com)
  • The high resolution of the approach should help researchers gain a more detailed understanding of how Parkin and PINK1 affect mitochondrial degradation in Parkinson's disease. (genengnews.com)
  • In a cross-sectional study of 48 AD patients without diabetes, 20 cognitively normal diabetic patients, 16 patients with frontotemporal dementia, and 84 cognitively normal controls, researchers found that dysfunctionally phosphorylated insulin receptor substrate-1 (IRS-1), a neuronal protein, is detectable in blood using exosome-based technology and may be able to predict AD up to 10 years before the appearance of symptoms. (medscape.com)
  • Here, we investigated whether this aberrant Cdk5 signalling contributes to the striatal neurodegeneration by altering mitochondrial dynamics processes. (bmj.com)
  • This protein is found in a cellular compartment called the mitochondria, which is responsible for supplying energy to the rest of the cell and therefore plays an important role in metabolic processes. (elifesciences.org)
  • Mitochondrial fusion and fission are fundamental processes underlying cellular dynamics [1]. (centrodinoferrari.com)
  • We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens. (frontiersin.org)
  • The Toll-like receptor (TLR) family in mammals comprises a set of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain, and in the IL-1 receptor motif in the cytoplasmic domain. (novusbio.com)
  • We are fascinated by mitochondrial fission, fusion, growth, transport, and network topology, and how they contribute to energy production and mitochondrial genome maintenance. (epfl.ch)
  • METHODS: One Mexican and two Peruvian T. solium mitochondrial genomes were assembled using reads available in the NCBI Sequence Read Archive and the reference genome from China as a template. (cdc.gov)
  • It suggests that mitochondrial recycling is critical to maintaining healthy mitochondria, and disruptions to this process can contribute to neurodegeneration … Our future studies will investigate how these pathways contribute to disease and how they can be targeted therapeutically. (genengnews.com)
  • Altogether, our findings support the hypothesis that Cdk5 plays a crucial role in mitochondrial defects involved in the striatal neurodegeneration in HD. (bmj.com)
  • Mitofusin-2: Functional switch between mitochondrial function and neurodegeneration. (nih.gov)
  • Functional analysis of the dysregulated proteins indicated a significant enrichment of proteins associated with mitochondrial dynamics, cholesterol biogenesis, and protein clearance. (nih.gov)
  • A mutation that has been found in multiple people with autosomal dominant optic atrophy and cataract results in the production of a protein with the building block (amino acid) glutamine replaced with the amino acid glutamic acid at position 105 (written as Gln105Glu or Q105E). (medlineplus.gov)
  • The serine/threonine kinase protein kinase D1 (PKD1) is a stress-responsive kinase and sensor for reactive oxygen species, which can initiate cell survival through NF-κB signaling. (biologists.com)
  • Increased levels of reactive oxygen species can damage the molecular fabric of the cell including lipids, proteins, and DNA. (bmglabtech.com)
  • In addition to less ATP production and higher levels of reactive oxygen species, mitochondria in the brains of individuals with Alzheimer's disease show mitochondrial abnormalities that include altered shape, decreased density, and impaired respiration. (bmglabtech.com)
  • They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)
  • 0.05), SJL decreased expression of mitochondrial fusion proteins MFN1 and OPA1 (Main Effect - SJL, p (wku.edu)
  • CoQ is synthesized upon the mitochondrial inner membrane by an ill-defined 'complex Q' metabolon. (biorxiv.org)
  • These data indicate that the glycolytic pathway is operative in distal axons and contributes to the rate of axon extension and growth cone dynamics in the presence of NGF and that, in the absence of NGF, the axonal glycolytic pathway is required for axon maintenance. (jneurosci.org)
  • Furthermore, I will perform mouse phenotyping experiments to reveal if the loss of mitochondrial SPIRE1 function contributes to the increased fear of SPIRE1-mutant mice. (uni-regensburg.de)
  • Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
  • Our goal is to reveal the biophysical principles underlying the dynamic organization of cellular organelles and protein assemblies. (epfl.ch)
  • Inner mitochondrial membrane constriction has been proposed to be an independent process regulated by calcium influx. (cam.ac.uk)
  • Using rationally-designed peptide inhibitors to study protein-protein interactions in cell signaling. (stanford.edu)
  • Examples of research topics include biomembranes, membrane proteins, sugars, and DNA, and the interactions of these molecular complexes with drugs and other signaling molecules. (helsinki.fi)
  • By quantifying the dynamic geometry of mitochondrial constrictions, we extract the energies and forces required for division and link them to interactions with the division machinery. (epfl.ch)
  • Using a cell-specific GAL4 driver, we verify that TurboID can biotinylate the bait protein CTPS, making possible the identification of protein-protein interactions (PPIs) in individual cells. (bvsalud.org)
  • Transcription factors are proteins that regulate the transcription of genes, or the production of mRNA from DNA. (biolegend.com)
  • These effects go parallel with improvement of impaired mitochondrial dynamics shifting back fission and fusion balance to the energetically more favorable fusion site. (nih.gov)
  • Impaired fission and fusion balance can also be induced by a reduction of the mitochondrial permeability transition pore (mPTP) function as atractyloside which indicates the mPTP has similar effects on mitochondrial dynamics. (nih.gov)
  • Mitochondria are highly dynamic organelles undergoing coordinated cycles of fission and fusion, referred as 'mitochondrial dynamics', in order to maintain their shape, distribution and size. (cam.ac.uk)
  • To determine the effect of SJL on mitochondrial fission and fusion signaling in the heart, and if exercise protects the heart against SJL. (wku.edu)
  • RUNX1 was first identified as a RUNX1-ETO fusion protein in acute myeloid leukemia (AML) and is frequently mutated in AML and myelodysplastic syndrome due to chromosomal translocation. (biolegend.com)
  • These proteins take part in the fusion pathway in two consecutive steps. (centrodinoferrari.com)
  • Accordingly, improving mitochondrial function has become an important strategy to treat the early stages of this continuum. (nih.gov)
  • These findings suggest the mPTP as an important target for the beneficial effects of piracetam on mitochondrial function. (nih.gov)
  • This opens a window to explore relationships between structural dynamics and function. (curefa.org)
  • The authors concluded that the contribution of particular side chains to the conformational stability of FXN might be highly subordinated to their impact on both the protein function and the stability of the functional supercomplex. (curefa.org)
  • The encoded protein contains two different binding sites that are known to bind DNA and function as a regulator of gene transcription. (biolegend.com)
  • The OPA3 gene provides instructions for making a protein whose exact function is unknown. (medlineplus.gov)
  • None of these seem to be causing differences in mitochondrial protein function between parasites of the two genotypes. (cdc.gov)
  • Compared to control rats, male rats exposed to 14 days of postnatal hyperoxia then aged to 1 year demonstrated higher skeletal muscle fatigability, lower muscle mitochondrial oxidative capacity, more mitochondrial damage, and higher glycolytic enzyme expression. (frontiersin.org)
  • This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
  • This suggests that variants of other genes and proteins may also be involved in providing protection. (elifesciences.org)
  • Mitochondrial elongation factor 2 is a protein that in humans is encoded by the MIEF2 gene. (wikipedia.org)
  • Multiple CTPS molecules can combine to form long strands of protein called cytoophidia, which have been seen in organisms ranging from humans to bacteria. (bvsalud.org)
  • Furthermore, we are investigating the metabolic and bioenergetic changes associated with mitochondrial division on a single-organelle level. (epfl.ch)
  • AGS ATP5G1 promotes metabolic stress resilience by modulating mitochondrial morphological change and metabolic functions. (elifesciences.org)
  • These findings provide the first evidence of a protein variant that is responsible for protecting cells during the metabolic stress conditions caused by hibernation. (elifesciences.org)
  • could be used to identify and study other proteins that increase resilience to metabolic stress. (elifesciences.org)
  • In accordance with its tumor suppressor role, the Retinoblastoma protein pRb can ensure pro-apoptotic functions. (sdbonline.org)
  • Rb , or retinoblastoma protein, is a key regulator of the cell cycle, particularly during the transition from the G1 to S phases. (biolegend.com)
  • Differences in mechanical and fatigue properties of diaphragm motor units are the result of expression of different contractile proteins and mitochondrial volume densities in corresponding muscle fiber types. (mayo.edu)
  • Although characterizing T. solium genotypes is crucial to understanding the genetic epidemiology of its diseases, not much is known about the differences between T. solium mitochondrial genomes from different genotypes. (cdc.gov)
  • Small angle neutron scattering (SANS) provides unique insight into biomacromolecular complexes by combining solvent contrast variation (H2O:D2O exchange) with either natural contrast between different classes of biomolecules (proteins, RNA/DNA, lipids/detergents) and/or by applying artificial contrast, i.e. deuteration of specific biomolecules. (lu.se)
  • These mitochondrial defects can be widely rescued by Cdk5 inhibition with roscovitine or Cdk5 knockdown with siRNA transfection. (bmj.com)
  • Here we present a structure and functional analyses of a substrate- and NADH-bound oligomeric complex comprised of two complex Q subunits: the hydroxylase COQ7, which performs the penultimate step in CoQ biosynthesis, and the prenyl lipid-binding protein COQ9. (biorxiv.org)
  • C) alters the way the OPA3 gene's instructions are put together to make the protein, which results in a lack of functional protein. (medlineplus.gov)
  • Cells without any functional OPA3 protein have abnormally shaped mitochondria with reduced energy-producing capabilities. (medlineplus.gov)
  • These results demonstrate that the in vivo localization of MreB observed in many different experiments, including those examining negative Gaussian curvature, can arise from translocation dynamics alone. (elifesciences.org)
  • In a first couple of examples, I will show how distance and shape restraints from SANS have helped to improve the uniqueness of structural models for two multi-protein-RNA complexes, in combination with NMR restraints and building blocks from crystallography [1, 2]. (lu.se)
  • Here, we have investigated the proteome dynamics of central synapses in P14 Smn 2B/- mice, a model of SMA. (nih.gov)