Rapid fission and fusion of the mitochondria in cultured fibroblasts has been shown to promote the redistribution of mitochondrial green fluorescent protein (GFP) from one mitochondrion to all of the other mitochondria. (wikipedia.org)
The heterotetramer with CBR4 has NADH-dependent 3-keto acyl-acyl carrier protein reductase activity, so it plays a role in the biosynthesis of mitochondrial fatty acids. (bocsci.com)
Cytochrome c, an electron carrier protein located in the mitochondrial matrix. (expasy.org)
This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain. (expasy.org)
The members of the mitochondrial transporter superfamily are likely to have evolved from a primordial protein containing two transmembrane helices that was then triplicated. (trsneurofeedback.com)
1] "The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein. (tcdb.org)
encodes the lysosomal polytopic CLN7 membrane protein of unknown function which contains sequence similarities with the drug: H+ antiporter family DHA1 of the major facilitator superfamily (MFS) (4,12). (kentlandsinitiative.org)
Our preliminary studies indicate that elevated SDHA increases mitochondrial pyruvate carrier 1 (MPC1) protein expression, which increases pyruvate import to mitochondrial leading to reversal of the Warburg effect and suppression of cell proliferation. (grantome.com)
Facilitator superfamily2
Overexpression of the genes cadA ( cis -aconitate decarboxylase) and mfsA (Major Facilitator Superfamily Transporter) enhanced the itaconate production level by 9.4% and 5.1% in shake flasks respectively. (biomedcentral.com)
Antibodies are glycoproteins belonging to the immunoglobulin superfamily . (wikipedia.org)
ICAM-1 and VCAM-1 are members of an immunoglobulin superfamily whose members have both a transmembrane region and a cytoplasmic tail. (medscape.com)
Inner mitochon1
Later in the apoptosis cycle, an alteration of OPA1/Mgm1 activity within the inner mitochondrial membrane occurs. (wikipedia.org)
Proteins4
The process of mitochondrial fusion involves a variety of proteins that assist the cell throughout the series of events that form this process. (wikipedia.org)
Mitochondrial dynamics in different cells are understood by the way in which these proteins regulate and bind to each other. (wikipedia.org)
Mitochondrial uncoupling proteins allow dissipation of the mitochondrial proton gradient associated with thermogenesis and regulation of radical formation. (guidetopharmacology.org)
The co-chaperone Hep1 is required to prevent the aggregation of mitochondrial Hsp70 proteins. (cipsm.de)
Transporter1
Citric acidis converted into cis -aconitate by aconitase (ACO), which is transported back into the cytosol with the help of mitochondrial tricarboxylic transporter(s) (MTT) and then decarboxylated into itaconate by cis -aconitate decarboxylase (CAD). (biomedcentral.com)
We will test the effect of SDHA on increasing mitochondrial-dependent respiration and ROS generation by performing respirometry analyses. (grantome.com)
Transmembrane1
therefore, in Drosophila (fruit flies) and yeasts, the process is controlled by the mitochondrial transmembrane GTPase, Fzo. (wikipedia.org)
Intracellular2
The process of cell death involves several signaling pathways, including the autophagic-lysosomal pathway, intracellular trafficking, mitochondrial dysfunction, and the ubiquitin-proteasome system. (biomedcentral.com)
CLN7 belongs to a group of atypical solute carriers of MFS type which are located at the plasma membrane and/or in intracellular compartments (14). (kentlandsinitiative.org)
Neurons1
The significance of mitochondrial fission and fusion is distinct for nonproliferating neurons, which are unable to survive without mitochondrial fission. (wikipedia.org)
Polyketide1
Kingdom-wide analysis of the evolution of the plant type III polyketide synthase superfamily. (mpg.de)
Gene1
Many gene products that control mitochondrial fusion have been identified, and can be reduced to three core groups which also control mitochondrial fission. (wikipedia.org)
Family2
Specific membrane-anchored dynamin family members mediate fusion between mitochondrial outer membranes known as Mfn1 and Mfn2. (wikipedia.org)
However, a single dynamin family member known as OPA1 in mammals mediates fusion between mitochondrial inner membranes. (wikipedia.org)
Subfamily1
2] "Characterization of a second member of the subfamily of calcium-binding mitochondrial carriers expressed in human non-excitable tissues. (tcdb.org)
Member1
HSD17B8 (Estradiol 17 beta-dehydrogenase 8) is a member of the short-chain dehydrogenase superfamily. (bocsci.com)
Defects2
These mitochondrial dynamics, first observed over a hundred years ago are important for the health of the cell, and defects in dynamics lead to genetic disorders. (wikipedia.org)
By enabling genetic complementation, fusion of the mitochondria allows for two mitochondrial genomes with different defects within the same organelle to individually encode what the other lacks. (wikipedia.org)
Plant1
Plant Mitochondrial Carriers: Molecular Gatekeepers That Help to Regulate Plant Central Carbon Metabolism. (mpg.de)
INTERACTION1
We have analyzed the interaction of Hep1 with mitochondrial Hsp70 (Ssc1) and the determinants in Ssc1 which make it prone to aggregation. (cipsm.de)
Role1
The immediate contribution of this project is to explore the novel role of SDHA in changing mitochondrial energy metabolism to improve ovarian cancer patient survival by suppressing of tumor growth and/or increasing the effectiveness of chemotherapy to kill tumor cells. (grantome.com)
Repeat1
From the abstract: 'Genome sequencing (GS) is one of the most comprehensive assays that interrogate single nucleotide variants, copy number variants, mitochondrial variants, repeat expansions, and structural variants in one assay. (cdc.gov)
Activity1
An increase in fusion activity leads to mitochondrial elongation, whereas an increase in fission activity results in mitochondrial fragmentation. (wikipedia.org)
Storage1
In these mice, loss of Cln7 leads to (i) autofluorescence and lysosomal storage of subunit c of mitochondrial ATP synthase and saposin D in the brain and retina, (ii) neurodegeneration in the olfactory bulb, cerebellum, cortex and retina, (iii) neuroinflammation, as well as (iv) reduced lifespan of mutant mice (19). (kentlandsinitiative.org)
Cell1
The changes in balance between the rates of mitochondrial fission and fusion directly affect the wide range of mitochondrial lengths that can be observed in different cell types. (wikipedia.org)
Data1
From a comprehensive analysis of metabolic pathways in our patient-derived ovarian tumors and The Cancer Genome Atlas (TCGA) data, we discovered that a key mitochondrial enzyme, succinate dehydrogenase (SDHA), is significantly upregulated in 19% of ovarian cancer patients, and is associated with significantly improved patient survival. (grantome.com)