• We are curious about whether suppression of excessive HDACs activity in diabetic heart protects against MI/R injury. (hindawi.com)
  • The purpose of this chapter is to present the current literature examining the role of mitochondria and metabolism in the healthy right heart, treatments to target deficits in the failing RV, and to identify knowledge gaps for future research in this clinically important area. (intechopen.com)
  • The Heart Foundation is a national leader in research into the causes, treatment and prevention of heart disease and related disorders. (heartfoundation.org.au)
  • Although critical to life, energy production is not the only function of mitochondria, and the composition of this organelle is tailored to meet the specific needs of each cell type. (mcponline.org)
  • Indeed the intimate association of mitochondria with the myofilaments minimizes diffusion distance and facilitates conversion of chemical energy to mechanical work. (mcponline.org)
  • The number and morphology of cristae are likely to reflect the response of the mitochondria to the energy demands of the cell. (mcponline.org)
  • Mitochondria are energy-generating structures found in the cells of complex organisms which possess their own much smaller genome. (newscientist.com)
  • It was shown that the level of 2′,3′-cyclicnucleotide-3′-phosphodiasterase (CNPase), which is capable of protecting cells in aging, increased in acute heart failure. (nih.gov)
  • MEL also retained the CNPase content in RHM both in control experiments and after ISO-induced heart damage. (nih.gov)
  • While LV failure is the most common form of HF, it is the ability of the right heart to function that predicts survival in many clinical settings. (intechopen.com)
  • ROS like superoxide, hydrogen peroxide, peroxynitrite and hydroxyl radicals all damage mitochondrial proteins, lipids, and DNA, impairing the proper function of the mitochondria. (holisticprimarycare.net)
  • 100 g monoclonal antibody which can immunocapture up to 50 g of Complex V from heart mitochondria. (bio-medicine.org)
  • When β-oxidation of hexadecanoyl-CoA in state III rat heart mitochondria was inhibited by titration of complex III activity, flux measured as 14 CO 2 release, acid-soluble radioactivity or as acetyl-carnitine was progressively decreased. (biochemj.org)
  • Heart failure (HF) is a clinically complex and heterogenous disease characterized by an inability of the heart to pump sufficient blood to the periphery. (intechopen.com)
  • While HF constitutes a complex syndrome of diseases, it generally refers to the inability of the heart to pump sufficient blood to the periphery. (intechopen.com)
  • The sequential transport mechanism of the aspartate/glutamate carrier, elucidated both in proteoliposomes and in mitochondria, also seems to be a common characteristic of other mitochondrial antiport carriers. (uni-bielefeld.de)
  • However, little is known about the mechanism of uptake in heart tissue. (naver.com)
  • As an organelle, the mitochondrion has been a popular subject for proteomic analysis, but quantitative proteomic methods have yet to be applied to tease apart subtle differences among mitochondria from different tissues or muscle types. (mcponline.org)
  • Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon. (nih.gov)
  • Basal (substrate alone) and maximum rates of H2O2 production, oxygen consumption and free radical leak in the respiratory chain were higher in heart mitochondria of the short-lived rat (4 years) than in the long-lived pigeon (35 years). (nih.gov)
  • Sign up and keep up to date with the best heart health tips, healthy recipes and our latest news - all in your inbox. (heartfoundation.org.au)
  • This goes hand-in-hand with what Cassie was talking about when it comes to heart health and cholesterol. (oneliferadio.com)
  • Plasma levels of CoQ10 are an independent predictor of survival in a cohort of patients with chronic heart failure. (inl.asia)
  • Please click here to visit my Zazzle store to purchase uniquely designed items from Stomach-vs-Heart: The Art of Survival. (stomach-vs-heart.com)
  • Type IIb fibers rely upon anaerobic glycolysis, contain few mitochondria, and have high levels of glycogen ( 3 ). (mcponline.org)