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  • miRNA
  • showed that there is dysregulation of miRs in PBMCs of HF patients and reported a specific miRNA signature in PBMCs of HF patients.11 They also showed that miRs alterations in PBMCs from HF patients do not mirror or overlap with cardiac miRs changes, suggesting that PBMCs may have their unique miRs signature in response to cardiac function. (deepdyve.com)
  • An exploratory miRNA analysis of 666 miRs by low density microRNA arrays was conducted on formalin fixed and paraffin embedded tissues (FFPE) from 10 older adults and 10 young adults including conventional melanoma and melanocytic neoplasms of uncertain biological significance. (nih.gov)
  • protein
  • We further identified CUG triplet repeat RNA-binding protein 2 (CUGBP2) as the downstream target of miR-95. (jove.com)
  • In reality, PP2A is not a single enzyme but rather a family of protein phosphatases that vary in the substrates they target, in the cell types where they are expressed, in the cellular compartments where they are found, and how they are regulated ( 1 - 5 ). (frontiersin.org)
  • In human cells and mouse hearts, carvedilol upregulates a subset of mature and pre-miRs but not their pri-miRs in β 1 AR-, G protein-coupled receptor kinase 5/6- and β-arrestin1-dependent manner. (ahajournals.org)
  • MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU PloS One. (jove.com)
  • Genomic PCR, reverse transcriptase-PCR (RT-PCR), and immunofluorescence microscopy confirmed the loss of Nopp140, its messenger RNA (mRNA), and protein products from all tissues examined. (jove.com)
  • Cells
  • Allorecognition of fetal placental cells by uNK cells is emerging as the key maternal-fetal immune mechanism that regulates placentation. (jci.org)
  • We identified microRNAs (miRs) that are regulated by EZH2 and studied their functions in PDAC cells. (jove.com)
  • However, little is known regarding the possible role of miRs during the physiologic development of human T cells or their significance in T cell-derived malignancies. (unipd.it)
  • In parallel, in order to deepen our knowledge about microRNA expression in T lymphoid cells, smallRNA libraries were generated from total RNA of unsorted thymocytes, DP thymocytes, CD4+ and CD8+ mature peripheral blood lymphocytes. (unipd.it)
  • We cultured HK-2 cells in control or high-glucose medium for 48 hours before quantifying miRs by mirVana Array. (asnjournals.org)
  • The self-renewal of leukemia stem cells depends on the activation of a microRNA-editing enzyme called ADAR1. (pharmaceuticalintelligence.com)
  • Delving into the mechanisms by which leukemia stem cells are primed, a team of scientists at the University of California, San Diego (UCSD), uncovered a misfiring RNA-editing system. (pharmaceuticalintelligence.com)
  • The article presented the first mechanistic link between pro-cancer inflammatory signals and RNA editing-driven reprogramming of precursor cells into leukemia stem cells. (pharmaceuticalintelligence.com)
  • In this study, we showed that cancer stem cells co-opt a RNA editing system to clone themselves. (pharmaceuticalintelligence.com)
  • While studies have shown that miRs can regulate the activity and interplay of vascular inflammatory cells, endothelial cells, smooth muscle cells and fibroblasts, all key elements leading to AAA formation, much work remains to be done. (stanford.edu)
  • By applying shear stress waveforms biomimetic of these in vivo hemodynamics to endothelial cells (ECs) in vitro , we identified several mechanosensitive miRs (-100, -199a, and -146a,) as potential negative regulators of arteriogenesis. (frontiersin.org)
  • miR-20a promotes migration and invasion by regulating TNKS2 in human cervical cancer cells," FEBS Letters , vol. 586, no. 6, pp. 897-904, 2012. (hindawi.com)
  • To identify function, expression levels or activity of miRs are modulated to observe the effects on cells. (mdpi.com)
  • Endothelial progenitor cells (EPCs) have shown the potential for treating ischemic stroke (IS), while microRNA-126 (miR-126) is reported to have beneficial effects on endothelial function and angiogenesis. (hindawi.com)
  • Other studies have identified that miR-125b and miR-326 regulate in several cells through suppressing the EMT process ( 18 - 20 ). (spandidos-publications.com)
  • C, E2F3 and PLK1 mRNA expression by qRT-PCR in PrE cells 24H after transfection with anti-miRs (25nM) and 24 H treatment with ethanol or 1,25D (n=5). (nih.gov)
  • mRNA
  • AU-rich elements (AREs) bind specific proteins to regulate mRNA stability or translation in response to external and internal stimuli ( 1 ). (sciencemag.org)
  • metastatic
  • MiR-211 was dramatically downregulated compared to nevi controls, decreased with increasing age and was among the miRs linked to metastatic processes. (nih.gov)
  • lncRNA
  • Interestingly, miR-205 is encoded within a long non-coding RNA (lncRNA), 4631405K08Rik. (jimmunol.org)
  • angiogenesis
  • Here, we tested whether miR-146a regulates in vitro angiogenic endothelial cell (EC) behaviors, as well as perfusion recovery, arteriogenesis, and angiogenesis in response to femoral arterial ligation (FAL) in vivo . (frontiersin.org)
  • sequences
  • In order to identify known and new candidate miRNAs among the short-RNA sequences, a computational pipeline was developed. (unipd.it)
  • MicroRNA sequences: wild-type miR369-3, seed mutant miRseedmtR369-3 (complementary to mtAREseed1 and mtAREseed2), and miRmt369-3 (complementary to mtARE). (sciencemag.org)
  • expression
  • Unique microRNA expression in the colonic mucosa during chronic HIV-1 infection. (physiciansweekly.com)
  • We identified expression of 103 of 328 microRNAs but did not observe glucose-induced changes in expression. (asnjournals.org)
  • 4 ), variations in miR expression in nonmalignant disease are not well explored, in part because standard diagnostic techniques in nonmalignant disease yield RNA quantities that are challenging to use for hybridization array-based miR profiling. (asnjournals.org)
  • We detected 103 of 328 human miRs examined ( Figure 1 A. For a complete listing of expression data, see supplemental data). (asnjournals.org)
  • Diet and genetics control the expression of obesity-regulated miRNAs in the visceral adipose of NZ10 mice. (omicsonline.org)
  • MiR-205 positively regulated Foxn1 transcription factor expression, the master regulator of TEC development and function. (jimmunol.org)
  • proteins
  • Nineteen hyperosmotic responsive proteins were detected (10 up-regulated and 9 down-regulated proteins) after 6h post FW to SW transfer. (jove.com)
  • We show that human microRNA miR369-3 directs association of these proteins with the AREs to activate translation. (sciencemag.org)
  • target
  • These miRs were further shown to directly target IL-6 and STAT3, respectively, with similar changes confirmed in an ex-vivo explant infection model. (physiciansweekly.com)
  • several
  • Despite there being only limited studies available, several other miRs also display clear potential for alteration of the disease process including miR-26a, the miR-17-92-cluster, miRs-221/222, miR-133 and miR-146a. (stanford.edu)
  • Several microRNAs (miRs) have been identified in the thymus based on their ability to mitigate the stress damage. (jimmunol.org)
  • hypoxia
  • We show miR-210-3p, miR-1275, miR-376c-3p, miR-23b-3p, miR-193a-3p and miR-145-5p to be up-regulated, while miR-92b-3p, miR-20a-5p, miR-10b-5p, miR-181a-2-3p and miR-185-5p are down-regulated by hypoxia. (biomedcentral.com)