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  • miScript
  • The Dog miFinder miScript miRNA PCR Array profiles the expression of the 84 most abundantly expressed and best characterized miRNAs in miRBase (www.miRBase.org). (qiagen.com)
  • The Human Cancer PathwayFinder miScript miRNA PCR Array profiles the expression of 84 miRNAs differentially expressed in tumors versus normal tissue. (qiagen.com)
  • miRNome
  • This set of known miRNAs for a given species (miRNome) is still small enough to easily screen the expression of all miRNAs in an experimental condition. (qiagen.com)
  • cause or indicator
  • Overwhelming evidence indicates that dysregulation of miRNA expression is a cause or indicator of several disease processes, including many cancers. (qiagen.com)
  • RNAs
  • As a consequence, in somatic mammalian cells it is observed a predominance of miRNA expression compared to other small RNAs [ 7 ]. (hindawi.com)
  • In fact, miRNAs are one of the most well-characterized small RNAs, although much about them still remains unclear. (hindawi.com)
  • transcripts
  • Overexpression of the 3′-untranslated regions (UTRs) of Per1 and Per2 in MEFs also reduced circadian periodicity, presumably by competing with endogenous Per1 and Per2 transcripts for binding to miRNAs. (sciencemag.org)
  • These findings imply that miRNA-mediated inhibition of translation of PER1 and PER2 may slow cytoplasmic accumulation of these proteins, thereby accounting for the observed delay between the accumulation of Per transcripts and PER proteins. (sciencemag.org)
  • siRNA
  • SMi is proud to present its 6th conference on RNAi, miRNA and siRNA which shall tackle some of the most prominent issues that stand in the way of the successful harnessing of the vast potential that the process possesses. (smi-online.co.uk)
  • Differentiation
  • Title: Differentiation therapy for GBM through synergic action of 11 miRNAs/drugs delivered via lipid/polymeric nanoparticles. (iit.it)
  • miRNAs play an important role in many biological processes, including differentiation and development, cell signaling, and response to infection, mostly by regulating genes involved in these processes. (qiagen.com)
  • This review highlights the roles of mechanosensitive miRNAs in osteogenic differentiation and bone formation and underlines their potential therapeutic application for bone loss induced by the altering of mechanical stimuli. (mdpi.com)
  • molecules
  • For these reasons, miRNAs were classified as a major class of gene regulatory molecules with expectancy of over 30% of human coding genes been directly regulated by them [ 11 ]. (hindawi.com)
  • MiRNAs are a class small, single-stranded noncoding RNA molecules that control the expression of target genes mainly at the post-transcriptional level. (iit.it)
  • Our lab contributed to uncover a prominent role for miRNAs as regulatory molecules that orchestrate gene expression in brain development, function and dysfunction. (iit.it)
  • Exosomes are extracellular membrane vesicles involved in cell-cell communication by shuttling various molecules including miRNAs from donor to recipient cells [ 10 ]. (hindawi.com)
  • prediction
  • Based on sequence analysis, miRNAs miR-24, miR-29a, and miR-30a were predicted to target the 3′ UTRS of Per1 and Per2 , and experiments with mutated Per1 and Per2 3′ UTRs coupled to fluorescent reporters were consistent with this prediction. (sciencemag.org)
  • cancers
  • Overwhelming evidence indicates that dysregulation of miRNA expression is a cause or indicator of several disease processes, including many cancers. (qiagen.com)
  • serum
  • The discovery that circulating miRNAs are detectable in serum and plasma, and that their expression varies as a result of disease, presents great potential for circulating miRNA expression signatures to be used as biomarkers in disease diagnosis and prevention. (qiagen.com)
  • They identified 14 miRNAs that were exclusively present in serum from patients with low-grade compared with high-grade prostatic cancer. (abcam.com)
  • Mirne
  • Zapadni krak "istarskog ipsilona" i most preko Mirne" [Western arm of Istrian Y and the Mirna Bridge] (PDF). (wikipedia.org)
  • Vijadukt preko Mirne na istarskoj brzoj cesti" [Viaduct across Mirna on the Istrian expressway] (in Croatian). (wikipedia.org)
  • functionally
  • Functionally verifying a biological or mechanistic effect of a specific miRNA's expression remains one of the major challenges in miRNA research. (qiagen.com)
  • inhibition
  • Optimal miRNA inhibition is provided after transfection due to the robust secondary structure of the inhibitor that is based upon the synthetic 'Tough Decoy' (TuD) 2 molecule. (sigmaaldrich.com)
  • regulation
  • Little is known about the regulation of miRNAs and understanding the events that lead to changes in their expression may provide new perspectives for cancer treatment. (hindawi.com)
  • Combinatorial regulation is a feature of miRNA regulation. (pearltrees.com)
  • This type of analysis is a key step towards improving our understanding of the complexity and mode of miRNA regulation. (pearltrees.com)
  • lipid
  • The packaging of miRNAs within the exosomal lipid bilayers protects them from enzymic degradation by body fluids resulting in a relatively long and stable duration of expression [ 11 , 12 ]. (hindawi.com)
  • expression
  • These alterations encompass reduction of piRNAs and siRNAs expression with a simultaneity increase of miRNA expression. (hindawi.com)
  • They demonstrated that miRNA lin-4 negatively regulates LIN-14 protein expression and it is indispensable for normal progress of postembryonic developmental events in this worm [ 8 ]. (hindawi.com)
  • This set of known miRNAs for a given species (miRNome) is still small enough to easily screen the expression of all miRNAs in an experimental condition. (qiagen.com)
  • Success of miRNA expression research relies on access to high-performance tools and technologies. (qiagen.com)
  • As miRNA research has expanded into a huge number of disease areas, it has become clear that expression levels of certain miRNAs are altered in many diseases. (abcam.com)
  • Alongside altered expression under different disease states, miRNAs have other features that make them ideally suited as biomarkers. (abcam.com)
  • As an example, two recently published papers have identified differences in miRNA expression in prostate cancer. (abcam.com)
  • Introduction Deep Sequencing technologies (Next Generation Sequencing) are increasingly used to obtain a more accurate depiction of miRNA expression profiles in living cells. (pearltrees.com)
  • Our package implements common steps taken in the analysis of such data, as well as adds unique features, such as data statistics and multiple mapping levels, generating a novel platform for the analysis of miRNA expression. (pearltrees.com)
  • The differential expression of exosomes and of exosomal miRNAs in disease has driven their promise as biomarkers of disease enabling noninvasive clinical diagnosis in addition to their use as therapeutic tools. (hindawi.com)
  • mRNAs
  • It is predicted that over 30% of mRNAs are regulated by miRNAs. (hindawi.com)
  • In contrast, animal miRNAs are able to recognize their target mRNAs by as little as 6-8 nucleotides (the seed region) at the 5' end of an animal miRNA. (pearltrees.com)
  • apoptosis
  • However, miRNAs can be detected in the circulation and in cerebrospinal fluid and are recognized by Toll-like receptor 7 (TLR7), and extracellular application of the miRNA let-7b triggers TLR7-mediated apoptosis of cortical neurons. (sciencemag.org)
  • diagnosis
  • Therefore, this review aims to discuss new findings about miRNAs in melanoma fields, underlying epigenetic processes, and also to argue possibilities of using miRNAs in melanoma diagnosis and therapy. (hindawi.com)
  • target
  • Exosomal miRNAs delivered to target cells can significantly affect biological pathways within target/recipient cells resulting in altered cellular function and the development of a pathological state [ 11 ]. (hindawi.com)