Mirna genes cdk6. Medical search. Frequent questions

This study aimed to identify the role of AA in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cell (VSMC) behaviours and to explore the effects of microRNAs (miRNAs). (hindawi.com)
MicroRNAs (miRNAs) are small noncoding sequences involved in the negative regulation of gene expression. (hindawi.com)
MicroRNAs (miRNAs) are associated with cytogenetics and molecular subtypes of acute myelogeneous leukemia (AML), but their impact on AML pathogenesis is poorly understood. (ashpublications.org)
SncRNAs are less than 200 nt in length, consisting of microRNAs (miRNAs), Piwi-interacting RNAs (piRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs) and transcription initiation RNAs (tiRNAs) [ 6 ]. (ijbs.com)
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
In this issue of Blood , Malouf et al characterize 2 microRNAs (miRNAs) that are effectors of malignant transformation by the MLL-AF4 fusion protein. (ashpublications.org)
MicroRNAs (miRNAs) are small noncoding RNAs that can function as either powerful tumor promoters or suppressors in numerous types of cancer. (biomedcentral.com)
In our research, microRNAs (miRNAs) binding to the genome sequences of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory-related coronavirus (MERS-CoV), and SARS-CoV-2 were identified by bioinformatic tools. (molcells.org)
MicroRNAs (miRNAs) are a class of small non-coding RNA, 20-22 nucleotides in length. (molcells.org)
MicroRNAs (miRNAs) are short (about 21 nucleotides long) strands of non-coding RNA that regulate the expression of multiple genes [ 1 ]. (biomedcentral.com)
Recent studies have shown that microRNAs may regulate the ABCB1 gene (ATP-binding cassette, sub-family B [MDR/TAP], member 1). (biomedcentral.com)
MicroRNAs (miRNA) are endogenous, noncoding RNAs that direct gene repression by inhibiting the mRNA stability or translation [ 2 ]. (biomedcentral.com)
Additionally, as competitive endogenous RNAs (ceRNAs), lncRNAs and messenger RNAs (mRNAs) can regulate one other by competing for the shared microRNAs (miRNAs/miRs) ( 14 , 15 ). (spandidos-publications.com)
MicroRNAs (miRNAs) are a kind of small noncoding RNAs that regulate the expression of protein through targeting the 3′UTR of messenger RNA (mRNA), resulting in mRNA degradation or suppression of translation [ 5 ]. (degruyter.com)
MicroRNAs (miRNAs) have been proven to regulate the development and progression of cancer through various mechanisms. (bjbms.org)

miRNAs are a recently discovered class of small evolutionary highly conserved non-coding RNAs of 18-25 nucleotides length which are generated by sequential processing of primary PD173955 and Mouse monoclonal to alpha Actin precursor miRNA by the ribonucleases Drosha and Dicer1. (careersfromscience.org)
Circular RNAs (circRNAs) are a new member of noncoding RNAs (ncRNAs) that have recently been described as key regulators of gene expression. (biomedcentral.com)
Some circRNAs contain miRNA response elements (MREs) and function as competing endogenous RNAs (ceRNAs) to interact with miRNAs and regulate the expression of target mRNAs. (biomedcentral.com)
As a group, miRNAs are small (17-27 nucleotides) noncoding RNAs that govern gene expression in a post-transcriptional manner by binding directly to the 3′UTRs of target mRNAs, thereby repressing their translation or inducing their degradation [ 6 ]. (biomedcentral.com)
With the accurate identification of m7G modifications within RNAs, their functional roles in the regulation of gene expression and different physiological functions have been revealed. (beds.ac.uk)
Using the GSE2223 and GSE59612 datasets, and RNA sequencing data of GBM from The Cancer Genome Atlas, differentially expressed (DE) genes including DE messenger RNAs (DEmRNAs) and DElncRNAs between GBM and normal controls were identified. (spandidos-publications.com)
More recently, small interfering RNAs are effective in inducing endogenous RNase of the RNA-induced silencing complex in the RNA interference pathway to inhibit gene expression and growth of several human viruses (5,10,11). (azd1152.com)
Equally unclear is usually whether the EGS RNAs are effective in blocking HCMV gene expression and replication. (azd1152.com)

The miR-129 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. (wikipedia.org)
More importantly, circRNAs serve as microRNA (miRNA) sponges and crucial regulators of gene expression. (ijbs.com)

1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
There is evidence to suggest that miR-129 directly targets Cdk6, cyclin dependant kinase 6- a cell proliferation regulator. (wikipedia.org)
A) HACAT cells were transiently transfected with Dicer1 siRNA (50 nM) or non-target control siRNA synchronized in serum-free medium for 48 h and harvested … Both p53 and miRNAs feed into the cyclin/CDK-driven cell cycle clock. (careersfromscience.org)
This finding is of utmost importance since p53 is known to be key for p21 expression.2 The results reported here suggest that depletion of Dicer1 restores p21 expression in p53-mutated cells and that miRNA critically contributes to cell cycle regulation at least in part through intervening with the cyclin/CDK system and its inhibitors. (careersfromscience.org)
p15INK4B is a member of your INK4 family members of CDK inhibitors, which binds to CDK4 and CDK6 subunits, inactivates their catalytic ac tivity and prevents cyclin D CDK4 six complex formation. (mirnaarray.com)

As a consequence, any modulations of the target transcript expression, miRNAs can affect various signalling pathways and cellular process such as apoptosis, proliferation or differentiation. (ukessays.com)
Keywords: Dicer p21 cell cycle apoptosis HACAT miRNA signaling pathway p53 5 Introduction p53 is a versatile transcription factor which integrates information from unbalanced mitotic oncogenic or metabolic stress into graded cellular responses such as cell cycle arrest senescence DNA repair block of angiogenesis or apoptosis. (careersfromscience.org)
A significant enrichment for apoptosis genes, including MCL-1 , was found among the mRNAs inversely correlated with miR-29b expression in 45 primary AML samples. (ashpublications.org)
Scientists consider this data to be able to solve many more answers in the longer run like how to get additional miRNAs under control of DNA methylation, or the influencing cell cycle and apoptosis. (mbpinc.net)
overexpression of these genes decreased proliferation or induced apoptosis of human MLL-AF4 + ALL cell lines, respectively. (ashpublications.org)

What pathways are this gene/protein implicaed in? (cancerindex.org)
A series of cellular pathophysiological mechanisms involved in AS (e.g., differentiation, proliferation, and signalling pathways) are under the control of miRNAs. (hindawi.com)
Scientists further worked showed that despite of the differences between cell lines in the gene expression level, the miRNAs-gene network is very slightly influenced or disrupted in these pathways. (mbpinc.net)
On the other hand, the miRNAs examined in this study can also be used to target other genes and pathways. (mbpinc.net)
The ability of miRs to target multiple genes and biological signaling pathways has created intense interest in their potential clinical utility as predictive and diagnostic biomarkers, and as innovative therapeutic agents. (biomedcentral.com)
Indeed, emerging evidence indicates that miRNAs function as a molecular rheostats that serve in fine-tuning cell signaling pathways [ 10 , 11 ], doing so by modulating the expression of large numbers of genes and, consequently, impacting the flux through essential regulatory nodes of vast signaling networks. (biomedcentral.com)
In PDAC, miRNAs have been demonstrated to modulate key targets and pathways such as KRAS, TP53, PI3K/AKT, NF-κB and Hedgehog signaling, and their aberrant expression is associated with chemoresistance (14). (biomedcentral.com)

Be it for development, differentiation, stemness, or sex chromosome dosage compensation, stable, cell specific regulation of gene expression is essential for normal function ( 1 ). (aacrjournals.org)
Indeed, early cancer research focused on the fact that neoplastic cells have aberrant gene expression and differentiation states, pointing to shared mechanisms between normal development and cancer ( 2 ). (aacrjournals.org)

(B) effect of miR-503 on the expression of endogenous genes. (biomedcentral.com)
Based on the competing endogenous RNA hypothesis, DElncRNA‑micro RNA (miRNA)‑DEmRNA interactions were obtained by target gene prediction. (spandidos-publications.com)
Importantly, circRNAs usually bind miRNAs to modulate the levels of downstream proteins, acting as competing endogenous RNA (ceRNA) and participating in tumor progression [ 11 ]. (biomedcentral.com)

A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
Conversely in the over expression of miR-129, proliferation of endometrial tumour cells is significantly reduced via the down regulation of Cdk6. (wikipedia.org)
SOX4, SRY-related HMG box 4 gene - an oncogene that is known to be deregulated in a number of cancers, is another target of miR-129 in which the aberrant regulation of miR-129 contributes to the proliferation of cancer cell lines. (wikipedia.org)
miR-128-5p directly targeted the 3′UTR-binding sequences of the p21 gene, negatively regulated p21 expression, and supported the proliferation of VSMCs. (hindawi.com)
Our research showed that the migration, phenotypic transformation, and proliferation of ox-LDL-induced VSMCs were repressed by AA through inhibiting miR-128-5p by targeting the p21 gene, which may provide an effective option for the treatment of atherosclerosis. (hindawi.com)
Several studies have shown that miRNAs play multiple roles in the phenotypic transformation, migration, and proliferation of VSMCs by inhibiting ERK1/2 activation [ 11 , 12 ], partly by regulating the tissue inhibitor of metalloproteinases (TIMPs)-MMPs and p21-cyclins interactions [ 13 - 18 ]. (hindawi.com)
Transfection with candidate miRNAs mimics significantly decreased neuroblastoma cells proliferation rate. (oncotarget.com)
miRNA-21 promotes proliferation and invasion of triple-negative breast cancer cells through targeting PTEN[J]. Am J Transl Res, 2017, 9: 953-961. (magtechjournal.com)

Therefore, miRNAs could consider as cancer targets. (ukessays.com)
miR-128-5p targets the tissue inhibitor of metalloproteinases (TIMPs), silent information regulator 2 (SIRT2), peroxisome proliferator-activated receptor (PPAR), and p21 genes, which are linked to the behaviours of VSMCs. (hindawi.com)
Our data strongly suggest that CDK6, DNMT3A, DNMT3B are targets of miR-29a-3p, while CCNE2 and E2F3 are targets of miR-34b-3p. (oncotarget.com)
Based on all these data, we propose that miR-29a-3p, miR-34b-3p, miR-181c-5p and miR-517a-3p are disallowed tumor suppressor genes in neuroblastoma and suggest them as new therapeutic targets in neuroblastoma. (oncotarget.com)
Results of these studies have led to the identification of a novel model for interplay between Myc, HDAC3, PRC2, and miRNAs and their contribution to Myc-associated lymphomagenesis, and HDAC3/EZH2/miRNAs as novel therapeutic targets. (oncotarget.com)
Also, miRNAs have the ability to influence the expression of several targets. (mbpinc.net)
As a result, the gene targets can be regulated with the help of a plethora of different miRNAs, simultaneously. (mbpinc.net)
This creates a great network of miRNAs-targets that greatly enhances the complexity of gene regulation. (mbpinc.net)
This also showed that there is an inverse correlation between methylation statuses of the above mentioned miRNAs along with the expression of their gene targets. (mbpinc.net)
Here we highlight prominent miRNAs that may represent potential therapeutic targets in human malignancies, as well as review current technologies available for inactivating or restoring miRNA activity in clinical settings. (biomedcentral.com)
Current debates in the field include the importance of miRNAs in general and their utility as targets in preventing tumorigenesis (Blood 119:513-520, 2012). (biomedcentral.com)

miR-34a inhibits CDK2 CDK4 and CDK6 as well as E2F a transcription factor that after release from the retinoblastoma tumor suppressor Rb initiates S-phase entry. (careersfromscience.org)

Involvement of several miRNAs in its pathogenesis has been ascertained. (oncotarget.com)
Overall, we identified several miRNAs with significantly altered expression in primary melanomas, including those reported for the first time in this type of cancer. (bjbms.org)

The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. (cancerindex.org)

Recently, accumulating preclinical studies have illustrated the feasibility of slowing tumor progression by either overexpressing tumor suppressive miRNAs, or by neutralizing the activities of oncogenic miRNAs in cell- and animal-based models of cancer. (biomedcentral.com)
In terms of resistance of PDAC to chemotherapeutic treatment, miR-21 is one of the most investigated oncogenic miRNAs related to gemcitabine resistance. (biomedcentral.com)

We recently explored the role of epigenetic regulation in Myc-mediated miRNA repression [ 5 ]. (oncotarget.com)
These miRNAs are known to be the "epigenetic controllers" since they impact gene expression without brining any changes in the genomic sequence. (mbpinc.net)
Just like the protein coding genes, miRNAs are also influenced to epigenetic changes and regulation by DNA methylation in their respective promoter regions. (mbpinc.net)
Although resistance is rather complex, emerging evidence has demonstrated that epigenetic alterations (e.g. miRNA) have important roles in PDAC progression as well as resistance to therapy. (biomedcentral.com)
Based on a large body of growing evidence, we know PDAC resistance is regulated, at least in part, by epigenetic alterations including miRNA. (biomedcentral.com)

Altered expression of this gene has been observed in multiple human cancers. (cancerindex.org)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
As miRNAs proposed to control the expression up to one third of all genes and possibly utilised as diagnostic and prognostic marker for many genetic based diseases. (ukessays.com)
But the idea of stably changing gene expression in vivo has transformative potential in cancer therapy and beyond. (aacrjournals.org)
Cells have built in machinery to turn off and on gene expression permanently. (aacrjournals.org)
Starting from a high-throughput expression profiling of 754 miRNAs and based on a proper selection, we focused on miR-29a-3p, miR-34b-3p, miR-181c-5p and miR-517a-3p as candidate miRNAs for our analysis. (oncotarget.com)
Therefore, it is likely that Myc hyperactivity contributes to widespread repression of miRNA expression and that Myc-driven miRNA repression underlies the molecular mechanisms related to lymphoma aggressive transformation. (oncotarget.com)
Notably, circRNAs display cell-type, tissue-type and developmental-stage specific expression patterns in eukaryotic transcriptome, which reveals their significant regulatory functions in gene expression. (ijbs.com)
ncRNAs play important roles in controlling gene expression at both transcriptional and post-transcriptional levels. (ijbs.com)
These miRNAs are around 22 nucleotides in size that are central and negative regulators of gene expression. (mbpinc.net)
Moreover, the block expression at the post-transcriptional levels and transcriptional levels, on the basis of perfect or imperfect match in sequences among miRNAs and target genes is also there. (mbpinc.net)
Changed and manipulated expression of miRNAs is commonly seen in several pathological conditions like cancer. (mbpinc.net)
As a result, the functionalities of DNA methylation are highly dependent on context and therefore have a completely opposite impact on gene expression, especially if it happens in the promoter of a coding gene or a miRNA. (mbpinc.net)
This reveals that DNA methylation regulates gene expression on a rich profusion of levels, and regulates cell homeostasis along with cancer progression. (mbpinc.net)
The expression levels of circRNAs, mRNAs and miRNAs in human tissues and cells were detected by quantitative real-time PCR (qRT-PCR). (biomedcentral.com)
Comparative transcriptomic analysis of tumor cells from diseased mice revealed the expression of several well-known MLL-rearranged leukemia-associated target genes, including Meis1 , Runx1 ( pMIRH-128a mice), HoxA9 , Flt3 ( pMIRH-130b mice), Cdk6 , and Bcl2 . (ashpublications.org)
Altered expression of many different genes (e.g. (biomedcentral.com)
The expression patterns of those miRNAs were examined in hamster lung samples infected by SARS-CoV-2. (molcells.org)
Five miRNAs (hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-221-3p, hsa-miR-140-3p, and hsa-miR-422a) showed differential expression patterns in lung tissues before and after infection. (molcells.org)
The seed region in miRNAs, approximately six nucleotides long, recognizes and binds to the complementary binding site of the target mRNA 3'untranslated region (3'UTR) to regulate its expression. (molcells.org)
Mechanistically, NGF could upregulate TDE-miR-21-5p levels, and DRG cells took up TDE to activate the Warburg effect and stimulate nociceptor gene expression. (hindawi.com)
Epigenetics refers to heritable changes in gene expression without changing the nucleotide sequence of the gene, including DNA methylation, histone modifications, and RNA modifications. (beds.ac.uk)
The detection of RNA modifications is fundamental to the study of m7G modifications in the regulation of gene expression. (beds.ac.uk)
miR-503 inhibited significantly the expression of CDK6 and the downstream genes of E2F3. (biomedcentral.com)
Gene expression was examined by Western blot. (biomedcentral.com)
PSME3 was a target gene of miR-504, and its expression in breast cancer tissues was significantly increased. (magtechjournal.com)
They are important post-transcriptional regulators of gene expression in plants, metazoans, and mammals, and are predicted to control the activity of 30% of all protein-coding genes [ 2 ]. (biomedcentral.com)
In this study, the gene expression profile in GBM was analyzed using a microarray dataset and RNA-sequencing (RNA-Seq) datasets. (spandidos-publications.com)
The aberrant expression of miRNAs is associated with the pathogenesis of sepsis. (degruyter.com)
Differential gene expression analysis, weighted gene co-expression network analysis, univariate COX regression analysis, random forest algorithm and multiple combinatorial screening were used to construct the prognostic gene signature. (biomedcentral.com)
The aim of the present study was to compare miRNA expression between primary melanomas from different sites. (bjbms.org)
We analyzed the expression of 84 miRNAs in 27 primary melanoma and 5 nevus formalin-fixed paraffin-embedded (FFPE) samples using the Human Cancer PathwayFinder miScript miRNA PCR Array. (bjbms.org)
Out of 84 miRNAs, 11 miRNAs showed altered expression in all types of melanoma compared with the nevi. (bjbms.org)
The highest similarity in miRNA expression pattern was found between uveal and mucosal melanoma groups, i.e., 15 miRNAs had altered expression in both groups. (bjbms.org)
In this study, one of these EGS variants was used to target the overlapping region of the mRNAs encoding HCMV essential immediately-early (IE) proteins IE1 and IE2, which are the viral major transcriptional activators responsible for activation of viral gene expression (1). (azd1152.com)
We investigated the activity of the EGS in inducing RNase P to cleave the target mRNA and its efficacy in inhibiting HCMV gene expression and growth in cultured cells. (azd1152.com)
gene expression and growth and furthermore, demonstrate the feasibility of developing effective EGS RNA variants for anti-HCMV applications by using selection procedures. (azd1152.com)

The PD173955 mechanisms however by which miRNAs interfere with cell survival and programmed cell death in transformed cells are still obscure. (careersfromscience.org)
In this review, we summarize the recent developments in miRNA research related to PDAC therapeutic resistance mechanisms and the potential of miRNAs as prognostic biomarkers for future clinical management of PDAC. (biomedcentral.com)
It synthesizes information from ten recent papers on miR-155, and includes an analysis and discussion of its association with cancer, interactions with other miRNAs, mechanisms of action, and the most promising available treatment options. (biomedcentral.com)

miRNAs are recognized as important regulators of lipid metabolism, inflammatory mediators, and VSMC behaviours in the progression of AS [ 10 ]. (hindawi.com)
miRNAs are critically implicated in the initiation process of and progression through cancerogenesis. (careersfromscience.org)
Results and Discussion To study the impact and extent to which miRNA contributes to cell cycle progression in transformed phenotypes we here employed the p53-mutated human keratinocyte cell line (HACAT) and RNA interference (siRNA) techniques. (careersfromscience.org)
MiRNAs 29a-3p and 34b-3p also resulted downregulated in vivo in a murine neuroblastoma progression model. (oncotarget.com)
This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. (cancerindex.org)
In general, the circRNA-miRNA-mRNA axis may function as an extensive regulatory network in progression of some diseases. (biomedcentral.com)

The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)
The binding of miRNA- protein complexes to mRNA causes translation inhibition or destabilisation of target transcripts. (ukessays.com)
1) The alternation of protein levels of critical oncogenes or tumour suppressor genes, which causes by miRNAs deregulation may also lead to proliferative diseases such as cancer. (ukessays.com)
Studies of human genome demonstrate that protein-coding genes only occupy less than 2% of the entire genome [ 1 ]. (ijbs.com)
miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. (cancerindex.org)
This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. (thermofisher.com)
Twenty-seven of these substitution mutations have been observed in genes encoding viral spike protein (S), although most differences were found in non-structural protein-coding genes. (molcells.org)

Approximately 30-60 % of the human genome, regulated by miRNAs. (ukessays.com)
A comparison of immune associated genes amid insect species On this review, the genome and transcriptome broad ana lysis revealed an intact innate immune network current ing in N. lugens. (cox2-inhibitors.com)
Defensins will be the distinctive antibacterial peptide genes out there within the N. lugens genome. (cox2-inhibitors.com)
Until now, more than 1000 miRNAs are reported in encoding in the human genome. (biomedcentral.com)

Unlike the amount of methylation of their encoding gene promoters, all these miRNAs were significantly overexpressed following treatment with 5'-AZA. (oncotarget.com)
The DNA methylation of miRNAs has an indirect impact on the regulation of the miRNA target genes. (mbpinc.net)
Most commonly aberrant methylation is not confined to few genes. (mbpinc.net)
If DNA methylation is present at the gene promoter, this can result in the downregulation of the gene. (mbpinc.net)
That being said, the DNA methylation of miRNAs also is a big factor that leads to overexpression in the target genes. (mbpinc.net)
Moreover, other literature and studies have demonstrated that many genes are directly silenced by methylation, and not by miRNAs. (mbpinc.net)

Transplant experiments in which miRNA knockdown was combined with target overexpression suggest that induction, as well as maintenance, of the disease phenotype is miRNA dependent and involves downregulation of NR2F6 and SGMS1. (ashpublications.org)

MiRNAs bind the 3' untranslated region (3'UTR) of target mRNAs. (ukessays.com)
The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
Based on the ceRNA hypothesis ( 15 ), the lncRNA-miRNA-mRNA network was constructed and Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genomes (KEGG) pathway analysis of mRNAs in the network were performed. (spandidos-publications.com)

Nucleic acid-based gene interference technologies represent encouraging gene-targeting strategies for specific inhibition of mRNA sequences of choice (5,6). (azd1152.com)
Targeted cleavage of mRNA by human RNase P provides a unique approach to inactivate any RNA of known sequence expressed efficiency of the EGS-induced RNase P cleavage as well as its efficacy is required in order to develop EGSs for practical use both as a research tool and as a therapeutic agent for gene-targeting applications. (azd1152.com)

We determined the crystal structures of HIPK3 and DYRK1A bound to abemaciclib, showing a similar binding mode to the hinge region of the kinase as observed for Cdk6. (nature.com)
This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). (thermofisher.com)

These are divided into two group, those miRNAs that are upregulated in cancer which are likely to be acting as oncogenes and those downregulated in cancer which are likely to be acting as tumour suppressors. (ukessays.com)
In cancer, they act as tumor suppressor genes and sometimes as oncogenes. (mbpinc.net)

Malouf et al found 2 miRNAs (miR-128a, miR-130b) that were significantly upregulated in tumor cells from pediatric MLL-AF4 + ALL patients. (ashpublications.org)

Myc, HDCA3, and PRC2 form a repressive complex tethered to miR-29a/b1 and miR-29b2/c promoter regulatory elements to epigenetically repress transcription of these miRNAs in Myc-expressing lymphoma cells and that subsequent miR-29 down-regulation results in induction of oncogenic proteins (CDK6 and IGF-1R) and Myc-driven lymphomagenesis. (oncotarget.com)
Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)
We also identified miRNAs that bind to receptor proteins, such as ACE2, ADAM17, and TMPRSS2, which are important for understanding the infection mechanism of SARS-CoV-2. (molcells.org)

1 Mixed lineage leukemia (MLL) gene fusions are the molecular hallmark of infant acute lymphoblastic leukemia (ALL) and are present in tumor cells in up to 80% of patients. (ashpublications.org)

Also, since BCL6 interacts with several co-repressor complexes to inhibit transcription, and its gene is frequently trans-located and hyper-mutated in diffuse large B cell lymphoma (DLBCL), miR-155 acts to enhance transcription and contribute to the pathogenesis of DLBCL. (biomedcentral.com)
These transcriptional factors belong to the basic helix-loop-helix-leucine zipper (bHLH-LZ) transcription factor family and bind the E-box DNA motifs in the promoter regions of target genes to enhance transcription. (molcells.org)

Increasing evidence has suggested that the dysregulation of miRNAs is associated with the pathogenesis of sepsis. (degruyter.com)

This miRNA is a member of the highly conserved miR-34 family. (cancerindex.org)

The transcriptome profiling data and hallmark gene sets in the Molecular Signatures Database was used to explore the cancer hallmarks most relevant to the prognosis of HNSCC patients. (biomedcentral.com)

Interestingly, most of their encoding genes reside in hypermethylated genomic regions: thus, their tumor suppressor function is normally disallowed in these tumors. (oncotarget.com)

Functional Assessment of Missense Variants in the ABCC6 Gene Implicated in Pseudoxanthoma Elasticum, a Heritable Ectopic Mineralization Disorder. (jefferson.edu)

Certain miRNAs have been identified as potential prognostic biomarkers in PDAC. (biomedcentral.com)
This study aims to construct a new prognostic gene signature in survival prediction and risk stratification for patients with Head and neck squamous cell carcinoma (HNSCC). (biomedcentral.com)

Gsk2118436 is a medication for the treatment of cancers associated with a mutated version of the gene BRAF. (gsk2118436inhibitor.com)

The absence of regulatory miRNAs however led to a substantial delay of anti-apoptotic signaling leaving pro-apoptotic stress unbalanced in Dicer1-deprived cells. (careersfromscience.org)

Five miRNAs (hsa-miR-15a-5p, hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-16-5p, and hsa-miR-196a-1-3p) were found to commonly bind to SARS-CoV, MERS-CoV, and SARS-CoV-2. (molcells.org)

miRNA microarray profiling was performed using Lianchuan biological small RNA sequencing analysis. (hindawi.com)

All in all, the data shows a very complex, multi-level interaction of all the epigenetically changed and influenced miRNAs that weren't able to completely regulate the cell cycle. (mbpinc.net)

Gene profiling analysis for patients with oral verrucous carcinoma and oral squamous cell carcinoma. (medscape.com)
Reactivating these miRNAs in Myc-transformed B lymphoma cell lines dramatically inhibits tumorigenesis [ 4 ], indicating that reconstituting lymphoma with these tumor suppressor miRNAs could be therapeutically beneficial in Myc-associated lymphomas. (oncotarget.com)
Both miRNAs increased the clonogenic B-cell potential of Mll-AF4 + cells. (ashpublications.org)
The BIC gene is activated by promoter insertion at a retroviral integration site on chromosome 21q21 in B cell lymphomas induced by avian leukosis virus. (biomedcentral.com)

In addition miRNA clusters miR-17-92 miR-106b miR-181 and miR-221/222 promote the induction of the CDK inhibitors p21CIP1 p27KIP1 and p57KIP2 thus enhancing the p53-mediated anti-proliferative effect. (careersfromscience.org)

The findings reported here contribute to the understanding of the complex interactions of miRNAs with the signalosom of PD173955 transformed phenotypes and may help to design novel strategies to fight cancer. (careersfromscience.org)

Remarkably, DYRK1A is inhibited by abemaciclib to the same extent as Cdk4/Cdk6 in vitro, raising the question of whether targeting of DYRK1A contributes to the transcriptional inhibition and therapeutic activity of abemaciclib. (nature.com)
known as RelA) and can directly influence chromatin accessibility at transcriptional memory genes by regulating H2B deposition through Ser32 phosphorylation. (bix02188.com)

Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genomes pathway analysis of DEmRNAs in the DElncRNA‑miRNA‑DEmRNA network was performed. (spandidos-publications.com)

Based on a database search, we identified abemaciclib, an FDA-approved Cdk4/Cdk6 inhibitor used for the treatment of metastatic breast cancer, as potent inhibitor of HIPK2, HIPK3, and DYRK1A. (nature.com)

Anatomy14

Organisms10

Diseases4

Chemicals and Drugs86

Analytical, Diagnostic and Therapeutic Techniques and Equipment24

Phenomena and Processes71

Disciplines and Occupations2

Technology, Industry, Agriculture1

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MicroRNAs15

RNAs8

MicroRNA2

Cyclin5

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Pathways7

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Targets11

CDK4 and CDK61

Several miRNAs2

Precursor miRNA1

Oncogenic miRNAs2

Epigenetic5

Expression37

Mechanisms3

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Protein8

Genome4

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