Mirna. Medical search. Frequent questions

MicroRNAs (miRNAs) are master regulators involved in multiple physiological and pathological processes. (genengnews.com)
MicroRNAs (miRNAs) are well-studied small noncoding RNAs involved in post-transcriptional gene regulation in a wide range of organisms, including mammals. (nih.gov)
MicroRNAs (miRNAs) can be released into circulation from injured tissues, enticing a potential role as noninvasive biomarkers. (hindawi.com)
MicroRNAs (miRNAs) are short noncoding RNA molecules that negatively affect gene expression through mRNA cleavage or inhibition of protein translation, resulting in profound and complex regulatory networks [ 7 ]. (hindawi.com)
The aberrant expression of circulating microRNAs (miRNAs/miRs) is reported in many tumors and can provide insights into the pathogenesis of tumor development and progression. (frontiersin.org)
Multiple components of biological fluids are being investigated as potential disease-related markers, including microRNAs (miRs, miRNAs) ( 8 ). (frontiersin.org)
During vesiculation, nucleic acids, including mRNAs, long non-coding RNAs (lncRNAs) and microRNAs (miRNAs or miRs) are encapsulated within EVs and when released, they are protected from degrading enzymes ( 8 - 10 ). (spandidos-publications.com)
Recently, much attention has focused on the impact of microRNAs (miRNAs) on tumorigenesis and cancer progression. (sarcomahelp.org)
MicroRNAs (miRNAs) are well-recognized for their abilities to regulate gene expression post-transcriptionally in plants and animals. (frontiersin.org)
MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and processed into mature miRNAs. (mdpi.com)
In addition to protein-coding genes, the human genome contains a large number of genes which are transcribed to non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) ( 7 , 8 ). (spandidos-publications.com)
Emphasis on microRNAs (miRNAs) as important regulators. (iasp-pain.org)
NLR family pyrin domain containing 3 (NLRP3) inflammasomes and peripheral neuropathic pain - Emphasis on microRNAs (miRNAs) as important regulators. (iasp-pain.org)
Utilizing microRNAs (miRNAs) as a potential biomarker to differentiate BRCA will allow for specialized treatment regimens and increased clinical care. (biogenex.com)
MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)
that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)

Continually growing evidence associates circulating miRNA expression with both normal and disease biology as miRNAs expressed in virtually all biofluids, including serum, plasma, cerebrospinal fluid (CSF) and urine. (qiagen.com)

the seat of the eponymous municipality Municipality of Mirna, a municipality in Slovenia Mount Mirna, a hill in Slovenia Mirna (name), a female name microRNA, abbreviated as miRNA USS Mirna (SP-1214), a United States Navy patrol boat in commission from 1917 to 1918 Mirna-class patrol boat (Type 171), a Yugoslav patrol boat class Search for "mirna" on Wikipedia. (wikipedia.org)
Non-coding RNA, including microRNA (miRNA) serves critical regulatory functions in the developing brain. (nih.gov)
Pharmacologic manipulation of microRNA expression has been undertaken in the form of in vivo miRNA delivery of downregulated miRNAs and "antagomirs" targeting upregulated miRNAs. (sarcomahelp.org)
Negative regulation of mRNA translation by microRNA (miRNAs) has emerged as an important regulation of osteogenic signalling pathways, osteoblast growth and differentiation, osteoclast-mediated bone resorption activity and bone homeostasis in the adult skeleton. (edu.au)

Mature miRNAs are naturally occurring, 22-nucleotide, non-coding RNAs that mediate posttranscriptional gene regulation. (qiagen.com)
mir Vana miRNA Isolation kits use a rapid procedure to isolate total RNA, including small RNAs such as miRNA, small interfering RNA (siRNA), and small nuclear RNA (snRNA), from tissues and cells. (thermofisher.com)
miRNAs are approximately 22-nucleotide non-coding RNAs that participate in post transcriptional gene expression regulation through mRNA degradation, translational inhibition or chromatin-based silencing mechanisms. (sarcomahelp.org)
Some miRNAs are hosted in pri-miRNAs annotated as long non-coding RNAs (lncRNAs) and defined as MIRHGs (for miRNA Host Genes). (mdpi.com)
Micro RNAs (MiRNAs) are fast emerging as a new class of therapeutic targets based on their pivotal roles in regulating multiple biological pathways. (edu.au)
miRNAs are small, evolutionarily conserved, noncoding RNAs that negatively regulate gene expression and have fundamental roles in cancer growth and metastasis. (biogenex.com)
miRNAs are small noncoding RNAs that have broad regulatory functions on gene expression. (lu.se)
We aimed to assess how preanalytical variables (urine storage temperature, isolation workflow) affect diabetic kidney disease (DKD)-linked miRNAs or kidney-linked miRNAs and mRNAs (kidney-RNAs) in uEV isolates and to discover stable reference mRNAs across diverse uEV datasets. (lu.se)
We focused on kidney-RNAs reviewing literature for DKD-linked miRNAs from kidney. (lu.se)
We focused on kidney-RNAs reviewing literature for DKD-linked miRNAs from kidney tissue, cell culture and uEV/urine experiments. (lu.se)
MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)

Functional analysis predicts that these miRNAs target numerous risk genes for type 1 diabetes mellitus (T1DM). (nature.com)
Using bioinformatic software to predict gene targets, the investigators showed that the miRNAs dysregulated by CVB5 infection were predicted to regulate 57 of 72 known T1DM risk genes. (nature.com)
We thus outline established and emerging models to give a perspective on the future developments needed to improve the identification of genes directly regulated by miRNAs. (nih.gov)
Multiple miRNA-mRNA prediction databases were searched by differentially expressed genes (DEGs) to obtain pairs of a miRNA-DEG regulatory network. (frontiersin.org)
Without appropriate regulation by miRNA, genes are likely expressed abnormally, which could cause cells to grow and divide uncontrollably and lead to tumor formation. (medlineplus.gov)
SNPs in 6 miRNA processing genes and in 78 miRNAs which target genes known to be important in breast cancer among 906 African American (AA) and 653 European American (EA) cases and Author Manuscript controls enrolled in the Women's Circle of Health Study (WCHS). (cdc.gov)
We found a number of SNPs in miRNAs and processing genes in association with breast cancer overall or stratified by estrogen receptor (ER) status. (cdc.gov)

Due to the growth of circulating miRNAs as potential biomarkers, the QIAseq miRNA Library Kit is optimized to map miRNA down to ultralow input levels. (qiagen.com)
Our data suggest that plasma levels of miRNA-23b and miRNA-143 could be useful as noninvasive biomarkers of ISR. (hindawi.com)
What we are measuring is PCR, which is fine, but it's time consuming," said James Dear, a reader in pharmacology at the University of Edinburgh and paper coauthor, whose work is related to investigating the use of miRNA biomarkers, such as miRNA-122, that are associated with liver toxicity, particularly those resulting from the overuse of acetaminophen. (genomeweb.com)
The identified set of miRNAs can serve as biomarkers for distinguishing MM with 1q21 gains from MM with normal FISH. (karger.com)
Owing to their stability in biological fluids and resistance to various storage conditions, miRNAs are considered as useful biomarkers for cancer diagnosis, prognosis, and prediction of treatment efficacy. (biogenex.com)
Recent studies have tested miRNAs as predictive biomarkers for determining BRCA mutated patient's prognosis. (biogenex.com)
The changes in miRNA and mRNA expression, and their respective regulatory networks, identified in this study may potentially serve as blood biomarkers for MWCNT-induced lung pathological changes. (cdc.gov)

In addition, the kit integrates Unique Molecular Indices (UMIs) into the reverse-transcription process, enabling unbiased and accurate miRNome-wide quantification of mature miRNAs by NGS. (qiagen.com)
They enable highly sensitive and specific quantification of mature miRNAs using qPCR. (thermofisher.com)

Using an Illumina human miRNA expression profiling V2 panel, the group measured miRNA expression levels from all 357 samples, comparing the group of patients with recurrence in two years against those who didn't recur for more than seven years. (genomeweb.com)

Only two miRNAs were differentially expressed in cells from control islets and CVB5-infected islets 1 day after infection. (nature.com)
They established which miRNAs were differentially expressed regardless of cancer subtype, as well as signatures for both adenocarcinoma and squamous cell carcinoma specifically, after finding that the miRNAs strongly differed between those two groups. (genomeweb.com)
Differentially expressed miRNAs were identified using Affymetrix TAC software. (karger.com)
We therefore propose that novel correlations exist between the differentially expressed mRNAs and miRNAs expressions of multiple signalling pathways in osteolysis/chronic inflammation. (edu.au)

mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice. (cdc.gov)

Expression of 754 different miRNAs was measured in cells harvested at three time points after infection, using high-throughput quantitative PCR nanofluidic assays. (nature.com)
For Lexington, Massachusetts-based Quanterix, which to date has deployed assays for protein analysis on its Single Molecule Array, or Simoa, platform, the approach demonstrates the applicability of its technology in nucleic acid detection, and miRNA detection in particular, as it prepares to launch a new system. (genomeweb.com)
Yet miRNA-122 is seen by some as a more sensitive biomarker that has not yet progressed in clinical research due to the challenges associated with detecting it using conventional PCR-based assays. (genomeweb.com)
TaqMan miRNA Assays are innovative tools for miRNA research-from isolation through discovery, profiling, quantitation, validation, and functional analysis. (thermofisher.com)
The newer TaqMan Advanced miRNA Assays use ligation-based universal reverse transcription for a streamlined and highly sensitive workflow. (thermofisher.com)
The standard TaqMan miRNA Assays, which employ target-specific stem-loop reverse transcription primers for 3' extended templates, continue to cover a range of species using standard TaqMan Assay-based real-time PCR. (thermofisher.com)
TaqMan Advanced miRNA Assays utilize a universal primer to reverse transcribe all of the miRNAs in the sample. (thermofisher.com)
TaqMan miRNA Assays employ an innovative target-specific stem-loop reverse transcription primer to address the challenge of the short length of mature miRNA. (thermofisher.com)
Also, the stem-loop structure in the tail of the primer confers a key advantage to these assays: specific detection of the mature, biologically active miRNA. (thermofisher.com)
The miRNA-mRNA interactions were verified by dual-luciferase reporter gene assays and experiments using mimics miRNA or their inhibitors. (frontiersin.org)
BioGenex miRNA ISH Panel Probes are currently one of the best products for complex diagnostic assays. (biogenex.com)

Used with the containers, the kit provides a complete preanalytical solution for collection, fixation, and stabilization through to purification of high-quality miRNA and total RNA for molecular analysis. (qiagen.com)
Purify high-quality miRNA from difficult sample types without hazardous chemicals. (thermofisher.com)

There were 7 overlapped miRNA-mRNA pairs identified during osteogenic differentiation of MC3T3-E1 cells, including mmu-miR-204-5p-Arhgap11a, mmu-miR-211-5p-Arhgap11a, mmu-miR-24-3p-H2afx, mmu-miR-3470b-Chek2, mmu-miR-3470b-Dlgap5, mmu-miR-466b-3p-Chek1, and mmu-miR-466c-3p-Chek1. (frontiersin.org)

We tested selected miRNAs on a training cohort and created a classifier by integrating miRNA expression and patients' clinical data. (frontiersin.org)

Collectively, these results suggest an important function for let-7 family miRNAs in regulation of human neuronal development and raise implications for understanding the complex molecular etiology of neurodevelopmental disorders, such as T21, where let-7c gene dosage is increased. (nih.gov)
consequently, no major conclusions regarding the expression and regulation of miRNA in LPS could be made. (sarcomahelp.org)
miRNAs and lncRNAs participate in the regulation of cell growth, proliferation, differentiation, migration and invasion by interacting with a number of signaling pathways ( 7 , 8 ). (spandidos-publications.com)
However, our understanding of how miRNAs control the regulatory interplay among multiple layers of mRNA regulation in osteolysis is minimal. (edu.au)
As binding of miRNAs to a target mRNA may result in an airway inflammatory disease closely correlates with either mRNA degradation or inhibition of protein immune regulation, more and more evidences suggest translation.1 More than 2000 miRNAs have been discovered in humans. (cdc.gov)
DC demonstrated that miRNAs participate in airway maturation, while downregulation of let-7i significantly inflammatory regulation in asthma. (cdc.gov)

Recently, miRNA-messenger RNA (mRNA) regulatory relationships have been confirmed during biological processes, including osteogenic differentiation. (frontiersin.org)

Specifically with cancers, numerous studies and reviews have associated the presence of various miRNAs with cancer cell proliferation, resistance to apoptosis, invasiveness and differentiation. (qiagen.com)
Several of the commonly used tools for identifying targets of various miRNAs perform poorly for non-model organisms (e.g., anything that is not a human, mouse, fly or worm). (lu.se)

To our knowledge this is the first demonstration of a treatment that inhibited a specific miRNA that resulted in a significant increase in survival. (genengnews.com)
You could use bowtie1 end2end with 1 mismatch or SHRiMP which has specific miRNA mode. (biostars.org)

For the application, Destina designed an abasic peptide nucleic acid probe for detecting miRNA with a reactive amine in lieu of a specific nucleic acid sequence. (genomeweb.com)
BioGenex has developed proprietary Super Sensitive Nucleic Acid (SSNA) miRNA probes that enhance signals from intrinsically low populated miRNAs. (biogenex.com)
BioGenex is pleased to launch two Super Sensitive TM Nucleic Acid miRNA in situ hybridization (SSNA miRNA ISH) probes and automated systems for differentiation of wild type and BRCA mutated breast cancer. (biogenex.com)

Molecules and mechanisms to target a MiRNA-mediated pathway that is involved in recovery from multiple conditions affecting the central nervous system. (edu.au)
miRNAs exert their function via base pairing with complementary mRNA molecules, resulting in gene silencing via transcriptional repression or target degradation. (biogenex.com)
BioGenex miRNA probes are dual-end labeled on 3' and 5' with five FAM molecules that amplify the signal, giving intense stains. (biogenex.com)

QIAseq miRNA sequencing enables superior data generation through an improved workflow. (qiagen.com)
Collectively, QIAseq miRNA offers an unrivaled Sample to Insight solution for differential expression analysis and discovery of novel miRNAs using next-generation sequencing (see figure QIAseq miRNA workflow). (qiagen.com)
Together with the TaqMan Advanced miRNA cDNA Synthesis Kit, this solution is designed to provide a streamlined workflow that allows for exceptional detection of multiple miRNA targets from a single sample. (thermofisher.com)

This study proposes a miRNA-based biomarker classifier for SCLC that considers clinical demographics with specific cut offs to inform SCLC diagnosis. (frontiersin.org)
As compared with wild type breast cancer, expression of miR-17 and miR-21 was downregulated in BRCA mutated breast cancer, suggesting that the miRNA expression pattern may serve as a potential biomarker in predicting BRCA mutation status in invasive breast cancer. (biogenex.com)
Micro-RNA ( miRNA ) emerges as a promising type of biomarker for cancer diagnosis . (bvsalud.org)

Identification of several targets of miRNAs associated with cancer suggests that networks of miRNAs linked to oncogenes or tumor suppressors play pivotal roles in cancer development. (genengnews.com)
there is increasing data to suggest that miRNAs may act as either tumor suppressors or oncogenes. (sarcomahelp.org)

In addition, the lipid nanoparticles (LNP) platform, which has proven to be effective with siRNAs, is also showing promise with miRNAs and miRNA mimics. (genengnews.com)

8 The results demonstrated that miRNA expression signatures were clearly distinct among the tumor types studied, suggesting their possible role in sarcomagenesis, and their potential as diagnostic markers or even therapeutic targets. (sarcomahelp.org)
Understanding the roles of Asthma is a worldwide problem, the prevalence of miRNAs in asthma pathogenesis may also aid to asthma ranged from 1% to 18% of the population in explore new therapeutic targets. (cdc.gov)

Given that most of the 33 miRNAs were significantly downregulated, it is highly plausible that alteration in levels of these miRNAs will exacerbate the immune response stimulated by the virus in genetically susceptible individuals, promoting the destruction or dysfunction of β cells. (nature.com)
Alix knockdown did not influence the number of EVs released by HLSCs, but it significantly decreased miRNA expression levels in the EVs and consequently their transfer to the endothelium. (spandidos-publications.com)
lncRNA‑NEF overexpression mediated the inhibition of miRNA‑21 expression in osteosarcoma cell lines, while miRNA‑21 overexpression did not significantly affect the expression of lncRNA‑NEF. (spandidos-publications.com)

In the cardiovascular system, miRNAs regulate basic functions in almost all cell types including cardiac muscle, endothelial cells, smooth muscle, inflammatory cells, and fibroblasts and, therefore, play a pivotal role in the pathogenesis of several cardiovascular diseases (CVDs). (hindawi.com)
Saki N, Abroun S, Hajizamani S, Rahim F, Shahjahani M: Association of chromosomal translocation and miRNA expression with the pathogenesis of multiple myeloma. (karger.com)

The involvement of miRNAs in cancer research emerged from studies demonstrating their aberrant expression in neoplastic tissues. (genengnews.com)
The PAXgene Tissue miRNA Kit provides purification of total RNA, including RNA from approximately 18 nucleotides, from tissues fixed and stabilized in PAXgene Tissue Containers. (qiagen.com)
There may be scope for future work comparing miRNA expression in different tissues between hybrids and parental species. (lu.se)

By partnering with Quanterix and Destina, Dear and his colleagues aimed to produce an assay for miRNA-122 that has the potential to give a more rapid result. (genomeweb.com)
Although numerous methods are available for gaining information about miRNA signatures, in situ hybridization (ISH) assay is a powerful tool that allows direct assessment of malignant cells. (biogenex.com)
miRNA Detection for Prostate Cancer Diagnosis by miRoll-Cas: miRNA Rolling Circle Transcription for CRISPR-Cas Assay. (bvsalud.org)
Herein, we developed a miRNA detection method termed miRoll-Cas, where miRNA is first amplified by rolling circle transcription and then subject to CRISPR -Cas13a assay. (bvsalud.org)

This week on the RUN ATL Podcast, Mirna Valerio & Erin Jobe sit down to talk about body type, stereotypes, and inspiring women to start trail running with a community of supportive women. (bigpeachrunningco.com)
Mirna Valerio has obliterated stereotypes and inspired people everywhere with her fierce determination and fun personality. (bigpeachrunningco.com)
Our own President and CEO Artis Stevens joins Merrell Ambassador Mirna Valerio, to kick-off a special series for Black History month. (bbbs.org)

Here, we clarify the role of miRNA let-7a and 23b post-injury and assess the efficacy of blocking let7a miRNA in vivo to accelerate the regeneration process. (cns.org)

Alterations in miRNA can be correlated with gene expression changes in development, differentiation, signal transduction, infection, aging and disease. (qiagen.com)
The EV-mediated transfer of miRNAs is a particularly good candidate for the epigenetic alterations observed in recipient cells. (spandidos-publications.com)
However, there is little information on the association between miRNA alterations and 1q21 gains. (karger.com)

The group found that Cox model risk scores estimated by miRNA expression gave better prediction that tumor stage information, with areas under the curve of 86 percent to 91 percent for the miRNA signature and only 64 percent to 69 percent for staging. (genomeweb.com)

We compared the miRNA expression profiles of MM with 1q21 gains and MM with normal fluorescence in situ hybridisation (FISH) by gene expression array. (karger.com)

What I would like to do is to predict a new miRNA that have similar function to the known miRNA and check if that new miRNA is in the cell line be informed that all miRNA extracted from different database and the sequence collected from miRBase. (biostars.org)

Dysregulation of miRNA could possibly be an important contributing factor to LPS sarcomagenesis, especially to the process of dedifferentiation. (sarcomahelp.org)
Dysregulation of miRNA has been widely reported in many cancer types, including breast cancer. (biogenex.com)

Basically, if miRNA repression is evolutionarily important for a gene, we expect the miRNA binding sites to be shared across closely related species. (lu.se)

We aimed to evaluate circulating levels of miRNA-23b, miRNA-143, and miRNA-145 as diagnostic markers of ISR. (hindawi.com)
Using miRoll-Cas, we realized the sensitive detection of multiple cancer -relevant miRNA markers (miR21, miR141, and Let7b) and specifically identified other variants of the Let7 family , which can accurately discriminate prostate cancer patients from healthy people. (bvsalud.org)

Together, these benefits highlight that the QIAseq miRNA Library Kit is designed to maximize the yield of miRNA available to sequence. (qiagen.com)
As detailed in the new paper, by pairing the Destina chemistry with Quanterix's platform, the investigators were able to develop a single-probe method for detecting miRNA from human serum using Quanterix's single-molecule arrays, which had the advantages of reading sequence specificity down to a single base without the need for amplification. (genomeweb.com)
The probe was coupled to Quanterix's superparamagnetic beads, and the beads were then incubated with a sample containing miRNA, a reactive nucleobase that complemented the missing base in the probe sequence, and a reducing agent. (genomeweb.com)
based on the previous known miRNA that linked to the disease.I have there name and sequence. (biostars.org)

Furthermore, adenoviral-mediated gene transfer of miRNA-145/143, which downregulate the expression of this miRNAs after injury, inhibits neointimal lesion formation in injured rat carotid arteries [ 11 ]. (hindawi.com)

Plasma lncRNA‑NEF and miRNA‑21 were negatively correlated in patients with osteosarcoma and healthy controls. (spandidos-publications.com)

Although many features required for miRNA-mediated repression have been described, the identification of functional interactions is still challenging. (nih.gov)

The expressions of candidate miRNAs and mRNAs were determined by real-time quantitative PCR(RT-qPCR) in MC3T3-E1 cells. (frontiersin.org)

Some of the same strategies already developed for delivery of siRNA for RNA interference (RNAi) also are being applied to miRNA. (genengnews.com)

This inhibitory effect was likely mediated through various routes including the increased production of antiviral cytokines (IFN-I), activation of mononuclear cell migration, and upregulation of the expression of antiviral miRNAs (has-miR-30e*, has-miR-133a, and has-miR-223) and inflammation-related miRNAs (has-miR-146a and has-miR-147). (unboundmedicine.com)

miRNA-21 may participate in tumorigenesis through interactions with lncRNA ( 12 ). (spandidos-publications.com)

We will apply this approach to a non-model sparrow study system to answer questions about how hybridization can disrupt evolved miRNA-mRNA interactions, leading to insights about the formation of new species. (lu.se)

lncRNA‑NEF overexpression inhibited, while miRNA‑21 overexpression promoted, migration and invasion of osteosarcoma cell lines in vitro. (spandidos-publications.com)
miRNA‑21 overexpression partially compensated the inhibitory effects of lncRNA‑NEF overexpression on osteosarcoma cell migration and invasion. (spandidos-publications.com)

The QIAseq miRNA Library Kit has fully optimized library process to virtually eliminate adapter dimerization, even from very low inputs of total RNA (see figure Adapter dimers (AD) and contaminating RNA steal your reads during miRNAseq experiments). (qiagen.com)

With several recent studies correlating miRNA expression with outcome in lung cancer, the investigators set out to try to identify miRNA signatures that could accurately predict prognosis in what they claim is the largest study of its kind to date. (genomeweb.com)
6 Furthermore, several recent studies have highlighted the potential of miRNA profiles for diagnosis and prognosis. (sarcomahelp.org)

Additionally, the group identified 10 miRNAs that were associated specifically with brain metastasis. (genomeweb.com)
miRNA deregulation has been identified in a variety of epithelial origin cancers, where changes in specific miRNAs expression possibly contribute to tumor growth, progression, metastasis, and chemoresistance. (sarcomahelp.org)

The researchers also identified a 27-miRNA predictive signature from only the adenocarcinoma samples, and a 17-miRNA signature from only those with squamous cell carcinoma. (genomeweb.com)
According to the researchers, several miRNAs in their predictive signatures are associated with important cancer-related pathways, including miR-31, and miR-34. (genomeweb.com)

The QIAseq miRNA Library Kit is intended for molecular biology applications. (qiagen.com)

Important functions of islet β cells, such as glucose sensing, insulin release and apoptosis, are regulated by miRNAs, and Kim and colleagues hypothesized that CVB5 infection in human islets would alter miRNA expression, providing a mechanistic link between viral infection and the development of T1DM. (nature.com)
It's been suggested that miRNAs regulate up to 50% of all mRNAs in the human genome. (genengnews.com)
The system consists of a tissue collection device (the PAXgene Tissue Container for collection, stabilization, storage, and transportation of human tissue specimens) and kits for purification of miRNA, total RNA, or DNA. (qiagen.com)
The aim of the present study was to evaluate whether Alix is involved in the packaging of miRNAs within EVs released by human liver stem‑like cells (HLSCs). (spandidos-publications.com)
EVs were instrumental in transferring selected miRNAs from HLSCs to human endothelial cells absent in the latter cells. (spandidos-publications.com)
In conclusion, anionic septapeptides exerted anti-DENV activity in human monocytes through the upregulation of innate immune responses and the activation of several previously reported antiviral and inflammation-related miRNAs. (unboundmedicine.com)
Using the latest Next Generation Sequencing technologies, we are investigating miRNA expression profiles in human trabecular bone, synovial fluid and plasma sourced from TJR revision surgery where wear particle associated osteolysis was evident. (edu.au)
Human let-7a miRNA blocks protein production on actively translating polyribosomes. (bvsalud.org)

Presumed mature miRNA positions are indicated by *'s. (ugent.be)
The TaqMan Advanced miRNA cDNA Synthesis Kit is used for preparation of cDNA templates from the entire pool of mature miRNAs in a sample. (thermofisher.com)

Downregulation of lncRNA‑NEF and upregulation of miRNA‑21 distinguished patients with osteosarcoma from healthy controls. (spandidos-publications.com)

This clearly demonstrates that miRNA expression signatures combined with stage information has higher classification power than the staging method to predict survival," the authors wrote. (genomeweb.com)

One of the methods that does seem to work well is TargetScan, which relies on both pairing of seed sequences (a subset of the 18-23 bp that make up a miRNA) and phylogenetic conservation of sites. (lu.se)
There is an urgent need for developing rapid, convenient, and precise miRNA detection methods that may be conducted with limited laboratory facilities, especially in underdeveloped areas. (bvsalud.org)

Our studies, supported by the Liddy Shriver Sarcoma Initiative, aimed to identify unique miRNA expression profiles of WDLPS and DDLPS with the hope that such signatures could provide insights into our understanding of the molecular determinants driving these two entities. (sarcomahelp.org)

however, little is known about the mechanisms of miRNA enrichment in EVs. (spandidos-publications.com)

The miRNA expression profile was evaluated in formalin-fixed paraffin-embedded (FFPE) invasive ductal carcinoma cases containing BRCA mutated and wild type breast carcinomas (1). (biogenex.com)

Anatomy22

Organisms27

Diseases15

Chemicals and Drugs55

Analytical, Diagnostic and Therapeutic Techniques and Equipment40

Phenomena and Processes88

Disciplines and Occupations5

Technology, Industry, Agriculture2

Information Science15

Health Care6

MicroRNAs16

Circulating miRNA expression1

MicroRNA4

RNAs11

Genes7

Biomarkers7

Quantification of mature miRNAs2

Measured miRNA expression levels1

Differentially4

MRNAs and miRNAs1

Assays11

High-quality miRNA2

Overlapped miRNA-mRNA1

Tested selected miRNAs1

Regulation6

Regulatory1

Various miRNAs2

Specific miRNA2

Nucleic acid3

Molecules3

Workflow3

Biomarker3

Tumor suppressors2

Mimics1

Targets2

Significantly3

Pathogenesis2

Tissues3

Assay4

Valerio3

Vivo1

Alterations3

Prediction1

Gene expression1

MiRBase1

Dysregulation2

Evolutionarily1

Markers2

Sequence4

Inhibits1

Negatively1

Repression1

Quantitative1

SiRNA1

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Tumorigenesis1

Hybridization1

Overexpression2

Fully optimized1

Prognosis2

Metastasis2

Predictive2

Biology1

Human8

Mature2

Upregulation1

Expression signatures1

Methods2

Signatures1

Mechanisms1

Formalin-fixed1