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  • cytotoxic T cel
  • Publications] Mikinori Miyazaki: 'Potential limitations in using minor histocompatibility antigen-specific cytotoxic T cells for targeting solid tumor cells'Clinical Immunology. (nii.ac.jp)
  • Publications] Yoshiki Akatsuka: 'Targeted cloning of cytotoxic T cells specific for minor histocompatibility antigens restricted by HLA class I molecules of interest'Transplantation. (nii.ac.jp)
  • Publications] Eisei Kondo: 'Efficient generation of antigen-specific cytotoxic T cells using retrovirally transduced CD40-activated B cells'Journal of Immunology. (nii.ac.jp)
  • MHC tetramers were originally developed using MHC class I molecules for the recognition of cytotoxic T cells, but over the last decade they have allowed for the recognition of CD4 T cells by a wide variety of antigens. (wikipedia.org)
  • She has made significant contributions to the area of minor histocompatibility antigens, showing that male-specific cytotoxic T cells recognize self-MHC and products of genes on the Y chromosome. (wikipedia.org)
  • genome-wide
  • We identified this antigen using genome-wide zygosity-genotype correlation analysis of a mHag-specific CD8(+) cytotoxic T lymphocyte (CTL) clone derived from a multiple myeloma patient who achieved a long-lasting complete remission after donor lymphocyte infusion from an human leukocyte antigen (HLA)-matched sibling. (sigmaaldrich.com)
  • molecules
  • MHC multimers are oligomeric forms of MHC molecules, designed to identify and isolate T-cells with high affinity to specific antigens amid a large group of unrelated T-cells. (wikipedia.org)
  • cells
  • These antigens are either ubiquitously expressed in most tissue like skin and intestines or restrictively expressed in the immune cells. (wikipedia.org)
  • Murine minor histocompatibility antigens detected by helper T cells. (mysciencework.com)
  • A limited number of studies have identified minor H Ags (defined by congenic strains) that stimulate Th cells. (mysciencework.com)
  • While repeated antigen exposure during the priming phase induced the decline of the antigen-specific population and the expression of PD-1 and KLRG-1 on antigen-specific CD8 + T cells, the prolongation of an antigen-free expansion phase induced proliferation arrest and the relative loss of antigen-specific cells without impairing polyfunctional cytokine secretion or inducing PD-1 and KLRG-1 expression. (biomedcentral.com)
  • Both immunization schemes resulted in an SV40 T antigen-specific immune response, indicating the presence of SV40 T antigen-positive cells in the spleens of these transgenic mice. (jax.org)
  • MHC multimers allow for ex vivo selection and proliferation of T-cells specific to viral or tumor-related antigens, which can then be reintroduced to augment the immune system. (wikipedia.org)
  • MHC pentamers have been used in the detection of antigen-specific CD8+ T cells in flow cytometry, and are cited in over 750 peer reviewed publications , including several in the journals Nature and Science. (wikipedia.org)
  • MHC pentamers can also be used in tissue staining, and in magnetic isolation of antigen-specific T cells. (wikipedia.org)
  • The immune system usually does not react to self-antigens under normal homeostatic conditions due to negative selection of T cells in the thymus and is supposed to identify and attack "non-self" invaders from the outside world or modified/harmful substances present in the body under distressed conditions. (wikipedia.org)
  • Depending on the antigen and the type of the histocompatibility molecule, different types of T cells will be activated. (wikipedia.org)
  • citation needed] Non-microbial non-self antigens can include pollen, egg white and proteins from transplanted tissues and organs or on the surface of transfused blood cells. (wikipedia.org)
  • Crucial was her work on the differential expression of minor antigens showing either overall expression on all body cells, such as the male specific H-Y antigens, or restricted expression on solely blood and blood cancer cells, such as HA-1. (wikipedia.org)
  • In a 1994 article entitled "Tolerance, Danger and the Extended Family", Matzinger went several steps further by laying out the idea that antigen-presenting cells respond to "danger signals" - most notably from cells undergoing injury, stress or "bad cell death" (as opposed to apoptosis, controlled cell death). (wikipedia.org)
  • Molecule
  • In immunology, an antigen is a molecule capable of inducing an immune response (to produce an antibody) in the host organism. (wikipedia.org)
  • The term antigen originally described a structural molecule that binds specifically to an antibody. (wikipedia.org)
  • It was expanded to refer to any molecule or a linear molecular fragment that can be recognized by highly variable antigen receptors (B-cell receptor or T-cell receptor) of the adaptive immune system. (wikipedia.org)
  • specificity
  • MHC multimers allow for a previously unattainable level of specificity in antigen-specific T-cell detection and isolation. (wikipedia.org)
  • because of this, many different antibodies are produced, each with specificity to bind a different antigen while sharing the same basic structure. (wikipedia.org)
  • human
  • Publications] Yoshiki Akatsuka: 'Efficient cloning and expression of HLA class I cDNA in human B-lymphoblastoid cell lines'Tissue Antigens. (nii.ac.jp)
  • binds
  • An antigen binds the highly variable immunoreceptor products (B-cell receptor or T-cell receptor) once these have been generated. (wikipedia.org)
  • cytolytic
  • The ability of normal mice to mount an SV40 T antigen-specific cytolytic T lymphocytes response when immunized in vivo with splenocytes from the SV40 T antigen transgenic 427-line mice and restimulated in vitro with SV40-transformed fibroblasts, or when immunized with SV40 and restimulated with 427-line splenocytes, was analyzed. (jax.org)
  • vitro
  • Large scale ex vivo T-cell expansion and effector differentiation can lead to robust antigen-specific cytolysis in vitro , but also to terminal effector differentiation and poor capacity to further expand and persist in vivo . (biomedcentral.com)
  • molecular
  • This simply readable yet complete textual content is the 1st to place jointly insightful ancient views with up to date advances within the molecular genetics, biochemistry and immunobiology of teen H antigens from either experimental and scientific issues of view. (larchecapebreton.org)
  • more moderen techniques have extracted molecular factors eventually permitting one to ascribe a rational molecular foundation to minor H minor antigens either in rodents and people. (larchecapebreton.org)
  • At the molecular level, an antigen can be characterized by its ability to bind to an antibody's variable Fab region. (wikipedia.org)
  • self-antigens
  • Many autoimmune diseases are caused by the uncontrolled or excessive immune response against self-antigens (e.g. rheumatic fever, asthma, glomerulonephritis, many dermatological disorders which may manifest as desquamative gingivitis, multiple sclerosis and etc. (periobasics.com)
  • The immune system usually does not react to self-antigens under normal homeostatic conditions due to negative selection of T cells in the thymus and is supposed to identify and attack "non-self" invaders from the outside world or modified/harmful substances present in the body under distressed conditions. (wikipedia.org)
  • citation needed] Non-microbial non-self antigens can include pollen, egg white and proteins from transplanted tissues and organs or on the surface of transfused blood cells. (wikipedia.org)
  • The regulatory T cells (Tregs /ˈtiːrɛɡ/), formerly known as suppressor T cells, are a subpopulation of T cells that modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease. (wikipedia.org)
  • leukocyte
  • While the ideal donor may be a young human leukocyte antigen (HLA)-identical male sibling, difficult decisions may arise for patients whose only available sibling donor is a sister with previous pregnancies. (ashclinicalnews.org)
  • major
  • NZB mice infected with B. burgdorferi developed higher degrees of joint swelling and higher anti- B. burgdorferi immunoglobulin M cross-reactive responses than other strains with identical major histocompatibility complex (DBA/2 and BALB/c). (asm.org)
  • The domains have binding regions for the Major Histocompatibility Complex Class II (MHC Class II) and the T cell receptor (TCR), respectively. (wikipedia.org)
  • Sudden falls, sometimes resulting in major injury to the skull or other bones, can occur, even from walking on minimally-irregular ground or from other minor imbalances outside or in the home, due to weakness of quadriceps and gluteus muscles depriving the patient of automatic posture maintenance. (wikipedia.org)
  • specific
  • In vitro studies show that BLyS increases B cell number, Ig production, antigen-specific immunoglobulin response, and induces production of secretory IgA. (bioportfolio.com)
  • highly
  • An antigen binds the highly variable immunoreceptor products (B-cell receptor or T-cell receptor) once these have been generated. (wikipedia.org)