AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceNamed Groups
Receptors, CollagenFibrillar CollagensCollagenCollagen Type IIntegrin alpha2beta1Receptors, MitogenIntegrin alpha1beta1Platelet Membrane GlycoproteinsIntegrinsCollagen Type IIICollagen Type VIntegrin alpha1Platelet AdhesivenessBlood PlateletsProcollagenExtracellular MatrixCollagen Type IVCollagen Type IICrotalid VenomsCollagen Type XIIntegrin alpha2Platelet AggregationFibroblastsPlatelet ActivationCell AdhesionCells, CulturedCollagen Type VIHydroxyprolineMolecular Sequence DataAmino Acid SequenceExtracellular Matrix ProteinsCollagenasesCaesalpiniaDecorinViperidaeMicroscopy, PolarizationBone Morphogenetic Protein 1FibronectinsCollagen DiseasesOsteonectinTendonsViper VenomsLamininProtein Bindingvon Willebrand FactorCollagen Type XVIIISkinCartilageProteoglycansMatrix MetalloproteinasesFibrosisReceptors, IgGLectins, C-TypeMegakaryocytesReceptors, LamininThrombosisPlatelet Glycoprotein GPIb-IX ComplexRNA, MessengerConnective TissueMatrix Metalloproteinase 1Receptors, Very Late AntigenReceptors, Cell SurfaceHeart Failure, DiastolicMice, KnockoutCorneal StromaHSP47 Heat-Shock ProteinsPhospholipase C gammaPeptidesReceptor Protein-Tyrosine KinasesCell MovementPeptide FragmentsMetalloendopeptidasesProcollagen N-EndopeptidaseHydroxylysineGelsFibril-Associated CollagensMicroscopy, ElectronPlatelet Glycoprotein GPIIb-IIIa ComplexBasement MembranePoriferaCollagen Type XProtein Structure, TertiaryBase SequenceCorneaCattleCell LineTissue Inhibitor of MetalloproteinasesMyocardiumMice, Inbred C57BLSignal TransductionHemostasisKineticsMicrobial CollagenaseCollagen Type XIIBinding SitesImmunohistochemistryCollagen Type VIIEhlers-Danlos SyndromeChick EmbryoPepsin A
Extracellular matrixDepositionFibroblastsFibrilsAffects collagenMoleculesBeta-2 adreneConnective tissueINTEGRINSTissueEGFRHeterotrimerVitreousFibrosisChainsCartilageProteinsProteinAmino acidPathwaysEncodesGlycoproteinsTissuesMutationGeneAmountsAbundantTypeFormationFoundRegulationBoneMajorCellFormChainABSTRACTProductionSingleLevelsDamageStudySize
Extracellular matrix4
Deposition3
  • Increased deposition of fibrillar collagens I and III is apparent [ 2 ], along with changes in the abundance and localisation of collagens V, XII and XIV, which help to organise and stabilise the growing fibrils [ 3 , 4 ]. (ersjournals.com)
  • Hepatic stellate cells (HSCs) are considered central ECM-producing cells within the injured liver,1 playing a significant role in Collagen-I deposition when hepatocellular injury is concentrated within the liver lobules and sinusoids. (ikksignal.com)
  • The principal cell type responsible for increased deposition of fibrillar collagen during active tissue fibrosis are myofibroblasts - a subset of activated fibroblasts characterized by expression of alpha-smooth muscle actin (α-SMA) [ 2 , 3 ]. (oncotarget.com)
Fibroblasts4
  • Activated fibroblasts secrete LOXL2 along with increased amounts of collagen [ 6 ]. (ersjournals.com)
  • Fine fibrillar collagen, marked edema, large fibroblasts, dilated and congested blood vessels, and inflammatory infiltrates (primarily polymorphonuclear leukocytes and eosinophils) are found. (medscape.com)
  • Early hyalinization is characterized by thickened collagen bundles, moderate numbers of fibroblasts, and inflammatory cells (primarily lymphocytes, eosinophils, and plasma cells). (medscape.com)
  • The MMT cells were a major source of collagen-producing fibroblasts in the fibrosing kidney, accounting for more than 60% of α-SMA+ myofibroblasts. (oncotarget.com)
Fibrils5
  • Type XI collagen also helps maintain the spacing and diameter of type II collagen fibrils. (wikipedia.org)
  • The size and arrangement of type II collagen fibrils is essential for the normal structure of these tissues. (wikipedia.org)
  • When mutations in the COL11A2 gene affect the structure of collagen fibrils, hearing loss can result. (wikipedia.org)
  • The sea cucumber collagen fibrils were previously confirmed to be heterotypic, nevertheless, the stoichiometry of collagen α-chains governing the complexity of collagen fibrils is still poorly understood. (bvsalud.org)
  • The assembly forms of sea cucumber collagen fibrils were further hypothesized according to the chain stoichiometry. (bvsalud.org)
Affects collagen1
  • This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (lookformedical.com)
Molecules3
  • This mutation prevents collagen molecules from being assembled properly, which disrupts the structure of type XI collagen. (wikipedia.org)
  • One important driver of matrix tension is lysyl oxidase-like 2 (LOXL2), an enzyme that catalyses covalent cross-linking of ECM molecules, including fibrillar collagens. (ersjournals.com)
  • Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. (lookformedical.com)
Beta-2 adrene1
  • The ADRB2 gene encodes the beta-2 adrenergic receptor. (genebase.com)
Connective tissue3
INTEGRINS2
  • Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI. (lookformedical.com)
  • By exploiting four monoclonal antibodies recognizing distinct conformational epitopes, we show that in endothelial cells (ECs), the extracellular βI domain, but not the hybrid or I-EGF2 domain of active β1 integrins, promotes their FAK-regulated clustering into tensin 1-containing fibrillar adhesions and impairs their endocytosis. (life-science-alliance.org)
Tissue4
  • Type II collagen is an important component of the eye and mature cartilage tissue. (wikipedia.org)
  • LOXL2 protein expression is observed in the fibroblastic foci and collagenous regions of diseased IPF lung tissue, with relatively minor expression in healthy lung tissue [ 9 ]. (ersjournals.com)
  • Dense bundles and sheets of collagen, thick bands of subepithelial hyalinization extending into the submucosal tissues (replacing fat or fibrovascular tissue), decreased vascularity, no edema, and inflammatory cells (lymphocytes and plasma cells) are found. (medscape.com)
  • Myofibroblasts are a main cell-type of collagen-producing cells during tissue fibrosis, but their origins remains controversial. (oncotarget.com)
EGFR1
  • Abnormal activation of epidermal growth factor receptor (EGFR) promotes the development of NSCLC. (bvsalud.org)
Heterotrimer2
  • Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. (wikipedia.org)
  • Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits. (lookformedical.com)
Vitreous2
Fibrosis3
  • We evaluated whether lysyl oxidase-like 2 (LOXL2), which promotes cross-linking of collagen in pathological stroma, was detectable in serum from idiopathic pulmonary fibrosis (IPF) patients, and assessed its relationship with IPF disease progression. (ersjournals.com)
  • [ 37 ] This new technique uses wavelet coefficients from transmission electron micrography images of subepithelial fibrillar collagen in healthy oral submucosa and in oral submucous fibrosis tissues. (medscape.com)
  • Up-regulation of fibrillar Collagen-I is thus a key event leading to scarring, the pathophysiological hallmark of liver fibrosis. (ikksignal.com)
Chains7
  • The pro-alpha2(XI) chain combines with pro-alpha1(XI) and pro-alpha1(II)collagen chains to form a procollagen molecule. (wikipedia.org)
  • This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. (wikipedia.org)
  • Most of these mutations result in a complete lack of pro-alpha2(XI) chains, which leads to a loss of function of type XI collagen. (wikipedia.org)
  • A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics. (lookformedical.com)
  • A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains. (lookformedical.com)
  • Herein, four representative collagen α-chains in sea cucumber including two clade A fibrillar collagens, one clade B fibrillar collagen, and one fibril-associated collagen with interrupted triple helices were selected. (bvsalud.org)
  • Consequently, the stoichiometry of the four collagen chains was determined to be approximately 100:54:3:4 based on the method. (bvsalud.org)
Cartilage3
  • Type XI collagen is normally found in cartilage as well as the fluid that fills the eyeball, the inner ear, and the center portion of the discs between the vertebrae in the spine (nucleus pulposus). (wikipedia.org)
  • Because this type of collagen is an important component of cartilage and other connective tissues, these mutations result in the characteristic signs and symptoms of OSMED. (wikipedia.org)
  • A fibrillar collagen found primarily in interstitial CARTILAGE. (lookformedical.com)
Proteins4
  • One family carries a mutation that substitutes the amino acid cysteine (a building block of proteins) for the amino acid arginine at position 549 (written as Arg549Cys) in the alpha 2 chain of type XI collagen. (wikipedia.org)
  • Contrary to reef building corals, the red coral organic matrix possesses a large number of collagen-like proteins. (biomedcentral.com)
  • The health and appearance of our skin, hair and nails depends on the health of several structural proteins they share, namely collagen, keratin and elastin. (lifeextension.com)
  • The appearance and integrity of our skin, hair, and nails are dependent upon a framework of structural proteins, especially keratin, collagen, and elastin. (lifeextension.com)
Protein3
  • Collagen alpha-2(XI) chain is a protein that in humans is encoded by the COL11A2 gene. (wikipedia.org)
  • Supplementation with specialized collagen peptides is one way to help support the collagen protein network that gives skin its supple, youthful appearance. (lifeextension.com)
  • The interaction of sGAG with α2-macroglobulin receptor-associated protein (LRPAP1), exportin-1 (XPO1), and serine protease HTRA1 (HTRA1) was confirmed in reverse assays. (degruyter.com)
Amino acid3
  • This mutation causes the amino acid glycine to be replaced with the amino acid glutamic acid at position 955 in the alpha 2 chain of type XI collagen (written as Gly955Glu). (wikipedia.org)
  • A hydroxylated derivative of the amino acid LYSINE that is present in certain collagens. (lookformedical.com)
  • [6] APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. (handwiki.org)
Pathways1
  • They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. (lookformedical.com)
Encodes3
  • The PPARA gene encodes a peroxisome proliferator-activated receptor that is important for the activation of other genes involved in energy metabolism, body weight regulation and vascular formation. (genebase.com)
  • The PPARD gene encodes a peroxisome proliferator-activated receptor that is important for the activation of other genes in response to fatty acid derivatives. (genebase.com)
  • In two families affected by a previously undefined CMS, we identified homozygous loss-of-function mutations in COL13A1, which encodes the alpha chain of an atypical non-fibrillar collagen with a single transmembrane domain. (ox.ac.uk)
Glycoproteins1
  • Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. (musc.edu)
Tissues1
Mutation1
  • Using CRISPR-Cas9 genome editing, modeling of the COL13A1 c.1171delG (p.Leu392Sfs(∗)71) frameshift mutation in the C2C12 cell line reduced acetylcholine receptor (AChR) clustering during myotube differentiation. (ox.ac.uk)
Gene2
  • The COL11A2 gene produces one component of this type of collagen, called the pro-alpha2(XI) chain. (wikipedia.org)
  • It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. (wikipedia.org)
Amounts1
  • repair, secreting large amounts of ECM, mostly Collagen-I and regulating ECM remodeling. (ikksignal.com)
Abundant1
  • Collagen is the most abundant and important structural biomacromolecule in sea cucumbers. (bvsalud.org)
Type9
Formation2
Found1
Regulation1
  • This receptor interacts with epinephrine to control smooth muscle relaxation, and is also involved in energy balance regulation. (genebase.com)
Bone1
  • In vitro studies in Smad3 null bone marrow macrophages also showed that Smad3 was required for TGF-β1-induced MMT and collagen production. (oncotarget.com)
Major2
  • In Caucasian populations, the increased muscle variant is the less common (minor) allele, but it is the more common (major) allele in other ethnicities (e.g. at, or near to, 100% in Han Chinese and Japanese). (genebase.com)
  • This graph shows the total number of publications written about "Fibronectins" by people in this website by year, and whether "Fibronectins" was a major or minor topic of these publications. (musc.edu)
Cell2
  • This pathological remodelling of the ECM probably results in the release of latent transforming growth factor (TGF)-β from the latency-associated peptide complex sequestered in the ECM [ 7 , 8 ], driving a feed-forward loop of cell activation, LOXL2 and collagen secretion, and matrix stiffening. (ersjournals.com)
  • Although different cell types contribute to the increase in fibrillar Collagen-I during hepatic fibrogenesis, they all undergo a common process of differentiation and acquisition of a classical myofibroblast-like phenotype. (ikksignal.com)
Form2
  • The most common form of fibrillar collagen. (lookformedical.com)
  • What are the consequences of expressing a constitutively activated form of the Toll receptor, Toll(10b), in anterior regions of the early embryo? (sdbonline.org)
Chain1
  • Some mutations affect the production of the pro-alpha2(XI) chain and disrupt normal collagen assembly. (wikipedia.org)
ABSTRACT1
  • The view Ду Abstract of response is attP, and was longitudinal shown on probability of Q-Q arguments for histones from a difficult functional related Cre-dependent receptor corresponded allowing the Invertase) elution from the R dysregulation nlme. (scoutconnection.com)
Production1
Single1
  • We analyzed the frequency and severity of perioperative complications and all minor adverse events in lumbar surgery at a single center. (researchgate.net)
Levels1
  • This receptor is expressed at higher levels in slow-twitch (endurance) muscle fibres compared to fast-twitch (power/sprinter) muscle fibres. (genebase.com)
Damage1
Study1
Size1
  • They proclaimed that, requested to recent rights, regional receptor-1 drugs have an requested size of waves in the Other gradient and otherwise in the construction development. (cdseidel.de)