• The tetracyclines are primarily bacteriostatic and are thought to exert their antimicrobial effect by the inhibition of protein synthesis. (nih.gov)
  • Tetracyclines may cause permanent discoloration of teeth and slow down the growth of bones. (mayoclinic.org)
  • A group of 145 men with non-gonococcal urethritis was treated for one week with either tetracycline hydrochloride 500 mg six hourly or minocycline 50 mg twice daily. (bmj.com)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of minocycline hydrochloride tablets and other antibacterial drugs, minocycline hydrochloride tablets should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (nih.gov)
  • Minocycline hydrochloride tablets for oral administration contain minocycline HCl equivalent to 50 mg, 75 mg or 100 mg of minocycline. (nih.gov)
  • Minocycline Hydrochloride Tablets, 50 mg contains FD&C Yellow No. 5 (Tartrazine) as color additive. (nih.gov)
  • Minocycline hydrochloride tablets are rapidly absorbed from the gastrointestinal tract following oral administration. (nih.gov)
  • Following a single dose of one 100 mg tablet of minocycline hydrochloride administered to 28 normal fasting adult volunteers, maximum serum concentrations were attained in 1 to 3 hours (average 1.71 hours) and ranged from 491.71 to 1292.70 ng/mL (average 758.29 ng/mL). (nih.gov)
  • Intestinal absorption of tetracyclines is greatly diminished in lactating infants due to the formation of non-absorbable chelates with milk calcium (Pfizer 2015, Sandoz 2013, Mitrano 2009, Chin 2001). (e-lactancia.org)
  • Minocycline is well-absorbed after oral administration, and its absorption is minimally affected by the presence of food in the stomach. (wedgewoodpharmacy.com)
  • The tetracyclines, including minocycline, have similar antimicrobial spectra of activity against a wide range of gram-positive and gram-negative organisms. (nih.gov)
  • Additionally, resistance can be readily induced in vitro in B. anthracis to a variety of antimicrobial classes including fluoroquinolones, tetracyclines, macrolides, penicillins, and other -lactams ( 8, 13- 16 ). (cdc.gov)
  • Tetracyclines are used to treat infections and to help control acne. (mayoclinic.org)
  • Minocycline is typically used to treat acne, but it can also reduce symptoms associated with mental illnesses, such as schizophrenia and depression, and it can improve decision-making. (rushlimbaugh.com)
  • Tetracyclines also treat inflammatory skin conditions, such as acne , rosacea, and perioral dermatitis. (healthline.com)
  • Minocycline extended-release tablet (Solodyn) is only used to treat acne. (medlineplus.gov)
  • Minocycline topical foam is used to treat moderate to severe acne vulgaris. (drugs.com)
  • Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of minocycline topical foam to treat acne vulgaris in children 9 years of age and older. (drugs.com)
  • This medication is used to treat severe cystic acne (also known as nodular acne) that has not responded to other treatment (such as benzoyl peroxide or clindamycin applied to the skin or tetracycline or minocycline taken by mouth). (kaiserpermanente.org)
  • Because many strains of the following gram-positive microorganisms have been shown to be resistant to tetracyclines, culture and susceptibility testing are especially recommended. (nih.gov)
  • Susceptibility testing should be performed with tetracycline since it predicts susceptibility to minocycline. (nih.gov)
  • Common genomic determinants defined most strains' phenotypic, reduced susceptibility to current and historic antibiotics (e.g. bla (TEM) plasmid for penicillin, tetM plasmid for tetracycline, gyrA for ciprofloxacin, 23S rRNA and/or mosaic mtr operon for azithromycin, and mosaic penA for cefixime and ceftriaxone). (cdc.gov)
  • Treatment of cellulitis caused by uncommon organisms, such as Vibrio species or gram-negative bacteria, should be individualized (eg, tetracyclines, fluoroquinolones or aminoglycosides for Vibrio infection). (medscape.com)
  • Tetracyclines have a wide spectrum of both gram-negative and gram-positive bacteria, including spirochetes and A.a - both of which are major players in periodontitis. (dentistryiq.com)
  • When penicillin is contraindicated, tetracyclines are alternative drugs in the treatment of infections caused by the cited microorganisms. (nih.gov)
  • Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of minocycline topical foam in the elderly. (drugs.com)
  • Tetracyclines are interchangeable for most indications, although minocycline has been most studied for methicillin-resistant S. aureus infections. (msdmanuals.com)
  • A. baumannii in our hospital were highly resistant to all antibiotics, including tigecycline, except for minocycline and colistin which are considered the last resort treatment for multidrug-resistant A. baumannii . (who.int)
  • Tetracycline antibiotics should not be used for streptococcal diseases unless the organism has been demonstrated to be susceptible. (nih.gov)
  • Minocycline is used in dogs to treat susceptible bacterial infections and infections caused by Rickettsia, Canine ehrlichiosis (anaplasmosis), Toxoplasma, Borrelia burgdorferi (Lyme disease), Leptospirosis, and Neorickettsia helminthoeca (salmon poisoning). (wedgewoodpharmacy.com)
  • Minocycline is used in cats to treat susceptible bacterial infections and infections caused by a number of other organisms including Bartonella, Mycoplasma, Dermatophilus, and Mycobacteria. (wedgewoodpharmacy.com)
  • Minocycline is used in horses to treat susceptible bacterial infections and tick-borne diseases such as Ehrlichia, Anaplasma, and Borrelia burgdorferi (Lyme disease). (wedgewoodpharmacy.com)
  • minocycline was more active in vitro against both organisms. (bmj.com)
  • Cross-resistance of these organisms to tetracyclines is common. (nih.gov)
  • Tetracyclines commonly have gastrointestinal side effects, like upset stomach and nausea. (clevelandclinic.org)
  • Minocycline comes as a regular capsule, a pellet-filled capsule, and an extended-release tablet (Solodyn) to take by mouth. (medlineplus.gov)
  • Tetracyclines are a group of antibiotics with anti-inflammatory properties that can treat several bacterial infections. (healthline.com)
  • Minocycline is also used to treat plague and tuleramia (serious infections that may be spread on purpose as part of a bioterror attack). (medlineplus.gov)
  • Minocycline is also sometimes used to treat rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function). (medlineplus.gov)
  • Tetracyclines are a class of antibiotics that treat several kinds of bacterial infections. (clevelandclinic.org)
  • What conditions do tetracyclines treat? (clevelandclinic.org)
  • Tetracyclines can treat several kinds of bacterial infections. (clevelandclinic.org)
  • Tetracycline antibiotics can treat a broad range of bacterial infections. (clevelandclinic.org)
  • The most common antibiotics used to treat ehrlichiosis belong to the tetracycline family of drugs. (petplace.com)
  • In previous studies with other minocycline dosage forms, the minocycline serum half-life ranged from 11 to 16 hours in 7 patients with hepatic dysfunction, and from 18 to 69 hours in 5 patients with renal dysfunction. (nih.gov)
  • The investigators are now conducting a phase I clinical trial to determine whether minocycline treatment is safe in human patients with subarachnoid hemorrhage and whether it reduces MMP-9 levels in the spinal fluid and blood. (wustl.edu)
  • If the trial is successful, the team will conduct a phase II study to look not only at safety and MMP-9 levels but also at whether the incidence of vasospasm is reduced in patients receiving minocycline. (wustl.edu)
  • Possible adverse effects of minocycline include drug hypersensitivity syndrome, autoimmune reactions, and dizziness and headache. (healthline.com)
  • Minocycline may be used in animals with decreased kidney function because it is extensively metabolized via the liver, and then primarily excreted as inactive metabolites in the feces and urine. (wedgewoodpharmacy.com)
  • Tetracycline and minocycline are excreted primarily in urine. (msdmanuals.com)
  • Comparison of tetracycline and minocycline in the treatment of non-gonococcal urethritis. (bmj.com)
  • The clinical results obtained were similar: 61 of 77 (79%) men treated with tetracycline and 53 of 68 (78%) men treated with minocycline were free from urethritis one to two weeks after completing treatment. (bmj.com)
  • Tetracyclines are not the drug of choice in the treatment of any type of staphylococcal infection. (nih.gov)
  • Cialis is indicated for the treatment of erectile dysfunction minocycline facial rash . (terminally-incoherent.com)
  • If we start to see that minocycline is safe and reduces MMP-9 levels and we have signs in phase II that the incidence of vasospasm is lower, then we will design a multicenter phase III trial to look at the long-term neurologic outcomes of minocycline treatment," Zipfel says. (wustl.edu)