• Akerlund K, Bjork L, Fehniger T, Pohl G, Andersson J, Andersson U (1996) Sendai virus-induced IFN-alpha production analysed by immunocytochemistry and computerized image analysis. (univ-amu.fr)
  • Based on the results, it can be estimated that these compounds imparting greatly to anti-inflammatory effects of M. pudica in vitro as well as in vivo through reduction of LPS-induced pro-inflammatory mediators which affirm the ethno-pharmacological use of this plant for prevention of inflammatory-related disorders. (tu-dortmund.de)
  • 6 , 7 Through the bubble-cell interactions, Ultrasound (US)-induced sonoporation may transiently disrupt the cell membrane to induce a temporary increase in the membrane permeability, which can benefit intracellular uptake of membrane-impermeable compounds into cells. (thno.org)
  • Considering its biochemical properties of inactivating various enzymes that require either bivalent metallic ions or PLP as cofactors, mimosine may have a role in plant defense, and based on its chemical composition, it may serve as a reservoir of carbon and nitrogen for survival and growth under nutrient-limiting conditions. (plantphysiol.org)
  • Finally, expression of dominant-negative versions of DP1, known to compromise E2F transcriptional activity, protects cortical neurons from death induced by camptothecin and sympathetic neurons from death evoked by UV treatment. (jneurosci.org)
  • In yeast ( Saccharomyces cerevisiae ) and animals, heavy metal-responsive elements (HMREs) and their corresponding metal-induced transcription factors have been characterized in detail. (plantphysiol.org)
  • When we gave the mice a pharmacologic agent called L -mimosine that stimulates the transcription factor, the agent knocked down Candida 100-fold, which translated into a 50 percent reduction in mortality from invasive Candida infection. (healthcanal.com)
  • Specifically, the researchers found that enhancing the transcription factor HIF-1α with L -mimosine led to increased production of the natural antibiotic peptide LL-37, which in turn killed the fungi. (healthcanal.com)
  • Such high mimosine content in the foliage indicates that mimosine may have some functional role in the plant. (plantphysiol.org)
  • The latter is loaded onto an RNA- hybridizing to the 3 untranslated region of messenger RNA induced silencing complex (RISC) and the functional strand (mRNA), promoting mRNA degradation or disrupting translation guides the RISC to potential mRNA targets . (deepdyve.com)
  • Particularly, it is still a major challenge to get a comprehensive understanding of the impact of cell cycle phase on the cellular responses simultaneously occurring in cell membrane and cytoskeleton induced by microbubble sonoporation. (thno.org)
  • Hypoxia-inducible factor 1α is the central regulator of the hypoxia-induced response which results in the up-regulation of angiogenic factors. (plos.org)
  • By using human cells expressing a foreign UV damage endonuclease (UVDE) and irradiating the cells with UV through tiny pores in membrane filters, we created SSB in restricted areas in the nucleus by the immediate action of UVDE on UV-induced DNA lesions. (asm.org)
  • More study is needed to pinpoint the optimal method of inducing the body's gut defense system, whether through use of an agent like L -mimosine or by administering short-chain fatty acids such as vinegar. (healthcanal.com)
  • Here, we aimed to reveal the effects of hypoxia and the hypoxia mimetic agent L-mimosine (L-MIM) on the production of sclerostin (SOST) and dickkopf-1 (DKK-1) in human dental pulp-derived cells (DPC). (biomedcentral.com)
  • A clastogen is a mutagenic agent giving rise to or inducing disruption or breakages of chromosomes, leading to sections of the chromosome being deleted, added, or rearranged. (wikipedia.org)
  • L -mimosine is a natural product derived from seeds of the koa haole tree that is not approved as a drug but is known to boost HIF-1α activity. (healthcanal.com)
  • Hypoxia-inducible factor 1α (HIF-1α) is the central regulator of the hypoxia-induced response. (plos.org)
  • In this study, we examined the anti-cancer effect of mimosine on human H226 lung cancer cells grown in nude mice. (spandidos-publications.com)
  • In this study, we isolated a 1,520-bp complementary DNA ( cDNA ) for mimosinase from L. leucocephala and characterized the encoded enzyme for mimosine-degrading activity. (plantphysiol.org)
  • The purified recombinant enzyme was used in mimosine degradation assays, and the chromatogram of the major product was found to be identical to that of 3-hydroxy-4-pyridone ( 3H4P ), which was further verified by electrospray ionization-tandem mass spectrometry. (plantphysiol.org)
  • Mimosine is abundant in all parts of L. leucocephala , and on a dry weight basis, L. leucocephala leaves contain approximately 5% mimosine ( Soedarjo and Borthakur, 1998 ). (plantphysiol.org)
  • The isolation of the mimosinase cDNA and the biochemical characterization of the recombinant enzyme will be useful in developing transgenic L. leucocephala with reduced mimosine content in the future. (plantphysiol.org)
  • it was considered a law of 2mg mimosine level and was designed by pcp vegas, featured for his scarce time. (leplanetarium.com)
  • Knockdown of miR-382, which was up-regulated by TGFβ1, attenuated TGFβ1-induced loss of the epithelial marker E-cadherin. (jove.com)
  • So diabetic-induced wound healing impairment is a significant challenge to surgeons. (plos.org)