Mimic the effects of caloric restriction. Medical search. Frequent questions

Studies have demonstrated that resveratrol activates SIRT I genes, which mimic the healthy aging effects of caloric restriction. (picknsave.com)
Last month, I linked to an article written by Harvard graduate student Laura Strittmatter about Resveratrol, a compound in red wine that had been linked to anti-aging effects in studies on rodents. (scienceblogs.com)
The latest Science in the News Flash is up, and it examines the anti-aging research surrounding the molecule resveratrol, which is present at low concentrations in red wine: If resveratrol were able to mimic the lifespan-extending effects of caloric restriction in people without requiring such an extreme diet, it would be very popular, especially if it gives people an excuse to drink more wine! (scienceblogs.com)
The arthritis went away over the next week or two, but of course I didn't know whether to attribute that to stopping the resveratrol, starting the latter supplements, or placebo effect. (dericbownds.net)
I tried in vain to find in the literature, on the web, any reported negative side effects reported by people taking resveratrol. (dericbownds.net)
Today, resveratrol is attracting attention for its unique ability to mimic the gene expression effects of caloric restriction, the only intervention that has been shown in peer-reviewed studies to prolong maximum life span and/or produce anti-aging effects in a variety of organisms, including mice, rats, dogs, and monkeys. (lifeextension.com)
A better option would be to find a means to mimic the beneficial effects of caloric restriction through a healthy, convenient dietary supplement such as resveratrol. (lifeextension.com)
4 That made resveratrol the first compound to show anti-aging effects in widely divergent species. (lifeextension.com)
Resveratrol, pterostilbene, quercetin, and extracts of grape seed rank among the most promising of CR mimics, while the polyphenols in black tea support these metabolic effects. (purehealthclinic.co.uk)
and includes a sixth substance, fisetin, which comes a lot from strawberries and appears to enhance the effect of the resveratrol. (purehealthclinic.co.uk)
Many concluded that resveratrol can mimic the effects of caloric restriction. (longevitylive.com)
A review published last year in the International Journal of Molecular Sciences examined the effects of resveratrol on cardiovascular health. (longevitylive.com)
However, the most unique application of resveratrol is that it mimics the effects of a calorie-restricted diet. (bodyenergyclub.com)
Resveratrol provides many of the beneficial effects of caloric restriction, making it a powerful addition to any anti-aging protocol. (bodyenergyclub.com)
Those in search of anti-aging nutrients, practicing life extension, those desiring the heart health benefits of wine without the negative effects of sugar and alcohol, could benefit from Acta-Resveratrol. (bodyenergyclub.com)
Each capsule of AOR's Acta-Resveratrol contains enough resveratrol to equal that found in approximately 180 glasses of red wine and without the negative side effects of alcohol. (bodyenergyclub.com)
Specifically, the researchers found that low doses of resveratrol mimic the helpful effects of what is known as caloric restriction, diets with the full range of nutrients but up to 30 per cent fewer calories than a typical diet, which extend lifespan and slow the progression of age related diseases such as obesity, diabetes and cancer. (b12partners.net)
Until now, researchers believed that high doses of resveratrol were necessary to ward off the ill effects of aging. (resvantage.com)
Several clinical trials have demonstrated the efficacy of low dose resveratrol to mimic the favorable gene expression changes seen with caloric restriction and numerous studies have linked caloric restriction to a longer, healthier life. (resvantage.com)
In the last few years, several animal studies have been conducted to study the effect of resveratrol on diabetes. (cofttek.com)

Another example of prolonged fasting, potentially safer and easier to complete, is the Fasting Mimicking Diet (FMD) where specific foods can be eaten while still allowing the body to remain in a fasting state and experience many of the same benefits. (prolon.eu)
The Fasting Mimicking Diet is the first and only meal program that has gone through clinical trials at the University of Southern California and been patented for its anti-aging effects. (prolon.eu)
New research into fasting, and specifically an approach called the Fasting Mimicking Diet (FMD), is shedding light on how to use foods and diet patterns to promote longevity and prevent or reverse degenerative diseases. (holisticprimarycare.net)
Given his risk of developing diabetes, I offered him four consecutive cycles of Fasting Mimicking Diet for three weeks under the strict supervision of his doctor and myself. (prolon.eu)
A fasting mimicking diet, comprises a low calorie, low protein diet which resembles fasting in its physiological response, and has been shown to enhance the healthspan, among other positive effects. (starvingneuron.com)

Third, fasting, or limiting eating to specific time windows, might mimic the benefits of caloric restriction by causing "hormesis," an adaptive response to mild stressors that boost resilience to aging-related changes. (bigthink.com)
More recently, science has shed light on the benefits of caloric restriction as a method for extending human lifespan. (naturallivingskills.com)
While benefits of caloric restriction have been demonstrated in various animal models, its impact on human longevity is less clear but still promising. (naturallivingskills.com)

Many people find the prospect of long-term caloric restriction too difficult and uncomfortable. (lifeextension.com)
Scientists have shown in mice that long-term caloric restriction can attenuate age-related immunosenescence on par with antibody-mediated clearance of senescent T-cells. (lifespan.io)

However, two studies in rats and mice with normal genetics and longevity have found no effect of metformin on maximum lifespan, and only a very small effect on median lifespan. (wikipedia.org)
[1] [2] The possible effect of calorie restriction on body weight management , longevity , and aging-associated diseases has been an active area of research. (wikipedia.org)
Intermittent fasting refers to periods with intervals during which no food but only clear fluids are ingested - such as a period of daily time-restricted eating with a window of 8 to 12 hours for any caloric intake - and could be combined with overall calorie restriction and variants of the Mediterranean diet which may contribute to long-term cardiovascular health and longevity. (wikipedia.org)
the underlying mechanism was found to be that caloric restriction is regulated by a series of interconnected nutrient-sensing pathways all leading to epigenetic confluence on genes known as the FOXO transcription genetic complex leading to the upregulation of factors that lead to improved healthspan and longevity. (physicianwrites.com)
Simply put, understanding the potential connection between the reduction of daily caloric intake and longevity has become a significant focal point of research in the fields of aging and gerontology. (naturallivingskills.com)
While the exact connections are still under study, some key mechanisms have been elucidated connecting caloric restriction to longevity. (naturallivingskills.com)
Another potential mechanism that connects caloric restriction to longevity is through the enhancement of autophagy - a process where cells get rid of their damaged parts, subsequently leading to better cellular function and health. (naturallivingskills.com)
Under conditions of caloric restriction, the rate of autophagy increases, thus helping cells to maintain their integrity over time, enhancing longevity. (naturallivingskills.com)

Calorie restriction mimetics (CRM), also known as energy restriction mimetics, are a hypothetical class of dietary supplements or drug candidates that would, in principle, mimic the substantial anti-aging effects that calorie restriction (CR) has on many laboratory animals and humans. (wikipedia.org)
In the short-lived roundworm Caenorhabditis elegans, supplementation with oxoacetate increases the ratio of reduced to oxidized nicotinamide adenine dinucleotide (NAD+:NADH) to activate AMPK and FOXO signaling pathways similar to what occurs in calorie restriction. (wikipedia.org)
It improves lipid profile, glucose tolerance, and waist measurement, and is therefore comparable in effect to calorie restriction (CR). (wikipedia.org)
In the recent past, there has been much research around this question, not surprisingly, and most experts agree that one of the most significant ways to slow ageing is calorie restriction. (purehealthclinic.co.uk)
I read a great article from Life Extension about this whole subject and learned that there are 5 or 6 what are termed 'mimetic' substances that can have a similar result on gene expression as the calorie restriction does. (purehealthclinic.co.uk)
Research shows that calorie restriction (CR) can extend life span and afford significant protection against age-related disease in many animal species. (purehealthclinic.co.uk)
The first, called 'Calorie Restriction Mimetic Formula' (snappy title! (purehealthclinic.co.uk)
Intermittent versus daily calorie restriction: Which diet regimen is more effective for weight loss? (researchgate.net)
The most common form of dietary restriction implemented is daily calorie restriction (CR), which involves reducing energy by 15-60% of usual caloric intake every day. (researchgate.net)
The most commonly employed strategy for weight loss is daily calorie restriction, which involves reducing usual caloric intake on a daily basis by 15-60% (9) . (researchgate.net)
Some evidence suggests that intermittent calorie restriction may be superior to daily calorie restriction for the retention of lean mass at the expense of fat mass (9) . (researchgate.net)
Intriguingly, many of these mechanisms utilize the same molecular pathways that are altered through calorie and/or carbohydrate restriction. (springer.com)
We review the possible roles for calorie restriction (CR) and very low carbohydrate ketogenic diets (KDs) in modulating the five R's of radiotherapy to improve the therapeutic window between tumor control and normal tissue complication probability. (springer.com)
However, we believe that it might be doable to get the constructive effects, without the detrimental ones, by taking vitamins and different dietary supplements which have the same results as a calorie restricted weight loss plan. (ymlp283.net)
First, caloric restriction - typically a 20% reduction in overall calorie intake - has been linked to increased lifespan in several animal models. (bigthink.com)
Calorie restriction (caloric restriction or energy restriction) is a dietary regimen that reduces the energy intake from foods and beverages without incurring malnutrition . (wikipedia.org)
[10] Mild calorie restriction may be beneficial for pregnant women to reduce weight gain (without weight loss) and reduce perinatal risks for both the mother and child. (wikipedia.org)
[11] [12] For overweight or obese individuals, calorie restriction may improve health through weight loss, although a gradual weight regain of 1-2 kg (2.2-4.4 lb) per year may occur. (wikipedia.org)
The term "calorie restriction" as used in the study of aging refers to dietary regimens that reduce calorie intake without incurring malnutrition . (wikipedia.org)
People losing weight during calorie restriction risk developing side effects , such as cold sensitivity , menstrual irregularities , infertility , or hormonal changes. (wikipedia.org)
More research, both in humans and in experimental animals, is required to fully understand the connections between single nutrient modifications, calorie restrictions, and regular exercise in the prevention of CVD , cancer, cognitive deficit , inflammatory diseases , sarcopenia , and immune senescence . (wikipedia.org)
[1] [19] As of 2021, there is a lack of adequately controlled long-term studies examining the impact of calorie restriction in humans. (wikipedia.org)
[1] Although calorie restriction has the advantage of slowing down the reduction of muscle mass with age, the initial reduction of mass may be substantial and have an effect on a person's strength and endurance. (wikipedia.org)
Decreasing caloric intake by 20-30%, while fulfilling nutrient requirements, has been found to remedy diseases of aging, including cancer, cardiovascular disease, dementia, and diabetes in humans, and result in an average loss of 7.9 kilograms (17 lb) in body weight, but because of the long lifespan of humans, evidence that calorie restriction could prevent age-related disease in humans remains under preliminary research. (wikipedia.org)
[1] [20] While calorie restriction leads to weight and fat loss, the precise amount of calorie intake and associated fat mass for optimal health in humans is not known. (wikipedia.org)
[1] Moderate amounts of calorie restriction may have harmful effects on certain population groups, such as lean people with low body fat. (wikipedia.org)
As of 2021, intermittent fasting and calorie restriction remain under preliminary research to assess the possible effects on disease burden and increased lifespan during aging, although the relative risks associated with long-term fasting or calorie restriction remain undetermined. (wikipedia.org)
The Minnesota Starvation Experiment examined the physical and psychological effects of extreme calorie restriction on 32 young and lean 24-year-old men during a 40% reduction in energy intake for 6 months. (wikipedia.org)
He studied biochemistry at University of North Texas and later went on to UCLA in 1992, where he joined the lab of Roy Walford-a colorful and controversial pioneer in the study of calorie restriction and health. (holisticprimarycare.net)
Caloric restriction (CR) refers to the dietary regimen where calorie intake is reduced without causing malnutrition. (naturallivingskills.com)

An effective CRM would alter the key metabolic pathways involved in the effects of CR itself, leading to preserved youthful health and longer lifespan without the need to reduce food intake. (wikipedia.org)
Excessive caloric intake is strongly associated with the onset of degenerative disease and shorter life span. (purehealthclinic.co.uk)
Not only does IF make reducing normal caloric intake by at least 20 percent a more viable option, it has been shown to outperform CR. (nutritionnews.com)
The diets in these regions are characterized by lower caloric intake compared to Western diets. (naturallivingskills.com)
One of the most prominent studies investigating the effect of caloric restriction on humans is the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE), a trial funded by the National Institute on Aging. (naturallivingskills.com)
A drastic reduction in caloric intake could lead to nutritional deficiencies if not well planned. (naturallivingskills.com)
However, since caloric restriction is a quite dramatic intervention involving between a 20-40% reduction in the caloric intake and therefore, among other issues, hard to maintain in the long term, here we present other alternative dietary interventions pursuing the same aim: to delay the aging process and promote a longer lifespan. (starvingneuron.com)
Both periodic and intermittent fasting have been shown to increase lifespan and to have effects on similar metabolic pathways as caloric restriction, even when the overall caloric intake is not reduced with fasting. (starvingneuron.com)
The most effective macronutrient restriction so far is reducing protein and/or aminoacid intake. (starvingneuron.com)
A high carbohydrate, low protein diet was shown to improve cardiovascular health and extend lifespan, but did however increase body fat and caloric intake. (starvingneuron.com)
Lastly, other than limiting caloric intake, in one way or another, we can act over the feeding schedule, which has been shown to have a strong influence on health and survival, probably due to the circadian nature of proteins like sirtuins, strongly involved in aging-feeding related metabolism. (starvingneuron.com)
In mice, restricting access to food to 8-9 hours of their active phase induced a reduction of metabolic diseases even in absence of a lowering of caloric intake, what's more, this restricted feeding schedule reversed the progression of pre-existing obesity and type II diabetes. (starvingneuron.com)
Most children with mild malnutrition respond to increased oral caloric intake and supplementation with vitamin, iron, and folate supplements. (medscape.com)

Nutrients known as "caloric restriction mimics" (or mimetics) afford a novel scientific solution. (purehealthclinic.co.uk)
We call those things mimetics, because they ?mimic? (ymlp283.net)
In terms of mitochondria biogenesis, these include caloric restriction, certain nutrient restrictions or shortages, caloric restriction mimetics, and exercise. (totalhealthmagazine.com)

it was unclear whether it had an effect on maximum lifespan. (wikipedia.org)
However, when tested by two independent groups of scientists across four university laboratories, oxaloacetate supplements had no effect on lifespan in healthy laboratory mice. (wikipedia.org)
This review describes, analyzes and compares the effects of different types of diets in reducing the onset of typical Western countries non-communicable diseases (NCDs) (cardiovascular diseases, tumors, chronic respiratory diseases, diabetes, etc.), thus increasing the average lifespan. (iospress.com)
However, it's not only the antioxidant value that it has which may promote lifespan, but rather its ability to mimic caloric restriction. (longevitylive.com)
Studies conducted on various species such as yeast, fruit flies, roundworms, and rodents established that caloric restriction could extend lifespan significantly. (naturallivingskills.com)
Caloric restriction has also been associated with a reduction in metabolic rate and a decrease in oxidative stress , which could contribute to increased lifespan. (naturallivingskills.com)
Consequently, the reduction in metabolic rate seen with caloric restriction could help to extend lifespan by decreasing the damage done to cells over time. (naturallivingskills.com)
Researchers concluded that caloric restriction could improve health and potentially extend lifespan in humans, but further long-term studies are needed to confirm these findings. (naturallivingskills.com)
The positive effect of sirtuins in extending lifespan, through a mechanism that mimics caloric restriction, has been demonstrated in a wide range of organisms. (cellr4.org)
The positive effect of CR in extending lifespan has been demonstrated in a wide range of organisms 4 . (cellr4.org)
Additionally, this powerful anti-aging nutrient has been shown to mimic some of the effects of caloric restriction, the only proven method of extending health span and lifespan. (synergsupplements.com)
In a previous article we discussed the principles behind caloric restriction as a means towards increasing lifespan and improving the healthspan (time to occurrence of aging-related disease). (starvingneuron.com)

It will first depict the most relevant characteristics, nutraceutical properties and effects on the populations of the Mediterranean, Japanese, Vegetarian and New Nordic Diet. (iospress.com)
[1] If a restricted diet is not designed to include essential nutrients, malnutrition may result in serious deleterious effects, as shown in the Minnesota Starvation Experiment . (wikipedia.org)
This quest was the main motivator for Longo and his colleagues in developing the "Fast Mimicking Diet. (holisticprimarycare.net)
Earlier studies have shown it can blunt the toxic effects of a diet very high in fat, which causes liver damage, but this is the first study to directly look at ageing. (b12partners.net)
The reflex can be prompted by a faminelike diet, known as caloric restriction, which extends the life of laboratory rodents by up to 30 percent but is far too hard for most people to keep to and in any case has not been proven to work in humans. (b12partners.net)
A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. (starvingneuron.com)

Effective energy restriction strategies are required, and continuous energy restriction (CER) is widely employed for weight management (9) . (researchgate.net)
Intermittent energy restriction (IER) is an alternative to continuous energy restriction (CER) for weight reduction. (researchgate.net)

A caloric restriction regimen strict enough to yield these benefits is difficult or impractical for most people. (purehealthclinic.co.uk)
The most recognized common strategy has been focused on caloric restriction (CR) defined as a dietary regimen low in calories without malnutrition. (cellr4.org)

Because of its parallel effects on these pathways, oxaloacetate was proposed as a CR mimetic. (wikipedia.org)
Among the new alternatives to a sustained caloric restriction stand time-restricted approaches such as short-term starvation, periodic fasting, fasting-mimetic diets and intermittent fasting. (starvingneuron.com)

Since cutting down on eating might not be so desirable for some, another alternative has been recently posed to improve healthy aging: normo-caloric diets with planned deficiencies (in particular macronutrients: proteins, carbohydrates, etc. (starvingneuron.com)

As the most common strategy to suppress metabolism, that is, cooling, does not reveal unequivocal beneficial effects and may even increase mortality, caloric restriction or modulation of energy-sensing pathways (i.e., sirtuins and AMP-activated protein kinase) may offer safe alternatives. (bvsalud.org)
In addition H2S may also confer beneficial effects through upregulation of antioxidant mechanisms, similar to the other gasotransmitters nitric oxide and carbon monoxide, which display antioxidant and anti-inflammatory effects in sepsis. (bvsalud.org)

At a time when obesity, diabetes, and heart disease are rampant, caloric restriction and its kinder, gentler cousin, intermittent fasting (IF), have profound implications for all of us. (nutritionnews.com)
Caloric restriction and intermittent fasting have been shown to be tratamiento coadyuvante novel and beneficial strategies in neurodegenerative diseases, through immune, metabolic, and physiological mechanisms. (bvsalud.org)

This 5-day meal program provides scientifically researched micro-and macro-nutrients in precise quantities and combinations that nourish you but are not recognized as food by your body and therefore mimics a fasting state. (prolon.eu)

conversely, mortality correlated with continuous caloric excess. (holisticprimarycare.net)

Working in tandem, their biomolecular action exerts similar effects on gene expression, providing the benefits of CR without severe dietary modification. (purehealthclinic.co.uk)

Hence, many effects of nutrition on the development and progression of cancer lack 'specificity' in their association, and such alimentary cues also affect the risk of developing metabolic syndrome, a prelude to arteriosclerosis and neurodegeneration ( Fig. 1 ). (nature.com)
All these alternative models to caloric restriction hold promise for the treatment and prevention of metabolic diseases and might be beneficial in promoting healthy aging without the negative implications of a strons caloric restriction. (starvingneuron.com)

The idea of why things like caloric restriction or fasting might actually improve our aging process is because we think this evokes this idea of 'hormesis' in our bodies. (bigthink.com)

Finally, it will describe the impact of different dietary restrictions in modulating the genetic pathways that regulate metabolism and aging. (iospress.com)
Bellegarrigue NA, Velásquez factor, and sirtuin enzyme pathways are considered, generating a neuroprotective effect. (bvsalud.org)

Boost mitochondrial health, improve glucose metabolism, and mimic caloric restriction, all while amplifying Vitality's effects. (tallyhealth.com)
On top of that, caloric restriction predictably improved glucose tolerance and lowered inflammation [1]. (lifespan.io)
This time, the researchers tried to evaluate the effect of long-term CR on the SA-T cells' subpopulation and on glucose tolerance, another important marker of health linked to chronic inflammation [3]. (lifespan.io)
The clearing out of SA-T cells largely recapitulated the effects of CR, improving glucose tolerance and attenuating insulin resistance. (lifespan.io)

So some researchers have figured out that it might not be the caloric restriction that's actually the beneficial thing. (bigthink.com)

Caloric restriction isn't starvation. (bigthink.com)

There have been a lot of studies to test this, variously reducing calories by 10-40% of the normal amount consumed and the effect this then has on genes. (purehealthclinic.co.uk)

You can tune up your mitochondria by eating healthy and taking nutritional supplements that mimic the positive effects of exercise and caloric restriction. (radiomd.com)

Dietary restriction is an effective strategy for weight loss in obese individuals. (researchgate.net)

So even if you can't restrict your calories, just moving away from overeating is probably gonna have a beneficial effect for most people. (bigthink.com)

By mimicking the effects that caloric restriction (fasting) has on cells in the body, it induces autophagy, the process of cellular renewal known to have antiaging benefits. (saylorstorm.com)

In this review we discuss the role of NAD + as main substrate for the beneficial effect mediated by sirtuins and PARP and its potential role to develop strategies to prevent aging. (cellr4.org)
CR exerts its effect by activating sirtuins 5 , 6 . (cellr4.org)

He and others have tested resveratrol's effects in mice, mostly at doses far higher than the minuscule amounts in red wine. (b12partners.net)

Called caloric restriction (CR), this scientifically validated method has extended the life span of a number of species, from microorganisms to mammals. (nutritionnews.com)

Children with chronic malnutrition may require caloric intakes of more than 120-150 kcal/kg/day to achieve appropriate weight gain. (medscape.com)

Prolonged caloric restriction, however, is obviously detrimental to health and wellbeing. (holisticprimarycare.net)

So having these short-term mild stressors, whether it be fasting or whether it be a small caloric deficit, actually makes our bodies more resilient against a lot of the changes we see that increase with aging. (bigthink.com)

A landmark 20-year study demonstrated that caloric restriction powerfully counters the effects of aging in primates closely related to humans. (purehealthclinic.co.uk)
In this review article, we discuss the potential benefits of IF on cognitive function and the possible effects on the prevention and progress of brain-related disorders in animals and humans. (mdpi.com)

Thus, the ultimate aim of caloric restriction will not just be about helping us live longer, but also ensuring that we live those extra years in good health. (naturallivingskills.com)

So if people can perhaps minimize their eating to a small window, we think that this can actually recapitulate a lot of the benefits that we're seeing in the caloric restriction studies. (bigthink.com)

In the context of a controlled caloric restriction such as fasting, the net result is regenerative and restorative. (holisticprimarycare.net)
The first is a controlled and safe 5-day caloric restriction, that consumption and cyclic application in patients suffering from pathologies, which must be established by a doctor, cause restorative and regenerative effects on the body. (prolon.eu)

This compound appears to mimic the effects of caloric restriction in some animals, and in some cases extends lifespans. (dericbownds.net)

Rimonabant (Acomplia) is an anti-obesity drug initially approved for use in the European Union but later withdrawn due to psychiatric side effects including anxiety and depression. (wikipedia.org)

Ayuno intermitente y caused by first-line treatments, it's necessary to implement better complementary therapeutic approaches that do not restricción calórica como produce major side effects and improve symptoms. (bvsalud.org)

But of course most drugs come with side effects. (ketoshop.com)
This delicious lemon-flavoured powder delivers an enhanced, dual formulation of magnesium designed for optimal cellular absorption, without the negative side effects which afflict some other types at therapeutic doses. (nutritionplus.com)

Metformin also exerts a protective effect to both vascular and neural-networks. (jaycampbell.com)

On day 16 I sign off on thinking that the positive effects reported above are long term. (dericbownds.net)
However, the positive effects may stem from avoiding overeating rather than restriction per se. (bigthink.com)

certain localized infections Note: Categories for "late effects" of infectious and parasitic diseases are to be found at 137. (cdc.gov)

Accordingly, this review examines the effects of daily CR versus intermittent CR on weight loss, fat mass loss and lean mass retention in overweight and obese adults. (researchgate.net)
We aimed to compare the effects of IER with those of CER on blood pressure control and weight loss in overweight and obese patients with hypertension during a 6-month period. (researchgate.net)

Anatomy6

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Diseases10

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Psychiatry and Psychology5

Phenomena and Processes37

Anthropology, Education, Sociology and Social Phenomena1

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Resveratrol20

Fasting Mimicking Diet5

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