Mimic membrane. Medical search. Frequent questions

It can infect both animals and humans through direct contact with non-intact skin (such as cuts or wounds) or mucous membranes, inhalation, or ingestion. (cdc.gov)

Drastic enhancement of molecular detectability over potentiometric sensor surface via ion-impermeation across the lipid membrane. (eurekalert.org)
The Korean team of researchers successfully developed a proprietary biosensor technology with significantly enhanced molecular sensitivity using the artificial lipid membrane that mimics cellular membrane. (eurekalert.org)
Model lipid membrane systems were studied in relation to chemical structure transport rate relationships applicable to the prediction of drug absorption through human skin. (cdc.gov)
The model skin lipid transport system incorporated a rotating diffusion cell comprised of a donor compartment containing a solution of penetrant in water or aqueous buffer, a receptor compartment containing the same solution without penetrant, and a lipid membrane between the compartments made up of an organic liquid supported within a cellulose-ester filter with a pore size of 0.22 micrometers. (cdc.gov)

Salimbeigi, Golestan (2023) Electrospinning of basement membrane-mimicking substrates for organ-on-chip applications. (dcu.ie)

Sterols play a unique role for the structural and dynamical organization of membranes. (mdpi.com)
Oxidized phospholipids significantly perturb the structural membrane organization and increase membrane dynamics. (scilifelab.se)
Structural basis for membrane attack complex inhibition by CD59 ' by Emma C. Couves, Scott Gardner, Tomas B. Voisin, Jasmine K. Bickel, Phillip J. Stansfeld, Edward W. Tate and Doryen Bubeck is published in Nature Communications . (imperial.ac.uk)
The structural differences in two distinct membrane-mimicking environments show that the micelle-bound VIP-G localized at the water-micelle boundary with these side chains toward micelle interior. (rcsb.org)
Using time-resolved infrared spectroscopy, they measured the structural changes in the bacterial membrane protein MsbA and its interaction partner ATP. (nanowerk.com)
Type IV collagen is a major structural component of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. (medlineplus.gov)

Within such membranes are thousands of receptor proteins that detect molecules in the environment. (medtelligence.net)
The MIT team modified some of these proteins so that they could survive outside the membrane, and anchored them in a layer of crystallized proteins atop an array of graphene transistors. (medtelligence.net)
One alternative approach that scientists have explored is building sensors based on the receptor proteins found in cell membranes, which cells use to monitor and respond to their environment. (medtelligence.net)
However, these receptor proteins are difficult to work with because once removed from the cell membrane, they only maintain their structure if they are suspended in a detergent. (medtelligence.net)
One various method that scientists have explored is constructing sensors primarily based on the receptor proteins present in cell membranes, which cells use to observe and reply to their atmosphere. (superpcparts.com)
Nevertheless, these receptor proteins are tough to work with as a result of as soon as faraway from the cell membrane, they solely keep their construction if they're suspended in a detergent. (superpcparts.com)
Proteins in lipid membranes are one of the fundamental building blocks of biological functionality. (phys.org)
More than half of all proteins interact with membranes. (phys.org)
Biological membranes consist of a phospholipid bilayer and a variety of proteins that accomplish vital biological functions. (phys.org)
Membrane receptor proteins serve as connection between the cell's internal and external environments. (phys.org)
Upon oxidative damage, the membrane undergoes severe reorganization causing an increase in cell death-causing apoptotic Bcl-2 proteins. (scilifelab.se)
Dr. Chul Ki Kim from KIST further added that "researches for applying the technology to various research fields such as diseases known to be caused by mutated proteins attached to cellular membranes like Alzheimer's disease, Parkinson's' disease, and diabetes, and technology to rapidly and precisely detect an extremely small number of infectious viruses such as COVID-19 and influenza are being conducted in parallel. (eurekalert.org)
Membrane-bound and secreted proteins are made on ribosomes found in the rough endoplasmic reticulum . (wikipedia.org)
ABC transporters are membrane proteins that transport various substances from one side of the cell membrane to the other. (nanowerk.com)
Some microorganisms either produce a functional mimic of a complement regulatory protein or hijack host's regulatory proteins. (lu.se)

[1] The membrane enclosing the vesicle is also a lamellar phase , similar to that of the plasma membrane , and intracellular vesicles can fuse with the plasma membrane to release their contents outside the cell. (wikipedia.org)

Vesicles form naturally during the processes of secretion ( exocytosis ), uptake ( endocytosis ), and the transport of materials within the plasma membrane . (wikipedia.org)
All these data indicate that diethyl ether anesthesia may partially mimic heat stress in plants through the effect on plasma membrane. (frontiersin.org)
Little research is available on how the Ebola virus buds from the plasma membrane of human cells," says senior study author Robert Stahelin of Indiana University School of Medicine. (eurekalert.org)
Past studies have shown that a part of VP40 called the C-terminal domain penetrates the plasma membrane surrounding host cells. (eurekalert.org)
But until now, it was not known exactly how VP40 binds to the plasma membrane to allow the virus to escape host cells. (eurekalert.org)
To address this question, Stahelin and his team made vesicles designed to mimic the plasma membrane of host cells and exposed these vesicles to VP40. (eurekalert.org)
Currently, we are trying to find small molecules that can inhibit VP40 interactions with the plasma membrane," Stahelin says. (eurekalert.org)
The Ebola Virus Matrix Protein Deeply Penetrates the Plasma Membrane: An Important Step in Viral Egress. (eurekalert.org)

Researchers created an artificial membrane system that closely mimics a cell surface. (imperial.ac.uk)
The team used cryo-electron microscopy (cryoEM) to image in detail forms of MAC that had been inhibited by CD59 on artificial membranes. (imperial.ac.uk)
Called ICX-SKN, the artificial skin mimics the process of natural wound healing. (newscientist.com)
Our research strategy widely relies of the use of artificial lipid bilayers to mimic in vitro the basic molecular architecture of the cell membrane. (lu.se)
Taken together, these examples illustrate the potential of artificial cell membrane mimics in the study of processes occurring at the surface of a cell and demonstrate how such biophysical data can complement more classical cell-biology experiments. (lu.se)

Electrospinning is a polymer processing technique capable of producing membranes with nano to micron-scale in diameter fibres which have the potential to replicate the fibrillated architecture of the basement membranes. (dcu.ie)

Biomimetic asymmetric bacterial membranes incorporating lipopolysaccharides. (mpg.de)
Specifically, they tested a novel method for breaking through the bacterial membranes of the Gram-negatives. (sc.edu)

VP40 also caused the vesicle membranes to bend into the shape of the Ebola virus, paving the way for its escape. (eurekalert.org)
This is followed by entry, involving membrane fusion or membrane deformation into an endocytic vesicle. (lu.se)

Qing and Mantian Xue PhD '23, are the lead authors of the research, which seems in Science Advances ( "Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays" ). (superpcparts.com)
This overall architecture replicates green bacterial light-harvesting function whereby these assemblies exhibit long-range order and three-dimensional morphology similar to native chlorosomes and are capable of energy transfer internally and to external acceptors, located in a supporting biomimetic polymer membrane. (nau.edu)
Controlled Membrane Transport in Polymeric Biomimetic Nanoreactors. (mpg.de)

The current study reports data on the membrane properties of the phytosterol (3β,5α,22 E )-stigmasta-7,22-dien-3-β-ol (α-spinasterol), which represents an important component of argan oil and have not been investigated so far in molecular detail. (mdpi.com)
Oxidatively stressed mitochondria-mimicking membranes: A molecular insight into their organization during apoptosis. (scilifelab.se)
It is greatly anticipated that this PSμM can be extended to mimic many other biostructures, therefore opening new avenues for surface molecular engineering. (acs.org)
While the membrane promotes a precise molecular separation, its catalytic activity enables surface self-cleaning, by reacting with any potentially adsorbed dye and recovering the original performance. (nature.com)
Membrane technology does not necessarily involve thermal transitions and can be an effective alternative for molecular fractionation and purification, particularly of systems sensitive to temperature. (nature.com)
After repeated tests for applying the cellular membrane to the surface of the FET-based molecular detection chip, it was confirmed that molecule detection is available without additional pretreatment, even in a high-concentration ionic solution. (eurekalert.org)
Using this system, they were able to catch MAC as it forms and see in high molecular detail how CD59 stops MAC on the membrane. (imperial.ac.uk)
2] In a last example, we use model membranes carrying glycosaminoglycans, to elucidate the molecular mechanisms modulating attachment and release of the herpes simplex virus. (lu.se)

Specifically, by using lipid nanodiscs as cellular membrane mimics, we obtained yields of up to 440 µg/mL for the single-subunit OST enzyme, 'Protein glycosylation B' (PglB) from Campylobacter jejuni , as well as for three additional PglB homologs from Campylobacter coli, Campylobacter lari , and Desulfovibrio gigas . (biorxiv.org)
The cellular membrane of humans not only controls the ion concentration of the internal and external environment but also prevents a high concentration of ions from entering the cell. (eurekalert.org)
The team thus focused on this specific characteristic of the cellular membrane-mimicking system. (eurekalert.org)

Knowledge for the conformation of VIP bound to membrane is important because the receptor activation is initiated by membrane binding of VIP. (rcsb.org)

Current OOCs often use commercial porous polymeric membranes as a barrier membrane for cell culture which is challenging due to the poor replication of the physiological architectures. (dcu.ie)
Nanoengineers at the University of California San Diego have developed immune cell-mimicking nanoparticles that target inflammation in the lungs and deliver drugs directly where they're needed. (phys.org)
A membrane protein is a protein molecule that is attached to, or associated with the membrane of a cell or an organelle. (phys.org)
Membrane enzymes produce a variety of substances essential for cell function. (phys.org)
citation needed] Brilacidin is an antibiotic that works by disrupting bacterial cell membranes, mimicking defensins that play a role in innate immunity. (wikipedia.org)
Light-Activated Membrane Transport in Polymeric Cell-Mimics. (mpg.de)
Among these MDR pathogens, Gram-positive bacteria, which have only a single cell membrane, have received most of the attention from researchers. (sc.edu)
Antimicrobial peptides selectively attack bacterial cell membranes. (sc.edu)
In addition, cell membrane permeability for ions also increased under anesthesia. (frontiersin.org)
Virus entry is a complex dynamic multistep process requiring a series of fine-tuned events mediating virus diffusion through the glycocalyx, its attachment to the cell membrane and lateral diffusion to the point of entry. (lu.se)
Cell Membrane Derived Platform To Study Virus Binding Kinetics and Diffusion with Single Particle Sensitivity. (lu.se)

Herein, we report thin film composite membranes prepared by the interfacial polymerization of porous organic cages (POCs) (RCC3 and tren cages). (nature.com)
The fabrication of 15 nm-thin silicon membranes in 2007 marks the beginning of this new era, where a porous silicon membrane was fabricated through silicon deposition, annealing, and etching ( Nature , 'Silicon for the perfect membrane' ). (nanowerk.com)
Diagram of the thickness-degree of order relationship of some illustrative sub-50 nm porous membranes. (nanowerk.com)

While commercial membranes have excellent performance in the separation of salts from water in large-scale desalination plants, they lack selectivity for molecules of similar size and charge. (nature.com)
With this new technology known as "Membrane coated-FET (lipid-FET)," molecules suspended in highly ionic concentrated solution, to a level of human blood, can be detected with higher sensitivity compared to that of the existing sensor, and dilution of the solution up to 100,000-fold is not required. (eurekalert.org)
The molecules are unique because they change shape, snaking their way into bacterial membrane defenses and splitting the cells open, killing the bacteria. (sc.edu)

The innate immune system has the ability to target pathogen membranes through the expression of short antimicrobial peptides (AMPs), which exert direct antimicrobial activity and can therefore act as antiviral agents against enveloped viruses. (bioworld.com)

Magainin 2 and PGLa in Bacterial Membrane Mimics I: Peptide-Peptide and Lipid-Peptide Interactions. (muni.cz)
The fabrication methods of each ultrathin membrane vary from case to case, but they can be generally divided into two types: chemical assembly and physical assembly depending on the interactions among membrane building units. (nanowerk.com)

These advances have driven their application in a broad range of biophysics domains ( 6 ) including membrane biophysics ( 7 - 9 ), mechanosensing ( 10 - 12 ), and even the creation of synthetic biological systems such as external mesh networks ( 13 , 14 ) and membrane-embedding nanopores ( 15 ). (allenpress.com)

Tailoring PVDF Membranes Surface Topography and Hydrophobicity by a Sustainable Two-Steps Phase Separation Process. (acs.org)
The Design Team at HTG Architects out of Minneapolis wanted the roof surface to flow and mimic the rolling topography of the site, and chose a membrane roof that fit within its budget. (roofingcontractor.com)
We wanted the roof surface to flow and mimic the rolling topography of the site. (roofingcontractor.com)

Therefore, the research team proposed the use of the model membrane to overcome this obstacle. (eurekalert.org)
A simplified model membrane system called a supported lipid bilayer (SLB) is often used to mimic the membrane of the APC. (lu.se)

These effects were particularly pronounced for the so-called synergistic mixture of 1:1 (mol/mol) L18W-PGLa/MG2a and cannot be accounted for by a linear combination of the membrane perturbations of two peptides individually. (muni.cz)

Ni, Lin, and members of Zhao s group teamed up with Nelson s lab and Radovitzky s group in MIT s Institute for Soldier Nanotechnologies, and Qin s lab at Syracuse University, to see if they could reproduce the lobster s bouligand membrane structure using their synthetic, fatigue-resistant films. (nanotech-now.com)
Photomanipulation of minimal synthetic cells: area increase, softening and interleaflet coupling of membrane models doped with azobenzene-lipid photoswitches. (mpg.de)
Dynamic and flexible nucleic acid models can provide current and future scientists with physical intuition for the structure of DNA and the ways that DNA and its synthetic mimics can be used to build self-assembling structures and advanced nanomachines. (allenpress.com)
To address these challenges, previous research has successfully used synthetic polymers, which mimic natural antimicrobial peptides produced by bacteria to kill other bacteria. (sc.edu)

Due to this unique mechanism of action (mimicking the host's natural immune response, proven to be successful in fighting off infections over millions of years of evolution), bacterial antibiotic resistance is less likely to develop. (wikipedia.org)

Each of our cells is surrounded by a complex membrane that functions as a biological border, letting ions and nutrients such as salt, potassium and sugar in and out. (phys.org)
This strategy opens opportunities for the development of other smart membranes combining different functions and well-tailored abilities. (nature.com)

In agreement with previous studies, both peptides, as well as their equimolar mixture, were found to remain upon adsorption in a surface-aligned topology and to induce significant membrane perturbation, as evidenced by membrane thinning and hydrocarbon order parameter changes in the vicinity of the inserted peptide. (muni.cz)
1] In a second example, I concentrate on the role of Influenza's matrix protein in virus budding and search for mechanisms by which the protein can induce membrane deformations. (lu.se)

They discovered how CD59 captures and redirects parts of the MAC that aim to breach the cell's membrane. (imperial.ac.uk)

Nielsen theorized that peripheral nerve dysfunction was related to an interference with the nerve axon membrane function and inhibition of Na + /K + -activated ATPase by toxic factors in uremic serum. (medscape.com)

Although the architecture of the nanomachines is known, a detailed understanding of how the splitting of the energy carrier ATP dynamically enables the transport of various substances across biological membranes has so far been lacking. (nanowerk.com)

[ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)

Researchers have developed models of bacterial outer membranes that can help develop better antibiotics to fight antibiotic-resistant bacteria. (phys.org)

Brilacidin, a non-peptide chemical mimic, is an arylamide foldamer designed to replicate the amphiphilic properties of antimicrobial peptides while solving the problems encountered by peptide-based antimicrobials. (wikipedia.org)
This work demonstrates the potential of short-chain amphiphilic block copolymers in generating self-assembled, bio-mimetic membrane architectures, and in doing so, generates scalable, spatial-energetic landscapes for photonic applications. (nau.edu)
Because each amphiphilic unit is attached to a flexible micromolecular chain, tens or perhaps hundreds of them can collectively work together and facilitate the entire macromolecule to penetrate through the membrane. (sc.edu)

Biological studies confirmed the formation of a stable in vitro alveolar model assessed by the formation of confluent layers of human lung carcinoma epithelial cells (A549) and human pulmonary microvascular endothelial cells (hPMEC) on the opposite sides of the selected membrane as relevant cells to those of the alveolar-capillary barrier in the lung. (dcu.ie)

Specifically, we demonstrate that the 2.5 kDa, poly(ethylene oxide)-block-poly(butadiene) (PEO-b-PBD), exhibits sufficient morphological flexibility as a membrane material and enables generation of mimics of three-dimensional chlorosomes as well as supported membrane bilayers containing energy acceptors. (nau.edu)

In their review, the authors provide a thorough review of sub-50 nm membranes, from fabrication methods, membrane structures to applications. (nanowerk.com)
In this study, we determined the three-dimensional structures of VIP-G in two distinct membrane-mimicking environments. (rcsb.org)

Brilacidin has low cytotoxicity against mammalian cells while selectively targeting bacteria, directly and rapidly disrupting their membranes, resulting in the bacteria's death. (wikipedia.org)
The team studied membrane attack complexes (MACs) - components of our immune system that punch holes in the membrane of invading bacteria. (imperial.ac.uk)
The dual membranes found in Gram-negative bacteria act as an impermeable barrier to many antibiotics. (sc.edu)
The researchers found these new polymers to be highly-effective against MDR Gram-negative bacteria, despite their double membranes. (sc.edu)

Lawrence Livermore researchers have figured out how to mimic their role using carbon nanotube porins. (phys.org)
Further pushing membrane thickness to sub-50 nm or even atomic level is appealing to researchers, with the ultrafast permeance that may be enabled and ultimate understanding of formation and transport at the extremely low thickness that can be significantly different from their thicker counterparts. (nanowerk.com)
When the researchers mutated the C-terminal domain of VP40, the protein was much less effective at binding to and bending membranes and forming virus-like particles that could escape from host cells. (eurekalert.org)

This leads to initiation of cascade of enzymatic cleavages and formation of crucial enzymatic complexes (C3 and C5 convertases), release of pro-inflammatory anaphylatoxins (C5a, C3a) that attract white blood cells and finally formation of membrane attack complex (MAC, pore in a membrane). (lu.se)

The review contains a detailed description of how new materials and advanced methods are developed to reduce membrane thickness and interesting mass transport phenomena across ultrathin layers, with attention to other factors concerning practical applications, that is, pore structure, stability and scalability. (nanowerk.com)

The authors conclude that the model skin lipid membranes mimic the in-vitro resistance of human skin and do not limit transport solely through simple diffusional resistance. (cdc.gov)
M1 from influenza C virus induces tubular membrane invaginations in vitro. (lu.se)

An overview of membrane structure (network, laminar, and framework structure), fabrication methods, and applications of sub-50 nm membranes. (nanowerk.com)
Critical step in tissue engineering is fabrication of three dimensional scaffolds which mimic the extracellular matrix of tissues and promote tissue regeneration process. (amrita.edu)

Invading pathogens activate complement either spontaneously due to differences in envelope/membrane composition compared to host (alternative and lectin pathways) or through antibody binding (classical pathway). (lu.se)

10 nm) membranes, metal-organic frameworks (MOFs), MXenes . (nanowerk.com)
The organic liquid membranes used were isopropyl-myristate (IPM) and tetradecane, and the penetrants tested included various esters of nicotinic-acid and phenol derivatives. (cdc.gov)

The lesion may show a peripheral erythema, a white or yellowish base and fibrinous membrane on the surface. (bvsalud.org)

In particular, the impact of α-spinasterol on the structure and organization of lipid membranes was investigated and compared with those of cholesterol. (mdpi.com)

The investigations were supported by the Protein Research Department at the RUB and funds of the collaborative research centre SFB 642 "GTP and ATP dependent membrane processes", whose speaker is Prof. Dr. Klaus Gerwert. (nanowerk.com)

Chemical structure - transport rate relationships for model skin lipid membranes. (cdc.gov)

While the development of xenografts (products of animal origin) and bioengineered alternatives is advancing, to date they cannot fully mimic or replace all human-sourced tissues on an equivalent basis. (who.int)

Adhesion molecule pairs of similar height as TCR-pMHC have been argued to facilitate the TCR-pMHC interaction by physically keeping the opposing membranes at an optimal distance for binding. (lu.se)

Better recapitulation of the native basement membrane (BM) characteristics is desirable for remodelling physical (e.g. intestine, skin and lung) and metabolic (e.g. liver) barrier models. (dcu.ie)
This thesis looks at the development of lung BM mimicking constructs utilising electrospinning regarding ultrastructural and mechanical characteristics. (dcu.ie)

Nanowerk Spotlight ) Ultrathin membranes play an important role in the desalination process and can transform even the dirtiest water into something potable for millions of people across the world (read more about the role of nanotechnology in water treatment ). (nanowerk.com)
This result suggests that these residues play an important role for the membrane binding of VIP and PACAP. (rcsb.org)
To illustrate the potential of such a biophysical approach, I will, in my presentation, first focus on the interaction between norovirus and glycolipid-containing membranes and investigate the role of ligands mobility and ligand clustering in modulating the affinity of the virus particle to the membrane. (lu.se)

An MIT team has fabricated a hydrogel-based material that mimics the structure of the lobster s underbelly, the toughest known hydrogel found in nature. (nanotech-now.com)
Now a separate MIT team has fabricated a hydrogel-based material that mimics the structure of the lobster s underbelly. (nanotech-now.com)
This rotating, layered configuration, known as a bouligand structure, enhanced the membrane s properties of stretch and strength. (nanotech-now.com)
The aircraft's bionic structure mimics the efficiency of bird bones, which are optimized to provide strength where needed. (mymodernmet.com)

findings can sometimes mimic toxic epidermal necrolysis. (msdmanuals.com)

Anatomy51

Organisms13

Diseases2

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes61

Disciplines and Occupations4

Technology, Industry, Agriculture8

Information Science3

Health Care1

Mucous membranes1

Lipid membrane4

20231

Structural6

Proteins15

Enclosing the vesicle1

Plasma membrane8

Artificial5

Basement membranes1

Bacterial membranes2

Vesicle2

Biomimetic3

Molecular8

Cellular membrane3

Receptor1

Cell11

Porous3

Molecules3

Antimicrobial activity1

Interactions2

Biophysics1

Topography3

Model membrane2

Perturbations1

Synthetic4

Host's1

Functions2

Induce2

Cell's1

Inhibition1

Substances1

Closely1

Antibiotic1

Amphiphilic3

Biological1

Enables1

Structures2

Bacteria4

Researchers3

Complexes1

Pore1

Vitro2

Fabrication2

Complement1

Organic2

Peripheral1

Organization1

Processes1

Chemical1

Tissues1

Adhesion1

Lung2

Role3

Structure4

Toxic1