Mimic lipid. Medical search. Frequent questions

The lipid bilayer (or phospholipid bilayer) is a thin polar membrane made of two layers of lipid molecules. (wikipedia.org)
The cell membranes of almost all organisms and many viruses are made of a lipid bilayer, as are the nuclear membrane surrounding the cell nucleus, and membranes of the membrane-bound organelles in the cell. (wikipedia.org)
The lipid bilayer is the barrier that keeps ions, proteins and other molecules where they are needed and prevents them from diffusing into areas where they should not be. (wikipedia.org)
Just like the heads, the tails of lipids can also affect membrane properties, for instance by determining the phase of the bilayer. (wikipedia.org)
The bilayer can adopt a solid gel phase state at lower temperatures but undergo phase transition to a fluid state at higher temperatures, and the chemical properties of the lipids' tails influence at which temperature this happens. (wikipedia.org)
The packing of lipids within the bilayer also affects its mechanical properties, including its resistance to stretching and bending. (wikipedia.org)
Integral membrane proteins function when incorporated into a lipid bilayer, and they are held tightly to the lipid bilayer with the help of an annular lipid shell. (wikipedia.org)
The lipid bilayer is very thin compared to its lateral dimensions. (wikipedia.org)
If a typical mammalian cell (diameter ~10 micrometers) were magnified to the size of a watermelon (~1 ft/30 cm), the lipid bilayer making up the plasma membrane would be about as thick as a piece of office paper. (wikipedia.org)
Hydrogel-supported protein-tethered bilayer lipid membranes: a new approach toward polymer-supported lipid membranes. (mpg.de)
Giga-seal solvent-free bilayer lipid membranes: from single nanopores to nanopore arrays. (mpg.de)
Protein tethered lipid bilayer: An alternative mimic of the biological membrane (Mini Review). (mpg.de)
Modeling ion transport in tethered bilayer lipid membranes. (mpg.de)
In doing so, our goal was to build lipid-bilayer-like membrane-mimetic 2D nanomaterials by using the six Nce groups to mimic polar lipid head groups and the six N 4-Cl pe groups to create aromatic counterparts of nonpolar lipid tails. (nature.com)
Within the crystals, the lipid molecules organized themselves around the several ion channel proteins, forming a lipid bilayer that mimicked the channel's natural environment. (sciencedaily.com)
We present an experimental protocol to form a supported lipid bilayer on solid substrates without using lipid vesicles. (jove.com)
We demonstrate a one-step method to form a lipid bilayer on silicon dioxide and gold as well as supported membranes with cholesterol-enriched domain for various biological applications. (jove.com)
Proteins and lipids are embedded in this bilayer forming the fluid mosaic model ( Figure 2 ) which was first proposed by Singer and Nicolson in 1972. (sigmaaldrich.com)
Proteins are held in the lipid bilayer by hydrophobic interactions between the lipid tails and hydrophobic protein domains. (sigmaaldrich.com)
Hydrophobic regions of membrane proteins, normally embedded in the membrane lipid bilayer, are now surrounded by a layer of detergent molecules and the hydrophilic regions are exposed to the aqueous medium. (sigmaaldrich.com)
When low concentrations of a detergent are added to biological membranes (a), the detergent monomers (shown in red with single tails) perturb the membrane structurally by partitioning into the lipid bilayer (b). (sigmaaldrich.com)
At concentrations equal to, or higher than the detergent's CMC, the lipid bilayer becomes saturated with detergent molecules and breaks apart generating lipid-protein-detergent mixed micelles (c). 8 A detergent/protein ratio of around 1-2 (w/w) is believed to be sufficient to solubilize IMPs to form lipid-protein-detergent mixed micelles. (sigmaaldrich.com)
To better understand the origins of this heterogeneity, as well as the degree to which monolayer systems mimic the dynamical properties of bilayer membranes, we use molecular simulations to contrast the dynamical behavior of a single-component dipalmitoylphosphatidylcholine (DPPC) lipid bilayer with that of a DPPC monolayer. (nist.gov)
A simplified model membrane system called a supported lipid bilayer (SLB) is often used to mimic the membrane of the APC. (lu.se)

We addressed the onset of synergistic activity of the two well-studied antimicrobial peptides magainin 2 (MG2a) and PGLa using lipid-only mimics of Gram-negative cytoplasmic membranes. (muni.cz)
Tethered bimolecular lipid membranes - A novel model membrane platform. (mpg.de)
Solid supported lipid membranes: New concepts for the biomimetic functionalization of solid surfaces. (mpg.de)
An ability to develop sequence-defined synthetic polymers that both mimic lipid amphiphilicity for self-assembly of highly stable membrane-mimetic 2D nanomaterials and exhibit protein-like functionality would revolutionize the development of biomimetic membranes. (nature.com)
Proteins in lipid membranes are one of the fundamental building blocks of biological functionality. (phys.org)
Non-specific lipid-transfer proteins (nsLTPs) are involved in the movement of phospholipids, glycolipids, fatty acids, and steroids between membranes. (rcsb.org)
Chemical structure - transport rate relationships for model skin lipid membranes. (cdc.gov)
The authors conclude that the model skin lipid membranes mimic the in-vitro resistance of human skin and do not limit transport solely through simple diffusional resistance. (cdc.gov)

Nanoengineers at the University of California San Diego have developed immune cell-mimicking nanoparticles that target inflammation in the lungs and deliver drugs directly where they're needed. (phys.org)
Noting that apolipoprotein E (apoE) has been shown to enhance cellular uptake and gene silencing for ionizable lipid nanoparticles, the scientists set out to study the effects various apolipoproteins would have on cKK-E12. (genomeweb.com)
In addition, the lipid nanoparticles (LNP) platform, which has proven to be effective with siRNAs, is also showing promise with miRNAs and miRNA mimics. (genengnews.com)
Alnylam Pharmaceuticals is using its lipid nanoparticles platform to enhance delivery of siRNAs in several models. (genengnews.com)

The amount of adsorbed DNA to cationic lipid bilayers was measured using a quartz crystal microbalance . (bvsalud.org)
Lipid bilayers are ideally suited to this role, even though they are only a few nanometers in width, because they are impermeable to most water-soluble (hydrophilic) molecules. (wikipedia.org)
Because lipid bilayers are fragile and invisible in a traditional microscope, they are a challenge to study. (wikipedia.org)
Since micelle-forming detergents provide an amphipathic environment that can mimic lipid bilayers, their use as solubilizing agents is essential for functional and structural investigations. (sigmaaldrich.com)
This molecular architecture allows phospholipids to assemble as lipid bilayers in which the hydrophobic chains face each other while the polar head groups face outward to the aqueous milieu ( Figure 1 ). (sigmaaldrich.com)

Hydrating Squalane: Acts as a hydrating ingredient that mimics skin's natural lipids. (sephora.com)
Plus, vitamin F and fatty acid-infused lipids mimic skin's natural ability to maintain elasticity. (bioelements.com)

Lipid-based nanoparticle (LBNP) systems represent one of the most promising colloidal carriers for bioactive organic molecules. (mdpi.com)
With this new technology known as "Membrane coated-FET (lipid-FET)," molecules suspended in highly ionic concentrated solution, to a level of human blood, can be detected with higher sensitivity compared to that of the existing sensor, and dilution of the solution up to 100,000-fold is not required. (eurekalert.org)
For example, self-assembly of lipid molecules and membrane proteins is crucial in defining cell architecture and enabling cell function 2 . (nature.com)
In the presence of lipid molecules, the hybrid ion channel formed a crystalline lattice that enabled MacKinnon and his team to describe the structure with unprecedented atomic detail. (sciencedaily.com)
Although nanomaterials inspired by natural molecules are under development as drug carriers, particularly for liver-based diseases, due to their delivery efficiency and specificity, none have shown to be as potent as traditional lipids or lipidoids, according to the MIT team, which included collaborators from Alnylam Pharmaceuticals. (genomeweb.com)

Common applications include cell lysis, solubilization of membrane proteins and lipids, protein crystallization, and reduction of background staining in blotting experiments. (sigmaaldrich.com)
In many T cell activation studies, the SLB contains the nickel-chelating lipid DGS-NTA(Ni) to functionalize the SLB with histidine-tagged proteins. (lu.se)

Moreover, dimerization of L18W-PGLa and MG2a leads to a relocation of the peptides within the lipid headgroup region as compared to the individual peptides. (muni.cz)
To that end, the team synthesized a collection of synthetic lipopeptides designed to mimic apolipoproteins by conjugating lipid tails to amino acids, peptides, and polypeptide head groups. (genomeweb.com)

Alnylam is developing two drugs to treat this condition, including one that uses a lipid nanoparticle technology developed by Tekmira Pharmaceuticals. (genomeweb.com)

has developed an antibody, dubbed mimAb1, that activates the Fibroblast Growth Factor 21 complex, which regulates glucose and lipid metabolism. (aol.com)
Initial preclinical research indicates that increased amounts of brown fat in animals may be responsible for additional caloric burning as well as reduced glucose and lipid levels. (biospace.com)

In some cases, the hydrated region can extend much further, for instance in lipids with a large protein or long sugar chain grafted to the head. (wikipedia.org)
Membrane solubilization by detergents can be described as a three stage process where the detergent-lipid-protein ratio is an important factor ( Figure 3 ). (sigmaaldrich.com)
5 A further increase of detergent concentration causes progressive delipidation of the lipid-protein-detergent mixed micelles. (sigmaaldrich.com)
This leads to the formation of lipid/detergent and protein/detergent mixed micelles (d). 8 A solubilized IMP in a complex with a bound detergent is called a protein-detergent complex, PDC. (sigmaaldrich.com)
Novel variant pathway in the synthesis of protein- and lipid-1inked, complex-type oligosaccharides. (or.jp)

Magainin 2 and PGLa in Bacterial Membrane Mimics I: Peptide-Peptide and Lipid-Peptide Interactions. (muni.cz)
The early onset of dimerization of L18W-PGLa and MG2a at low peptide concentrations consequently appears to be key to their synergistic dye-releasing activity from lipid vesicles at high concentrations. (muni.cz)
Recently, we developed a high-density lipoprotein-mimicking peptide-phospholipid scaffold (HPPS) and demonstrated its direct cytosolic delivery of siRNA in vitro, thereby bypassing endosomal trapping. (utoronto.ca)
DNA Delivery Systems Based on Peptide-Mimicking Cationic Lipids-The Effect of the Co-Lipid on the Structure and DNA Binding Capacity. (bvsalud.org)
In continuation of previous work , we present a new promising DNA carrier, OO4, a highly effective peptide -mimicking lysine -based cationic lipid . (bvsalud.org)

Other thyroid hormone analogues developed over the past 30 years have failed because of hyperthyroid and cardiovascular side effects -- even those thought to be more selective for lipid metabolism. (second-opinions.co.uk)
Thyroid hormones have been a draw for pharma developers because they modulate lipid metabolism primarily through increasing liver uptake of cholesterol. (second-opinions.co.uk)
Tumor necrosis factor-alpha (TNF-alpha), a pivotal pro-inflammatory cytokine in RA may be involved in the development of the disturbed lipid metabolism. (researchgate.net)

Specifically, we coupled a joint analysis of small-angle x-ray and neutron scattering experiments on fully hydrated lipid vesicles in the presence of MG2a and L18W-PGLa to all-atom and coarse-grained molecular dynamics simulations. (muni.cz)

All these features make peptoids highly attractive as synthetic analogues of lipids for self-assembly of membrane-mimetic 2D materials. (nature.com)
The synthetic virus-like particle will be made of lipids that are similar to those in the membrane of the virus itself, and will include a piece of the HIV outer envelope that binds to the sought-after neutralizing antibodies," Duke explained in the announcement. (wraltechwire.com)

HBEpC were transfected with miRNAs inhibitor oligonucleotide or mimic oligonucleotide (Thermo Fisher Scientific, Carlsbad, CA) using the lipid-based Lipofectamine 2000. (cdc.gov)

The Akonino® solution supplies a blended lipid ingredient guaranteed to meet requested specifications. (aak.com)

Knowing how the lipids organized themselves around the ion channel, the researchers were then able to demonstrate how positively charged amino acids within the voltage sensor's paddle remained stable despite the potentially destabilizing forces surrounding them. (sciencedaily.com)

Patients with rheumatoid arthritis (RA) frequently display an atherogenic lipid profile which has been linked with inflammation. (researchgate.net)
Other genes that are associated with blood fat (lipid) levels, inflammation, and the cardiovascular and immune systems contribute significantly to longevity because they reduce the risk of heart disease (the main cause of death in older people), stroke, and insulin resistance. (medlineplus.gov)

Here we report the assembly of lipid-like peptoids into highly stable, crystalline, free-standing and self-repairing membrane-mimetic 2D nanomaterials through a facile crystallization process. (nature.com)
Herein we report the first example of self-assembling highly stable and self-repairing membrane-mimetic 2D nanomaterials by designing lipid-like sequence-defined peptoids. (nature.com)

If prostate biopsies are performed following hormonal therapy for prostatic adenocarcinoma, the appearance of residual tumor cells can mimic xanthoma cells. (medscape.com)
Flat tumors, termed en plaque, infiltrate the dura and grow as a thin carpet or sheet of tumor along the convexity dura, falx, or tentorium. (medscape.com)

We previously described the synthesis of 1-O-octadecyl-2-O-benzyl-glycero-3-phospho-RVn (V2043), an orally bioavailable lipid prodrug of remdesivir nucleoside (RVn, GS-441524) with broad spectrum antiviral activity against viruses with pandemic potential. (cdc.gov)
Thus, citric acid cycle intermedi- ates are not used for adenosine triphosphate (ATP) production and are shuttled out of the mitochondria, providing precursors for nucleotide, amino acid, and lipid synthesis path- ways for the dividing cell [13]. (who.int)

The C18:1 ricinoleate with its hydroxyl group hydrogen bonding to Ala68 possibly mimics cutin monomer binding which is of biological importance. (rcsb.org)

Drastic enhancement of molecular detectability over potentiometric sensor surface via ion-impermeation across the lipid membrane. (eurekalert.org)
The Korean team of researchers successfully developed a proprietary biosensor technology with significantly enhanced molecular sensitivity using the artificial lipid membrane that mimics cellular membrane. (eurekalert.org)

Enzymotec currently offers lipid ingredients for infant nutrition products, most notably Infat, which mimics the fat structures and properties of human milk fat. (nutraingredients.com)
Akonino® lipid ingredients are our custom-designed products for infant nutrition. (aak.com)

Drug absorption was mimicked by in situ quantification of drug partitioning into a decanol layer. (ruc.dk)
Model lipid membrane systems were studied in relation to chemical structure transport rate relationships applicable to the prediction of drug absorption through human skin. (cdc.gov)

The structural characteristics of the polynucleotide carrier system OO4 mixed with the commonly used co- lipid DOPE and the saturated phospholipid DPPE have been studied in two-dimensional and three-dimensional model systems to understand their influence on the physical- chemical properties . (bvsalud.org)

BAT is intended to mimic naturally occurring brown adipose depots that regulate metabolic homeostasis in humans. (biospace.com)
Some phytosterols have structures similar to animal steroid hormones, thus they can weakly mimic or regulate the mammalian human hormone/hormone precursors they resemble. (naturalproductsinsider.com)

Enzymotec, which produces lipid ingredients for products including infant formula, announced this week it plans to bring all its current expertise on breast milk composition under one "umbrella" to create a project it has dubbed the Human Milk Center. (nutraingredients.com)
With its natural composition and unique characteristics, Akonino® lets the lipid part of your formula mimic the golden standard of breast milk. (aak.com)

Lawrence Livermore researchers have figured out how to mimic their role using carbon nanotube porins. (phys.org)

Here we review single gene disorders that have the potential to mimic multiple sclerosis, provide an overview of clinical and investigational characteristics of each disorder, and present guidelines for when clinicians should suspect an underlying heritable disorder that requires diagnostic confirmation in a patient with a definite or probable diagnosis of multiple sclerosis. (medscape.com)

The vaccine candidate mimics a virus particle. (wraltechwire.com)

For the in vitro assay, HepG2 cells were treated with FFAs (oleate/palmitate = 2:1) with or without treatment with R. oldhamii leaf ethyl acetate (EtOAc) fraction to observe lipid accumulation using Nile red and oil red O stains. (medsci.org)
SeraCon II D Lipid Depleted diluent is an ideal lipid-free matrix for use in assay development and manufacture. (seracare.com)

The model skin lipid transport system incorporated a rotating diffusion cell comprised of a donor compartment containing a solution of penetrant in water or aqueous buffer, a receptor compartment containing the same solution without penetrant, and a lipid membrane between the compartments made up of an organic liquid supported within a cellulose-ester filter with a pore size of 0.22 micrometers. (cdc.gov)

An experimental agent that mimics thyroid hormone in the liver enhanced the lipid-lowering effect of statins in a randomized controlled trial. (second-opinions.co.uk)

The impact of high fat palatable food and dietary lipids on endocannabinoid formation is reviewed in its pathogenetic potential for the derangement of feeding homeostasis. (frontiersin.org)

The best-known sterol is cholesterol, hence the lipid lowering effects of "nutty" diets. (naturalproductsinsider.com)

These results support the continued development of V2043 and sn-2 glycerol modified RVn lipid prodrugs for the treatment of a broad range of RNA viruses for which there are limited therapies. (cdc.gov)

Liquid Crystal O/W Emulsions (LCE) mimic the organization of lipids in human skin. (cosmeticsdesign-europe.com)
Safflower oil is a plant derived emollient that mimics the lipid content of the skin. (myalchemilla.com)
Powered by a lipid-based delivery system that actively nourishes with skin-mimicking phytoactive lipids from Argan, Rosehip Seed and Golden Jojoba oils. (dermalogica.com)
Grapeseed Oil is also one of several plant emollients that mimic the lipid content of the skin. (skin-etc.com)
Glycolic acid reacts to the skin weakening the binding properties of the lipid that hold the dead skin cells together. (skin-etc.com)

The team demonstrated that macromolecular crowding slows down lipid droplet transport both in fruitfly embryos and in petri dishes in the lab. (natureasia.com)

The team thus focused on this specific characteristic of the cellular membrane-mimicking system. (eurekalert.org)

Velev says that the research team hopes to "learn how to mimic the materials by which nature harnesses solar energy. (nanowerk.com)

The candidate is a man-made lipid called a liposome and mimics a virus particle. (wraltechwire.com)

Prostate xanthomas may mimic high-grade prostatic acinar adenocarcinoma with foamy cytoplasm, as well as adenocarcinoma with posthormonal therapy effect, particularly androgen deprivation therapy. (medscape.com)

The findings prove the concept for making solar cells that more closely mimic nature. (nanowerk.com)

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Bilayer24

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