• Rationale : Telomerase is a nuclear regulator of telomere elongation with recent reports suggesting a role in regulation of mitochondrial reactive oxygen species. (hypertension.qc.ca)
  • Production of both cytosolic and mitochondrial reactive oxygen species (ROS) is elevated in diabetes, and increased oxidative stress is considered as one of the major metabolic abnormalities associated with the development of diabetic retinopathy 2 . (nature.com)
  • Atmospheric pressure plasma jets generate reactive oxygen and nitrogen species (RONS) in liquids and biological media, which find application in the new area of plasma medicine. (upc.edu)
  • Scavenging of reactive oxygen and nitrogen species by the prodrug sulfasalazine and its metabolites 5-aminosalicylic acid and sulfapyridine. (jru-b.com)
  • [ 10 ] Such alterations in genetic makeup and the cytokine milieu cause impairment of cellular signaling between keratinocytes and melanocytes, which presumably leads to the formation of melanocytic nevi. (medscape.com)
  • The liver plays a central role in detoxifying LPS and producing a balanced cytokine milieu. (wjgnet.com)
  • The altered cytokine milieu correlated with increased GLUT-4 and IRS-1 expression, suggesting improved insulin sensitivity. (borgesonlab.org)
  • We provide new evidence that this increased intracellular ROS milieu uniquely predisposes metastatic tumor cells to hypoxia-mediated regulation of the matrix metalloproteinase MMP-1. (psu.edu)
  • Schistosomes are parasitic worms that require several coordinated morphological and biochemical changes that guarantee adaptation to various environments such as water and the internal milieu of their vertebrate and invertebrate hosts [ 15 , 16 ]. (biomedcentral.com)
  • The loosening up of the tight junctions of the blood-brain barrier also occurs from cellular damage by reactive oxygen species (free radicals) produced by inflammation in the body. (vidacleanse.com)
  • After the first phase, these toxicant metabolites are even more reactive and can cause cellular damage and must undergo further phases of detoxification to convert them to less inflammatory compounds that are more easily excreted via the feces and urine. (vidacleanse.com)
  • On the one hand, reactive oxygen species (ROS) are mandatory mediators for essential cellular functions including the function of germ cells (oocytes and spermatozoa) and thereby the fertilization process. (hindawi.com)
  • The latter acts as a cellular guardian, neutralizing reactive oxygen species and thereby safeguarding the cell against oxidative damage. (microbiologynote.com)
  • I think the wording is misleading, since high redox potential is a consequence of oxygen being present, not the other way around (as that would imply something like high redox potential attracting atmospheric oxygen into water). (stackexchange.com)
  • In this very different metabolic milieu, it is not clear how metformin might impact on the multiple biosynthetic and signalling functions that the placenta performs during the first trimester to ensure successful pregnancy and if effects impact positively or negatively on the feto-placental unit. (cam.ac.uk)
  • The last few years have brought a rising body of evidence that adiponectin is a multipotential protein with anti-inflammatory, metabolic, anti-atherogenic, and reactive oxygen species (ROS) protective actions. (encyclopedia.pub)
  • The large quantities of antioxidant enzymes are correlated with the low levels of reactive oxygen species, which allow the down-regulation of tumor suppressors and accessory DNA repair partners, eventually leading to the compromise of telomere shortening. (peerj.com)
  • C-reactive protein (CRP) was often increased and very high CRPs were associated with a less favorable outcome for the patient. (spandidos-publications.com)
  • Why does low redox potential mean less oxygen? (stackexchange.com)
  • I am wondering if it is because under the low redox potential conditions, dissolved molecular oxygen is easily reduced, is that correct? (stackexchange.com)
  • The higher the redox potential is, the higher the oxygen dissolved in the media will be. (stackexchange.com)
  • I did not quite understand the original purpose of adding reducing agents (to lower the redox potential) and the concomitant results (to reduce the contaminated oxygen). (stackexchange.com)
  • To describe aggressive oxidative features of oxygen, it's useful to use the more generalized term „ reactive oxygen species " (ROS) instead of 'oxygen', since redox potential doesn't care which exact compound acts as an electron donor. (stackexchange.com)
  • This review is focused on the effects of the reactive oxygenated species in disturbing the redox balance and inducing oxidative injury that leads to androgenic alopecia. (jru-b.com)
  • However in early pregnancy, the placenta tends to rely more heavily on nonoxidative metabolism, potentially due to high sensitivity to reactive oxygen species 5. (cam.ac.uk)
  • High steady-state reactive oxygen species (ROS) production has been implicated with metastatic disease progression. (psu.edu)
  • It inhabits chimney walls of deep-sea hydrothermal vents along the East Pacific Rise (EPR) and is exposed to various challenging conditions (e.g. high temperature, hypoxia and the presence of sulphides, heavy metals and radiations), which increase the production of dangerous reactive oxygen species (ROS). (nih.gov)
  • However, innate immunity is also involved in the development of inflammatory responses that occur in a sterile milieu ( 2 ). (spandidos-publications.com)
  • When toxins are allowed to enter the central nervous system, there can be many changes that occur in the natural milieu of the brain. (vidacleanse.com)
  • Previous studies have indicated that reactive oxygen species (ROS) generation, potassium (K + ) efflux, and the release of cathensin B can activate the NLRP3 inflammasome ( 3 ). (spandidos-publications.com)
  • Such reactions can lead to the formation of triplet excited species, which release photons upon returning to a lower energy level in a process analogous to phosphorescence. (wikipedia.org)
  • Flow-mediated dilation in patients with cardiovascular disease is dependent on the formation of reactive oxygen species. (hypertension.qc.ca)
  • Trace metals are reported to play important roles in catalyzing the formation of highly reactive oxygen species (ROS), which are implicated in enhanced disease development. (cdc.gov)
  • In our lab, we are studying a process by which pancreatic cancer cells lower the amount of oxygen, producing reactive oxygen species," Dr. Tuveson said. (ascopost.com)
  • Moderate levels of reactive oxygen species facilitate carcinogenesis, but excessive levels are damaging to cancer cells. (ascopost.com)
  • Specifically, the chronic exposure of cells to a chemokine-laced milieu is associated with macrophage and T cell accumulation, chronic activation of macrophages, abnormal angiogenesis and DNA damage due to the presence of reactive oxygen species [ 2 , 3 ]. (thno.org)
  • The universal outreach of cells in an injured state has myriad consequences to distant organ cells and their milieu. (biomedcentral.com)
  • This suggests a complex interaction between local adiponectin action, comorbidities, and uremic milieu. (encyclopedia.pub)
  • This is likely because metals, such as Ni, Co, and Cr, can produce greater levels of ROS in a biological milieu with reductants than in a noncellular system. (cdc.gov)
  • They operate during sensitive periods of gestation by disrupting endocrine systems and altering the hormonal milieu necessary for fetal brain development. (europa.eu)
  • These ndings suggest a new target for reducing the oxidative milieu in the microvasculature of patients with CAD. (hypertension.qc.ca)
  • I often see statements about adding reducing agents like cysteine to anaerobic medium to decrease the amount of the dissolved oxygen. (stackexchange.com)
  • Hence, reducing agents could increase viability by scavenging any kind of oxidative species from the medium. (stackexchange.com)