• Knock-down of PRL-3 expression using short-hairpin RNA (shRNA) in human T-ALL cell lines significantly impeded T-ALL cell migration capacity in vitro and reduced their ability to engraft and proliferate in vivo in xenograft mouse models. (uky.edu)
  • Taken together, our study identifies PRL-3 as an oncogenic driver in T-ALL both in vitro and in vivo and provides a strong rationale for targeted therapies that interfere with PRL-3 function. (uky.edu)
  • Using pharmacological approaches along with in vitro and in vivo experiments, we found that Nogo-A/NgR1 signaling regulates the pace of neuronal neogeneration by reducing NSC proliferation. (jneurosci.org)
  • Juice of eclipta prostrata inhibits cell migration in vitro and exhibits anti-angiogenic activity in vivo. (cri.or.th)
  • Furthermore, lipopolysaccharide/12-o-tetradecanoylphorbol 13-acetate, but not lipopolysaccharide or 12-o-tetradecanoylphorbol 13-acetate, induces tumoral invasion and migration in vitro and in vivo, and those are blocked by kaempferol and wogonin addition. (tmu.edu.tw)
  • Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo. (silverchair.com)
  • Evidence is provided that the NPXY structural motif within the beta 3 subunit, comprising residues 744-747, is essential for cell morphological and migratory responses mediated by integrin alpha v beta 3 in vitro and in vivo. (silverchair.com)
  • The predictions were confirmed using a functional in vitro assay (scratch assay) as well as an ex vivo multicellular environment (aortic ring angiogenesis assay), validating the concept that endothelial cells can be used as an effective screening tool of exposed workers for determining bioactivity of altered circulatory factors. (cdc.gov)
  • Furthermore, POGLUT2 knockdown of breast cancer cells was established, followed by in vitro biological function assays and in vivo tumor growth study. (frontiersin.org)
  • In vitro and in vivo results showed that POGLUT2 knockdown could delay tumor growth and progression. (frontiersin.org)
  • The focus here is placed on developing, evaluating, validating and utilizing tailored in vitro and in vivo models. (fraunhofer.de)
  • To address this issue, the expression levels of Snail, RhoA and fibronectin, as well as MMP‑2, were reduced in the breast tumor cell lines MDA‑MB‑231 and MDA‑MB‑435S, and their biological responses were studied in vitro and in vivo. (spandidos-publications.com)
  • It also covers the chemical diversity of isothiocyanates and their detailed mechanisms of action as reported by various in vitro and in vivo studies. (frontiersin.org)
  • Zong C, Bronckaers A, Vande Velde G, Willems G, Cadenas de Llano-Pérula M. (2022) In Vivo Micro-Computerized Tomography Tracking of Human Periodontal Ligament Stem Cells Labeled with Gold Nanocomplexes. (uhasselt.be)
  • The scratch assay is an in vitro technique used to assess the contribution of molecular and cellular mechanisms to cell migration. (ox.ac.uk)
  • Application of this new method will enable quantification of migration rates from in vitro scratch assay data that cannot be analysed using existing methods. (ox.ac.uk)
  • The cells were then treated with different concentrations of IL-17, ranging from 10 pg/mL to 100 ng/mL, and evaluated for IL-17 ability to modify tumor cell proliferation and viability through cell counting and MTT assay. (austinpublishinggroup.com)
  • Cell migration capacity and intracellular signaling pathways activated by IL-17 were assessed by wound healing assay and flow cytometry, respectively. (austinpublishinggroup.com)
  • In the chemotaxis migration assay, pretreatment with fluvastatin and simvastatin inhibited the migration of human CD4+ T cells towards CCL20. (nih.gov)
  • The present study aimed to investigate the effect of factors released from placental-derived MSCs (PL-MSCs) on EPC migration, which is a critical step of vasculogenesis, using an in vitro migration assay. (hindawi.com)
  • Cell invasion was evaluated by transwell invasion assay, and cell migration was detected by transwell migration and wound-healing assays. (cams.cn)
  • In addition, a functional restoration assay was performed to investigate whether miR-18a promotes HCC cell migration and invasion by directly targeting Dicer 1. (cams.cn)
  • Transwell matrigel invasion assay of HepG2 cells (C) or HepG2.2.15 cells (D) expressing miR-18a inhibitor or inhibitor NC. (cams.cn)
  • To investigate the putative anti-proliferative effect, apoptosis assay, microRNA expression profile and study of cell cycle were performed. (biomedcentral.com)
  • Cell migration was evaluated by using the wound-healing assay and by measuring transendothelial migration of cancer cells. (scirp.org)
  • Malignant transformation in vitro was determined by using the anchorage- independent growth assay on soft agar. (scirp.org)
  • Moreover, the migration of MDA-MB231/S283E/Tm1 cells in a wound closure assay is reduced compared to parental cells or those expressing the non-phosphorylatable form of Tm1 (S283A). (scirp.org)
  • Altogether, by identifying a pro-angiogenic VEGF/miR-101/EZH2 axis in endothelial cells we provide evidence for a functional link between growth factor-mediated signaling, post-transcriptional silencing, and histone-methylation in the angiogenesis process. (plos.org)
  • For several decades, neovascularization is believed to be accomplished by proliferation of mature endothelial cells residing in the local vessels through the process of angiogenesis [ 6 ]. (hindawi.com)
  • Changes in relative mRNA patterns indicated that serum from rats exposed to MMA-SS, and not GMA-MS or PBS, could influence several functional aspects related to endothelial cells, including cell migration, angiogenesis, inflammation, and vascular function. (cdc.gov)
  • ETP augmented fibrosis, angiogenesis, and inflammation through recruitment of macrophages and endothelial cells. (jci.org)
  • These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
  • This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
  • The present data provide evidence that Snail promotes tumor cell motility and angiogenesis which is mainly mediated through the regulation of RhoA activity. (spandidos-publications.com)
  • Current quantification methods of scratch assays deal poorly with irregular cell-free areas and crooked leading edges which are features typically present in the experimental data. (ox.ac.uk)
  • In cell proliferation assays, asiaticoside induced an increase in the number of normal human dermal fibroblasts. (indexindex.com)
  • Transwell migration assays of HepG2 cells (A) or HepG2.2.15 cells (B) expressing miR-18a inhibitor or inhibitor negative control (inhibitor NC). (cams.cn)
  • Wound healing assays of HepG2 cells (A) and HepG2.2.15 cells (B) after treatment with miR-18a inhibitors or inhibitor NC. (cams.cn)
  • CCK-8 and Transwell assays were performed to detect cell proliferation, invasion, and migration abilities. (hindawi.com)
  • Traditional assays struggle with evaluating cell phenotypes over time and correlating time-dependent responses with changes in the extracellular environment. (clarkson.edu)
  • Adhesion assays were performed at various periods of time on cells grown on plastic. (scirp.org)
  • The effects of PIP5K1α and its inhibitor on growth and invasion of BC were confirmed by using in vitro assays including. (lu.se)
  • Treatment of normal mesothelial MeT-5A cells with malignant PF increased cell viability , proliferation, and migration, and activated different survival -related signaling pathways. (bvsalud.org)
  • In conclusion, CAPE can inhibit the proliferation and migration of HCSMCs by inducing cell cycle arrest. (cellmolbiol.org)
  • Furthermore, the induction of collective cell migration at the colony edge using an endodermal induction media enhanced endodermal differentiation efficiency in association with cadherin switching, which is involved in the epithelial-mesenchymal transition. (biomedcentral.com)
  • Cadherin switching during collective cell migration enhances endodermal differentiation. (biomedcentral.com)
  • Local inflammation induces the differentiation of bronchial fibroblasts into α-smooth muscle actin (α-SMA) positive myofibroblasts and increases their longevity ( 5 ) through paracrine (for example TGFβ-dependent) and cell adhesion-dependent mechanisms ( 3 , 6 , 7 ). (spandidos-publications.com)
  • Pattern formation in cell differentiation and body form development. (clarkson.edu)
  • The differentiation of endometrial stromal cells into decidual cells, termed decidualization, is an integral step in the establishment of pregnancy. (bioone.org)
  • Gene ontology and upstream regulator pathway analysis showed that WNK1 regulates cell migration, differentiation, and proliferation. (bioone.org)
  • Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)
  • Furthermore, SALPs markedly promoted cell migration via EGFR transactivation and ERK1/2 phosphorylation and accelerated artificial wound closure in keratinocytes. (nature.com)
  • However, the incubation of IL-17 was able to promote tumor cell migration and AKT, ERK and P38 phosphorylation in vitro . (austinpublishinggroup.com)
  • Background: Tropomyosin 1 alpha chain (Tm1) is an actin-binding protein that regulates the endothelial cell response to oxidative stress following its phosphorylation at Serine 283 (S283). (scirp.org)
  • Conclusion: Phosphorylation of Tm1 at Ser283 contributes to its anti-tumor properties, and this effect results mainly from an increase in cell adhesion associated with a decrease in their migratory and invasive potentials. (scirp.org)
  • Simoneau, B., Houle, F. and Huot, J. (2012) Regulation of Endothelial Permeability and Transendothelial Migration of Cancer Cells by Tropomyosin-1 Phosphorylation. (scirp.org)
  • GL261 mouse glioma cells, M059J and U138 human glioma cells and T24 human bladder transitional cell carcinoma cells were obtained from ATCC (Rockville, Maryland, USA). (austinpublishinggroup.com)
  • These data suggest that combination of lipopolysaccharide and 12-o-tetradecanoylphorbol 13-acetate promotes tumoral progression via activating metalloproteinase 9 enzyme activity and inducible nitric oxide synthase gene expression, which is located downstream of mitogen-activated protein kinases activation, in rat glioma cells C6. (tmu.edu.tw)
  • Based on antineoplastic effect of brivaracetam and lacosamide on glioma cells, we assume that patients with glioma could benefit by the treatment with these two molecules, in addition to standard therapeutic options. (biomedcentral.com)
  • We have examined the role of oxidized LDL in regulating the wound-healing response of vascular EC in vitro. (rupress.org)
  • Previous studies demonstrated that MSCs could ameliorate the pathology associated with ischemic heart disease, ischemic stroke, and peripheral vascular disease by releasing several critical factors that increase cell survival, provide an appropriate microenvironment for repairing damaged tissue, and induce neovascularization [ 3 - 5 ]. (hindawi.com)
  • Vascular Cell, 4, 18. (scirp.org)
  • Finally to appraise how tissue function might be affected by endothelial cell hypoxia the contractility of vascular smooth muscle was examined. (bl.uk)
  • Human brain vascular pericytes treated with either scrambled or RGS5 targeting siRNA, will be co-cultured in a spheroid model of the BBB together with human brain endothelial cells and human astrocytes. (lu.se)
  • Human induced pluripotent stem cells (hiPSCs) provide an in vitro system to identify the impact of cell behavior on the earliest stages of cell fate specification during human development. (biomedcentral.com)
  • However, creating a culture platform with spatiotemporal control of cell behavior to study signaling dynamics during development remains challenging. (biomedcentral.com)
  • Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
  • To estimate the effect of the asthmatic microenvironment on the invasiveness of lung cancer cells, the present study compared the behavior of human non‑small cell lung cancer A549 cells exposed to the signals from human bronchial fibroblasts (HBFs) derived from non‑asthmatic donors (NA HBFs) and from asthmatic patients (AS HBFs). (spandidos-publications.com)
  • To elucidate the links between their function and the progression of lung cancer, we compared the behavior of human non-small cell lung cancer A549 cells exposed to the signals from monolayers of AS HBFs and from HBFs derived from non-asthmatic (NA) donors. (spandidos-publications.com)
  • Characterizing collective cell behavior in vitro. (clarkson.edu)
  • An alternate approach is to track the dynamics of live cells through time-lapse imaging and utilize knowledge based data-driven modeling to understand the individual and collective behavior of cells at high spatio-temporal precision. (clarkson.edu)
  • MicroRNAs Present in Malignant Pleural Fluid Increase the Migration of Normal Mesothelial Cells In Vitro and May Help Discriminate between Benign and Malignant Effusions. (bvsalud.org)
  • In this study, the crosstalk between stromal cells and tumor cells was investigated in vitro in order to reveal factors that are present in PF which can mediate MPE formation and aid in discriminating between benign and malignant etiologies. (bvsalud.org)
  • Malignant PF produces phenotypic and functional changes in normal mesothelial cells . (bvsalud.org)
  • In an earlier study, we reported that nitric oxide is involved in lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate-induced malignant transformation via increases in metalloproteinase 9 enzyme activity and inducible nitric oxide synthase gene expression in rat glioma C6 cells, however the mechanism has remained undefined. (tmu.edu.tw)
  • Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)
  • In HL-60 leukaemia cells, di-GA activated caspase 3 and dose-dependently induced apoptosis. (nature.com)
  • These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
  • In addition, IL-17 enhanced the cytotoxic effects of NK cells against tumor cells [6]. (austinpublishinggroup.com)
  • Aim of this study was to evaluate possible in vitro cytotoxic effects of two new-generation antiepileptic drugs on a human glioma cell line U87MG. (biomedcentral.com)
  • NA HBFs did not significantly affect A549 motility, whereas AS HBFs and the media conditioned with AS HBF/A549 co‑cultures increased Snail‑1/connexin43 expression and motility of A549 cells. (spandidos-publications.com)
  • Gadkin negatively regulates cell spreading and motility via sequestration of the actin-nucleating ARP2/3 complex. (nih.gov)
  • Tumor cell motility is the hallmark of invasion and an essential step in metastasis. (spandidos-publications.com)
  • Motility is determined by both properties of the cells and the extracellular environment. (clarkson.edu)
  • Journal of Muscle Research & Cell Motility, 22, 5-49. (scirp.org)
  • Journal of Muscle Research and Cell Motility, 36, 147-153. (scirp.org)
  • Adipocytes represent a major cell type in the mammary tumor microenvironment and are important for tumor growth. (jci.org)
  • It further stabilizes the tumor microenvironment and potentially facilitates collective colonization of novel bronchial loci by cancer cells. (spandidos-publications.com)
  • POGLUT2 was mainly expressed in stromal cells as verified by StromalScore, ESTIMATEScore, ImmuneScore, and Tumor purity, and POGLUT2 was positively correlated with cancer-associated fibroblasts, macrophages, monocytes, and neutrophils in the tumor microenvironment. (frontiersin.org)
  • Increased levels of POGLUT2 could result in the dysregulated immune cell infiltration and tumor microenvironment and showed a significant regulatory effect on the progression of breast cancer through Notch-related signaling. (frontiersin.org)
  • A main goal will be to use both mathematical modeling and learning techniques to understand fundamental scientific principles by which cells interact, and how this interaction depends on the local microenvironment. (clarkson.edu)
  • Decreased cell cycle genes and associated signaling pathway target gene expression may mediate anti-proliferative and anti-migration effects of CAPE. (cellmolbiol.org)
  • Mesenchymal stem cells (MSCs) are multipotent stem/progenitor cells which can differentiate to several mesodermal derivatives and possess an ability to secrete factors involved in neovascularization and immunomodulation [ 1 , 2 ]. (hindawi.com)
  • 1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
  • Maintaining multipotent trunk neural crest stem cells as self-renewing crestospheres. (lu.se)
  • In vitro maintenance of multipotent neural crest stem cells as crestospheres. (lu.se)
  • Department of Cell Biology, Cleveland Clinic Research Institute, Ohio 44195. (rupress.org)
  • Our exciting programme brings together the Biochemical Society, the British Society for Cell Biology and the European Cytoskeletal Forum to provide a platform for the cell migration community. (biochemistry.org)
  • In vitro , the sprouting and migratory properties of primary endothelial cell cultures were reduced by inhibiting EZH2 through up-regulation of miR-101, siRNA-mediated knockdown of EZH2, or treatment with 3-Deazaneplanocin-A (DZNep), a small molecule inhibitor of EZH2 methyltransferase activity. (plos.org)
  • In the adult mammalian subventricular zone (SVZ), GFAP-positive neural stem cells (NSCs) generate neuroblasts that migrate tangentially along the rostral migratory stream (RMS) toward the olfactory bulb (OB). (jneurosci.org)
  • In addition, the number and the migratory activity of these cells are inversely correlated with risk factors such as hypertension, hypercholesterolemia, diabetes, and metabolic syndrome. (intechopen.com)
  • The latter findings point to the participation of Nogo-A/NgR1 signaling in the regulation of other aspects of growth, such as tissue expansion or turnover by cell proliferation. (jneurosci.org)
  • We studied the secretome profile of gestational tissue-derived MSCs and their effects on functions of endothelial progenitor cells (EPCs), another angiogenic cell type that plays an important role during the neovascularization. (hindawi.com)
  • These effects were partially mediated through enhanced TGF-β signaling, which contributes to tissue fibrosis and epithelial-mesenchymal transition (EMT) of tumor cells. (jci.org)
  • Chronic inflammation and tissue fibrosis have long been considered to induce phenotypic shifts in cancer cells, such as epithelial-mesenchymal transition (EMT), which accounts for the formation of cancer invasive front. (spandidos-publications.com)
  • During lung cancer progression, the connective tissue of bronchial walls provides the scaffold for developing tumors, forms tissue barriers against immune responses of the host and/or constitutes the routes for the invasion of cancer cells ( 12 ). (spandidos-publications.com)
  • Expression, gene mutation and amplification, methylation, and copy number alteration (CNA) of POGLUT2 were evaluated using The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), and Genotype-Tissue Expression (GTEx) databases. (frontiersin.org)
  • Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
  • Cultured meat (i.e., meat produced in vitro using tissue engineering techniques) is being developed as a potentially healthier and more efficient alternative to conventional meat. (researchgate.net)
  • Besides stroke, my lab has also a main interest in using (dental) stem cells for tissue regeneration . (uhasselt.be)
  • Altered cell movement can also be characteristic of pathological conditions, for example, cancer cells invasion to healthy tissue. (clarkson.edu)
  • of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)
  • Eighteen PF samples, in different proportions, were exposed in vitro to mesothelial MeT-5A cells to determine the biological effects on these cells . (bvsalud.org)
  • The biological consequences of these observations are underscored by the finding that CS-1 cells expressing wild-type alpha v beta 3 acquire the capacity to form spontaneous pulmonary metastases in the chick embryo when grown on the chorioallantoic membrane. (silverchair.com)
  • Biological members will be involved in image acquisition and analysis of time-lapse images of cultured cells. (clarkson.edu)
  • Mathematical members will utilize both mechanistic principles and individual cell data to discover interaction rules in many-particle biological systems that depend on both local interactions and environmental factors. (clarkson.edu)
  • Cell migration touches upon a range of biological processes, including development, cancer and wound healing. (biochemistry.org)
  • However, recent studies have demonstrated that other angiogenic cells called endothelial progenitor cells (EPCs) also play an important role during the formation of new vessels through the process of vasculogenesis [ 7 - 9 ]. (hindawi.com)
  • Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
  • Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
  • Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)
  • Merckx G, Hosseinkhani B, Kuypers S, Deville S, Irobi J, Nelissen I, Michiels L, Lambrichts I, Bronckaers A. (2020) Angiogenic Effects of Human Dental Pulp and Bone Marrow-Derived Mesenchymal Stromal Cells and their Extracellular Vesicles. (uhasselt.be)
  • Primary human endometrial stromal cells (HESCs) were subjected to small interfering RNA knockdown of WNK1 followed by in vitro decidualization. (bioone.org)
  • VEGF, produced in large amounts by cancer cells during tumor growth, interacts with its receptors VEGFR1 and VEGFR2 thereby causing endothelial cell survival, proliferation, and sprouting [7] . (plos.org)
  • Then, can it repress the cancer cells' metastasis potential? (scielo.br)
  • These data indicated that the interactions between lung cancer cells and HBFs in asthmatic bronchi may facilitate the colonization of lung tumors by fibroblasts. (spandidos-publications.com)
  • However, the contribution of asthmatic bronchial fibroblasts in systemic dissemination of lung cancer cells remains unaddressed. (spandidos-publications.com)
  • We examined the efficacy of lapatinib, an inhibitor of the epidermal growth factor receptor (EGFR) and HER2 kinases, for preventing the outgrowth of breast cancer cells in the brain in a mouse xenograft model of brain metastasis. (nih.gov)
  • After analyzing different tumor stem cell markers (SOX2, OCT4, CD133, CD44 and CD24) in pancreatic cancer cells treated with different chemotherapeutic protocols by means of RT-qPCR, Oxaliplatin and Gemcitabine in monotherapy were the chemotherapies that selected the most cancer stem cells while the FOLFIRI protocol decreased them. (isciii.es)
  • Methods: MDA MB231 breast cancer cells stably overexpressing wild type form of Tm1 or Tm1 mutants (S283A and S283E) were generated. (scirp.org)
  • In ER+ cancer cells, PIP5K1α acted on pSer-473 AKT, and was in complexes with VEGFR2, serving as co-factor of ER-alpha to regulate activities of target genes including cyclin D1 and CDK1. (lu.se)
  • Our findings reveal a new unprecedented function for Nogo-A and NgR1 in the homeostatic regulation of the pace of neurogenesis in the adult mouse SVZ and in the migration of neuroblasts along the RMS. (jneurosci.org)
  • Neuronal regulation of astroglial morphology and proliferation in vitro. (wikipedia.org)
  • To modulate cell migration in these networks they manipulated an enzyme that is centrally involved in the regulation of the neuronal cytoskeleton. (sciencedaily.com)
  • Therapeutic potentials of mesenchymal stem cells (MSCs) depend largely on their ability to secrete cytokines or factors that modulate immune response, enhance cell survival, and induce neovascularization in the target tissues. (hindawi.com)
  • We designed a study to find theoretical evidence for the induction, movement, fusion, proliferation, and safety of human adipose mesenchymal stem cells (hADSCs) in intraocular application. (molvis.org)
  • Therefore, in this study, we assessed the ability of human adipose mesenchymal stem cells (hADSCs) to express the characteristics of ECs after induction in vitro to evaluate the theoretical feasibility of maintaining or restoring the function of ECs after intraocular application. (molvis.org)
  • In this study, we found that caffeic acid phenethyl ester (CAPE) displayed an inhibitory effect on human coronary smooth muscle cell (HCSMC) growth and migration. (cellmolbiol.org)
  • PCME cells were challenged for 4h with serum collected from exposed rats, and 84 genes related to endothelial function were analyzed. (cdc.gov)
  • This abrogated expression of the decidual marker genes, insulin like growth factor binding protein 1 ( IGFBP1 ) and prolactin ( PRL ), and prevented adoption of decidual cell morphology. (bioone.org)
  • abstract = "T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood cancer. (uky.edu)
  • The aim of this study was to determinate the effect of different chemotherapy protocols used in the clinic on tumor stem cell markers in vitro . (isciii.es)
  • and stem cell regeneration. (lu.se)
  • Great Iranian Muslim scholars netics, stem cell research, and organ trans- laid huge emphasis on teaching and practis- plantation are some of the medical issues ing ethics. (who.int)
  • Enhanced expression of MycN/CIP2A drives neural crest toward a neural stem cell-like fate: Implications for priming of neuroblastoma. (lu.se)
  • By observing the numbers of cells attached and the area occupied by the cells, we concluded that asiaticoside also enhanced the initial skin cell adhesion. (indexindex.com)
  • Hatten discovered the neuron-glial adhesion protein astrotactin (ASTN1), a receptor critical for glial-guided migration. (wikipedia.org)
  • RhoA has been implicated in the formation of stress fibers and cell adhesion in fibroblasts. (spandidos-publications.com)
  • Results: We found that cells expressing the phosphomimetic form of Tm1 S283E/Tm1 are characterized by an increased adhesion to the substratum. (scirp.org)
  • Methods were initially developed to examine the adhesion of neutrophils to monolayers of a cultured endothelial cell line (ECV304) after periods of hypoxia and reoxygenation. (bl.uk)
  • Neutrophil adhesion to ECV304 cells, which had been hypoxic for 4 hours and then reoxygenated for 30 minutes, was significantly increased. (bl.uk)
  • ROS generation in turn caused the release of a soluble factor (s) which induced a conformational change on the neutrophil surface allowing it to bind to the intercellular adhesion molecule 1 (ICAM-1) on the endothelial cell. (bl.uk)
  • These findings demonstrate that the NPXY motif within the integrin beta 3 cytoplasmic tail is essential for alpha v beta 3-dependent post-ligand binding events involved in cell migration and the metastatic phenotype of melanoma cells. (silverchair.com)
  • The brain is increasingly being recognized as a sanctuary site for metastatic tumor cells in women with HER2-overexpressing breast cancer who receive trastuzumab therapy. (nih.gov)
  • Cancer stem cells are responsible for tumor chemoresistance and recurrence in adjuvant and metastatic settings. (isciii.es)
  • In conducting her research, the Hatten lab spearheaded the use of video imaging methods in viewing the dynamics of CNS neuronal migration along glial fibers. (wikipedia.org)
  • Central nervous system neuronal migration. (wikipedia.org)
  • IL-17RA mRNA expression was detected on the cell lines tested, but the incubation of IL-17 did not alter tumor cell viability or proliferation. (austinpublishinggroup.com)
  • Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate, but not lipopolysaccharide or 12-o-tetradecanoylphorbol 13-acetate alone, induced transformation in glioma C6 cells (but not in human glioblastoma cells GBM-8401 cells) without affecting their viability. (tmu.edu.tw)
  • Proliferation and cell viability were assayed by means of the enzymatic cleavage of the tetrazolium salt WST-1 to formazan dye by cellular mitochondrial dehydrogenases. (scirp.org)
  • Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. (mdpi.com)
  • Hereby we focus on the use of extracellular vesicles derived from dental pulp stem cells, a project with dr. (uhasselt.be)
  • In LPS-stimulated human monocyte-derived dendritic cells and Langerhans-like cells, the peptides blocked IL-6 secretion, downregulated expression of maturation markers and inhibited dendritic cell migration. (nature.com)
  • Loss of Gadkin Affects Dendritic Cell Migration In Vitro. (nih.gov)
  • Furthermore, suppression of Dicer l expression by small interfering RNA essentially abolished the inhibition of cell migration and invasion induced by miR-18a inhibitor, restorating these activities to levels similar to the parental HCC cells. (cams.cn)
  • Neurons are sociable cells that, on the long run, die in isolation. (sciencedaily.com)
  • The scientists tested the model predictions experimentally by investigating how cell migration, neurite outgrowth and activity interact in developing networks of cultured rat cortical neurons. (sciencedaily.com)
  • Primary c57B6 neurons from mouse 19 days in vitro. (lu.se)
  • Immunoblot analyses validated that manipulation of PRL-3 expression in T-ALL cells affected the SRC signaling pathway, which is directly involved in cell migration, although Src was not a direct substrate of PRL-3. (uky.edu)
  • It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
  • In addition, even in the absence of exogenous supplements, ectoderm, mesoderm, endoderm, and extraembryonic cells differentiated following the induction of collective cell migration at the colony edge by removing the ring-barrier. (biomedcentral.com)
  • After induction, hADSCs expressed von Willebrand Factor (vWF), the cell marker of ECs. (molvis.org)
  • Quantifying the mechanics and growth of cells and tissues in 3D using high resolution computational models. (crossref.org)
  • Based on in vitro studies and computational modeling, neuroscientists have now made an important contribution to the understanding of brain networks and their development: in their current study, they show how neuronal outgrowth and migration interact in shaping network architecture and the degree of modularity in mature networks. (sciencedaily.com)
  • Based on in vitro studies and computational modeling, neuroscientists Dr. Samora Okujeni and Prof. Dr. Ulrich Egert from the Bernstein Center Freiburg now made an important contribution to the understanding of brain networks and their development: in their current study, they show how neuronal outgrowth and migration interact in shaping network architecture and the degree of modularity in mature networks. (sciencedaily.com)
  • Our results suggest that not all, but specific types of statins may be of benefit in alleviating psoriasis partially via interrupting CCL20/CCR6 chemotactic interaction, the mechanism which may eventually lessen the infiltration of Th17 cells. (nih.gov)
  • In contrast to NA HBFs, which formed A549‑impenetrable lateral barriers, α‑SMA+ AS HBFs actively infiltrated A549 monolayers and secreted chemotactic factors that arrested A549 cells within AS HBF/A549 contact zone. (spandidos-publications.com)
  • Enstrom A, Carlsson R, Ozen I, and Paul G. RGS5: a novel role as a hypoxia-responsive protein that suppresses chemokinetic and chemotactic migration in brain pericytes. (lu.se)
  • Bacteria can release endotoxins like lipopolysaccharide (LPS) or other pathogenicity factors such as lipopoteins/peptides (LP) from their cell envelope, even due to treatment with conventional antibiotics, being able to activate Toll-like receptors (TLRs) and induce a strong inflammatory response. (nature.com)
  • Our data show, for the first time, the ability of IL-17RA/IL-17 to induce migration of human tumor cell lines in vitro , possibly via activation of MAP kinases and AKT. (austinpublishinggroup.com)
  • We previously showed that VEGF signaling in primary endothelial cell cultures caused overexpression of VEGFR2 in a positive feed-forward loop, which is at least partly regulated by loss of miRNA-mediated control of VEGF receptor degradation. (plos.org)
  • Analysis of the supernatant from hypoxic/reoxygenated endothelial cell cultures and studies using inhibitors of secretion suggested platelet activating factor (PAF) may be a major component in this overall sequence of events. (bl.uk)
  • Confluent cultures of bovine aortic EC were "wounded" with a razor, and migration was measured after 18 to 24 h as the number of cells moving into the wounded area and the mean distance of cells from the wound edge. (rupress.org)
  • Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells. (cancerindex.org)
  • Objective To investigate the effects of microRNA-18a (miR-18a) on migration and invasion of hepatocellular carcinoma (HCC) cells, and its possible mechanism associated with Dicer l. (cams.cn)
  • microRNA-18a Promotes Cell Migration and Invasion Through Inhibiting Dicer l Expression in Hepatocellular Carcinoma In Vitro △ [J].Chinese Medical Sciences Journal, 2017, 32(1): 34-43. (cams.cn)
  • In addition, TWIST overexpression can reverse the inhibition of lncRNA SNHG3 knockdown or miR-326 overexpression on cell proliferation, migration, and invasion. (hindawi.com)
  • Targeted overexpression or knockdown of PIP5K1α were introduced into BC cell lines. (lu.se)
  • Collective cell migration modulates self-organized fate patterning decisions in iPSC-derived gastrulation-stage meso-endoderm. (biomedcentral.com)
  • Oxidized LDL markedly reduced migration in a concentration- and oxidation-dependent manner. (rupress.org)