Migration of monocytes. Medical search. Frequent questions

Monocyte-derived macrophages (MDM) drive the inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and they are a major source of eicosanoids in airway inflammation. (nature.com)
In the presence of elevated levels of oxidized LDL (ox-LDL), monocytes are converted to activated macrophages. (wikipedia.org)
Proteins derived from macrophages and monocytes were later called monokines. (cdc.gov)
It involves interactions between oxidized low-density lipoprotein (LDL) deposits, endothelial cells, leukocytes, monocytes, macrophages, T-lymphocytes and smooth muscle cells, all of which are involved in promoting cellular migration and proliferation to drive the formation of foam cell clusters abundant in atherosclerotic plaque [ 4 ]. (springer.com)
Tumor-associated macrophages (TAMs) are a well-known component of the inflammatory infiltrate in the tumor microenvironment, originating from monocytes. (researchsquare.com)
CCL5 is expressed by T cells and monocytes/macrophages. (biolegend.com)
M2 macrophages derived from human monocyte cell line THP-1 secreted high levels of IL-8 and leukotriene D4 (LTD4), which induced colon cancer cell migration, and Th2 cytokines (IL-4, IL-10) to maintain a tumoral immunosuppressive environment. (lu.se)

Studying the influence of chemokine receptors (CCRs) on monocyte fate may reveal information about which subpopulations of monocytes convert to dendritic cells (DCs) and the migration pathways that they use. (wustl.edu)
These cells include dermal resident dendritic cells (DC), epidermal Langerhans cells, neutrophils and monocytes, which are released from the blood when the dermal capillary is disrupted and a reputed blood lake is formed [ 3 - 6 ]. (biomedcentral.com)
CC chemokines induce the migration of monocytes and other cell types such as NK cells and dendritic cells. (immunochemistry.com)
Defective migration of monocyte-derived dendritic cells in LAD-1 immunodeficiency. (lu.se)

oxidized LDL causes endothelial cells to secrete molecules that cause monocytes to penetrate between the endothelial cells and accumulate in the intima. (wikipedia.org)
Cell permeability, migration, and reactive oxygen species induced by multiwalled carbon nanotube s in human microvascular endothelial cells. (cdc.gov)

Notably, treatment of supernatants with Apyrase to remove ATP potently inhibited migration of THP-1 monocytes and partially blocked migration of primary human monocytes. (elsevierpure.com)
We found that treatment with these septapeptides strongly and rapidly downregulated the multiplication of DENV-1 16007, DENV-3 16562, and DENV-4 1036 but not that of DENV-2 16681 in primary human monocytes. (unboundmedicine.com)

Also, through the activation of collagenases, ox-LDL contributes to a process which may lead to the rupture of the fibrous plaque Oxidized LDL decreases the availability of endothelial nitric oxide (NO), which, in turn, increases the adhesion of monocytes to the endothelium. (wikipedia.org)
oxLDL was found to significantly increase the expression of ICAM‑1 and VCAM‑1 in ECs under HG conditions whilst also enhancing the adhesion of monocytes to ECs. (spandidos-publications.com)
Subsequently, rosmarinic acid treatment significantly reversed oxLDL‑induced overexpression of adhesion molecules and monocyte‑EC adhesion, oxLDL‑induced endothelial junction hyperpermeability and monocyte transmigration through the endothelial monolayer under HG conditions, in a dose‑dependent manner. (spandidos-publications.com)
These results indicate that the effects of GMFG on monocyte migration and adhesion probably occur through preventing ubiquitin-mediated proteasome degradation of alpha5beta1-integrin and facilitating effective beta1-integrin recycling back to the plasma membrane. (genscript.com)
CD97 reportedly plays roles in leucocyte signaling, adhesion, and migration. (bdbiosciences.com)
Upon lymphoid, myeloid cells and neutrophil activation, CD97 is upregulated to promote adhesion and migration to sites of inflammation. (abcam.com)
Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. (cancerindex.org)
Mechanistically, MWCNT exposure elevated the levels of monocyte chemoattractant protein-1 (MCP-1) and intercellular adhesion molecule 1 (ICAM-1) in HMVEC. (cdc.gov)

LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA 1-6 , to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. (hindawi.com)
These growth factors promote cell migration, proliferation, and differentiation, which are essential for wound healing. (thieme-connect.de)
On the other hand, it is known that the differentiation of monocytes into TAMs is in direct relationship with the severity of prognosis and clinical outcomes. (researchsquare.com)
Monocytes from healthy African American donors and those from patients with SSc had low caveolin-1 levels, enhanced migration toward the CXCR4 ligand SDF-1, and enhanced differentiation to fibrocytes. (nih.gov)
Enhanced migration and differentiation of monocytes from African Americans and patients with SSc appeared to be attributable to the lack of caveolin-1, because restoring caveolin-1 function using a caveolin-1 scaffolding domain peptide inhibited these processes. (nih.gov)
African Americans may be predisposed to SSc-related ILD due to low baseline caveolin-1 levels in their monocytes, potentially affecting signaling, migration, and fibrocyte differentiation. (nih.gov)

In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes, and eosinophils. (southernbiotech.com)

First, we examined whether prominent CCRs on different monocyte subsets, CCR2 or CX 3 CR1, mediated migration events upstream of the accumulation of monocyte-derived DCs in lymph nodes (LNs). (wustl.edu)
However, absence of CCR2 led to an increased labeling of the minor Gr-1 int monocyte population, and the number of latex + DCs that emigrated to LNs was correspondingly increased. (wustl.edu)
Inhibition of the CCL2 receptor (CCR2) on THP-1 monocytes with RS102895, a specific CCR2 inhibitor, did not block migration induced by lipoapoptotic supernatants. (elsevierpure.com)
It also interferes with CCR2, a receptor that binds to monocyte chemo-attractant protein 1 (MCP-1), a cytokine that promotes migration of monocytes. (aidsmap.com)

Continued cell migration and proliferation eventually result in the formation of a fibrous plaque. (wikipedia.org)
After activation in the wound area, platelets will release growth factors to regulate cell migration, proliferation, and matrix deposition and reduce the risk of infection from the wound, increasing the quality of healing and tissue repair. (thieme-connect.de)
CircPAPPA Regulates the Proliferation, Migration, Invasion, Apoptosis, and Cell Cycle of Trophoblast Cells Through the miR-3127-5p/HOXA7 Axis. (nih.gov)

We show that ApoBDs generated from IAV-infected monocytes contained IAV mRNA, protein and virions and consequently, could facilitate viral propagation in vitro and in vivo, and induce a robust antiviral immune response. (nature.com)
IAV was able to induce monocyte apoptosis and apoptotic cell disassembly in both in vitro and in vivo settings. (nature.com)

Simultaneous stimulation of toll-like receptors (TLRs) and triggering receptor expressed on myeloid cells (TREM-1) activating receptor on monocytes results in the amplification of the inflammatory signal and multiple increase in proinflammatory cytokine production. (hindawi.com)
The dynamics of those receptors expression on monocyte surface of patients with uncomplicated SIRS course followed coronary artery bypass surgery (CABG) was studied. (hindawi.com)

Because of the importance of cell migration in angiogenesis, oncology, neurology, and especially immunology, there is an increased interest in understanding the underlying biological mechanisms at a single cell level. (sigmaaldrich.com)

A homing receptor-bearing cortical thymocyte subset: implications for thymus cell migration and the nature of cortisone-resistant thymocytes. (southernbiotech.com)

Thus, SARS-CoV-2 infection leaves an inflammatory imprint in the monocyte/ macrophage compartment that drives aberrant macrophage effector functions and eicosanoid metabolism, resulting in long-term immune aberrations in patients recovering from mild COVID-19. (nature.com)
There was no consistent decrease in the migration of CD11b + F4/80 + (macrophage) or SSC hi GR-1 + (neutrophil) populations. (biomedcentral.com)
In 1974, Cohen and colleagues reported production of macrophage migration inhibitory factors in virus-infected fibroblasts, which led (finally) to proposal of the term cytokine. (cdc.gov)

CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes. (southernbiotech.com)

Endothelial inflammation increases the adhesiveness of monocytes to the endothelium in addition to increasing vascular permeability, promoting diabetic atherogenesis. (spandidos-publications.com)

Lipoapoptotic supernatants stimulated monocyte migration with the magnitude similar to a monocyte chemoattractant protein, CCL2 (MCP-1). (elsevierpure.com)

The small chemotactic cytokine CCL4 (MIP-1 beta) is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. (immunochemistry.com)
CCL4 (MIP-1 beta) is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. (immunochemistry.com)

Monocytes are the main source of cytokines in the early inflammatory phase. (hindawi.com)
It induces monocyte activation, migration, and production of inflammatory cytokines and VEGF. (rndsystems.com)
This inhibitory effect was likely mediated through various routes including the increased production of antiviral cytokines (IFN-I), activation of mononuclear cell migration, and upregulation of the expression of antiviral miRNAs (has-miR-30e*, has-miR-133a, and has-miR-223) and inflammation-related miRNAs (has-miR-146a and has-miR-147). (unboundmedicine.com)

All monocyte subsets from LTBI individuals exhibited higher mean fluorescence intensity (MFI) of CX3CR1 and CD36 compared with non-LTBI individuals. (bvsalud.org)
Among LTBI individuals, CAD was associated with lower CX3CR1 MFI on classical monocytes and lower CD36 MFI across all monocyte subsets. (bvsalud.org)

Recruitment of monocytes in the liver is a key pathogenic feature of hepatic inflammation in nonalcoholic steatohepatitis (NASH), but the mechanisms involved are poorly understood. (elsevierpure.com)
Such changes in dendritic cell migration may be associated with immunological events that maintain inflammation at the sites of infection. (biomedcentral.com)
In conclusion, anionic septapeptides exerted anti-DENV activity in human monocytes through the upregulation of innate immune responses and the activation of several previously reported antiviral and inflammation-related miRNAs. (unboundmedicine.com)

Given that the monocyte count at the time of diagnosis dynamically reflects the systemic inflammatory response to cancer, studies often measure monocyte count at the time of diagnosis in their patients. (researchsquare.com)
Individuals with LTBI have distinct monocyte alterations suggestive of an exacerbated inflammatory response and tissue migration. (bvsalud.org)

Millicell® µ-Migration Assay Kit This Kit overcomes the limitations of traditional multiwell migration assays. (sigmaaldrich.com)
Traditional multiwell (Boyden chamber) migration assays can have limitations, such as: (1) gradients are not linear, well-established, or controlled, (2) quantification of migratory cells is based on an endpoint measurement rather than a dynamic determination, and (3) imaging of the cells while they are migrating is currently not possible. (sigmaaldrich.com)
Designed for video microscopy assays, the µ-Migration Slide is made from a plastic with high optical qualities similar to those of glass. (sigmaaldrich.com)
Assays of monocyte migration toward stromal cell-derived factor 1 (SDF-1) were performed using monocytes from Caucasian and African American healthy donors and patients with SSc. (nih.gov)

Together, this study reveals a previously unrecognised function of apoptotic monocyte disassembly in the pathogenesis of IAV infections. (nature.com)

Infected alveolar epithelial cells release a series of chemoattractants, such as CCL2, which recruit inflammatory monocytes to the site of infection 11 . (nature.com)
CD47 binding to α2β1 integrin could regulate cyclooxygenase-2 expression and cell migration on collagen I surface in intestinal epithelial cells. (lu.se)

Severe COVID-19 is associated with profound changes in the myeloid compartment, including expansion of dysfunctional, pro-inflammatory monocytes during the first weeks after SARS-CoV-2 infection 6 , 7 . (nature.com)
To investigate the function of apoptotic monocyte disassembly, we used influenza A virus (IAV) infection as a proof-of-concept model, as IAV commonly infects monocytes in physiological settings. (nature.com)
Therefore, we utilised IAV infection as a model to further dissect the functional consequence of the disassembly of apoptotic monocytes. (nature.com)
HIV infection and cardiovascular disease have both shared and distinct monocyte gene expression features: Women's Interagency HIV study. (academictree.org)
Pro-Inflammatory Alterations of Circulating Monocytes in Latent Tuberculosis Infection. (bvsalud.org)

Although they differed from monocytes from Caucasians, monocytes from both African Americans and patients with SSc were not identical, because SSc monocytes showed major increases from baseline in ERK, JNK, p38, and Smad2/3 activation, while monocytes from African Americans showed only limited ERK activation and no activation of JNK, p38, or Smad2/3. (nih.gov)

This is followed by the attachment of leukocytes, monocytes, and T-lymphocytes to the endothelial cell surface. (wikipedia.org)

Monocytes (MC) are bone marrow (BM) derived mononuclear phagocytes that play an important role in innate immune response and are the major immune cell population in chronic tissue inflammatory ( 1 , 2 ). (frontiersin.org)

ApoBDs generated by IAV-infected monocytes contained a series of IAV components, including IAV mRNA, proteins, and infectious virions. (nature.com)

This interaction enhanced cell migration of CRC cells and TAMs. (lu.se)

Regulates Monocyte Migration through Modulation of ?1-Integrin. (genscript.com)

Loss of mTORC2-induced metabolic reprogramming in monocytes uncouples migration and maturation from production of proinflammatory mediators. (nih.gov)

The increase in TLR2 and TREM-1 expression on the first day after CABG induces proinflammatory and amplification potentials of monocytes in that period. (hindawi.com)
The highest level of TLR2, TLR4, and TREM-1 surface expression was observed in CD14 hi CD16 + monocyte subpopulation, confirming its proinflammatory profile. (hindawi.com)

We also identified an antipsychotic, Haloperidol, as an unexpected inhibitor of monocyte cell disassembly which could impair ApoBD-mediated viral propagation under in vitro conditions. (nature.com)
Cell migration occurs in a variety of biological processes including wound healing, embryonic development, and immune response. (sigmaaldrich.com)
At specific time intervals, images of the observation area can be acquired, allowing real-time monitoring and quantitative measurements of cell migration. (sigmaaldrich.com)
Monocyte, an element of the immune system, is a heterogeneous cell showing different responses to different stimuli. (researchsquare.com)
Monocytes activated by tumour-derived microvesicles from pancreatic, colon and lung cancer cell lines have been found to show increased expression of human leukocyte antigen (HLA)-DR and a resulting increase in production of reactive oxygen intermediates and TNF-α 11 . (ersjournals.com)
is associated with colorectal cancer metastasis and its downregulation suppresses colorectal cancer cell migration and invasion in vitro. (genscript.com)
In addition, it was found that MWCNT promoted cell migration in HMVEC. (cdc.gov)
Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain. (medlineplus.gov)

The role of CCR8 in emigration from tissues also applied to human monocyte-derived cells in a model of transendothelial trafficking. (wustl.edu)
Here, we studied migration of human monocytes in response to supernatants obtained from liver cells after inducing lipoapoptosis with saturated free fatty acids (FFA). (elsevierpure.com)
Inhibition of c-Jun NH 2 -terminal kinase (JNK) in liver cells with SP600125 blocked migration of monocytes in a dose-dependent manner, indicating that JNK stimulates release of chemoattractants in lipoapoptosis. (elsevierpure.com)
Importantly, inhibition of Panx1 expression in liver cells with short hairpin RNA (shRNA) decreased supernatant eATP concentration and inhibited monocyte migration, indicating that monocyte migration is mediated in part by Panx1-dependent eATP release. (elsevierpure.com)
However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
In addition, CCL5 plays a crucial role in the migration and metastasis of cancer cells. (biolegend.com)

However, it remains unclear whether oxLDL‑mediated inflammasome activation can regulate the interaction between monocytes and ECs. (spandidos-publications.com)

CCR7 and CCR8 pathways were used by monocyte-derived DCs during mobilization from skin to LNs. (wustl.edu)
Interactions of Monocytes, HIV, and ART Identified by an Innovative scRNAseq Pipeline: Pathways to Reservoirs and HIV-Associated Comorbidities. (academictree.org)

These results suggest that JNK regulates activation of Panx1 channels, and provide evidence that Pannexin1-dependent pathophysiological eATP release in lipoapoptosis is capable of stimulating migration of human monocytes, and may participate in the recruitment of monocytes in chronic liver injury induced by saturated FFA. (elsevierpure.com)
A STUDY TO CHECK THE ROLE OF HOMOEOPATHIC MEDICINES IN STRESS MANAGEMENT OF MIGRANTS (human migration involves the moments of people from one place to another with intention of settling permanently or temporarily at the new location) STUDYING IN DEGREE COLLEGES. (who.int)

Characterization of Gr-1 int monocytes revealed that they selectively expressed CCR7 and CCR8 mRNA in blood. (wustl.edu)

In the present study, we aimed to investigate whether the monocyte count measured at the time of diagnosis can be used as a new prognostic biomarker in predicting disease-free survival in patients with esophageal cancer. (researchsquare.com)

We investigated the activation and pro-inflammatory profile of monocytes in individuals with LTBI and their association with coronary artery disease (CAD). (bvsalud.org)
Individuals 40-70 years old in Lima, Peru , underwent QuantiFERON-TB testing to define LTBI, completed a coronary computed tomography angiography to evaluate CAD, and provided blood for monocyte profiling using flow cytometry . (bvsalud.org)

These results suggest that rosmarinic acid can exert a protective effect against oxLDL‑mediated endothelial dysfunction under HG conditions by reducing the interaction between monocytes and ECs in addition to preventing monocyte diapedesis. (spandidos-publications.com)

Therefore, the present study aimed to elucidate the mechanisms involved in oxLDL‑induced endothelial permeability and monocyte diapedesis under HG conditions, in addition to the potential effects of rosmarinic acid. (spandidos-publications.com)

Reasons for internal migration of plastic bile duct stents and there methods of retrieval. (who.int)

Our findings showed that monocyte count is a prognostic factor affecting disease-free survival in patients with esophageal cancer, regardless of histological subtype. (researchsquare.com)

In contrast, SDF-1 exposure caused no additional ERK activation in SSc monocytes but did cause significant additional activation in monocytes from African Americans. (nih.gov)

The aim of this study was to evaluate the relationship between the monocyte count assessed at diagnosis and disease-free survival and prognosis in patients with esophageal cancer. (researchsquare.com)
The effect of monocyte count assessed in the blood samples taken at the time of diagnosis prior to the initiation of the treatment on disease-free survival was investigated. (researchsquare.com)
Disease-free survival was 17.3 months (95% CI: 8.4-26.2) in patients with a monocyte count ≥515/μL as opposed to 38.5 months (95% CI: 28. (researchsquare.com)

The monocytes of African Americans may lack caveolin-1 due to high levels of transforming growth factor β in their blood. (nih.gov)

Anatomy40

Organisms8

Diseases8

Chemicals and Drugs125

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Psychiatry and Psychology1

Phenomena and Processes45

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science5

Health Care2

Macrophages7

Dendritic cells4

Endothelial cells2

Primary human monocytes2

Adhesion8

Differentiation6

Neutrophils1

CCR24

Proliferation3

Induce2

Receptors2

Immunology1

Receptor1

Macrophage3

Lymph1

Endothelium1

Protein1

Chemoattractant2

Cytokines3

Subsets2

Inflammation3

Inflammatory response2

Assays4

Pathogenesis1

Epithelial cells2

Infection5

Increases1

Lymphocytes1

Innate1

Proteins1

TAMs1

Modulation1

Maturation1

Proinflammatory2

Cell8

Cells6

Regulate1

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Human2

MRNA1

Investigate1

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Interaction1

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Levels1