• Allegra M, Gagnoux-Palacios L, Gache Y, Roques S, Lestringant G, Ortonne JP,Meneguzzi G. Rapid decay of alpha6 integrin caused by a mis-sense mutation in thepropeller domain results in severe junctional epidermolysis bullosa with pyloric atresia. (encyclopedia.pub)
  • The α6β4 integrin protein is found primarily in epithelial cells, which are cells that line the surfaces and cavities of the body. (encyclopedia.pub)
  • The α6β1 integrin protein has not been as well studied as α6β4 integrin. (encyclopedia.pub)
  • Data indicate that S100 calcium binding protein P (S100P) increased lung cancer cell migration by binding integrin alpha7. (cusabio.com)
  • The results obtained indicate that alpha6beta1 is necessary for VEGF expression because the ability of hypoxia to activate HIF-1 and to stimulate VEGF transcription in MDA-MB-435 cells is dependent on alpha6beta1 expression by a mechanism that involves protein kinase C-alpha. (umassmed.edu)
  • Integrin alpha-2 or CD49b (cluster of differentiation 49b) is a protein which in humans is encoded by the CD49b gene . (wikidoc.org)
  • The CD49b protein is an integrin alpha subunit. (wikidoc.org)
  • The ITGA6 gene provides instructions for making one part (the α6 subunit) of two proteins known as α6β4 integrin and α6β1 integrin. (encyclopedia.pub)
  • Integrins are a group of proteins that regulate the attachment of cells to one another (cell-cell adhesion) and to the surrounding network of proteins and other molecules (cell-matrix adhesion). (encyclopedia.pub)
  • As part of a complex network of proteins in hemidesmosomes, α6β4 integrin helps to hold the layers of skin together. (encyclopedia.pub)
  • The integrin proteins activate key signaling molecules, which trigger cancer cells to migrate through the body and invade other tissues. (encyclopedia.pub)
  • Integrins also transmit chemical signals that regulate cell growth and the activity of certain genes. (encyclopedia.pub)
  • Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy. (cusabio.com)
  • Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. (cusabio.com)
  • Researchers believe that both α6β1 integrin and α6β4 integrin may play critical roles in the progression of cancerous tumors called carcinomas. (encyclopedia.pub)
  • Changes in the location and activity of α6β1 integrin and α6β4 integrin within cancer cells are associated with the progression of carcinomas. (encyclopedia.pub)
  • Recent studies suggest that, in addition to their roles in the progression of existing carcinomas, α6β1 integrin and α6β4 integrin may be involved in the initial formation of these tumors. (encyclopedia.pub)
  • The alpha6beta1 integrin has been implicated in breast carcinoma progression, but the mechanisms involved remain elusive. (umassmed.edu)
  • The other integrin made with the α6 subunit, α6β1 integrin, functions during the formation of organs and tissues before birth. (encyclopedia.pub)
  • These mutations alter the normal structure and function of the α6 integrin subunit or prevent cells from producing enough of this subunit. (encyclopedia.pub)
  • The ITGA6 gene mutations responsible for EB-PA lead to a loss of functional α6β4 integrin. (encyclopedia.pub)
  • The resulting shortage of functional α6β4 integrin causes cells in the epidermis to be fragile and easily damaged. (encyclopedia.pub)
  • As knockdown of Integrin alpha7 (ITGA7) can effectively reduce the stemness of oesophageal squamous cell carcinoma (OSCC) cells, ITGA7 could be a potential therapeutic target in OSCC treatment. (cusabio.com)
  • The absence of either alpha7beta1 integrin or alpha6beta1 integrin impairs the ability of Schwann cells to spread and to bind laminin. (cusabio.com)
  • MDA-MB-435 cells engineered to be deficient in alpha6beta1 expression form primary tumors that are highly apoptotic and unable to metastasize, although they exhibit no increased apoptosis in vitro under standard culture conditions. (umassmed.edu)
  • Based on the hypothesis that alpha6beta1 is necessary for the survival of these cells in the tumor microenvironment, we report here that hypoxia protects these cells from apoptosis induced by serum deprivation and that hypoxia-mediated protection requires alpha6beta1 expression. (umassmed.edu)
  • We investigated the influence of alpha6beta1 on vascular endothelial growth factor (VEGF) expression because autocrine VEGF is necessary for the survival of serum-deprived cells in hypoxia. (umassmed.edu)
  • Alpha 6 beta4 integrin abnormalities in junctional epidermolysis bullosa with pyloricatresia. (encyclopedia.pub)
  • Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). (cusabio.com)
  • Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. (wikidoc.org)
  • Liver carcinogenesis is associated with striking changes in the integrin repertoire of hepatocytes, including the overexpression of the laminin and collagen receptors alpha1beta1 and the de novo induction of the laminin receptor alpha6beta1. (nih.gov)
  • 1. Integrin laminin receptor profile of pulmonary squamous cell and adenocarcinomas. (nih.gov)
  • 3. Identification of the cleavage sites in the alpha6A integrin subunit: structural requirements for cleavage and functional analysis of the uncleaved alpha6Abeta1 integrin. (nih.gov)
  • 20. Increased levels of alpha6 integrins are associated with the metastatic phenotype of human breast cancer cells. (nih.gov)
  • Chung J, Mercurio AM. Contributions of the alpha6 integrins to breast carcinoma survival and progression. (medlineplus.gov)
  • 12. Knockout of alpha6 beta1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells. (nih.gov)
  • Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. (wikipedia.org)
  • It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. (reference.md)
  • 2. Immunolocalization of integrins in the normal lung and in pulmonary carcinomas. (nih.gov)
  • Researchers believe that both α6β1 integrin and α6β4 integrin may play critical roles in the progression of cancerous tumors called carcinomas. (medlineplus.gov)
  • Changes in the location and activity of α6β1 integrin and α6β4 integrin within cancer cells are associated with the progression of carcinomas. (medlineplus.gov)
  • Recent studies suggest that, in addition to their roles in the progression of existing carcinomas, α6β1 integrin and α6β4 integrin may be involved in the initial formation of these tumors. (medlineplus.gov)
  • 8. The role of extracellular and cytoplasmic splice domains of alpha7-integrin in cell adhesion and migration on laminins. (nih.gov)
  • Integrin expression was assessed by qualitative methods (immunocytochemistry, Western blotting) and semi-quantitative techniques (FACS, cellular ELISA), before and after stimulation by TNFalpha, IL1-beta, TGF-beta, FGF2, interferon gamma and interferon alpha-2b. (nih.gov)
  • A 24 to 48-hr stimulation with pro-inflammatory cytokines, TGF-beta and FGF2 induced a significant increase in the concentrations of all integrin chains. (nih.gov)
  • 16. Different phenotypes in human prostate cancer: alpha6 or alpha3 integrin in cell-extracellular adhesion sites. (nih.gov)
  • The integrin proteins activate key signaling molecules, which trigger cancer cells to migrate through the body and invade other tissues. (medlineplus.gov)
  • 15. Reduced integrin alpha3 expression as a factor of poor prognosis of patients with adenocarcinoma of the lung. (nih.gov)
  • 5. Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment. (nih.gov)
  • 10. Laminin-binding integrins in rat lens morphogenesis and their regulation during fibre differentiation. (nih.gov)
  • Alpha 6 beta 4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia. (medlineplus.gov)
  • 14. Downstream events in mammary gland morphogenesis mediated by reexpression of the alpha2beta1 integrin: the role of the alpha6 and beta4 integrin subunits. (nih.gov)