Middle repetitive sequences repetitive sequences nucleic acid. Medical search. Frequent questions

To estimate the genome-wide pattern of mutations at STR loci, we analyze blood-derived whole-genome sequencing data for 544 individuals from 29 three-generation CEPH pedigrees. (biomedcentral.com)
SARS-CoV-2 whole-genome sequencing was performed using a tiled-amplicon sequencing approach. (biomedcentral.com)
Using whole-genome sequencing of OS, we found features of TP53 intron 1 rearrangements suggesting a unique mechanism correlated with transcription. (oncotarget.com)
Software Update: Interpreting Killer-cell Immunoglobulin-like Receptors from Whole Genome Sequence Data with PING. (cdc.gov)

The rising potential of spatial genomic analysis as a cancer detection tool and the introduction of the fourth generation of sequencing are anticipated to further fuel the growth. (grandviewresearch.com)
The genomic sequences of ten geographically and phenotypically diverse clinical isolates of M. catarrhalis were determined and analyzed together with two publicly available genomes. (biomedcentral.com)
During the past decade, two major developments-the emergence of massively parallel, ultra-cheap DNA sequencing technologies and the use of these technologies as digital readouts for functional genomic assays-have led to a profusion of data describing various features of genomes, epigenomes, and transcriptomes 1 , 2 . (biorxiv.org)
Genomic sequencing for epidemic and pandemic preparedness and response: EMRO's vision and strategic interventions. (cdc.gov)

Similarities in amino acid sequences between various organisms also suggest common descent, and the fossil record also shows cases in which one plant or animal type evolved into different types over time. (rationalwiki.org)
Regardless of the slight differences, all organisms use the same coding mechanism for translating the code into amino acid sequences. (rationalwiki.org)
The many biochemical reactions catalyzed by PLP-dependent enzymes are involved in essential biological processes, such as hemoglobin and amino acid biosynthesis, as well as fatty acid metabolism . (oregonstate.edu)
serotonin from the amino acid tryptophan and dopamine from L-3,4-dihydroxyphenylalanine (L-Dopa). (oregonstate.edu)
The dietary requirement for niacin and the niacin coenzyme , nicotinamide adenine dinucleotide (NAD), can be also met, though to a fairly limited extent, by the catabolism of the essential amino acid tryptophan in the tryptophan-kynurenine pathway ( Figure 2 ). (oregonstate.edu)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
Irrespective of the LAB biodiversity, a large majority of the sugar and amino acid metabolites were detected in all sourdough samples. (who.int)

Sequence homology is an indication of the genetic relatedness of different organisms and gene function. (lookformedical.com)
Evolutionary turnover may cause inconsistencies between sequence orthology and functional homology that substantially limit this type of analysis. (biorxiv.org)

This study reveals a new mechanism for the fluid gain of beneficial mutations in genetic regions undergoing active recombination in viruses and illustrates the value of long read sequencing technologies for investigating complex genome dynamics in diverse biological systems. (elifesciences.org)
Following duplication events, the resulting stretches of homologous sequence can promote recombination between gene copies. (elifesciences.org)

The structures and functions of all living organisms are encoded in the same basic nucleic molecules, DNA and RNA . (rationalwiki.org)
Typical applications of design include novel therapeutic strategies, control principles for existing biological systems, or sensors for the presence of small molecules [3], but designed sequences can also provide an objective experimental assessment of functional hypotheses, where designs are synthesized and their effect on the cellular context can be tested in vitro and, in turn, in vivo. (dagstuhl.de)
But these information molecules are much more than their core sequences. (pharmaceuticalintelligence.com)
G-quadruplexes are secondary semi-stable folded structures found in our DNA and RNA which tend to assemble around guanine-rich sequences in the presence of cation molecules like potassium. (anti-agingfirewalls.com)
With the concomitant increase in liquid biopsy analyses for cancer screening, for detection of minimal residual disease after surgery, and for monitoring cancer patients, the need for high-precision analyses of circulating tumor-derived nucleic acid molecules is obvious, but not necessarily implemented. (biomedcentral.com)

The human genome in particular is known to contain a large amount of SRP RNA related sequence, including Alu repeats. (wikipedia.org)
The regions near the 5′- and 3′-ends of the mammalian SRP RNA are similar to the dominant Alu family of middle repetitive sequences of the human genome. (wikipedia.org)
The completion of the first human genome drafts (Yamey 2000 ) was just a start of the modern DNA sequencing era which resulted in further invention, improved development toward new advanced strategies of high-throughput DNA sequencing, so called the " high-throughput next generation sequencing " (HT-NGS). (springer.com)
Year 2011 is celebrated as the 10th anniversary since the human genome was first sequenced ( www.nature.com/natureconferences/hg10years/index.html ). (springer.com)
During this period, tremendous success has been achieved in the fields of decoding of human genome, technological advancement of new era of human genome applications, toward personalized genomes and discovery of rare variants, leveraging genome sequencing to impact on cancer researches and mammalian evolution and population structure. (springer.com)
The T2T consortium used the now-complete genome sequence as a reference to discover more than 2 million additional variants in the human genome. (drishtiias.com)

IC1 has a unique primary structure, the N-terminal part is homologous to the sequence of thioredoxin, the middle part consists of three repetitive sequences homologous to the sequence of nucleoside diphosphate kinase, and the C-terminal part contains a high proportion of negatively charged glutamic acid residues. (embl.de)

For the future direction, we need the in-depth genome sequence information and analysis for most of the mammals, including human to fully understand genome variation of economic traits, genetic susceptibility to diseases, and pharmacogenomics of drug response. (springer.com)
Every organism's genetic code is contained in its Deoxyribose Nucleic Acid (DNA) , the building blocks of life. (drishtiias.com)
The findings have revealed a large number of genetic variations , and these variations appear in large part within these repeated sequences. (drishtiias.com)
Genome sequencing can be used to identify genetic markers for disease resistance and drought tolerance in various crop plants. (drishtiias.com)

NDK isozymes have been sequenced from prokaryotic and eukaryotic sources. (embl.de)

The high-throughput - next generation sequencing (HT-NGS) technologies are currently the hottest topic in the field of human and animals genomics researches, which can produce over 100 times more data compared to the most sophisticated capillary sequencers based on the Sanger method. (springer.com)
Next-generation sequencing (NGS) approaches have surpassed Sanger for generating long viral sequences, yet how variants affect NGS de novo assembly remains largely unexplored. (biomedcentral.com)
For many years, Sanger sequencing has been used to complement classical epidemiological and laboratory methods for investigating viral infections [ 1 ]. (biomedcentral.com)

TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. (lookformedical.com)

More generally, RNA design addresses the generation of sequences of nucleotides targeting a given biological function. (dagstuhl.de)
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. (lookformedical.com)
Many computational methods for gaining functional insights from sequence data are based on the simple, but powerful, observation that functionally important nucleotides tend to remain unchanged over evolutionary time, because mutations at these sites generally reduce fitness and are therefore eliminated by natural selection 7 - 15 . (biorxiv.org)

citation needed] Yeast SRP RNA genes have a TATA box and additional intragenic promoter sequences (referred to as A- and B-blocks) which play a role in regulating transcription of the SRP gene by Pol III. (wikipedia.org)
The euchromatin contained more genes that were simpler to sequence with the tools available at the time. (drishtiias.com)
Sequences of DNA in the genes that are located between the EXONS. (lookformedical.com)
A total of 1,194 potential lactic acid bacterium (LAB) isolates were tentatively grouped and identified by repetitive element sequence-based PCR, followed by sequence-based identification using 16S rRNA and pheS genes from a selection of genotypically unique LAB isolates. (who.int)

A variety of chemical modifications decorate the nucleic acids, increasing the alphabet of DNA to about a dozen known nucleotide variants. (pharmaceuticalintelligence.com)
It is also called nucleotide sequence. (lookformedical.com)
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. (lookformedical.com)

With the ongoing developments of high throughput sequencing machines and advancement of modern bioinformatics tools at unprecedented pace, the target goal of sequencing individual genomes of living organism at a cost of $1,000 each is seemed to be realistically feasible in the near future. (springer.com)
Methylated CG (mCG) is the most abundant form of mC in plant genomes and predominantly occurs in noncoding regions such as transposable elements and other repetitive DNA regions 14 , 15 . (nature.com)
Since many sequencing technologies produce reads that are significantly shorter than the target genome size, a process to construct contigs, scaffolds, and full-length genomes is needed. (biomedcentral.com)

There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. (lookformedical.com)
DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom. (lookformedical.com)

950 discounted pricing valid for sequencing-only orders with 105G data output (350M reads) and 10 business day turnaround time. (azenta.com)
Using long sequencing reads from the Oxford Nanopore Technologies platform, we phased SNVs within large gene copy arrays for the first time. (elifesciences.org)
Identification of highly variable sequence fragments in unmapped reads for rapid bacterial genotyping. (cdc.gov)

Some of these tools are designed to detect STR expansions at disease-related loci, while others detect expansions and contractions of STRs genome-wide but are constrained by sequencing read length and the STR motif size. (biomedcentral.com)

the m 6 A-containing fragments are then sequenced and aligned to the genome, thus allowing us to locate the positions of methylation marks. (pharmaceuticalintelligence.com)

RiboNucleic Acids (RNAs) are ubiquitous macromolecules within biological systems, capable of performing a wide range of regulatory and catalytic functions. (dagstuhl.de)
In addition, about 250 noncoding RNA sequences-including well-characterized long noncoding RNAs (lncRNAs), such as the XIST transcripts that have a key role in X-chromosome inactivation-are decorated by m 6 A. In almost all cases, the epigenetic mark was found on adenosines embedded in the predicted A/G-methylated A-C sequence. (pharmaceuticalintelligence.com)

Long read single cell RNA sequencing reveals the isoform diversity of Plasmodium vivax transcripts. (cdc.gov)

For many functional RNA families [11], decades of research have produced a deep understanding of the sequence and structural basis underlying their biological function(s). (dagstuhl.de)
Owing to the discrete nature of RNA sequence and popular structural representations (e.g. secondary structure), RNA design has inspired the contribution of a large number of diverse algorithms [9, 20, 14, 4] for the inverse folding problem, i.e. the design of an RNA sequence which preferentially and effectively folds into a predefined (secondary) structure. (dagstuhl.de)
The first two precepts of Cell Theory were enunciated near the middle of the 19th century, after many observations of plant and animal cells revealed common structural features (e.g., a nucleus, a wall or boundary, a common organization of cells into groups to form multicellular structures of plants and animals and even lower life forms). (eduhyme.com)

80 hydrolysis, nicotinic acid, nitrate reductase and urease, (rep-PCR) has been used to differentiate mycobacterial distinct fatty and mycolic acid patterns, and unique 16S strains associated with disease outbreaks in mesotherapy rRNA and 65-kDa heat-shock protein gene sequences. (cdc.gov)

The common SINE family Alu probably originated from a 7SL RNA gene after deletion of a central sequence. (wikipedia.org)
One hundred sixteen patients with classical and atypical RTT were studied for mutations of the MeCP2 gene by using DHPLC and direct sequencing. (neurology.org)
or the transmembrane protein gene cassettes of some pathogenic bacteria ( Santoyo and Romero, 2005 ), gene conversion can also generate sequence diversity. (elifesciences.org)

Conserved RBPs harbour defined repetitive motifs within disordered regions, which display striking evolutionary expansion. (nature.com)

2003 ). The NHGRI has categorized new sequencing approaches into those that offer near-term and revolutionary benefits with a 100-fold cost reduction per base pair (bp) within the next five years. (springer.com)

Additional charges for nucleic acid extraction and/or data analysis will apply. (azenta.com)
Due to the repetitive structure of STRs and their high mutability, sequencing and genotyping these loci is difficult, especially using short-read sequencing data. (biomedcentral.com)
Due to the sequence of events and full genome sequence data, one person was considered the index case for this outbreak, directly infecting 67 to 83% of the teammates. (biomedcentral.com)
We have generated fitCons scores for three human cell types based on public data from EN-CODE. (biorxiv.org)

The invention of new methods of DNA sequencing and computational analysis helped complete the reading of the remaining 8% of the genome. (drishtiias.com)

in particular, PLP is the cofactor for the enzyme kynureninase, which catalyzes the conversion of 3-hydroxykynurenine to 3-hydroxyanthranilic acid. (oregonstate.edu)
The Alu sequence family (named for the restriction endonuclease cleavage enzyme Alu I) is the most highly repeated interspersed repeat element in humans (over a million copies). (lookformedical.com)

In some embodiments, the non-naturally occurring microbial organism includesat least two enzymes of the 1,three-butanediol pathway are encoded by exogenous nucleic acids. (ehd.org)

Obstructive sleep apnea syndrome (OSAS) is a sleep related breathing disorder which is characterized by repetitive episodes of respiratory pauses (apnea) or partial upper airway obstruction (hypopnea). (oncotarget.com)
The causative agent is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a betacoronavirus, related to SARS-CoV and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). (biomedcentral.com)

The new reference genome, called T2T-CHM13 , includes highly repetitive DNA sequences found in and around the telomeres (structures at the ends of chromosomes) and the centromeres (at the middle section of each chromosome). (drishtiias.com)
The negative supercoiling of DNA can induce sequence-dependent conformational changes that give rise to local DNA structures and alternative DNA conformations such as cruciforms, A-DNA, left-handed DNA (Z-DNA), triplexes, four-stranded DNA (quadruplexes) and others [ 2 , 3 ]( ref )" But we don't really get into most of those other types here. (anti-agingfirewalls.com)
G-quadruplex and i-motif nucleic acid structures are believed to fold through kinetic partitioning mechanisms. (bvsalud.org)
Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the stability of four-stranded nucleic acids structures. (bvsalud.org)

Highly repeated sequences, 6K-8K base pairs in length, which contain RNA polymerase II promoters. (lookformedical.com)
The sequences are about 300 base pairs long and are repeated several thousand times throughout the genome. (ojp.gov)

Assessing the hidden diversity underlying consensus sequences of SARS-CoV-2 using VICOS, a novel bioinformatic pipeline for identification of mixed viral populations. (cdc.gov)

Sequences of DNA or RNA that occur in multiple copies. (lookformedical.com)

In 2012, we (D.D. and G.R.) combined the power of next-generation sequencing (NGS) with traditional antibody-mediated capture techniques to perform high-resolution transcriptome-wide mapping of m 6 A, an approach we termed m6A-seq. (pharmaceuticalintelligence.com)

Offer applies to orders in North America, Europe, the Middle East, and Africa only. (azenta.com)

TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES). (lookformedical.com)

Moreover, there is an increasing adoption rate of in situ sequencing techniques, which would further boost the segment's growth. (grandviewresearch.com)

Advertised starting price is based on a Standard RNA-Seq project with library preparation and sequencing of 16 RNA samples on one lane of the Illumina® HiSeq™ with 2x150 bp configuration (20M read-pairs/sample) and Value package turnaround time (starting at ≤30 business days). (azenta.com)
The segment dominance is due to the accessibility of automated sequencing methodologies to cater to the growing demand for nucleic acid sequencing of biological samples or single cells. (grandviewresearch.com)

In addition, DGGE band sequence analysis demonstrated the presence of Acetobacter sp. (who.int)

Discount applies to sequencing-only orders - NovaSeq S4 2x150bp (single or dual index) at $5,000/lane for 10 business days turnaround time. (azenta.com)
Sequencing of a nucleic acid of single cells or specific biological specimens has increased, which has driven the need for automated, robust, and scalable library preparation solutions. (grandviewresearch.com)

A reduction in PLP availability appears to primarily affect kynureninase activity, limiting NAD production and leading to higher concentrations of kynurenine, 3-hydroxykynurenine, and xanthurenic acid in blood and urine ( Figure 2 ) (9) . (oregonstate.edu)

As a result, sequence divergence is usually higher when comparing viral strains compared to quasispecies. (biomedcentral.com)

These results call for careful interpretation of contigs and contig numbers from de novo assembly in viral deep sequencing. (biomedcentral.com)

The sequence of NDK has been highly conserved through evolution. (embl.de)
The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. (abcam.cn)
Highly repeated sequences, 100-300 bases long, which contain RNA polymerase III promoters. (lookformedical.com)

afterwards, this variant sequence may have significantly expanded to cultivated groups, thereby improving adaptation during the domestication process. (biomedcentral.com)

DNA isn't the only decorated nucleic acid in the cell. (pharmaceuticalintelligence.com)
The S. cerevisiae ORC binds to specific DNA sequences throughout the cell cycle but becomes active only when it binds to the replication initiator Cdc6. (imperial.ac.uk)

Two pairs of co-dominant polymorphisms were detected, and were converted into sequence-specific PCR markers desirable for routine marker implementation. (cropscience.org.au)

It seems most likely that this abnormal chromosome has been rescued by the mechanism of telomere capture which may reflect a more general process by which subtelomeric sequences are normally dispersed between chromosomal ends. (ox.ac.uk)

Anatomy24

Organisms22

Diseases7

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Phenomena and Processes123

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture3

Information Science7

Health Care5

Whole genome4

Genomic4

Amino acid7

Homology2

Recombination2

Molecules5

Human genome6

Homologous1

Genetic4

Eukaryotic1

Sanger3

Repeats1

Nucleotides3

Genes4

Nucleotide3

Genomes3

Transposable elements2

Reads3

Genome wide1

Fragments1

RNAs2

Reveals1

Structural3

RRNA1

Gene3

Motifs1

Approaches1

Data4

Computational1

Enzyme2

Pathway1

Respiratory2

Structures4

Base pairs2

Consensus1

Occur1

Next generation1

Africa1

Copies1

Adoption1

Samples2

Analysis1

Single2

Primarily1

Strains1

Viral1

Highly3

Significantly1

Cell2

Specific1

Ends1