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MidazolamPreanesthetic MedicationPremedicationHypnotics and SedativesAnti-Anxiety AgentsAdjuvants, AnesthesiaMeperidineAcepromazineDiazepamClonidineAnesthetics, IntravenousConscious SedationAnesthesia, DentalDrug HypersensitivityPromethazineFentanylPropofolKetamineDouble-Blind MethodAmbulatory Surgical ProceduresAnesthesia, GeneralAnesthesia, IntravenousAnesthesia Recovery PeriodAnesthesia, InhalationButorphanolAdministration, BuccalCandyMethyl EthersAnxiety, SeparationMedetomidineDiphenhydramineAdministration, RectalThiopentalButylscopolammonium BromideAnesthetics, InhalationInfusions, IntravenousLorazepamNeuroleptanalgesiaAnesthetics, DissociativeAdrenergic alpha-AgonistsPaclitaxelBelladonna AlkaloidsAntineoplastic Agents, PhytogenicIntubation, IntratrachealAdministration, OralAtropineAnesthesia, LocalInjections, IntramuscularClemastineBenperidolAnesthesiaHistamine H1 AntagonistsNitrous OxideAnesthetics, CombinedDental AnxietyOphthalmologic Surgical ProceduresIodine CompoundsOpiumFlumazenilSympatholyticsAdministration, SublingualDrug InteractionsAnestheticsGastroscopySuccinylcholineAnalgesicsIsonipecotic AcidsBenzodiazepinesCytochrome P-450 CYP3AGABA ModulatorsInjections, IntravenousMiosisHeart RateAnxietyAnalgesics, OpioidTaxoidsAnesthesia, SpinalPain, PostoperativeDose-Response Relationship, DrugVomitingIsofluraneProspective StudiesXylazineDrug Administration ScheduleRespirationDimethylpolysiloxanesGynecologic Surgical Procedures
Intravenous or intramuscularInjectionDoseShown
Intravenous or intramuscular1
  • Midazolam hydrochloride is a water-soluble benzodiazepine available as a sterile, nonpyrogenic parenteral dosage form for intravenous or intramuscular injection. (nih.gov)
Injection1
  • Midazolam should not be administered by rapid injection in the neonatal population. (nih.gov)
Dose3
  • The initial pediatric dose of midazolam for sedation/anxiolysis/amnesia is age, procedure, and route dependent (see DOSAGE AND ADMINISTRATION for complete dosing information). (nih.gov)
  • The effects of midazolam on the CNS are dependent on the dose administered, the route of administration, and the presence or absence of other medications. (nih.gov)
  • the time of onset is affected by total dose administered and the concurrent administration of narcotic premedication. (nih.gov)
Shown2
  • Under the acidic conditions required to solubilize midazolam in the product, midazolam is present as an equilibrium mixture (shown below) of the closed ring form shown above and an open-ring structure formed by the acid-catalyzed ring opening of the 4,5-double bond of the diazepine ring. (nih.gov)
  • In pediatric patients, up to 85% had no recall of pictures shown after receiving intramuscular midazolam compared with 5% of the placebo controls. (nih.gov)