• These data indicate that food grade TiO 2 exposure resulted in the loss of microvilli from the Caco-2 BBe1 cell system due to a biological response, and not simply a physical artifact of in vitro exposure. (springer.com)
  • Their apical surfaces frequently elaborate microvilli, which vary in structure according to the specific type and function of each epithelium. (mcponline.org)
  • 5. In contrast with other plasma membranes in the rat, the polar lipids of the microvillus membrane were rich in glycolipid. (biochemj.org)
  • We have investigated whether raft lipids of Madin-Darby canine kidney (MDCK) cells play any role in microvilli maintenance using a combination of atomic force microscopy (AFM) and laser scanning confocal microscopy. (biomedsearch.com)
  • The basis of this morphological heterogeneity is poorly understood and is likely to be related to the specialized function and specific molecular composition of the microvilli in each epithelial cell type. (mcponline.org)
  • We show that Myo7A and Cad99C form a molecular complex and that the cytoplasmic tail of Cad99C recruits Myo7A to microvilli. (biologists.org)
  • The effect of raft lipid depletion on microvilli formation in MDCK cells, visualized by atomic force microscopy. (biomedsearch.com)
  • It was observed that inhibition of either sphingolipid or cholesterol biosynthesis led to a reduction in the number of microvilli on the surface of MDCK cells. (biomedsearch.com)
  • The subsequent extraction of cholesterol from cells grown in the presence of inhibitors led to a further reduction in microvilli on the surface of the cells and, in some cases, resulted in monolayers devoid of full length microvilli. (biomedsearch.com)
  • Our data indicate that Myo7A regulates the structure and spacing of microvilli, and interacts with Cad99C in vivo . (biologists.org)
  • Treatment duration was not significantly correlated with ferning test/impression cytology grade (P = 0.1), although it was significantly correlated with microvilli count (P = 0.01). (aao.org)
  • 100 nm), and disrupted the normal organization of the microvilli as a consequence of TiO 2 sedimentation. (springer.com)
  • We achieved a more dramatic demonstration of the microvilli by developing a surface-replica technique which retains their spatial arrangement and permits characterization of the distribution of their number, length, and diameter. (rupress.org)
  • We further describe the phase diagram and the resulting morphology of the microvilli aggregates on the cell surface. (semanticscholar.org)
  • Reporting this month in the journal Current Biology , the researchers showed that IRTKS tracks to the distal tips of growing microvilli through the I-BAR domain. (vumc.org)