Microvascular ischemic. Medical search. Frequent questions

MicroRNA (miRNA) dysfunction has been confirmed as a key event of ischemic stroke appearance. (hindawi.com)
These results suggest that ultrafine PM exposure causes significantly more microvascular dysfunction than fine PM. It is probable that such disturbances in coronary microvascular function contribute to the cardiac events associated with particle pollution exposure. (cdc.gov)
Studies evaluating intracoronary administration of adenosine for prevention of microvascular dysfunction and ischemic-reperfusion injury in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) have yielded mixed results. (nih.gov)
Microvascular angina (previously known as syndrome X) is cardiac microvascular dysfunction or constriction causing angina in patients with normal epicardial coronary arteries on angiography. (msdmanuals.com)
Coronary microvascular dysfunction: an update. (msdmanuals.com)
Thrombotic thrombocytopenic purpura (TTP) is characterised by a thrombotic, haemolytic microangiopathy leading to microvascular occlusion, haemolysis and ischaemic dysfunction of various organs including the brain. (eur.nl)
Yet identifying coronary microvascular dysfunction (CMD) as an additional player in patients with coronary artery disease (CAD) may provide explanations of why symptoms may persist frequently following and why global coronary flow reserve may be more prognostically important than fractional flow reserve measured in a single vessel before percutaneous coronary intervention. (internationalheartspasmsalliance.org)
Role of genetic polymorphisms of ion channels in the pathophysiology of coronary microvascular dysfunction and ischemic heart disease. (cdc.gov)
Coronary Microvascular Dysfunction and Heart Failure With Preserved Ejection Fraction as Female-pattern Cardiovascular Disease: The Chicken or the Egg? (medscape.com)
A variety of observations suggest that coronary microvascular dysfunction (CMD) is related to the pathogenesis of cardiovascular disease, including myocardial ischaemia and heart failure. (medscape.com)

More than 70% of stroke can contribute as ischemic type, and nearly 30% patients were related with primary hemorrhage [ 3 ]. (hindawi.com)
Angiogenesis is a complicated and sequential process, which occurs in the ischemic penumbra within hours after stroke and lasts for weeks. (hindawi.com)
Patients with higher blood vessel density showed better functional recovery after ischemic stroke impact. (hindawi.com)
Therefore, improving the angiogenesis of patients has been increasingly recognized as a promising therapeutic strategy for the treatment of ischemic stroke. (hindawi.com)
For ischemic stroke studies induced by middle cerebral artery occlusion, rodents are frequently used as animal models. (medindia.net)
The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
Ischemic stroke is attributed to a high disability rate with limited or no therapeutic options for functional recovery [ 1 - 3 ]. (hindawi.com)
Intrinsically, ischemic stroke indicates the cascade of congesting events, i.e., thrombus formation and embolism, that ultimately decreases the local blood flow and cause oxygen deprivation in affected brain tissue. (hindawi.com)
Besides, systemic hypoperfusion is another major factor in the occurrence of ischemic stroke [ 4 ]. (hindawi.com)
According to the World Health Organization (WHO), ischemic stroke is the most ubiquitous subclass of stroke that affects almost 15 million people globally [ 5 ]. (hindawi.com)
Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)
According to previously established studies [ 8 ], the ischemic avalanche followed by a stroke is comprised of three phases, i.e., (i) acute phase, (ii) the subacute phase, and (iii) the chronic phase (Figure 1 ). (hindawi.com)
Conclusion: The ginsenoside Rg1 nanoparticles may be an available blood-brain barrier penetrating agent for ischemic stroke. (cbinsights.com)
According to its etiology, a stroke can be divided into ischemic and hemorrhagic types, of which ischemic stroke accounts for about 60%-80% of stroke patients. (cbinsights.com)
1 Ischemic stroke represents the common form of cerebrovascular disease. (cbinsights.com)
Patients with microvascular angina are at higher risk for major adverse cardiac events including MI, stroke, heart failure with preserved ejection fraction and death but to date there are no clear evidence-based guidelines for diagnosis and treatment. (internationalheartspasmsalliance.org)
For many years, it was used routinely in acute ischemic stroke. (medscape.com)
In addition, several new oral and parenteral anticoagulants are in different stages of clinical trials for use in the prophylaxis of ischemic thromboembolic stroke. (medscape.com)
Current data do not support routine use of anticoagulation for acute ischemic stroke. (medscape.com)
Planned projects include health economic evaluations of stroke care (Ullberg), analyses of the 3 and 5 year follow-up surveys (Ullberg), and studies on acute ischemic stroke and intracerebral hemorrhage occurring during anticoagulant therapy (Apostolaki-Hansson). (lu.se)

In 162 patients with acute CMR data, limb RIC had no effect on acute MI size, microvascular obstruction and LVEF when compared to control. (au.dk)
In a subgroup of anterior STEMI patients, RIC was associated with lower incidence of microvascular obstruction and higher LVEF on the acute scan when compared with control, but this was not associated with an improvement in LVEF at 6 months. (au.dk)

Diffuse and focal epicardial coronary disease and coronary microvascular abnormalities may exist side-by-side. (internationalheartspasmsalliance.org)
Previous work has demonstrated that coronary microvascular abnormalities contribute critically to cardiac impairment in hypertrophic cardiomyopathy. (medscape.com)

The drug also modulates nitric oxide synthase (NOS) expression and reduces ischemic-reperfusion injuries in rat hearts (PMID: 15914111). (pediatriconcall.com)
Additionally, neuroprotectants could mitigate the ischemia/reperfusion injury, including edaravone and fingolimod, 3 but their clinical effects cannot achieve the desired condition, primarily due to the rigid blood-brain barrier (BBB) that limits drug delivery to the ischemic regions. (cbinsights.com)
4 On the other hand, a large number of neurons cause irreversible degeneration and necrosis in ischemic regions, which results from ischemia/reperfusion injury. (cbinsights.com)
Sometimes, the ischemic event persists long enough without reperfusion and becomes destined to its final outcome: necrosis of the whole bowel wall. (ajronline.org)
In fact, this description represents a reperfused instead of a nonreperfused ischemic bowel because there should not be a lot of erythrocytes or plasma extravasating through the damaged and ruptured microvascular wall into the mucosa, submucosa, or bowel lumen if the arterial supply is severely reduced, either occlusively or nonocclusively, without a subsequent reperfusion taking place. (ajronline.org)
The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)

Transient ischemic dilation (TID) in the setting of abnormal stress-rest cardiac SPECT myocardial perfusion imaging (MPI) has been linked with increased cardiovascular risk. (snmjournals.org)
Transient ischemic dilation (TID) on stress SPECT myocardial perfusion imaging (MPI) is defined as the apparent presence of left ventricular (LV) dilation on poststress relative to rest images. (snmjournals.org)

Ginsenoside Rg1 composite nanoparticles were employed to induce the expression of several key epigenetic enzymes and then activate the VEGF and Notch pathways after the onset of ischemic brain lesions. (cbinsights.com)

Vascular dementia is a heterogeneous entity with a large clinicopathological spectrum that has been classically linked to cortical and subcortical ischemic changes resulting from systemic, cardiac, or local large- or small-vessel disease occlusion. (medscape.com)
Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. (kb.se)
Diabetic retinopathy is a progressive vision-threatening complication of diabetes, characterized by capillary occlusion, formation of microvascular lesions, and retinal neovascularization adjacent to ischemic areas of the retina ( 1 - 2 ). (diabetesjournals.org)

We hypothesized that TRPA1 channels in endothelial cells are activated by hypoxia-derived reactive oxygen species, leading to cerebral artery dilation and reduced ischemic damage. (elifesciences.org)
SNAI2, an angiogenesis-related factor, was highly expressed under the high glucose condition and also led to viability and migration of human brain microvascular endothelial cells (HBMECs) [ 13 ]. (hindawi.com)
Through in vivo and in vitro experiments, we found that it promotes the proliferation, migration, and tubular formation of brain microvascular endothelial cells (BMECs). (cbinsights.com)

True color image shows several microvascular abnormalities, exudates and neovascularization. (zeiss.com)
Fluorescein angiography enhance the identification of the microvascular abnormalities, such as microaneurysms, IRMA's, ischemic areas and several neovascularizations. (zeiss.com)

Effect of remote ischaemic conditioning on infarct size a. (au.dk)

Evidence on whether or not there is any significant difference between the two current surgical approaches to treat patients with severe ischemic mitral regurgitation -- mitral valve repair and mitral valve replacement was reported for the first time by the Cardiothoracic Surgical Trials Network (CTSN), whose Data and Clinical Coordinating Center is at Icahn School of Medicine at Mount Sinai. (medindia.net)
These results may impact the surgical care of patients experiencing severe ischemic mitral regurgitation and offer the strongest evidence to date to inform future surgical practice guidelines," says Michael K. Parides, PhD, Professor of Biostatistics in the Department of Health Evidence and Policy at Icahn School of Medicine at Mount Sinai, the principal statistician for the CTSN. (medindia.net)
It evaluated the safety and effectiveness of mitral valve repair and mitral valve replacement in patients with severe ischemic mitral regurgitation. (medindia.net)
Thus, MSCs were suggested as a promising candidate for ischemic brain injury patients[ 11 ]. (hindawi.com)
Chronically, microvascular and macrovascular complications are the major reasons for increasing morbidity and mortality in patients with diabetes. (spandidos-publications.com)
In this review, the authors will illustrate the updated approach to the diagnosis of microvascular angina and address evidence-based pharmacological and non-pharmacological treatments for patients with the condition. (internationalheartspasmsalliance.org)
In patients with angina symptoms but with no coronary artery disease, as revealed by normal or near-normal coronary angiogram, a potential diagnosis of microvascular angina (MVA) might be considered. (internationalheartspasmsalliance.org)
Clinical characteristics and prognosis of patients with microvascular angina: an. (internationalheartspasmsalliance.org)
To provide multi-national, multi-ethnic data on the clinical characteristics and prognosis of patients with microvascular angina (MVA). (internationalheartspasmsalliance.org)
Les données ont été recueillies à partir des dossiers de 920 patients atteints de diabète, d'hypertension et d'hypercholestérolémie en consultation dans des hôpitaux, des cliniques et des laboratoires d'analyses de Bagdad, et de 200 témoins en bonne santé. (who.int)

Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)

[ 5 ] Benefits of tight glycemic control include not only continued reductions in the rates of microvascular complications but also significant differences in cardiovascular events and overall mortality. (medscape.com)
Connective Tissue Growth Factor (CTGF) has recently been shown to be over-expressed in kidney, myocardium and aorta in diabetic animals, implicating CTGF role in the pathogenesis of both microvascular and macrovascular diabetic complications ( Brownlee, 2001 ). (scialert.net)
Diabetes leads to numerous complications associated with the heart, including ischemic heart disease, peripheral vascular disease, and cerebrovascular disease ( 3 ). (spandidos-publications.com)
Normoglycemia is the key to attenuate the microvascular and neurological complications of type 1 diabetes. (spandidos-publications.com)

Each frame illustrates a single time point in the full-phase angiography sequence: baseline, arterial, microvascular, venous and residual, from a patient undergoing off-pump coronary artery bypass. (medscape.com)

Rosuvastatin exerts an anti-inflammatory effect on rat mesenteric microvascular endothelium by attenuating leukocyte rolling, adherence and transmigration (PMID: 11375257). (pediatriconcall.com)

Pain is a common feature of microvascular ischaemic ocular motor cranial nerve palsies (MP). (bmj.com)

Coronary artery disease (CAD) or ischemic heart disease are the terms used to describe narrowing of the coronary arteries. (wikipedia.org)
Cardiac PET, myocardial blood flow quantification in ischemic and non-ischemic heart disease, myocardial inflammation, myocardial viability, cardiac magnetic resonance imaging, cardiomyopathies. (upenn.edu)
We synthesised the literature of chronic occupational exposure to LDIR and cardiovascular disease, particularly for ischaemic heart disease (IHD). (bmj.com)
Peripheral artery disease (PAD) is a morbid condition whereby ischemic peripheral muscle causes pain and tissue breakdown. (edskilling.com)
Recognition of suspected ischaemia with no obstructive coronary artery disease - termed INOCA - has increased over the past decades, with a key contributor being microvascular angina. (internationalheartspasmsalliance.org)
The Role of IL-6 and ET-1 in the Diagnosis of Coronary MicroVascular Disease in Women. (cdc.gov)
30 kg/m2], smoking history programme to state that, in terms of car- (either active or less than 5 years since ces- diovascular risk, DM was equivalent to sation of smoking) were recorded from the having ischaemic heart disease [ 3 ]. (who.int)

This bioactive natural compound turns out to have relevant therapeutic effects in a range of pathological conditions, for its tissue repairing, anti-ischemic, and anti-inflammatory properties [6]. (scienceopen.com)

We have recently shown that systemic microvascular function is impaired after inhalation exposure to fine and ultrafine particulate matter (PM). Studies have shown that exposure to airborne particle pollution increases the risk of ischemic cardiovascular events. (cdc.gov)

Ischemic colitis: clinical practice in diagnosis and treatment. (scienceopen.com)
Recently, the Coronary Vasomotion Disorders International Study Group proposed standardised criteria for diagnosis of microvascular angina using invasive and non-invasive approaches. (internationalheartspasmsalliance.org)

These categories are called epicardial (above the epicardium, or the outermost tissue of the heart) and microvascular (close to the endocardium, or the innermost tissue of the heart). (wikipedia.org)
As a compensatory mechanism, in the first stage of the colonic hypoxic state, vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1α (HIF-1α) are induced, and they paracrinally act to preserve tissue from ischemic damage. (scienceopen.com)
Moreover, PDRN acts with a "salvage pathway" through the cell internalization of PDRN-derived purine and pyrimidine, mostly where de novo synthesis of DNA is severely impaired by ischemic condition, allowing a rapid tissue recovery [6]. (scienceopen.com)

The etiology of ischemic colitis is multifactorial and the clinical presentation variable. (scienceopen.com)

In this regard, the effects of PDRN in the experimental model of ischemic colitis are abolished using DMPX, a specific adenosine A2AR antagonist. (scienceopen.com)

These data establish a fundamental link between CO and prevention of ischemic injury based on the ability of CO to derepress the fibrinolytic axis. (nih.gov)

Ischemic mitral regurgitation occurs when blood backflows into the left atrium from the left ventricle of the heart due to improper closure of the mitral valve. (medindia.net)
TherOx's SuperSaturated Oxygen Therapy system delivers a 60-minute infusion of the patient's super-oxygenated blood to a targeted ischemic area of the heart via a small catheter. (massdevice.com)

The analysis of myocardial perfusion change is derived from the arterial and microvascular image data. (medscape.com)

We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)

There was immediate macromolecular tracer leakage and leukocyte activation was significantly increased in both ischemic and arterialized groups (15 cells vs 156 and 178 cells respectively). (pcs.org.ph)

Ischemic brain injury is associated with a high rate of mortality and disability with no effective therapeutic strategy. (hindawi.com)

Biomarkers of microvascular health could then represent possible markers for the early detection of poor cardiovascular outcomes. (frontiersin.org)

1], focusing on the potential therapeutic effects of polydeoxyribonucleotide (PDRN) as an ischemic colitis medical treatment. (scienceopen.com)

The resulting ischemic preconditioning may offer protective effects to the involved organ(s). (bvsalud.org)

Currently, practice guidelines recommend valve repair or replacement for severe ischemic mitral regurgitation. (medindia.net)

The HBMECs were treated with oxygen and glucose deprivation (OGD) to establish the ischemic cell model. (hindawi.com)

Passive heat therapy (repeated hot tub or sauna use) reduces cardiovascular risk, but its effects on the mechanisms underlying improvements in microvascular function have yet to be studied. (edskilling.com)

The damage starts with the mucosa, which is most vulnerable to the ischemic insult, extends outward through the submucosa and the proper muscular layer, and ends at the serosa. (ajronline.org)

Ischemic colitis is the most common form of ischemic injury of the gastrointestinal tract and can present either as an occlusive or a non-occlusive form. (scienceopen.com)

We tested the hypothesis that microvascular reactivity is impaired after PM exposure in rat coronary arterioles. (cdc.gov)

We describe different conditions of the ischemic event and their corresponding CT appearances. (ajronline.org)

Anatomy47

Organisms13

Diseases41

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes46

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science2

Health Care4

Dysfunction10

Stroke21

Acute2

Coronary microvascular abnormalities2

Reperfusion7

Transient2

Onset of ischemic1

Occlusion3

Endothelial cells3

Abnormalities2

Infarct size1

Patients10

Retinopathy1

Complications4

Venous1

Endothelium1

Ocular1

Disease7

Anti-inflammatory1

Systemic1

Diagnosis2

Tissue3

Etiology1

Adenosine1

Prevention1

Heart2

Myocardial perfusion1

Clinical1

Leukocyte1

Brain Injury1

Outcomes1

Therapeutic1

Organ1

Practice1

Establish1

Mechanisms1

Damage1

Common1

Exposure1

Describe1