Microtubules tumor suppressor proteins. Medical search. Frequent questions

This heterodimer of HIF is a transcription factor that activates genes that encode for proteins such as vascular endothelial growth factor (VEGF) and erythropoietin, proteins that are both involved in angiogenesis. (wikipedia.org)
The protein encoded by this gene is a member of the RP/EB family of genes. (nih.gov)
The Ras-assocation family (RASSF) of tumour suppressor genes (TSGs) contains 10 members that encode proteins containing Ras-assocation (RA) domains. (bath.ac.uk)
Genes down-regulated in myeloid-derived suppressor cells from colon tumors: wildtype versus HDC [GeneID=3067] knockout. (gsea-msigdb.org)
Differentially expressed genes of CD11b+Gr-1+ immature myeloid cells (IMCs) in the bone marrow and colonic tumor setting of histidine decarboxylase (HDC)-KO mice were examined by microarray (Affymetrix Mouse 430.2 array). (gsea-msigdb.org)
Pairwise comparison identified genes with splicing changes and/or whole gene expression changes in high stage tumors. (biomedcentral.com)
In stage 4- compared with stage 1- tumors, alternatively spliced candidate genes had little overlap with genes showing whole gene expression changes, and most of them were involved in different biological processes. (biomedcentral.com)
In contrast, a larger number of genes exhibited either exon-level splicing, gene-level expression or both changes in stage 4+ versus stage 1- tumors. (biomedcentral.com)
The identification of differentially spliced genes and pathways in neuroblastoma tumors of different stages and molecular subtypes may be important to the understanding of cancer biology and the discovery of diagnostic markers or therapeutic targets in neuroblastoma. (biomedcentral.com)
tumor suppressor genes. (upstate.edu)
Mutations in the tumor suppressor genes encoding TSC1 (Hamartin) and TSC2 (Tuberin) cause a multisystemic tumor syndrome termed tuberous sclerosis complex (TSC). (springer.com)
Delineation of the minimal commonly deleted segment and identification of candidate tumor-suppressor genes in del(9q) acute myeloid leukemia. (nih.gov)
The study of oncogenes or suppressor genes crossing with PTEN will facilitate drug discovery and interpretation of chemotherapy resistance mechanisms. (aging-us.com)
These VHL alterations lead to a predisposition to a somatic second hit, causing of a variety of tumors and fluid filled cysts, sporadic tumors, such as cerebellar hemangioblastoma, pheochromocytoma, clear cell renal cell carcinoma, familial erythrocytosis type two, that result in increased expression of HIF target genes. (standardofcare.com)
The VHL syndrome, generally caused by hereditary allele inactivation plus a tissue somatic mutation, is characterized by the occurrence of malignancies and increased expression of oncogenic genes, including VEGF, that allow tumor development and progression. (standardofcare.com)
From experimentally validated target genes of these 86 miRNAs, pan-sensitive and pan-resistant genes with concordant mRNA and protein expression associated with in-vitro drug response to 19 NCCN-recommended breast cancer drugs were selected. (cdc.gov)
The mRNA and protein expression of the 26 genes was associated with sensitivity or resistance to 18 NCCN-recommended drugs for treating breast cancer. (cdc.gov)

The main action of the VHL protein is thought to be its E3 ubiquitin ligase activity that results in specific target proteins being 'marked' for degradation. (wikipedia.org)
CUL4A acts as a scaffold proteins to create a CUL4A-DDB1-Band complicated and regulates many mobile pathways by concentrating on a number of protein for ubiquitination and degradation. (healthandwellnesssource.org)
NQO1 binds to and thereby stabilizes the important tumor suppressor p53 against proteasomal degradation. (dundee.ac.uk)
These findings suggest that NQO1 may exercise a selective "gatekeeping" role in regulating the proteasomal degradation of specific proteins, thereby broadening the cytoprotective role of NQO1 far beyond its highly effective antioxidant functions. (dundee.ac.uk)
Conversely, during starvation mTORC1 is inhibited and autophagy is induced by AMP-activated protein kinase (AMPK), leading to generation of intracellular nutrients and energy during degradation of non-functional or non-essential organelles or protein aggregates [ 4 , 6 ], in turn contributing to cell survival. (springer.com)
ATR-Chk1-mediated protein degradation of Cdc25A protein phosphatase is also a mechanism conferring intra-S-phase checkpoint activation. (kegg.jp)
The process of the degradation of the hypoxia-inducible factors (HIFs) that mainly regulate oxygen and iron dependent activity of enzymes require DHL tumor suppressor. (standardofcare.com)
The main action of the VHL protein is ubiquitin ligase activity resulting in protein degradation. (standardofcare.com)
Autophagy is a cellular catabolic process that eliminates damaged cell organelles, unfolded proteins, and various intracellular pathogens through lysosomal degradation. (hindawi.com)
In general, autophagy degrades long-lived damaged intracellular proteins, in contrast to the ubiquitin-proteasome system, which controls the degradation of short-lived proteins [ 2 ]. (hindawi.com)
After the degradation of damaged proteins and lipids, amino acids and fatty acids are released into the cytoplasm and recycled for new biosynthesis of cellular components or energy production [ 4 ]. (hindawi.com)

Despite a decade-long analysis building RASSF1A as a significant tumor suppressor that has a crucial function in cell development control and apoptosis small is well known about its legislation at the proteins level. (healthandwellnesssource.org)
TGF-β proteins normally help control many critical cell functions, including the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). (encyclopedia.pub)
These pathways link RASSF proteins into the control of motility, genetic stability, apoptosis, the cell cycle, regulation of protein stability, senescence and DNA repair. (louisville.edu)
This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. (cancerindex.org)

In types 1, 2A and 2B the mutant pVHL is defective in HIF regulation, while type 2C mutant are defective in protein kinase C regulation. (wikipedia.org)
It suggests that the tumour suppressor effect of TET1 seems to be mediated by regulating the level of autophagy, and the regulation of TET1 on autophagy is at an early stage. (nih.gov)
Ectopic up-regulation of PTPRD in neuroblastoma dephosphorylates tyrosine residues in AURKA resulting in a destabilization of this protein culminating in interfering with one of AURKA's primary functions in neuroblastoma, the stabilization of MYCN protein, the gene of which is amplified in approximately 25 to 30% of high risk neuroblastoma. (biomedcentral.com)
Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. (cusabio.com)
Obviously even more studies are had a need to investigate the regulation of the important tumor suppressor protein further. (healthandwellnesssource.org)
BRCA1 forms a heterodimer with BRCA1-associated RING domain protein 1 (BARD1) and functions in multiple cellular processes, including DNA repair and centrosome regulation. (bvsalud.org)
BRCA1/BARD1 function in centrosome regulation together with Obg-like ATPase (OLA1) and receptor for activating protein C kinase 1 (RACK1). (bvsalud.org)
Our results demonstrated a significant role of alternative splicing in high stage neuroblastoma, and suggested a MYCN -associated splicing regulation pathway in stage 4+ tumors. (biomedcentral.com)
The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. (cancerindex.org)
Elucidate the structure, dynamics and functions of intrinsically disordered proteins and protein regions (IDPs/IDRs) and their biological regulation by Post-translational modifications. (upstate.edu)
Similarly, primary cilia have been implicated in regulation of mTOR signaling, in which Tuberous Sclerosis Complex proteins 1 and 2 (TSC1/2) negatively regulate protein synthesis by inactivating the mTOR complex 1 (mTORC1) at energy limiting states. (springer.com)
Kinesins and protein kinases: key players in the regulation of microtubule dynamics and organization. (nih.gov)
Function and Regulation of G Protein-Coupled. (hhmi.org)
The regulation of microfilaments and microtubules has received a great deal of attention (Bugyi and Carlier 2010 Etienne-Manneville 2010 Lee and Dominguez 2010 In contrast the regulatory mechanisms of cytoplasmic IF rearrangements are still poorly characterized. (biongenex.com)
2008 APC contributes to cell migration through the regulation of the actin and microtubule cytoskeletons (Etienne-Manneville 2009 Although two APC isoforms exist (APC and APC2) only APC is expressed in astrocytes (Cahoy et al. (biongenex.com)

The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene. (nih.gov)
Germline mutations in the tumor suppressor adenomatous polyposis coli gene (APC) on chromosome 5q22.2 are responsible for the most cases of FAP. (spandidos-publications.com)
Adenomatous polyposis coli protein is a protein in humans that is encoded by APC gene. (cusabio.com)
Adenomatous polyposis coli (APC) is a tumor suppressor regulating cell differentiation via the Wnt pathway (N?thke 2004 Segditsas and Tomlinson Rilmenidine 2006 and cell polarity and motility in several cell types including astrocytes (Etienne-Manneville et al. (biongenex.com)

Phosphorylation and activity of the tumor suppressor Merlin and the ERM protein Moesin are coordinately regulated by the Slik kinase. (uchicago.edu)
As a molecular mechanism, we demonstrate that PTPRD interacts with aurora kinase A (AURKA), an oncogenic protein that is over-expressed in multiple forms of cancer, including neuroblastoma. (biomedcentral.com)
Cyclin-dependent kinase inhibitor p27Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma. (ox.ac.uk)
Macroautophagy is regulated by numerous cellular factors, including the Class III PI3K (phosphoinositide 3-kinase) Vps34 (vacuolar protein sorting 34). (nih.gov)
We show that guanylate kinase-associated kinesin (GAKIN), a kinesin-like motor protein, directly interacts with a PIP 3 -interacting protein, PIP 3 BP, and mediates the transport of PIP 3 -containing vesicles. (silverchair.com)
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
Active mTORC1 phosphorylates the eukaryotic initiation factor 4E-binding protein-1 (4E-BP1) and 40S ribosomal protein S6 kinase 1 (S6K1) to promote protein synthesis [ 3 , 4 ]. (springer.com)
In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 tumor suppressor protein. (kegg.jp)
In these cells, activation from the actin-binding proteins non-muscle myosin-II (NMII) with the myosin light string kinase (MLCK) is vital for tPCP establishment15. (opioid-receptors.com)
Neuronal loss of the serine-threonine protein kinase Tao , a regulator of the Hippo signaling pathway, results in supernumerary boutons, each of which contain a normal number of active zones. (sdbonline.org)

As a result, TAp73 modulates, and/or indirectly directly, transcriptional programs regulating microtubules and actin dynamics and Golgi organization signaling pathways. (opioid-receptors.com)

In order to further examine the possibility that PTPRD acts as a tumor suppressor gene in neuroblastoma, we initially analyzed the levels of PTPRD mRNA transcripts in a set of 88 neuroblastoma tumors using the R2: microarray analysis and visualization platform ( http://r2.amc.nl ) (University of Amsterdam). (biomedcentral.com)
Studies have also suggested that the HTRA1 enzyme acts as a tumor suppressor, a protein that helps prevent the development of cancerous tumors by keeping cells from growing and dividing in an uncontrolled way. (encyclopedia.pub)
BRCA1 acts as a tumor suppressor by promoting homologous recombination (HR) repair, and alterations in BRCA1 cause HR deficiency, not only in breast and ovarian tissues but also in other tissues. (bvsalud.org)

Multiple endocrine neoplasia syndrome type 1 (MEN-1), loss-of-function germline mutations in the tumor suppressor gene MEN1 increase the risk of developing pituitary, parathyroid and pancreatic islet tumors, and less commonly thymic carcinoids, lipomas and benign adrenocortical tumors. (intechopen.com)

Therefore, targeting drugs molecules in the PTEN signaling pathway may be another strategy to suppress tumor cells by inhibiting tumor activity [ 7 , 8 ]. (aging-us.com)
These ATG proteins also perform an important parallel role in 'noncanonical' autophagy, a lysosome-associated signaling pathway with key functions in immunity, inflammation, cancer, and neurodegeneration. (babraham.ac.uk)

Aurora-A phosphorylates and modulates the power of RASSF1A to associate with microtubule during mitosis (17). (healthandwellnesssource.org)
2009). Spatiotemporal control of mitosis by the conserved spindle matrix protein megator . (up.pt)
The overgrown hematopoietic organs-31 tumor suppressor gene of Drosophila encodes an Importin-like protein accumulating in the nucleus at the onset of mitosis. (rupress.org)
During the interphase of early embryonic cell cycles, the OHO31 protein is present in the cytoplasm and massively accumulates in the nucleus at the onset of mitosis in late interphase and prophase. (rupress.org)
Moreover, the cell cycle-dependent accumulation of OHO31 in the nucleus indicates that this protein may be required for critical nuclear reactions occurring at the onset of mitosis. (rupress.org)

The Von Hippel-Lindau tumor suppressor also known as pVHL is a protein that, in humans, is encoded by the VHL gene. (wikipedia.org)
von Hippel-Lindau (VHL) disease, or von Hippel-Lindau syndrome, is a rare genetic disorder characterized by visceral cysts and benign tumors in multiple organ systems that have subsequent potential for malignant change. (medscape.com)
The resultant 2 encoded von Hippel-Lindau protein (pVHL) products, a 30-kD full-length form (p30) and a 19-kD form (p19), shuttle between the nucleus and the cytoplasm, where they form complexes with other proteins. (medscape.com)

In Drosophila, Hpo and Warts kinases are core components of this pathway and function as tumor suppressors by inhibiting Yorkie (Yki) . (sdbonline.org)

The HTRA1 enzyme also attaches (binds) to proteins in the transforming growth factor-beta (TGF-β) family and slows down (inhibits) their ability to send chemical signals. (encyclopedia.pub)
K-Ras binds RASSF1A to stimulate its tumor suppressing effects. (louisville.edu)

It is a necessity of cell division and plays a role by regulating microtubule dynamics and chromosome aggregation [ 12 ]. (aging-us.com)

nonetheless, the incidence of pediatric colorectal tumors is rising. (medscape.com)
Most cases of colorectal cancer in adolescents and young adults are sporadic, but several genetic syndromes are associated with these tumors in young patients. (medscape.com)
Frameshift mutation of MAPRE3, a microtubule-related gene, in gastric and colorectal cancers with microsatellite instability. (nih.gov)

Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. (cusabio.com)
It may play a role in the stabilization of microtubules, which are rigid, hollow fibers that make up the cell's structural framework (cytoskeleton). (encyclopedia.pub)

The neurofibromatosis-2 homologue, Merlin, and the tumor suppressor expanded function together in Drosophila to regulate cell proliferation and differentiation. (uchicago.edu)
Protein tyrosine phosphatase receptor delta (PTPRD) is a member of a large family of protein tyrosine phosphatases which negatively regulate tyrosine phosphorylation. (biomedcentral.com)
2009). γ-Tubulin ring complexes regulate microtubule plus end dynamics . (up.pt)
NQO1 appears to regulate the degradative fate of other proteins. (dundee.ac.uk)
Several anterograde and retrograde signaling pathways, including the canonical Bone Morphogenic Protein (BMP) pathway , regulate synaptic development in vertebrates and invertebrates. (sdbonline.org)

Neuroblastoma is a major childhood cancer arising from precursor cells of the sympathetic nervous system which is known to acquire deletions and alterations in the expression patterns of PTPRD , indicating a potential tumor suppressor function for this gene. (biomedcentral.com)
This gene is regarded as a potential tumor suppressor gene. (cancerindex.org)
Twelve miRNAs showed concordant expression in tumors vs. normal breast tissues and patient survival (n = 1093), with seven as potential tumor suppressors and five as potential oncomiRs. (cdc.gov)

HIFs are necessary for tumor growth because most cancers demand high metabolic activity and are only supplied by structurally or functionally inadequate vasculature. (wikipedia.org)
HIF is necessary for tumor growth. (standardofcare.com)

Several mechanisms have already been identified because of its actions on cell routine control for instance RASSF1A-mediated G1/S cell routine arrest continues to be from the inhibition of cyclin D1 accumulating in the nucleus (15) and M-phase of cell routine legislation is certainly from the capability of RASSF1A to modulate the experience of anaphase-promoting complicated (16) and microtubule dynamics (8 11 -14). (healthandwellnesssource.org)
We determine a novel function of the tumor suppressor gene, the TAp73 isoform in particular, as an essential regulator of purchase Pitavastatin calcium PCP through the modulation of actin and microtubule cytoskeleton dynamics, demonstrating that is a key player in the organization of ependymal ciliated epithelia. (opioid-receptors.com)
Furthermore, TAp73 is necessary for the asymmetric localization of PCP-core and global signaling modules and regulates polarized microtubule dynamics, which create the rotational PCP. (opioid-receptors.com)

In further studies we have defined novel Ras signaling pathways modulated via RASSF proteins that include the microtubule skeleton, Bax, Salvador, PAR-4, SCF-B-TRCP, XPA and HIPK2. (louisville.edu)
What pathways are this gene/protein implicaed in? (cancerindex.org)

membranous co-expression of CADM1 and LATS2 in lung tumors predicts good prognosis. (cancerindex.org)
Recombinant Kinesin Family, Member 18A ( KIF18A ) belongs to Recombinant Kinesin Family [ 9 ], which is highly expressed in tumors and associated with poor prognosis [ 10 , 11 ]. (aging-us.com)

The heterodimeric TSC complex negatively regulates mTORC1 activity via the GTPase activity of TSC2, towards the small G-protein RHEB (Ras homologue enriched in brain) [ 5 ]. (springer.com)
The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment. (babraham.ac.uk)

Aberrant splicing of the 5' UTR also has been noted in neuroblastoma cell lines and primary tumors, which could potentially cause destabilization of the mRNA sequence [ 10 ]. (biomedcentral.com)
We identified the RASSF1 gene and showed that its protein served as a K-Ras apoptotic effector that was frequently down-regulated in primary tumors. (louisville.edu)

Introduction The cytoskeleton composed of actin microfilaments microtubules and intermediate filaments (IFs) is a fundamental element of eukaryotic cells. (biongenex.com)
PCP establishment depends on the polarization of cytoskeleton and requires the asymmetric localization of core and global regulatory modules, including membrane proteins like Vangl1/2 or Frizzled. (opioid-receptors.com)
There can be an preliminary polarization from the apical microtubule (MT) cytoskeleton, which induces the asymmetric distribution of purchase Pitavastatin calcium PCP-core complexes at apical junctions13. (opioid-receptors.com)
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network. (embl.de)
Crystal structure of the cytoskeleton-associated protein glycine-rich(CAP-Gly) domain. (embl.de)
Sequence homologies between four cytoskeleton-associated proteins. (embl.de)

They have complementary mechanisms to hinder the carcinogenic process by searching free radicals, inhibiting survival and multiplication of malignant cells, as well as reducing invasiveness and angiogenesis of tumors. (researchsquare.com)

2017). Protein phosphatase 1 inactivates Mps1 to ensure efficient spindle assembly checkpoint silencing . (up.pt)
Centrosomes are the major microtubule-organizing centers and function in bipolar spindle formation. (bvsalud.org)
Occupational exposure limits with proteins such as topoisomerase inhibitors, and mitotic and meiotic spindle poisons. (cdc.gov)

actin related protein 2/3 comple. (gsea-msigdb.org)

The resultant protein is produced in two forms, an 18 kDa and a 30 kDa protein that functions as a tumor suppressor. (wikipedia.org)
Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin. (uchicago.edu)
Protein tyrosine phosphatase receptor delta ( PTPRD ) is an important regulator of axon growth and guidance and is highly expressed in the central nervous system where it functions as a transmembrane homophilic neuronal cell adhesion molecule [ 1 ]. (biomedcentral.com)
However the in-depth molecular systems where RASSF1A functions being a tumor suppressor stay to become elucidated recent proof signifies that cell routine legislation is an essential requirement of its function. (healthandwellnesssource.org)
The BRCA1-interacting protein Obg-like ATPase 1 (OLA1) functions in centriole duplication. (bvsalud.org)
Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)
The protein functions as a tumor suppressor. (standardofcare.com)

During interphase, the centrosome nucleates microtubule outgrowth. (lookformedical.com)
The function of BRCA1 in the translocation of the DNA damage signal from the nucleus to the centrosome to induce centrosome amplification after CDDP treatment might support its role as a tumor suppressor. (bvsalud.org)
Cancer-derived variants of BRCA1, BARD1, OLA1, and RACK1 do not interact, and aberrant expression of these proteins results in abnormal centrosome duplication in mammary-derived cells, and rarely in other cell types. (bvsalud.org)

It has been reported that TET1 is a tumour suppressor in several cancers. (nih.gov)
Alterations in breast cancer gene 1 (BRCA1), a tumor suppressor gene, increase the risk of breast and ovarian cancers. (bvsalud.org)

In vivo functional analysis of the human NF2 tumor suppressor gene in Drosophila. (uchicago.edu)
The tumor suppressor gene overgrown hematopoietic organs-31 (oho31) of Drosophila encodes a protein with extensive homology to the Importin protein of Xenopus (50% identity), the related yeast SRP1 protein, and the mammalian hSRP1 and RCH1 proteins. (rupress.org)
This study shows that Schip1 , a Drosophila homolog of the mammalian Schwannomin interacting protein 1 (SCHIP1), provides a link between Ex and Hpo. (sdbonline.org)

Autophagy is a fundamental catabolic process coordinated by a network of autophagy-related (ATG) proteins. (babraham.ac.uk)
Conjugation of the Atg8 (autophagy related 8) family of ubiquitin-like proteins to phospholipids of the phagophore is a hallmark of macroautophagy/autophagy. (babraham.ac.uk)
The autophagophore membrane then elongates and encloses the molecules to be degraded forming an autophagosome, which occurs in two separate conjugation reactions catalyzed by autophagy-related proteins (ATGs). (hindawi.com)

Breast Cancer Type 2 susceptibility protein (BRCA2) is a tumor-suppressor protein reported to be involved in double-strand break repair, homologous recombination and S-phase checkpoint activation. (thermofisher.com)

Silent information regulator 2 (Sir2) proteins, or sirtuins, are protein deacetylases dependent on nicotine adenine dinucleotide (NAD) and are found in organisms ranging from bacteria to humans. (biomedcentral.com)

A recombinant fusion protein containing a sequence corresponding to amino acids 2800-3050 of human BRCA2. (thermofisher.com)

The APC protein, which comprises of 2843 amino acids, plays an important role in the β-catenin nuclear localization ( 8 ). (spandidos-publications.com)
The gene encodes a phosphoprotein of 522 amino acids made of three domains: a central hydrophobic domain of eight repeats of 42-44 amino acids each, displaying similarity to the arm motif found in junctional and nucleopore complex proteins, and flanked by two hydrophilic NH2- and COOH-terminal domains. (rupress.org)

The C terminus of CUL4A interacts with Band proteins which recruits the E2 (22 23 The N terminus of CUL4A interacts using the substrate adaptor DDB1 which either straight interacts using a substrate or indirectly recruits a substrate through a second adaptor. (healthandwellnesssource.org)

We subsequently identified several more RASSF family members and were the first to show they also have Ras death effector/tumor suppressor properties. (louisville.edu)

But in the cellular environment, newly synthesized proteins are at great risk of aberrant folding and aggregation, potentially forming toxic species. (nature.com)
Recent advances suggest that an age-related decline in proteostasis capacity allows the manifestation of various protein-aggregation diseases, including Alzheimer's disease and Parkinson's disease. (nature.com)
Figure 1: Competing reactions of protein folding and aggregation. (nature.com)
Ellis, R. J. & Minton, A. P. Protein aggregation in crowded environments. (nature.com)
Aβ1-40 mediated aggregation of proteins and metabolites unveils the relevance of amyloid cross-seeding in amyloidogenesis. (shengsci.com)

PTEN (phosphatase and tensin homolog deleted on chromosome 10) belongs to a cancer suppressor gene (one of the protein phosphatases). (aging-us.com)

Herein we selected a Mendelian genetics form of familial cancer such as hereditary tumor syndromic endocrine neoplasias caused by highly penetrant germline mutations leading to pheochromocytoma-paraganglioma syndromes. (intechopen.com)
In the case of multiple endocrine neoplasia type 2 (MEN 2), gain-of-function germline mutations clustered in specific codons of the RET proto-oncogene increase the risk of developing medullary thyroid carcinoma (MTC), phaeochromocytoma and parathyroid tumors. (intechopen.com)

In the presence of nutrients, mTORC1 is activated and promotes cell growth, including protein synthesis and energy storage. (springer.com)

2002 2003 Astrocytes express the astrocyte-specific glial fibrillary acidic protein (GFAP) vimentin nestin and in some circumstances synemin (Sultana et al. (biongenex.com)

Recombinant GAKIN and PIP 3 BP form a complex on synthetic liposomes containing PIP 3 and support the motility of the liposomes along microtubules in vitro. (silverchair.com)
2000 The expression levels of these proteins vary during LRRC48 antibody astrocyte differentiation astrogliosis and also in astrogliomas suggesting Rilmenidine that IFs may contribute to astrocyte motility (Dahlstrand et al. (biongenex.com)
2005 In fact GFAP and vimentin knockout mice have revealed that these IF proteins are essential for astrocyte motility both in vivo and in vitro (Lepekhin et al. (biongenex.com)

1998 Depolymerization of microtubules leads to a retraction of IFs close to the nucleus. (biongenex.com)

Patients who suffer from FAP also have increased risk of extra-colonic manifestations, including duodenal polyposis, sebaceous cysts, congenital hypertrophy of the retinal pigment epithelium (CHRPE) and tumors in the upper gastrointestinal tract, thyroid gland and brain ( 5 , 6 ). (spandidos-publications.com)
Clinical hallmarks of VHL disease include the development of retinal and central nervous system (CNS) hemangioblastomas (blood vessel tumors), pheochromocytomas , multiple cysts in the pancreas and kidneys, and an increased risk for malignant transformation of renal cysts into renal cell carcinoma. (medscape.com)

In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)

2012 We show here that in addition to its connection with microtubules and microfilaments (Watanabe et al. (biongenex.com)

Cancer is a complex genetic disease caused by abnormal alteration (mutations) in DNA sequences that leads to dyregulation of normal cellular processes thereby driving tumor growth. (intechopen.com)
Hartl, F. U. Molecular chaperones in cellular protein folding. (nature.com)
Skach, W. R. Cellular mechanisms of membrane protein folding. (nature.com)

The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling. (uchicago.edu)

Here, we reported that the expression of TET1 in glioma tissue was significantly lower than the corresponding non-tumour normal tissues, and the concentration of TET1 is negatively correlated with the glioma WHO classification. (nih.gov)
Thereafter, the OHO31 protein is predominantly expressed, albeit at reduced levels, in proliferating tissues. (rupress.org)
The HTRA1 gene provides instructions for making a protein that is found in many of the body's organs and tissues. (encyclopedia.pub)

Role of tau N-terminal motif in the secretion of human tau by End Binding proteins. (nih.gov)
Self-masking in an intact ERM-merlin protein: an active role for the central alpha-helical domain. (uchicago.edu)
Most of these studies focus on the identification of splicing variants in tumor, while little has been explored on the role of alternative splicing in tumors of different stages and molecular subtypes. (biomedcentral.com)
Biochemical and genetic data suggest a role as a tumor suppressor. (cancerindex.org)
2001 Here we use an in vitro wound-healing assay to characterize IF rearrangements during astrocyte migration and determine the role of microtubules and associated proteins in these events. (biongenex.com)
We have shown that this process is triggered by recruitment of ATG16L1 by the vacuolar-type H-translocating ATPase (V-ATPase) proton pump, suggesting a role for pH sensing in recruitment of Atg8-family proteins to single membranes. (babraham.ac.uk)

Six miRNAs had concordant expression in both tumors and breast cancer patient blood samples compared with the normal control samples. (cdc.gov)

Neuroblastoma is derived from primitive cells of the sympathetic nervous system, and is the most common extracranial solid tumor in children accounting for 15% of all childhood cancer deaths [ 13 ]. (biomedcentral.com)
The HTRA1 enzyme helps break down many other kinds of proteins in the space surrounding cells (the extracellular matrix). (encyclopedia.pub)
Stage, age, and other biological features in tumour cells are important prognostic factors for risk stratification and disease management. (biomedcentral.com)
1982 Herrmann and Wiche 1987 Moreover microtubule-associated motors promote the transport of IFs along microtubules in fibroblasts and neuronal cells and contribute to axon elongation (Liao and Gundersen 1998 Yabe et al. (biongenex.com)
Cells were lysed and analyzed by immunoblotting (A) or fixed and … Prime candidates were microtubule-associated motor proteins that bind vimentin and neurofilaments and. (biongenex.com)
Cytokinesis in animal cells relies on a centralspindlin complex consisting of male germ cell RacGap (MgcRacGAP) and mitotic kinesin-like protein 1 (MKLP1). (shengsci.com)
We analyzed the subcellular localization of select proteins that make up these modules in ependymal KPNA3 cells and the effect of loss on their localization. (opioid-receptors.com)
The foamy stromal cells between the capillaries stain positive for glial fibrillary acid protein and neuron-specific enolase. (medscape.com)
A highly expressed protein in tumor cells, encoded by Tpt1 gene. (bvsalud.org)

ERM proteins and merlin: integrators at the cell cortex. (uchicago.edu)
Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex. (uchicago.edu)

We further demonstrate that PTPRD has a tumor suppressor function in neuroblastoma through dephosphorylating and destabilizing AURKA, leading to a downstream decrease of MYCN protein. (biomedcentral.com)
It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization. (cusabio.com)
The VHL syndrome is inherited by one mutation in the VHL protein that causes the protein's normal function to be lost or altered. (standardofcare.com)
Within this function we examined the subcellular localization of PCP-regulatory protein in ECs and the result of gene reduction on the localization. (opioid-receptors.com)

The decrease in centrosomal OLA1 caused by Aurora A-mediated polyubiquitination promotes the recruitment of pericentriolar material proteins in G2 phase. (bvsalud.org)

Anatomy21

Organisms9

Diseases25

Chemicals and Drugs103

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes68

Disciplines and Occupations1

Information Science3

Health Care1

Genes17

Degradation11

Apoptosis4

Regulation15

Adenomatous4

Kinase10

Transcriptional1

Acts as a tumor3

Mutations in the tumor1

Signaling pathway2

Mitosis5

Hippel-Lindau3

Kinases1

Binds2

Regulating microtubule dynamics1

Colorectal3

Stabilization of microtubules2

Regulate5

Potential tumor3

Necessary for tumor growth2

Dynamics3

Pathways2

Prognosis2

Regulates2

Primary tumors2

Cytoskeleton6

Angiogenesis1

Spindle3

Actin1

Functions7

Centrosome3

Cancers2

Drosophila3

Autophagy-related3

Homologous recombination1

Humans1

Recombinant fusion1

Amino acids2

Interacts1

RASSF1

Aggregation5

Homolog1

Germline2

Including protein synthesis1

20021

Motility3

Nucleus1

Cysts2

Oncogenes1

Microfilaments1

Cellular3

Endocytosis1

Tissues3

Role6

MiRNAs1

Cells9

Cell cortex2

Function4

Promotes1