Microtubules cell cycle arrest. Medical search. Frequent questions

Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)
Further experiments proved that it induced cell death by mitotic catastrophe and apoptosis. (bvsalud.org)
Ultimately triggers programmed cell death, also known as apoptosis. (buy-pharma.md)
induce apoptosis (cell death) of rapidly proliferating parasites and cancer cells! (cures.news)
Taxol disrupts normal microtubule dynamics, activating the spindle checkpoint, which triggers mitotic arrest and/or cell death via apoptosis [3,4]. (nanolive.ch)
To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (worldsbest.rehab)
Crocin, the main active saffron constituent, mitigates dichlorvos-induced oxidative stress and apoptosis in HCT-116 cells. (sciendo.com)
Oncaspar (pegaspargase) is a pegylated version of L-asparaginase, which converts L-asparagine to ammonia and L-aspartic acid, reducing available asparagine resulting in decreased protein synthesis, inhibition of tumor cell proliferation, and increased apoptosis (NCI Drug Dictionary). (jax.org)
Yatein has also been found to induce apoptosis, or programmed cell death, in cancer cells, making it a potential anti-cancer agent. (thebiotek.com)
Its specifically induces cell cycle arrest and apoptosis of tumour cells but not normal cells by downregulating the expression of CDC25c (cell division cycle 25C) in tumor cells. (biokine.com)
They also found that both the free and the FEN/RAPA-loaded microparticles induced apoptosis in these cancer cells. (cab-aurel.com)

Its mechanism of action is complex and includes depolymerization of microtubules. (medscape.com)
Microtubule polymerization and depolymerization dynamics were examined in living cells and under cell-free conditions. (cytoskeleton.com)
It is a cytotoxic antimicrotubule agent that binds to the β-tubulin subunit of microtubulin, resulting in stabilization of microtubules and prevention of depolymerization, leading to inhibition of microtubule dynamics, cell-cycle arrest and eventually apoptotic cell death ( 3 , 4 ). (iiarjournals.org)
2002). G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells. (sciendo.com)

Our study demonstrates that survivin and APE1/Ref-1 are significantly higher in human prostate cancer specimens compared to noncancerous controls and that APE1/Ref-1 redox-specific inhibition with small molecule inhibitor, APX3330 and a second-generation inhibitor, APX2009, decreases prostate cancer cell proliferation and induces cell cycle arrest. (oncotarget.com)
IMB5046 is a nitrobenzoate microtubule inhibitor we reported previously. (bvsalud.org)
Conclusively, our data reveal a novel nitrobenzoate microtubule inhibitor with improved aqueous solubility and can overcome multidrug resistance. (bvsalud.org)
Rosabulin (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. (medchemexpress.cn)
Stivarga (regorafenib) is an inhibitor of several kinases including VEGFR, RET, KIT, PDGFR and RAF, thereby inhibiting tumor angiogenesis and tumor cell proliferation ( PMID: 24756792 ). (jax.org)
In-vitro BKT300 synergizes with SoC therapies in inhibiting tumor cell growth including: BCL-2 inhibitor Ventoclax, topoisomerase inhibitor Irinotecan, and alkylating agent Temozolomide. (biokine.com)
Vinflunine Tartrate is a tartrate salt of vinflunine that is a new microtubule inhibitor with IC50 of 18.8 nM. (activebiopharma.com)

It also directly binds to BubR1, a kinetochore-associated kinase implicated in the mitotic checkpoint, the major cell cycle control pathway in which unattached kinetochores prevent anaphase onset. (rupress.org)
Tubeimoside I binds tubulin at the colchicine site, inhibiting microtubule polymerization. (lktlabs.com)
These effects follow internalization of the C36L1 peptide which then selectively binds to microtubules and destabilizes the tubulin filaments. (cytoskeleton.com)
It is a cytoskeletal drug, which binds to a specific site on β-tubulin [2], a major component of the microtubules that form the structure and shape of eukaryotic cells. (nanolive.ch)
Oncovin (vincristine) binds microtubules and prevents mitotic spindle formation, resulting in cell-cycle arrest (NCI Drug Dictionary). (jax.org)
In helminthes, ABZ binds to β-tubulin and inhibits microtubule polymerisation. (edu.au)
Zilovertamab vedotin (VLS-101, MK-2140) binds to ROR1-expressing tumor cells, resulting in internalization of the ADC-ROR1 complex. (adcreview.com)

The mechanism of action for Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle [1] . (medchemexpress.cn)

Reversible proteasome inhibition disrupts pathways supporting cell growth, thus decreasing cancer cell survival. (medscape.com)
Binding of MMAE to tubulin disrupts the microtubule network within the tumor cell, subsequently inducing cell-cycle arrest and apoptotic tumor cell death. (adcreview.com)
They found that FZ disrupts microtubules by interacting with tubulin at the colchicine binding site and causing a conformation change that blocks microtubule formation. (cab-aurel.com)

elicits antiproliferative and proapoptotic activities in vitro in solid and hematologic tumor cells. (medscape.com)
Because APE1/Ref-1 is expressed and elevated in prostate cancer, we sought to characterize APE1/Ref-1 expression and activity in human prostate cancer cell lines and determine the effect of selective reduction-oxidation (redox) function inhibition on prostate cancer cells in vitro and in vivo . (oncotarget.com)
We have combined the proteomic analysis of Xenopus laevis in vitro-assembled chromosomes with RNA interference and live cell imaging in HeLa cells to identify novel factors required for proper chromosome segregation. (rupress.org)
The authors found that the peptide induces apoptotic effects on multiple cancer cells both in vitro and in vivo , inhibits tumor cell migration and invasion, and arrests cell cycle primarily in the G2M phase. (cytoskeleton.com)
BK011P) was an essential reagent in this study, complementing the in vivo results and in vitro cell culture data which demonstrated conclusively that the C36L1 peptide targets microtubules in exerting its anti-tumor effects. (cytoskeleton.com)
2015. A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays anti-tumor activity against melanoma in vitro and in vivo . (cytoskeleton.com)
In recent years, our group has focused on the effect of desmopressin in combination with docetaxel in different prostate cancer cell lines in vitro as well as in preclinical models including xenograft animal models ( 9 , 10 ). (iiarjournals.org)
MATERIALS AND METHODS: We examined the effects of IMB5036 on cancer cells by in vitro assays, a molecular docking model and in vivo tumour models. (bvsalud.org)
Rosabulin (STA 5312) demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, including hematologic and solid tumor cell lines of various origins (e.g. leukemia, lymphoma, breast, colon, uterine), with IC 50 values extending down into the nanomolar range. (medchemexpress.cn)
Our experiment shows that this cell line at least, can tolerate multinucleation over short periods of time, which may prove useful for understanding of the properties of multinucleated cells, a subject of interest for researchers attempting to use cells cultured in vitro for tissue engineering [11]. (nanolive.ch)
Researchers from the University of Toronto found that fenbendazole (FZ) can disrupt microtubules, cause cell cycle arrest and kill cancer cells in human melanoma cells in the laboratory (in vitro). (cab-aurel.com)

The knockdown of KSRP inhibited the proliferation of MCF7 and MCF7/adriamycin (MCF7/ADR) cells. (bvsalud.org)
Commonly used drugs act to block signal transduction and cell cycle progression in different phases, thereby blocking smooth muscle cell (SMC) proliferation or intimal hyperplasia in the stented arterial site. (statpearls.com)
Aberrant migration and proliferation of cancer cells are the hallmark of metastatic tumors. (biokine.com)
The scientists investigated the cellular effects of FZ by using a clonogenic assay, in which H460 cells were treated with 1 uM FZ for 48 hours and their colony formation was assessed after Hoechst 33342 staining (i & ii) or TdT staining (iv & v). In this test, both free FZ and the FEN/RAPA-loaded micelles effectively inhibited cancer cell proliferation at concentrations up to 2090 nM. (cab-aurel.com)
However, potentially erroneous characterization of cytotoxicity and cell proliferation can arise if verification of baseline interaction of test article with method employed is neglected. (cdc.gov)
Non-tumorigenic Beas-2B cells were treated with graded concentrations of benzo[a]pyrene (B[a]P) for 24 and 48h prior to cytotoxicity and proliferation assessment with commonly used MTT, MTS, WST1, and Alamar Blue assays. (cdc.gov)

Another reason synchrony is important is the control for amount of DNA content, which varies at different parts of the cell cycle based on whether DNA replication has occurred since the last round of completed mitosis and cytokinesis. (wikipedia.org)
M: A mutant screen of budding yeasts with mitotic arrest identified CDC16, CDC23, and CDC27 as key genes that, when mutated, cause arrest in mitosis. (wikipedia.org)
While in G1 the cell synthesizes messenger RNA (mRNA) and proteins in preparation for subsequent steps of interphase leading to mitosis. (wikipedia.org)
Vincristine inhibits cellular mitosis by inhibition of intracellular tubulin function, binding to microtubules, and synthesis of spindle proteins in the S phase. (medscape.com)
As each chromosome contains a single centromere, it remains unclear how acentric fragments derived from shattered chromosomes are inherited between daughter cells during mitosis 6 . (nature.com)
Here we tracked micronucleated chromosomes with live-cell imaging and show that acentric fragments cluster in close spatial proximity throughout mitosis for asymmetric inheritance by a single daughter cell. (nature.com)
We have already written a detailed blogpost about the characteristic phases of mitosis but as a reminder, metaphase describes the stage when the cell's chromosomes align along an invisible line in the center of the cell called the metaphasic plate. (nanolive.ch)
Cells entering mitosis in the presence of Taxol form abnormal spindles that contain additional spindle poles. (nanolive.ch)
The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (worldsbest.rehab)
Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (worldsbest.rehab)
Another drug category is taxanes, which interfere with microtubule function, which is necessary for the M phase (mitosis). (statpearls.com)
Required for normal cell cycle progression from G2 to mitosis. (helixlabs.ai)

Vinflunine, similar to vinorelbine, vinblastine and vincristine, inhibited microtubule assembly at micromolar concentrations (IC50 =3.1 μM). (activebiopharma.com)

Centromere-associated protein-E (CENP-E) is an essential mitotic kinesin that is required for efficient, stable microtubule capture at kinetochores. (rupress.org)
Mapping movement: the coloured lines chart the movement (purple to yellow) of kinetochores (green dots) as microtubules hook onto them to separate the chromosomes (cyan). (scienceinschool.org)
By examining mouse egg cells under the microscope, EMBL scientist Tomoya (Tomo) Kitajima was the first to track the movements of all of an egg cell's kinetochores during the whole of cell division - all 10 hours of it. (scienceinschool.org)
We were able, for the first time, to keep track of all the kinetochores throughout cell division - so there's not a single time point where it's ambiguous where that part of the chromosome is - and that's really a breakthrough in the field, achieving this in these very large and light-sensitive cells," says Jan Ellenberg, who heads the research group. (scienceinschool.org)
Bod1-depleted cells form syntelic attachments that can oscillate and generate enough force to separate sister kinetochores, suggesting that microtubule-kinetochore interactions were intact. (rupress.org)

Taxol works by stabilizing the microtubule polymer, preventing the disassembly of microtubules during the fourth phase of cell division, metaphase [3,4]. (nanolive.ch)

Like the child's rod pulling a toy fish by its magnet, a microtubule catches a chromosome by its kinetochore - a cluster of protein and genetic material at the centre of the chromosome's X shape. (scienceinschool.org)
Mitotic chromosome segregation requires the coordination of both regulatory and mechanical molecular machines and culminates in the delivery of two complete sets of chromosomes to two daughter cells. (rupress.org)
The stochastic inheritance of chromosome fragments by both newly formed daughter cells could in part contribute to the alternating DNA copy-number states that are characteristic of chromothripsis 2 . (nature.com)
The maintenance of a single centromere per chromosome is critical for establishing bipolar microtubule attachments to the mitotic spindle and achieving high-fidelity genome segregation 17 . (nature.com)

It stops cancer from spreading by interfering with the microtubule dynamics which in turn leads to cell cycle arrest and eventually cell death. (edu.au)

1996). Resistance to apoptotic cell death in a drug resistant T cell leukaemia cell line. (sciendo.com)

Its proposed mechanism of action is an iron/zinc chelator that depletes iron within the cell. (wikipedia.org)
It is an alkylating agent, and its mechanism of action of active metabolites may involve cross-linking of DNA, which may interfere with growth of normal and neoplastic cells. (medscape.com)
lation can be a preponderant regulatory mechanism of signal transduction cascades in eukaryotic cells that is catalyzed by kinases and reversed by protein phosphatases. (gabapathway.com)
The scientists suggest that these multiple mechanisms of cytotoxicity are the collective underlying mechanism of FZ induced preferential elimination of cancer cells in a model system in vivo. (cab-aurel.com)

However, most fragments derived from pulverized chromosomes are acentric and cannot directly bind to spindle microtubules 14 . (nature.com)

The proteasome pathway is an enzyme complex existing in all cells, which degrades ubiquitinated proteins that control the cell cycle and cellular processes and maintains cellular homeostasis. (medscape.com)

Cellular processes like genome duplication and cell division stop. (wikipedia.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
in other, similar cellular and animal models, this compound inhibits cell and tumor growth. (lktlabs.com)
Specifically, it hinders the breakdown of microtubules in the cellular cytoskeleton. (buy-pharma.md)
The sub-cellular resolution of the microscopes allows us to observe the consequences of mitotic catastrophe in spectacular detail while EVE Analytics , Nanolive's complete software allows to quantify the increase in average cell dry mass density resulting from multinucleation. (nanolive.ch)
Modulation of glutathione content and the effect on methionine auxotrophy and cellular distribution of homocysteine and cysteine in mouse cell lines. (shengsci.com)

Notably, it was a poor substrate of P-glycoprotein and exhibited potent cytotoxicity against drug-resistant tumor cells. (bvsalud.org)
We found that these compounds exhibit potent anticancer effects through the reaction with microtubules, causing cell cycle arrest. (shengsci.com)

It is an artificial activation of naturally occurring cell cycle checkpoints, induced by exogenous stimuli controlled by an experimenter. (wikipedia.org)
Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. (helixlabs.ai)

Alkenyl group is responsible for the disruption of microtubule network formation in human colon cancer cell line HT-29 cells. (shengsci.com)
However, other effects, such as induction of cell cycle arrest at G2+M (associated with mitotic accumulation), disruption of the microtubular network of interphase cells and formation of paracrystals, generally required 3- to 17-fold higher concentrations of vinflunine than the other vinca alkaloids. (activebiopharma.com)
Cells had been released by mechanised disruption by moving the cells 15C20 moments through a cup pipette. (bms-911543.com)

Bod1 depletion does not affect the activity or localization of Aurora B but does cause mislocalization of the microtubule depolymerase mitotic centromere- associated kinesin and prevents its efficient phosphorylation by Aurora B. Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles. (rupress.org)
PTOX prevents cell growth via polymerization of tubulin, leading to cell cycle arrest and suppression of the formation of the mitotic-spindles microtubules. (ac.ir)

and microtubule-disturbing agents paclitaxel and docetaxel. (jcancer.org)
In this study, the ability of CRPC cells to grow and develop in vivo tumors in an animal model was evaluated, in order to investigate the anti-tumor effect of desmopressin in combination with docetaxel. (iiarjournals.org)
Thus, as 'proof of principle', the aim of this study was to evaluate the effect of desmopressin and docetaxel on in vivo tumor growth and development in an orthotopic animal model using CRPC PC3 cells. (iiarjournals.org)

Together, these results revealed for the first time that ABZ interacts with microtubules in human cancer cells and causes their polymerisation. (edu.au)
It also interacts with the p53 protein to stabilize it, and it interferes with glucose metabolism by inhibiting hexokinase activity in cancer cells. (cab-aurel.com)

Rather than mounting a long-term mitotic arrest, these cells enter anaphase and divide their chromosomes in multiple directions, resulting in a multi-nucleated cell. (nanolive.ch)

This CDR exhibits both anti-tumor activity and functions as a microtubule destabilizing molecule. (cytoskeleton.com)
Here, the authors investigated whether its microtubule-destabilizing effect is responsible for its anti-tumor activity. (cytoskeleton.com)

Yatein has been found to have a variety of effects on cell function and signal transduction. (thebiotek.com)

Furthermore, synchronization of large numbers of cells into the same phase allows for the collection of large enough groups of cells in the same cycle for the use in other assays, such as western blot and RNA sequencing. (wikipedia.org)
Cell growth assays revealed that the anti-proliferative activity of ABZ was not only effective on the PTX-sensitive human ovarian carcinoma cell line lA9, but also on its PTX-resistant sub-line, lA9PTX22. (edu.au)

Sequencing of daughter cell pairs derived from micronucleated mother cells demonstrated that complex rearrangements are indeed a common outcome of micronucleus formation. (nature.com)
BKT300 Inhibits cancer cell migration by inhibition of F-actin and microtubules formation. (biokine.com)
Confocal images demonstrated that ABZ disrupted the microtubule network and caused formation of short microtubule bundles in both cell lines. (edu.au)

As an egg cell, or oocyte, matures inside a woman's ovary, it undergoes a type of cell division called meiosis, in which the pairs of chromosomes inside it are lined up and fished apart, and half of them are expelled. (scienceinschool.org)
In each of these cells, after DNA duplication, homologous chromosomes exchange genetic material during crossing over. (scienceinschool.org)
Homologous chromosomes line up at the primary egg cell's equator and are then fished apart by microtubules. (scienceinschool.org)
Tomo used software that had been previously developed in Jan's lab, which allowed him to programme a laser scanning microscope to find the chromosomes in the egg cell's vast inner space, and then film them during cell division. (scienceinschool.org)
The oocyte is a big cell, but the chromosomes sit in only a small part of that cell, and that's what we were interested in. (scienceinschool.org)
By focusing the microscope only on the part of the cell where the chromosomes are, Tomo was able to obtain high-resolution images at short intervals of only one and a half minutes, which gave him a very clear picture of the process. (scienceinschool.org)
Only when all chromosomes are aligned, and every kinetochore is properly attached to a bundle of microtubules, can the cell proceed to enter anaphase. (nanolive.ch)

Overall survival was statistically superior for cisplatin/pemetrexed versus cisplatin/gemcitabine in patients with adenocarcinoma and large-cell carcinoma histology, while patients with squamous cell histology had a significant improvement in survival with cisplatin/gemcitabine versus cisplatin/pemetrexed [ 81 ] . (encyclopedia.pub)

Induced cell cycle arrest is the use of a chemical or genetic manipulation to artificially halt progression through the cell cycle. (wikipedia.org)
The cells can be induced to arrest as they arrive (at different time points) at a certain phase, so that when the arrest is lifted (for instance, rescuing cell cycle progression by introducing another chemical) all the cells resume cell cycle progression at the same time. (wikipedia.org)
Mimosine is a plant amino acid that has been shown to reversibly inhibit progression beyond G1 phase in some human cells, including lymphoblastoid cells. (wikipedia.org)
The use of serum deprivation - partially or completely removing the serum and its nutrients - has been shown to arrest and synchronize cell cycle progression in G0 phase, for example in neonatal mammalian astrocytes and human foreskin fibroblasts. (wikipedia.org)
This intracellular complex increases the expression of p27 and blocks the progression of the cell cycle from the G1 phase to the S phase (DNA synthesis). (statpearls.com)

Synthesis of folic acid functionalized gold nanoclusters for targeting folate receptor-positive cells. (nottingham.ac.uk)

Since the antibody is targeted (can recognize cancer cell surface antigens), the cytotoxic molecules can be selectively "transported" directly into the tumor cells to exert an anti-cancer effect while avoiding effects on healthy cells. (biochempeg.com)

Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin. (lktlabs.com)

And, because the microscope was only firing light at that small region of the oocyte, it did less damage to the cell, which enabled the scientists to keep up the imaging for the 10 hours of cell division (see box for more on smart microscopy ). (scienceinschool.org)

Lung cancer is the leading cancer killer in both men and women in the Unites States, with over 135,000 deaths expected during 2020 [ 1 ] Small cell lung cancer accounts for 15%, and non-small cell lung cancer (NSCLC) for 85% of lung cancer cases [ 2 ] . (encyclopedia.pub)

Patients should have an ophthalmic examination (including visual acuity and slit lamp examination) performed by an eye care professional at baseline, before the subsequent 3 treatment cycles, and as clinically indicated whilst on treatment (see section 4.4). (medicines.org.uk)

these 2 events, in turn, can inhibit growth of neoplastic cells. (medscape.com)

3T3-derived pre-adipocyte cells were exposed to 1 μM of Taxol and imaged using the 3×3 gridscan mode (a field of view of 275 μm 2 ) on Nanolive's automated microscope the CX-A . Images were captured every 3 mins for 20 h. (nanolive.ch)

In this study, by comparing the activity of normal cell lines and cancer cell lines after treating with resveratrol, it was found that resveratrol has more significant cytotoxicity in cancer cell lines. (mdpi.com)

J Cell Biol (2003) 162 (4): 551-563. (rupress.org)
J Cell Biol (2007) 179 (2): 187-197. (rupress.org)
6] Gorbsky G.J. Trends Cell Biol. (nanolive.ch)

Tubeimoside I inhibits LPS-stimulated production of TNF-α, IL-1β, and IL-6, preventing the development of pulmonary edema and infiltration of inflammatory cells in vivo. (lktlabs.com)
Among these derivatives, 8a exhibited more than 10-fold antiproliferation activity in several tumor cells than KX01 and significantly improved in vivo antitumor effects. (mirnainhibitors.com)

Intrinsic apoptotic pathway and G2/M cell cycle arrest involved in tubeimoside I-induced EC109 cell death. (lktlabs.com)

Twenty-five of these cell cultures stemmed from normal and 21 from tumor tissues. (shengsci.com)

14-16 Imatinib, cediranib, and pexidartinib have also demonstrated activity in some of the rarest, chemo-refractory STS subtypes, including dermatofibrosarcoma protuberans, 17,18 alveolar soft part sarcoma (ASPS), 19 and tenosynovial giant cell tumour. (emjreviews.com)

Frog egg cell extracts have been used extensively in cell cycle research because they are relatively large, reaching a diameter of 1mm, and so contain large amounts of protein, making protein levels more easily measurable. (wikipedia.org)
p27Kip1 protein levels are elevated in arresting cells. (wikipedia.org)

Laboratory studies suggest that ginger can protect brain cells from the plaques that cause Alzheimer's disease, but this effect has not been studied in humans. (mskcc.org)
Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (worldsbest.rehab)
The results presented in this study provide some information on the effect of ABZ on the microtubule network which could relate to its apoptotic effect in human ovarian carcinoma cells. (edu.au)

Squamous cell carcinoma, c. (encyclopedia.pub)

Anatomy41

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Depolymerization4

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Mitosis12

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Kinetochores5

Disassembly1

Chromosome4

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Proteins1

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Mitotic arrest1

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