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  • PMID
  • They contain an N-terminal region that targets the protein to microtubule polymers and a C-terminal region that is able to associate with Janus kinase (Jak) family members, such as Tyk2 or Jak1 [ PMID: 15277531 ]. (ebi.ac.uk)
  • JAKMIP1 has also been shown to interact with GABA(B) receptor R1 subunits [ PMID: 14718537 ], and may be involved in microtubule-dependent transport of the GABA-B receptor [ PMID: 17532644 ]. (ebi.ac.uk)
  • Vitro
  • Kinetics of Microtubule Polymerization in Vitro . (pnas.org)
  • These complexes formed spontaneously in vitro when taxol-stabilized microtubules were mixed with sonically disrupted axoplasm from the giant axon of the squid Loligo pealei. (rupress.org)
  • These results appear to provide a molecular explanation for inhibition by chlorpromazine of fast axonal transport of proteins in vitro in frog sciatic nerve, and provide a fresh clue as to the primary mechanism for the psychotropic effect of this drug. (aspetjournals.org)
  • neuron
  • The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. (wikipedia.org)
  • Another example that involves symmetry breaking is the establishment of dendrites and axon during neuron development, and the PAR protein network in C. elegans. (wikipedia.org)
  • induces
  • Nocodazole, a microtubule-disrupting agent, induces a major retraction of neurites in control cultures, but pretreatment with PREG/MePREG is protective. (pnas.org)
  • stability
  • Vinca alkaloids, such as vincristine and vinblastine, are a group of natural product antimitotic drugs that disrupt microtubule stability and induce mitotic arrest and apoptosis ( 5 ). (aacrjournals.org)
  • The research group has ascertained that a molecule known as MAP1A connects NMDA glutamate receptors as they are being transported to the synapses to the microtubules, stabilizing the receptors and preventing them from becoming "derailed," and playing a role in improving the overall efficiency and stability of the transport process. (eurekalert.org)
  • MAPs bind to the tubulin subunits that make up microtubules to regulate their stability. (wikipedia.org)
  • Thus, the hyperphosphorylation of tau leads to massive detachment, which in turn greatly reduces the stability of microtubules in nerve cells. (wikipedia.org)
  • One of tau's main functions is to modulate the stability of axonal microtubules. (wikipedia.org)
  • 1997
  • In 1997, Wischik and his team moved to the University of Aberdeen, where they continued their research into tau pathology and protein aggregation inhibition. (wikipedia.org)
  • mammalian
  • LC3-II is the first mammalian protein identified that specifically associates with autophagosome membranes. (labome.org)
  • Mutant Chinese hamster cells resistant to podophyllotoxin are affected in a protein P1 that was later identified as the mammalian HSP60 or chaperonin protein. (wikipedia.org)
  • polypeptides
  • Taking porcine MAP 2 as a reference, we have detected polypeptides with the same electrophoretic mobility in brain microtubules from cow, sheep, rat and chicken. (springer.com)
  • These data allow the identification of several vesicle-associated proteins of the squid giant axon and suggest that one or more of these polypeptides mediates vesicle binding to microtubules. (rupress.org)